scholarly journals Comparative study of chitosan/fibroin–hydroxyapatite and collagen membranes for guided bone regeneration in rat calvarial defects: micro-computed tomography analysis

2014 ◽  
Vol 6 (2) ◽  
pp. 87-93 ◽  
Author(s):  
Jae Min Song ◽  
Sang Hun Shin ◽  
Yong Deok Kim ◽  
Jae Yeol Lee ◽  
Young Jae Baek ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Comparative Study ◽  
Bone Regeneration ◽  
Guided Bone Regeneration ◽  
Micro Computed Tomography ◽  
Calvarial Defects ◽  
Collagen Membranes ◽  
Tomography Analysis

scholarly journals Evaluation of 1-Ethyl-3-(3-Dimethylaminopropyl) Carbodiimide Cross-Linked Collagen Membranes for Guided Bone Regeneration in Beagle Dogs

Materials ◽  
2020 ◽  
Vol 13 (20) ◽  
pp. 4599
Author(s):  
Jong-Ju Ahn ◽  
Hyung-Joon Kim ◽  
Eun-Bin Bae ◽  
Won-Tak Cho ◽  
YunJeong Choi ◽  
...  
Keyword(s):  
Tensile Strength ◽  
Physical Properties ◽  
Bone Regeneration ◽  
Enzymatic Degradation ◽  
Test Group ◽  
Guided Bone Regeneration ◽  
Control Group ◽  
Collagen Membrane ◽  
Micro Computed Tomography ◽  
Collagen Membranes

The purpose of this study was to evaluate the bone regeneration efficacy of an 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)-cross-linked collagen membrane for guided bone regeneration (GBR). A non-cross-linked collagen membrane (Control group), and an EDC-cross-linked collagen membrane (Test group) were used in this study. In vitro, mechanical, and degradation testing and cell studies were performed. In the animal study, 36 artificial bone defects were formed in the mandibles of six beagles. Implants were inserted at the time of bone grafting, and membranes were assigned randomly. Eight weeks later, animals were sacrificed, micro-computed tomography was performed, and hematoxylin-eosin stained specimens were prepared. Physical properties (tensile strength and enzymatic degradation rate) were better in the Test group than in the Control group. No inflammation or membrane collapse was observed in either group, and bone volumes (%) in defects around implants were similar in the two groups (p > 0.05). The results of new bone areas (%) analysis also showed similar values in the two groups (p > 0.05). Therefore, it can be concluded that cross-linking the collagen membranes with EDC is the method of enhancing the physical properties (tensile strength and enzymatic degradation) of the collagen membranes without risk of toxicity.

scholarly journals Guided bone regeneration produced by new mineralized and reticulated collagen membranes in critical-sized rat calvarial defects

2014 ◽  
Vol 240 (2) ◽  
pp. 175-184 ◽  
Author(s):  
Denusa M Veríssimo ◽  
Renata FC Leitão ◽  
Sônia D Figueiró ◽  
Júlio C Góes ◽  
Vilma Lima ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Guided Bone Regeneration ◽  
Calvarial Defects ◽  
Collagen Membranes

scholarly journals Comparable efficacy of silk fibroin with the collagen membranes for guided bone regeneration in rat calvarial defects

2014 ◽  
Vol 6 (6) ◽  
pp. 539 ◽  
Author(s):  
Jwa-Young Kim ◽  
Byoung-Eun Yang ◽  
Jin-Hee Ahn ◽  
Sang O Park ◽  
Hye-Won Shim
Keyword(s):  
Bone Regeneration ◽  
Silk Fibroin ◽  
Guided Bone Regeneration ◽  
Comparable Efficacy ◽  
Calvarial Defects ◽  
Collagen Membranes

scholarly journals Acid Dentin Lysate Failed to Modulate Bone Formation in Rat Calvaria Defects

Biology ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 196
Author(s):  
Jila Nasirzade ◽  
Karol Alí Apaza Alccayhuaman ◽  
Zahra Kargarpour ◽  
Ulrike Kuchler ◽  
Franz Josef Strauss ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Formation ◽  
Alveolar Bone ◽  
Control Group ◽  
Micro Computed Tomography ◽  
Calvarial Bone ◽  
Critical Size Defects ◽  
Tooth Roots ◽  
Calvarial Defects ◽  
Collagen Membranes

Autogenous tooth roots are increasingly applied as a grafting material in alveolar bone augmentation. Since tooth roots undergo creeping substitution similar to bone grafts, it can be hypothesized that osteoclasts release the growth factors stored in the dentin thereby influencing bone formation. To test this hypothesis, collagen membranes were either soaked in acid dentin lysates (ADL) from extracted porcine teeth or serum–free medium followed by lyophilization. Thereafter, these membranes covered standardized 5-mm-diameter critical-size defects in calvarial bone on rats. After four weeks of healing, micro-computed tomography and histological analyses using undecalcified thin ground sections were performed. Micro-computed tomography of the inner 4.5 mm calvaria defects revealed a median bone defect coverage of 91% (CI: 87–95) in the ADL group and 94% (CI: 65–100) in the control group, without significant differences between the groups (intergroup p > 0.05). Furthermore, bone volume (BV) was similar between ADL group (5.7 mm3, CI: 3.4–7.1) and control group (5.7 mm3, CI: 2.9–9.7). Histomorphometry of the defect area confirmed these findings with bone area values amounting to 2.1 mm2 (CI: 1.2–2.6) in the ADL group and 2.0 mm2 (CI: 1.1–3.0) in the control group. Together, these data suggest that acid dentin lysate lyophilized onto collagen membranes failed to modulate the robust bone formation when placed onto calvarial defects.

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