Lower vitamin D levels are associated with increased risk of early-onset neonatal sepsis in term infants

Introduction: There is increasing evidence concerning adverse health consequences of low vitamin D levels. We determined whether there is any surrogate for measuring vitamin D in people older than 70 years and the relation between index of multiple deprivation (IMD) and vitamin D levels. Methods: Blood samples from 241 patients were included in this analysis. Concurrent measurements for 25-hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH), and bone profile are reported. Results: The prevalence of total vitamin D insufficiency/deficiency (defined as total vitamin D <50 nmol/L) was 57.5% overall. Even for patients with vitamin D deficiency, a significant proportion had PTH, normal calcium, phosphate, and alkaline phosphatase levels. For patients with vitamin D <25 nmol/L, 62.7% had a PTH within reference range, 83.1% had normal serum-adjusted calcium, 80.6% had normal phosphate, and 85.1% had a normal serum alkaline phosphatase. With increasing quintiles of IMD, there was a 22% increased risk of vitamin D deficiency/insufficiency from quintiles 1 to 5, in age- and sex-adjusted logistic regression models (odds ratio [OR] = 1.22, 95% confidence interval [1.01, 1.47]; p = .034). Conclusion: No other parameter is currently adequate for screening for vitamin D deficiency in older people. A higher IMD is associated with lower vitamin D levels in older people.

Download Full-text

The Relation Between Maternal / Neonatal Vitamin D Levels and Early Onset Neonatal Sepsis

American Journal of Pediatrics ◽

10.11648/j.ajp.20200601.18 ◽

2020 ◽

Vol 6 (1) ◽

pp. 46

Author(s):

Dina Kamal Ali ◽

Iman Abdel Mohsen Shaheen

Keyword(s):

Vitamin D ◽

Neonatal Sepsis ◽

Early Onset ◽

Vitamin D Levels

Download Full-text

Low Vitamin D Levels Increase the Risk of Early Onset Neonatal Sepsis

Indonesian Journal of Obstetrics and Gynecology ◽

10.32771/inajog.v8i2.1129 ◽

2020 ◽

pp. 87-91

Author(s):

Lisnawati Yuyun ◽

Ali Sungkar ◽

Rinawati Rohsiswatno ◽

Noroyono Wibowo ◽

Denni Hermartin ◽

...

Keyword(s):

Vitamin D ◽

Umbilical Cord ◽

Neonatal Sepsis ◽

Medical Records ◽

Early Onset ◽

Study Data ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Preterm Premature Rupture ◽

Vitamin D Levels

Abstract Objective: To identify the association between maternal and umbilical cord vitamin D levels with suspects of early-onset of neonatal sepsis (EONS) in newborns from mothers with preterm premature rupture of membranes (PPROM).Methods: This is a retrospective cohort study conducted from January 2017 to Augusts 2018. Data was taken consecutively from medical records and previous study data at Dr. Cipto Mangunkusumo and Persahabatan Hospital, Jakarta.Results: From total of 72 infants from mothers with PPROM, 22 infants (31%) were EONS-suspected and 50 infants (69%) were not EONS-suspected. There was a significant association between maternal and umbilical cord vitamin D levels with EONS.Conclusion: There was a significant association between maternal and umbilical cord vitamin D levels with EONS.Keywords: early-onset neonatal sepsis, preterm premature rupture of membrane, vitamin D, Abstrak Tujuan: Untuk mengetahui hubungan antara kadar vitamin D maternal dan tali pusat dengan risiko tejadinya Sepsis Neonatal Awitan Dini (SNAD) pada bayi dari ibu dengan Ketuban Pecah Dini (KPD).Metode: Desain penelitian kohort retrospektif secara consecutive sampling. Data diambil dari rekam medis dan data penelitian sebelumnya di Rumah Sakit Umum Pusat Nasional (RSUPN) Dr. Cipto Mangunkusumo dan Rumah Sakit Umum Pusat (RSUP) Persahabatan, Jakarta. Hasil: Dari 72 bayi yang dilahirkan dari ibu dengan KPD, 22 bayi (31%) diantaranya diduga mengalami SNAD, sedangkan 50 bayi lainnya tidak mengalami SNAD. Terdapat hubungan yang bermakna antara kadar vitamin D maternal dan tali pusat dengan kejadian SNAD. Kesimpulan:Terdapathubungan yang bermakna antara kadar vitamin D maternal dan tali pusat dengan kejadian SNAD.Kata kunci: ketuban pecah dini, sepsis neonatal awitan dini, vitamin D

Download Full-text

Association between vitamin D plasma concentrations and VDR gene variants and the risk of premature birth

BMC Pregnancy and Childbirth ◽

10.1186/s12884-019-2671-2 ◽

2019 ◽

Vol 20 (1) ◽

Cited By ~ 3

Author(s):

Letícia Veríssimo Dutra ◽

Fernando Alves Affonso-Kaufman ◽

Fernanda Ramires Cafeo ◽

Milene Saori Kassai ◽

Caio Parente Barbosa ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Premature Birth ◽

Plasma Concentrations ◽

Serum Vitamin ◽

Plasma Vitamin ◽

Serum Vitamin D ◽

Increased Risk ◽

Vitamin D Levels ◽

Lower Vitamin

Abstract Background Premature birth is the main cause of mortality in children under 1 year, and vitamin D deficiency during gestation is associated with prematurity. The effects of vitamin D are mediated by its receptor, which is encoded by the VDR gene. VDR variants—such as single nucleotide variation (SNV)—are associated with increased risk of prematurity, but there are conflicting results. We evaluated serum vitamin D concentrations and the frequency of TaqI/A > G, BsmI/C > T, ApaI/C > A, and FokI/A > T VDR variants in mothers and preterm (PTN) and full-term (FTN) newborns. Methods We conducted a case-control study comprising 40 pairs of mothers and their PTNs (gestational age < 32 weeks and/or weight < 1500 g), and 92 pairs of mothers and FTNs as controls. Genotyping was performed by real-time PCR, and plasma vitamin D concentrations were measured by electrochemiluminescence. Results Vitamin D levels were significantly lower in PTN mothers. Genotypes TaqI/GG and BsmI/TT, and haplotypes AAG (TaqI/A-ApaI/A-FokI/G) and GCA (TaqI/G-ApaI/C-FokI/A) were significantly more frequent in PTN mothers, and genotypes TaqI/AG, ApaI/AA, and FokI/AG resulted in significantly lower vitamin D levels. Genotypes BsmI/TT and ApaI/AA were associated with vitamin D deficiency and 2.36 and 7.99 times greater likelihood of PTB, respectively. Vitamin D levels were also lower in PTNs, although it was not statistically significant. Genotypes BsmI/TT, ApaI/AA, and FokI/GG, and haplotype GAG (TaqI/G-ApaI/A-FokI/G) were significantly more frequent in PTNs. Those with FokI/GG genotypes had significantly lower vitamin D levels. Conclusions VDR variants contribute to variations in vitamin D concentrations and the increased risk of prematurity.

Download Full-text

Neonatal Vitamin D status and the risk of neonatal sepsis

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.35.2.342 ◽

2019 ◽

Vol 35 (2) ◽

Cited By ~ 2

Author(s):

Abdurrahman Avar Ozdemir ◽

Yakup Cag

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Neonatal Sepsis ◽

Neonatal Intensive Care ◽

Sepsis Group ◽

Control Group ◽

Vitamin D Status ◽

Term Infants ◽

Creative Commons ◽

Vitamin D Levels

Objective: To evaluate the maternal and neonatal 25-hydroxyvitamin D [25(OH)D] levels and the effect of 25(OH)D levels on the development of neonatal sepsis. Methods: This prospective study was performed in the neonatal intensive care unit of Medicine Hospital/Biruni University between November 2017 and September 2018. Fifty one term infants with sepsis group and 56 term infants with control group were included in this study. Blood samples for whole blood count, CRP, Ca, P, ALP, 25(OH)D and culture were obtained from all neonates. Results: Mean vitamin D levels for the neonates and their mothers were found to be 12.4±8.5 ng/ml and 13±8.7 ng/ml, respectively. There was a significant correlation between maternal and newborn 25(OH)D levels (r=0.72, p<0.01). The number of the newborns with vitamin D deficiency was significantly higher in the sepsis group (n=31, 60.8%) than in the control group (n=30, 53.6%; p=0.00), corresponding to significantly lower levels of vitamin D in the sepsis group (11±5.5 ng/ml vs. 13.8±10.6 ng/ml; p=0.012). Similarly, maternal vitamin D levels was significantly lower in the sepsis group than in the control group (10.8±5.6 ng/ml vs. 14.9±10 ng/ml; p=0.001). Conclusion: Our findings suggest that there may be an association between vitamin D deficiency and neonatal sepsis. How to cite this:Ozdemir AA, Cag Y. Neonatal Vitamin D status and the risk of neonatal sepsis. Pak J Med Sci. 2019;35(2):---------. doi: https://doi.org/10.12669/pjms.35.2.342 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download Full-text

Association Between Maternal and Neonatal Serum Vitamin D Levels and the Incidence of Early-Onset Sepsis

Journal of Comprehensive Pediatrics ◽

10.5812/compreped.115193 ◽

2021 ◽

Vol In Press (In Press) ◽

Author(s):

Ali Naseh ◽

Azade Shabani ◽

Hanieh Ghane

Keyword(s):

Vitamin D ◽

Birth Weight ◽

Neonatal Sepsis ◽

Early Onset ◽

Serum Vitamin ◽

Sepsis Group ◽

Control Groups ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

And Control

Background: Early-onset neonatal sepsis (EOS) is a systemic infection that occurs within the first week of life. Objectives: This study investigated the association of serum vitamin D levels in pregnant women and their neonates with the prevalence of EOS. Methods: This case-control study was performed among 50 term/late pre-term neonates admitted to our NICU due to EOS, alongside 50 healthy neonates matched for gestational age range and sex. Maternal and neonatal serum vitamin D levels were measured. The criteria for diagnosing EOS included any/combination of: respiratory, cardiovascular, hemodynamic, neurological, gastrointestinal, body temperature, or metabolic signs. For sepsis cases, CBC, CRP, blood type, blood culture, chest X ray, and in some cases, and CSF analysis and culture were tested. Mothers’ clinical history was collected. Results: Each group included 30 (60%) male and 20 (40%) female neonates. Birth weight averages were 2772 ± 667 and 3215 ± 349 grams in the case and control groups, respectively (P < 0.001). The mean serum vitamin D levels were 49.75 ± 25.53 and 56.41 ± 18.17 nmol/L in the case and control groups, respectively. The control group mothers had a significantly higher vitamin D level (68.24 nmol/L versus 55.01 in mothers of sepsis cases, p=0.005) and showed a correlation with the vitamin D levels of their neonates (R = 0.731, P < 0.001), while the data failed to show a correlation between vitamin D level in mothers and their neonates in the sepsis group (R = 0.241, P = 0.115). C-section delivery was more prevalent among the sepsis cases (P < 0.001). Conclusions: Early-onset neonatal sepsis is associated with vitamin D deficiency in neonates and their mothers, low birth weight, and being delivered by C-section.

Download Full-text

Is Lower Vitamin D Level Associated with Increased Risk of Neonatal Sepsis? A Prospective Cohort Study

The Indian Journal of Pediatrics ◽

10.1007/s12098-020-03188-0 ◽

2020 ◽

Vol 87 (6) ◽

pp. 427-432 ◽

Cited By ~ 2

Author(s):

Chinmay Kumar Behera ◽

Jagdish Prasad Sahoo ◽

Saumya Darshana Patra ◽

Pratap Kumar Jena

Keyword(s):

Vitamin D ◽

Cohort Study ◽

Prospective Cohort Study ◽

Neonatal Sepsis ◽

Prospective Cohort ◽

Increased Risk ◽

Lower Vitamin

Download Full-text

The Relationship between Vitamin D Levels and Clinical Outcomes of Neonatal Sepsis in Haji Adam Malik Hospital Medan, Indonesia

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2021.6530 ◽

2021 ◽

Vol 9 (B) ◽

pp. 698-703

Author(s):

Kamsiah Kamsiah ◽

Beby Syofiani Hasibuan ◽

Karina Sugih Arto

Keyword(s):

Vitamin D ◽

Hospital Stay ◽

Vitamin D Deficiency ◽

Clinical Outcomes ◽

Neonatal Sepsis ◽

Ventilatory Support ◽

Length Of Hospital Stay ◽

Increased Risk ◽

Vitamin D Levels ◽

The Relationship

BACKGROUND: Vitamin D deficiency in neonates is associated with neonatal sepsis incidence. It is also significantly correlated to the increased risk in the outcomes of sepsis, such as mortality, length of hospital stay, and use of ventilatory support. AIM: The aim of the study is to observe the relationship between Vitamin D levels and clinical outcomes of sepsis in the neonatal unit. METHODS: An analytical cross-sectional study was conducted to neonates in neonatology Haji Adam Malik hospital from June 2019 to February 2020. A Chi-square test was carried out to observe the relationship between Vitamin D levels and sepsis outcomes, and a Mann-Whitney test was done to assess the significance between Vitamin D levels and length of hospital stay. RESULTS: Among 41 full-term and pre-term neonates, there were 75.6% (31/41) neonates with Vitamin D deficiency, while 24.4% (10/41) had normal Vitamin D levels and did not suffer from deficiency. The relationship of Vitamin D levels with mortality, use of ventilatory support, length of stay, and blood culture was p = 0.660 (95% confidence interval [CI] = 0.810–1.677), p = 0.013 (p < 0.05), p = 0.940 (median 21 days), and p =0.712 (95% CI = 0.623–1.353), respectively. CONCLUSION: Vitamin D deficiency had a significant relationship with ventilatory support requirement as one of the sepsis outcomes in neonates.

Download Full-text