scholarly journals The Relation Between Maternal / Neonatal Vitamin D Levels and Early Onset Neonatal Sepsis

2020 ◽  
Vol 6 (1) ◽  
pp. 46
Author(s):  
Dina Kamal Ali ◽  
Iman Abdel Mohsen Shaheen
Keyword(s):  
Vitamin D ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Vitamin D Levels

scholarly journals Low Vitamin D Levels Increase the Risk of Early Onset Neonatal Sepsis

2020 ◽  
pp. 87-91
Author(s):  
Lisnawati Yuyun ◽  
Ali Sungkar ◽  
Rinawati Rohsiswatno ◽  
Noroyono Wibowo ◽  
Denni Hermartin ◽  
...  
Keyword(s):  
Vitamin D ◽  
Umbilical Cord ◽  
Neonatal Sepsis ◽  
Medical Records ◽  
Early Onset ◽  
Study Data ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Preterm Premature Rupture ◽  
Vitamin D Levels

Abstract Objective: To identify the association between maternal and umbilical cord vitamin D levels with suspects of early-onset of neonatal sepsis (EONS) in newborns from mothers with preterm premature rupture of membranes (PPROM).Methods: This is a retrospective cohort study conducted from January 2017 to Augusts 2018. Data was taken consecutively from medical records and previous study data at Dr. Cipto Mangunkusumo and Persahabatan Hospital, Jakarta.Results: From total of 72 infants from mothers with PPROM, 22 infants (31%) were EONS-suspected and 50 infants (69%) were not EONS-suspected. There was a significant association between maternal and umbilical cord vitamin D levels with EONS.Conclusion: There was a significant association between maternal and umbilical cord vitamin D levels with EONS.Keywords: early-onset neonatal sepsis, preterm premature rupture of membrane, vitamin D,   Abstrak Tujuan: Untuk mengetahui hubungan antara kadar vitamin D maternal dan tali pusat dengan risiko tejadinya Sepsis Neonatal Awitan Dini (SNAD) pada bayi dari ibu dengan Ketuban Pecah Dini (KPD).Metode: Desain penelitian kohort retrospektif secara consecutive sampling. Data diambil dari rekam medis dan data penelitian sebelumnya di Rumah Sakit Umum Pusat Nasional (RSUPN) Dr. Cipto Mangunkusumo dan Rumah Sakit Umum Pusat (RSUP) Persahabatan, Jakarta. Hasil:  Dari 72 bayi yang dilahirkan dari ibu dengan KPD, 22 bayi (31%) diantaranya diduga mengalami SNAD, sedangkan 50 bayi lainnya tidak mengalami SNAD. Terdapat hubungan yang bermakna antara kadar vitamin D maternal dan tali pusat dengan kejadian SNAD. Kesimpulan:Terdapathubungan yang bermakna antara kadar vitamin D maternal dan tali pusat dengan kejadian SNAD.Kata kunci: ketuban pecah dini,  sepsis neonatal awitan dini, vitamin D

scholarly journals PS-221 Lower Maternal/neonatal Vitamin D Levels Are Associated With Increased Risk Of Early Onset Neonatal Sepsis In Term Infants

2014 ◽  
Vol 99 (Suppl 2) ◽  
pp. A192.3-A193
Author(s):  
M Cetinkaya ◽  
F Cekmez ◽  
G Buyukkale ◽  
T Erener-Ercan ◽  
F Demir ◽  
...  
Keyword(s):  
Vitamin D ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Term Infants ◽  
Increased Risk ◽  
Vitamin D Levels

scholarly journals Association Between Maternal and Neonatal Serum Vitamin D Levels and the Incidence of Early-Onset Sepsis

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Ali Naseh ◽  
Azade Shabani ◽  
Hanieh Ghane
Keyword(s):  
Vitamin D ◽  
Birth Weight ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Serum Vitamin ◽  
Sepsis Group ◽  
Control Groups ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
And Control

Background: Early-onset neonatal sepsis (EOS) is a systemic infection that occurs within the first week of life. Objectives: This study investigated the association of serum vitamin D levels in pregnant women and their neonates with the prevalence of EOS. Methods: This case-control study was performed among 50 term/late pre-term neonates admitted to our NICU due to EOS, alongside 50 healthy neonates matched for gestational age range and sex. Maternal and neonatal serum vitamin D levels were measured. The criteria for diagnosing EOS included any/combination of: respiratory, cardiovascular, hemodynamic, neurological, gastrointestinal, body temperature, or metabolic signs. For sepsis cases, CBC, CRP, blood type, blood culture, chest X ray, and in some cases, and CSF analysis and culture were tested. Mothers’ clinical history was collected. Results: Each group included 30 (60%) male and 20 (40%) female neonates. Birth weight averages were 2772 ± 667 and 3215 ± 349 grams in the case and control groups, respectively (P < 0.001). The mean serum vitamin D levels were 49.75 ± 25.53 and 56.41 ± 18.17 nmol/L in the case and control groups, respectively. The control group mothers had a significantly higher vitamin D level (68.24 nmol/L versus 55.01 in mothers of sepsis cases, p=0.005) and showed a correlation with the vitamin D levels of their neonates (R = 0.731, P < 0.001), while the data failed to show a correlation between vitamin D level in mothers and their neonates in the sepsis group (R = 0.241, P = 0.115). C-section delivery was more prevalent among the sepsis cases (P < 0.001). Conclusions: Early-onset neonatal sepsis is associated with vitamin D deficiency in neonates and their mothers, low birth weight, and being delivered by C-section.

Lower vitamin D levels are associated with increased risk of early-onset neonatal sepsis in term infants

2014 ◽  
Vol 35 (1) ◽  
pp. 39-45 ◽  
Author(s):  
M Cetinkaya ◽  
F Cekmez ◽  
G Buyukkale ◽  
T Erener-Ercan ◽  
F Demir ◽  
...  
Keyword(s):  
Vitamin D ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Term Infants ◽  
Increased Risk ◽  
Vitamin D Levels ◽  
Lower Vitamin

Vitamin D Levels and Early Onset Sepsis in Newborns

2021 ◽  
Vol 35 (2) ◽  
pp. 64-69
Author(s):  
Balveer Jeengar ◽  
Sunil Gothwal ◽  
Kailash Kumar Meena ◽  
Vijendra Kumar Garg ◽  
Vivek Athwani ◽  
...  
Keyword(s):  
Vitamin D ◽  
Early Onset ◽  
Care Center ◽  
Tertiary Care ◽  
Area Under The Curve ◽  
Vitamin D Supplementation ◽  
Control Group ◽  
Maternal Vitamin ◽  
Early Onset Sepsis ◽  
Vitamin D Levels

Aim: To find out association between vitamin D level and early onset neonatal sepsis (EONS). Methods: This case control study was conducted at a tertiary care center in Northern India during June 2018 to May 2019. Neonates with culture-proven EONS were included as case and neonates without EONS were enrolled as control. 25OH-D levels were evaluated with other routine blood samples. Statistical analysis was done by using unpaired t test and chi-square test. Results: Sixty-two infants were enrolled in each group; baseline characteristics were comparable in both groups. Risk of EONS increased 8 times in neonates with 25OH-D level <30 ng/mL (odds ratio = 8.2; 95% confidence interval [CI]: 3.08-21.82; P = .000). The 25OH-D level was significantly lower in EONS group than control group. Optimal cut-off for 25OH-D was 25 ng/mL to predict EONS with a sensitivity and specificity of 88.7% and 79%, respectively (area under the curve: 0.84; 95% CI: 0.76-0.92; P = .000). Conclusions: Vitamin D insufficiency is significantly associated with EONS. Vitamin D deficiency significantly increases risk of EONS. Maternal vitamin D supplementation may improve neonatal vitamin D levels and may decreases risk of EONS. Further studies including maternal vitamin D level are required for implementation.

scholarly journals Effects of cord blood vitamin D levels on the risk of neonatal sepsis in premature infants

2017 ◽  
Vol 60 (8) ◽  
pp. 248 ◽  
Author(s):  
Birgul Say ◽  
Nurdan Uras ◽  
Suzan Sahin ◽  
Halil Degirmencioglu ◽  
Serife Suna Oguz ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cord Blood ◽  
Premature Infants ◽  
Neonatal Sepsis ◽  
Vitamin D Levels

scholarly journals Neonatal Vitamin D status and the risk of neonatal sepsis

2019 ◽  
Vol 35 (2) ◽  
Author(s):  
Abdurrahman Avar Ozdemir ◽  
Yakup Cag
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Neonatal Sepsis ◽  
Neonatal Intensive Care ◽  
Sepsis Group ◽  
Control Group ◽  
Vitamin D Status ◽  
Term Infants ◽  
Creative Commons ◽  
Vitamin D Levels

Objective: To evaluate the maternal and neonatal 25-hydroxyvitamin D [25(OH)D] levels and the effect of 25(OH)D levels on the development of neonatal sepsis. Methods: This prospective study was performed in the neonatal intensive care unit of Medicine Hospital/Biruni University between November 2017 and September 2018. Fifty one term infants with sepsis group and 56 term infants with control group were included in this study. Blood samples for whole blood count, CRP, Ca, P, ALP, 25(OH)D and culture were obtained from all neonates. Results: Mean vitamin D levels for the neonates and their mothers were found to be 12.4±8.5 ng/ml and 13±8.7 ng/ml, respectively. There was a significant correlation between maternal and newborn 25(OH)D levels (r=0.72, p<0.01). The number of the newborns with vitamin D deficiency was significantly higher in the sepsis group (n=31, 60.8%) than in the control group (n=30, 53.6%; p=0.00), corresponding to significantly lower levels of vitamin D in the sepsis group (11±5.5 ng/ml vs. 13.8±10.6 ng/ml; p=0.012). Similarly, maternal vitamin D levels was significantly lower in the sepsis group than in the control group (10.8±5.6 ng/ml vs. 14.9±10 ng/ml; p=0.001). Conclusion: Our findings suggest that there may be an association between vitamin D deficiency and neonatal sepsis. How to cite this:Ozdemir AA, Cag Y. Neonatal Vitamin D status and the risk of neonatal sepsis. Pak J Med Sci. 2019;35(2):---------. doi: https://doi.org/10.12669/pjms.35.2.342 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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