scholarly journals Epigenetic regulation of human β-defensin 2 and CC chemokine ligand 20 expression in gingival epithelial cells in response to oral bacteria

2011 ◽  
Vol 4 (4) ◽  
pp. 409-419 ◽  
Author(s):  
L Yin ◽  
W O Chung
Keyword(s):  
Epithelial Cells ◽  
Epigenetic Regulation ◽  
Oral Bacteria ◽  
Cc Chemokine ◽  
Gingival Epithelial Cells ◽  
Chemokine Ligand ◽  
Cc Chemokine Ligand 20

Corneal epithelial cells and stromal keratocytes efficently produce CC chemokine-ligand 20 (CCL20) and attract cells expressing its receptor CCR6 in mouse herpetic stromal keratitis

2004 ◽  
Vol 28 (5) ◽  
pp. 297-306 ◽  
Author(s):  
Jumi Shirane ◽  
Takashi Nakayama ◽  
Daisuke Nagakubo ◽  
Dai Izawa ◽  
Kunio Hieshima ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Corneal Epithelial Cells ◽  
Herpetic Stromal Keratitis ◽  
Corneal Epithelial ◽  
Cc Chemokine ◽  
Chemokine Ligand ◽  
Stromal Keratitis ◽  
Cc Chemokine Ligand 20

scholarly journals Protease-Activated Receptor 2 Mediates Human Beta-Defensin 2 and CC Chemokine Ligand 20 mRNA Expression in Response to Proteases Secreted by Porphyromonas gingivalis

2007 ◽  
Vol 75 (9) ◽  
pp. 4326-4333 ◽  
Author(s):  
Henrik Dommisch ◽  
Whasun O. Chung ◽  
Maryam G. Rohani ◽  
David Williams ◽  
Minnie Rangarajan ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Epithelial Cells ◽  
Protease Inhibitor ◽  
Mrna Expression ◽  
Porphyromonas Gingivalis ◽  
Gene Knockdown ◽  
Protease Activated Receptors ◽  
Cc Chemokine ◽  
Chemokine Ligand ◽  
Cc Chemokine Ligand 20

ABSTRACT The oral pathogen Porphyromonas gingivalis secretes proteases such as Arg-gingipain B (RgpB) that activate protease-activated receptors (PARs). Human beta-defensins (hBDs) and the macrophage inflammatory protein 3α/CC chemokine ligand 20 (CCL20) produced by epithelial cells are antimicrobial peptides that provide cytokine function and play an important role in innate immunity. The aim of the present study was to determine whether specific members of the PAR family mediate the expression of these innate immunity markers in gingival epithelial cells (GECs) when exposed to P. gingivalis cell-free culture supernatant or purified RgpB. hBD-2 mRNA in GECs was induced in response to supernatant and purified RgpB from P. gingivalis (P = 0.02 and P = 0.016, respectively). This effect was abrogated by the protease inhibitor tosyl-l-lysine chloromethyl ketone (TLCK) (P < 0.05). In response to P. gingivalis supernatant and to purified RgpB, the hBD-2 mRNA expression was significantly decreased in PAR-2 gene knockdown cells, whereas no change was detected in PAR-1 gene knockdown cells. CCL20 mRNA expression also increased in response to the supernatant of P. gingivalis, and this effect was blocked by the protease inhibitor, TLCK (P = 0.05 and P = 0.024, respectively), and was blocked in PAR-2 gene knockdown cells. Our data indicate that hBD-2 and CCL20 mRNA up-regulation by P. gingivalis supernatant and purified RgpB was mediated via PAR-2, but not via PAR-1, and that proteases play a role in the regulation of innate immune responses in GECs. GECs use PARs to recognize P. gingivalis and mediate cell responses involved in innate immunity.

OC.09.8 INTERLEUKIN-34 INDUCES CC-CHEMOKINE LIGAND 20 IN GUT EPITHELIAL CELLS

2016 ◽  
Vol 48 ◽  
pp. e106
Author(s):  
E. Franzè ◽  
I. Marafini ◽  
V. De Simone ◽  
I. Monteleone ◽  
F. Caprioli ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Cc Chemokine ◽  
Chemokine Ligand ◽  
Cc Chemokine Ligand 20

scholarly journals Interleukin-34 Induces Cc-chemokine Ligand 20 in Gut Epithelial Cells

2015 ◽  
Vol 10 (1) ◽  
pp. 87-94 ◽  
Author(s):  
Eleonora Franzè ◽  
Irene Marafini ◽  
Veronica De Simone ◽  
Ivan Monteleone ◽  
Flavio Caprioli ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Cc Chemokine ◽  
Chemokine Ligand ◽  
Cc Chemokine Ligand 20

Up-regulation of CC chemokine ligand 20 and its receptor CCR6 in the lesional skin of early systemic sclerosis

2011 ◽  
Vol 21 (5) ◽  
pp. 731-736 ◽  
Author(s):  
Juan Tao ◽  
Lin Li ◽  
Zhijian Tan ◽  
Yan Li ◽  
Jing Yang ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Lesional Skin ◽  
Cc Chemokine ◽  
Chemokine Ligand ◽  
Early Systemic Sclerosis ◽  
Cc Chemokine Ligand 20

scholarly journals Hypoxia Modifies the Transcriptome of Primary Human Monocytes: Modulation of Novel Immune-Related Genes and Identification Of CC-Chemokine Ligand 20 as a New Hypoxia-Inducible Gene

2006 ◽  
Vol 177 (3) ◽  
pp. 1941-1955 ◽  
Author(s):  
Maria Carla Bosco ◽  
Maura Puppo ◽  
Clara Santangelo ◽  
Luca Anfosso ◽  
Ulrich Pfeffer ◽  
...  
Keyword(s):  
Human Monocytes ◽  
Cc Chemokine ◽  
Chemokine Ligand ◽  
Immune Related Genes ◽  
Cc Chemokine Ligand 20 ◽  
Inducible Gene

scholarly journals Interactions between Periodontal Bacteria and Human Oral Epithelial Cells: Fusobacterium nucleatum Adheres to and Invades Epithelial Cells

2000 ◽  
Vol 68 (6) ◽  
pp. 3140-3146 ◽  
Author(s):  
Yiping W. Han ◽  
Wenyuan Shi ◽  
George T.-J. Huang ◽  
Susan Kinder Haake ◽  
No-Hee Park ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Epithelial Cell ◽  
Epithelial Cells ◽  
Periodontal Diseases ◽  
Fusobacterium Nucleatum ◽  
Oral Bacteria ◽  
Metabolic Inhibitors ◽  
Kb Cells ◽  
Gingival Epithelial Cells ◽  
Oral Epithelial

ABSTRACT Bacteria are causative agents of periodontal diseases. Interactions between oral bacteria and gingival epithelial cells are essential aspects of periodontal infections. Using an in vitro tissue culture model, a selected group of gram-negative anaerobic bacteria frequently associated with periodontal diseases, includingBacteroides forsythus, Campylobacter curvus,Eikenella corrodens, Fusobacterium nucleatum,Porphyromonas gingivalis, and Prevotella intermedia, were examined for their ability to adhere to and invade primary cultures of human gingival epithelial cells (HGEC). The effects of these bacteria on the production of interleukin-8 (IL-8), a proinflammatory chemokine, were also measured. These studies provided an initial demonstration that F. nucleatum adhered to and invaded HGEC and that this was accompanied by high levels of IL-8 secretion from the epithelial cells. The attachment and invasion characteristics of F. nucleatumwere also tested using KB cells, an oral epithelial cell line. The invasion was verified by transmission electron microscopy and with metabolic inhibitors. Invasion appeared to occur via a “zipping” mechanism and required the involvement of actins, microtubules, signal transduction, protein synthesis, and energy metabolism of the epithelial cell, as well as protein synthesis by F. nucleatum. A spontaneous mutant, lam, of F. nucleatum, isolated as defective in autoagglutination, was unable to attach to or invade HGEC or KB cells, further indicating the requirement of bacterial components in these processes. Sugar inhibition assays indicated that lectin-like interactions were involved in the attachment of F. nucleatum to KB cells. Investigation of these new virulence phenotypes should improve our understanding of the role of F. nucleatum in periodontal infections.

scholarly journals Lysophosphatidic Acid Inhibits CC Chemokine Ligand 5/RANTES Production by Blocking IRF-1–Mediated Gene Transcription in Human Bronchial Epithelial Cells

2010 ◽  
Vol 185 (8) ◽  
pp. 4863-4872 ◽  
Author(s):  
Shinichi Matsuzaki ◽  
Tamotsu Ishizuka ◽  
Takeshi Hisada ◽  
Haruka Aoki ◽  
Mayumi Komachi ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Gene Transcription ◽  
Lysophosphatidic Acid ◽  
Bronchial Epithelial Cells ◽  
Human Bronchial Epithelial Cells ◽  
Bronchial Epithelial ◽  
Cc Chemokine ◽  
Chemokine Ligand ◽  
Rantes Production

scholarly journals IL-9 Promotes Th17 Cell Migration into the Central Nervous System via CC Chemokine Ligand-20 Produced by Astrocytes

2011 ◽  
Vol 186 (7) ◽  
pp. 4415-4421 ◽  
Author(s):  
Yan Zhou ◽  
Yoshifumi Sonobe ◽  
Tomohiko Akahori ◽  
Shijie Jin ◽  
Jun Kawanokuchi ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cell Migration ◽  
Th17 Cell ◽  
Cc Chemokine ◽  
Chemokine Ligand ◽  
The Central Nervous System ◽  
Cc Chemokine Ligand 20

Modulation of hepatitis C virus core DNA vaccine immune responses by co-immunization with CC-chemokine ligand 20 (CCL20) gene as immunoadjuvant

2014 ◽  
Vol 41 (9) ◽  
pp. 5943-5952 ◽  
Author(s):  
Christine Hartoonian ◽  
Zargham Sepehrizadeh ◽  
Mehdi Mahdavi ◽  
Arash Arashkia ◽  
Yon Suk Jang ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Immune Responses ◽  
Dna Vaccine ◽  
Cc Chemokine ◽  
Virus Core ◽  
Chemokine Ligand ◽  
Cc Chemokine Ligand 20
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