scholarly journals Correction for the Effect of Rising Plasma Glucose Levels on Quantification of MRglc with FDG-PET

2009 ◽  
Vol 29 (5) ◽  
pp. 1059-1067 ◽  
Author(s):  
Joel T Dunn ◽  
Karen Anthony ◽  
Stephanie A Amiel ◽  
Paul K Marsden
Keyword(s):  
Positron Emission Tomography ◽  
Steady State ◽  
Blood Glucose ◽  
Emission Tomography ◽  
Fdg Uptake ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Positron Emission ◽  
Correction Scheme ◽  
Arterial Glucose

Positron emission tomography (PET) using the tracer [18F]-fluorodeoxyglucose (FDG) is commonly used for measuring metabolic rate of glucose ( MRglc) in the human brain. Conventional PET methods (e.g., the Patlak method) for quantifying MRglc assume the tissue transport and phosphorylation mechanisms to be in steady state during FDG uptake. As FDG and glucose use the same transporters and phosphorylation enzymes, changing blood glucose levels can change the rates of FDG transport and phosphorylation. Compartmental models were used to simulate the effect of rising arterial glucose, from normal to hyperglycemic levels on FDG uptake for a typical PET protocol. The subsequent errors on the values of MRglc calculated using the Patlak method were investigated, and a correction scheme based on measured arterial glucose concentration ( Gp) was evaluated. Typically, with a 40% rise in Gp over the duration of the PET study, the true MRglc varied by only 1%; however, the Patlak method overestimated MRglc by 15%. The application of the correction reduced this error to −2%. In general, the application of the correction resulted in values of MRglc consistently significantly closer to the true steady state calculation of MRglc independently of changes to the parameters defining the model.

scholarly journals Assessment of Myocardial Blood Flow and Cardiac FDG Uptake Using Positron Emission Tomography

2017 ◽  
Vol 3 (1) ◽  
pp. 205-209 ◽  
Author(s):  
Osamu Manabe ◽  
Masanao Naya ◽  
Keiichiro Yoshinaga ◽  
Noriko Oyama-Manabe ◽  
Hiroshi Ohira ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Emission Tomography ◽  
Fdg Uptake ◽  
Positron Emission

Clinical molecular imaging in intestinal graft-versus-host disease: mapping of disease activity, prediction, and monitoring of treatment efficiency by positron emission tomography

Blood ◽  
2008 ◽  
Vol 111 (5) ◽  
pp. 2909-2918 ◽  
Author(s):  
Matthias Stelljes ◽  
Sven Hermann ◽  
Jörn Albring ◽  
Gabriele Köhler ◽  
Markus Löffler ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Graft Versus Host Disease ◽  
Fdg Pet ◽  
Emission Tomography ◽  
Hematopoietic Stem ◽  
Host Disease ◽  
Graft Versus Host ◽  
Fdg Uptake ◽  
Positron Emission ◽  
Intestinal Gvhd

Gastrointestinal graft-versus-host disease (GVHD) is a common and potentially life-threatening complication after allogeneic hematopoietic stem-cell transplantation (HSCT). Noninvasive tests for assessment of GVHD activity are desirable but lacking. In the present study, we were able to visualize intestinal GVHD-associated inflammation in an allogeneic murine transplantation model by 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in vivo. A predominant localization of intestinal GVHD to the colon was verified by histology and fluorescence reflectance imaging of enhanced green fluorescent protein (EGFP)–expressing donor cells. Colonic infiltration by EGFP+ donor lymphocytes matched increased FDG uptake in PET examinations. These preclinical data were prospectively translated into 30 patients with suspected intestinal GVHD beyond 20 days after transplantation. A total of 14 of 17 patients with a diagnostic histology showed significant FDG uptake of the gut, again predominantly in the colon. No increased FDG uptake was detected in 13 patients without histologic evidence of intestinal GVHD. Our findings indicate that FDG-PET is a sensitive and specific noninvasive imaging technique to assess intestinal GVHD, map its localization, and predict and monitor treatment responsiveness. Novel targeted tracers for PET may provide new insights into the pathophysiology of GVHD and bear the potential to further improve GVHD diagnosis.

Positron Emission Tomography/Computed Tomography Predicts and Detects Complications After Endovascular Repair of Abdominal Aortic Aneurysms

2019 ◽  
Vol 26 (4) ◽  
pp. 520-528 ◽  
Author(s):  
Audrey Courtois ◽  
Georgios Makrygiannis ◽  
Mounia El Hachemi ◽  
Rebecka Hultgren ◽  
Eric Allaire ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Endovascular Aneurysm Repair ◽  
Aortic Aneurysms ◽  
Emission Tomography ◽  
Fdg Uptake ◽  
Positron Emission ◽  
Abdominal Aortic ◽  
Pet Ct ◽  
D Dimer

Purpose: To assess if aortic 18F-fluorodeoxyglucose (FDG) uptake on positron emission tomography/computed tomography (PET/CT) could play a role in predicting complications after endovascular aneurysm repair (EVAR). Materials and Methods: This study involved 2 cohorts of men with abdominal aortic aneurysm treated by EVAR: those who underwent a PET/CT scan before EVAR (n=17) and those who had a PET/CT during follow-up (n=34). Uptake of FDG was measured as the standardized uptake value (SUV). D-dimer, a marker of fibrinolysis, was measured in blood drawn concomitantly with the PET/CT. Results: A significant uptake of FDG in the aneurysm wall was detected by PET/CT before EVAR in 6 of 17 patients. During the first year after EVAR, type II endoleaks developed in 5 of these FDG+ patients vs 3 of 11 FDG– patients (p=0.04). Two of the FDG+ patients had continued sac growth and required conversion to open repair. A significant association between sac growth rate, SUV, and the presence of endoleak was found in the 34 patients who underwent PET/CT after EVAR. Finally, D-dimer was significantly increased in patients with both endoleak and positive PET/CT in the post-EVAR group. Conclusion: This study suggests that the presence of FDG uptake in the aortic wall might be a useful tool to predict patients at high risk of developing post-EVAR complications.

GLUCOSE CONSUMPTION BY THE PERFUSED, ISOLATED RAT LIVER

1963 ◽  
Vol 41 (1) ◽  
pp. 1611-1620 ◽  
Author(s):  
Ellen R. Gordon ◽  
Audrey Camire
Keyword(s):  
Steady State ◽  
Blood Glucose ◽  
Glucose Consumption ◽  
Perfused Liver ◽  
Isolated Rat Liver ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Per Se ◽  
Isolated Liver ◽  
Isolated Rat

It is shown that the perfusion of an isolated liver is a suitable and useful technique for distinguishing and investigating liver function per se. Steady state conditions were used to determine net glucose consumption by the liver. The results indicate a linear relation exists between blood glucose level and net glucose consumption by the isolated, perfused liver. Net glucose consumption was achieved at blood glucose levels as low as 100 mg/100 ml.

scholarly journals Detection of Lymphoma in Bone Marrow by Whole-Body Positron Emission Tomography

Blood ◽  
1998 ◽  
Vol 91 (9) ◽  
pp. 3340-3346 ◽  
Author(s):  
Robert Carr ◽  
Sally F. Barrington ◽  
Bella Madan ◽  
Michael J. O'Doherty ◽  
Catherine A.B. Saunders ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Disease Status ◽  
Pet Scan ◽  
Emission Tomography ◽  
Whole Body ◽  
Whole Body Imaging ◽  
Visual Interpretation ◽  
Fdg Uptake ◽  
Positron Emission ◽  
Pet Scans

Abstract Positron emission tomography (PET) is a whole-body imaging technique using 18 fluorine-fluorodeoxyglucose (FDG), whose uptake is increased in tumor cells. Published studies have shown PET to be an effective method of staging lymphoma and to be more sensitive than CT at detecting extranodal disease. The purpose of this study was to determine whether the increased marrow uptake of FDG observed in some lymphoma patients during routine staging PET scans represented marrow involvement by disease. PET scans of 50 patients with Hodgkin's (12) and non-Hodgkin's (38) lymphoma were analyzed by three independent observers and the marrow graded as normal or abnormal using a visual grading system. Unilateral iliac crest marrow aspirates and biopsies were performed on all patients. The PET scan and marrow histology agreed in 39 patients (78%), being concordant positive in 13 and concordant negative in 26 patients. In 8 patients the PET scan showed increased FDG uptake but staging biopsy was negative; in 4 of these 8 patients the PET scan showed a normal marrow background with focal FDG “hot spots” distant from the site biopsied. In 3 patients the marrow biopsy specimen was positive but the PET scan normal; 2 of these 3 patients had non-Hodgkin's lymphoma whose malignant cells did not take up FDG at lymph node or marrow disease sites. Therefore, there were only 5 patients (10%) in whom there was a difference between the PET scan and biopsy result which could not be fully explained. Visual interpretation of marrow FDG uptake during whole-body staging PET scans can correctly assess marrow disease status in a high proportion of lymphoma patients. PET has the potential to reduce the need for staging marrow biopsy.

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