scholarly journals Postpartum questionnaire survey of women who tested negative in a non-invasive prenatal testing: examining negative emotions towards the test

2020 ◽  
Author(s):  
Tatsuko Hirose ◽  
Nahoko Shirato ◽  
Mikiko Izumi ◽  
Keiko Miyagami ◽  
Akihiko Sekizawa
Keyword(s):  
Genetic Counseling ◽  
Negative Emotion ◽  
Negative Emotions ◽  
Prenatal Testing ◽  
Anxiety And Depression ◽  
Control Group ◽  
Psychosocial Status ◽  
Non Invasive ◽  
Fetal Aneuploidy ◽  
One Year

AbstractNon-invasive prenatal testing (NIPT) is used worldwide to screen for fetal aneuploidy. Although previous studies on the psychosocial aspects of NIPT have focused on satisfaction regarding the test, we surveyed women who experienced negative emotions after receiving NIPT. From January 2018 to March 2019, we surveyed pregnant women whose NIPT results were negative, one year after the test. Of the 526 respondents, 35 (6.7%) regretted receiving NIPT and blamed themselves for taking it. We assigned this 6.7% of respondents to the negative emotion group. Although, 76.5% of the participants in the negative emotion group reported they would like to take NIPT for their next pregnancy, it was significantly lower as compared to the control group (92%). Furthermore, 31.9% of respondents in the control group reported that they would recommend similar tests to their relatives and friends. Conversely, in the negative emotion group, this proportion was lower at 17.1%. This suggests that guilt over testing may be meaningful. Thus, this study showed that some NIPT examinees regretted taking the test and blamed themselves. Respondents reported experiencing stress, anxiety, and depression even before NIPT affirming that it is important to address pregnant women’s psychosocial status during pre-test genetic counseling.

scholarly journals VP29.11: High‐positive predictive values across maternal ages in non‐invasive prenatal testing for fetal aneuploidy

2020 ◽  
Vol 56 (S1) ◽  
pp. 183-184
Author(s):  
S. Leonard ◽  
P. Benn ◽  
E. Valenti ◽  
W. Di Nonno ◽  
Z. Demko ◽  
...  
Keyword(s):  
Prenatal Testing ◽  
Predictive Values ◽  
Non Invasive ◽  
Fetal Aneuploidy

scholarly journals A survey on awareness of genetic counseling for non-invasive prenatal testing: the first year experience in Japan

2016 ◽  
Vol 61 (12) ◽  
pp. 995-1001 ◽  
Author(s):  
Junko Yotsumoto ◽  
◽  
Akihiko Sekizawa ◽  
Nobuhiro Suzumori ◽  
Takahiro Yamada ◽  
...  
Keyword(s):  
Genetic Counseling ◽  
Prenatal Testing ◽  
First Year Experience ◽  
First Year ◽  
Non Invasive

Current status of non-invasive prenatal testing (NIPT): genetic counseling, dominant methods and overall performance

2016 ◽  
Vol 40 (5) ◽  
Author(s):  
Thomas Harasim ◽  
Imma Rost ◽  
Hanns-Georg Klein
Keyword(s):  
Genetic Counseling ◽  
Paradigm Shift ◽  
Sex Chromosome ◽  
Prenatal Testing ◽  
Diagnostic Procedures ◽  
Trisomy 13 ◽  
Current Status ◽  
Non Invasive ◽  
Overall Performance ◽  
Aneuploidy Testing

Abstract:The introduction of non-invasive prenatal testing (NIPT) into prenatal care represents a paradigm shift. With the absence of any intervention risk in contrast to invasive diagnostic procedures, NIPT has been widely adopted for the detection of fetal trisomy 13, 18 and 21. Additionally, fetal sex chromosome aneuploidy testing and sex determination are available, but can be compromised by both, medical and legal factors. Available validation studies were predominantly based on patients with a high

Non-invasive prenatal testing for fetal aneuploidy by massively parallel DNA sequencing of maternal plasma: the future has arrived today/Nicht-invasiver Pränatal-Test auf fetale Aneuploidie mittels massiv-paralleler DNA-Sequenzanalyse im mütterlichen Plasma: in der Zukunft angekommen

2012 ◽  
Vol 36 (5) ◽  
Author(s):  
Amy Swanson ◽  
Christin Coffeen ◽  
Amy J. Sehnert
Keyword(s):  
Massively Parallel Sequencing ◽  
Prenatal Testing ◽  
The United States ◽  
Maternal Blood ◽  
Maternal Plasma ◽  
Massively Parallel ◽  
Clinical Implementation ◽  
Maternal Cell ◽  
Non Invasive ◽  
Fetal Aneuploidy

AbstractAfter decades of research, non-invasive prenatal testing (NIPT) using maternal blood to determine fetal chromosome status has found its way from the research laboratory into clinical practice, triggering a long-awaited paradigm shift in prenatal care. A variety of methods using sequencing of maternal cell-free DNA (cfDNA) have now been studied, primarily demonstrating their ability to detect the most common fetal aneuploidy, trisomy 21 (T21). The focus of this article is on massively parallel sequencing (MPS) with optimized sequence tag mapping and chromosome quantification, which accurately detects T21 as well as multiple other aneuploidies across the genome. The power of this technique resides in its high precision and reduction of variation within and between sequencing runs. Using MPS, classification of aneuploidy status for a given sample can be reliably assigned from the genetic information alone without the need to factor in other maternal pre-test risk or other clinical variables. Performance of this method has been prospectively demonstrated in a rigorous, blinded, multi-center study in the United States. The findings suggest that MPS can be incorporated into existing prenatal screening algorithms to reduce unnecessary invasive procedures. This technology and key considerations for clinical implementation are discussed.

scholarly journals Qualitative investigation of the factors that generate ambivalent feelings in women who give birth after receiving negative results from non-invasive prenatal testing

2020 ◽  
Author(s):  
Junko Yotsumoto ◽  
Akihiko Sekizawa ◽  
Satomi Inoue ◽  
Nobuhiro Suzumori ◽  
Osamu Samura ◽  
...  
Keyword(s):  
Genetic Counseling ◽  
Pregnant Women ◽  
Qualitative Data ◽  
Prenatal Testing ◽  
Qualitative Investigation ◽  
Anticipatory Anxiety ◽  
Related Factors ◽  
Non Invasive ◽  
Negative Results

Abstract Background: Women who receive negative results from non-invasive prenatal genetic testing (NIPT) may find that they later have mixed or ambivalent feelings, for example, feelings of accepting NIPT and regretting undergoing the test. This study aimed to investigate the factors generating ambivalent feelings among women who gave birth after having received negative results from NIPT. Methods: A questionnaire was sent to women who received a negative NIPT result, and a contents analysis was conducted focusing on ambivalent expressions for those 1562 women who responded the questionnaire. The qualitative data gathered from the questionnaire were analyzed using the N-Vivo software package. Results: Environmental factors, genetic counseling-related factors, and increased anticipatory anxiety, affected the feeling of ambivalence among pregnant women. Furthermore, pregnant women desired more information regarding the detailed prognosis for individuals with Down syndrome and living with them and/or termination, assuming the possibility that they were positive. Conclusions: Three major interrelated factors affected the feeling of ambivalence in women. High-lighting and discussing such factors during genetic counseling may resolve some of these ambivalences, thereby enhancing the quality of decisions made by pregnant women.

Analysis of the correlation between students’ self-compassion and external pressure under chronic stress response

Work ◽  
2021 ◽  
pp. 1-13
Author(s):  
Shengtao Ren ◽  
Juzhe Xi ◽  
Angel Ray
Keyword(s):  
Stress Response ◽  
Chronic Stress ◽  
Negative Emotion ◽  
Negative Emotions ◽  
External Pressure ◽  
Mediating Effect ◽  
Control Group ◽  
Entrance Examination ◽  
Preparation Time ◽  
Self Compassion

BACKGROUND: Although the environment of college students is relatively safe, they are faced with the pressure of study, interpersonal relationship, and even future employment, which leads to a variety of psychological disorders, among which stress response is the most common one. As a new concept of healthy self, it is not clear how self - compassion affects students’ stress response. OBJECTIVE: This study aimed to analyze the role of students’ self-compassion based on chronic stress response in negative emotional regulation and coping style selection caused by external pressure, and to provide a theoretical basis for the application of self-compassion in regulating individual emotions in the future. METHODS: The 427 students from many universities in China who have applied for the 2020 postgraduate entrance examination and were preparing for the examination were classified into S1 group (preparation time <  2 months), S2 group (2 months <  5 months), and S3 group (preparation time >  5 months). The students who didn’t apply for the examination were set as D0 control group. The total stress response score, learning pressure, and positive and negative emotional scores of each group were compared. The Bootstrapping sampling method was used to examine the mediating effect of self - compassion. The students applying for the examination were classified into high-level self-compassion group (G1) and low-level self-compassion group (G2). RESULTS: The scores of learning stress and negative emotion in S1, S2, and S3 groups were significantly higher than those in D0 group, and S1 >  S2 >  S3 (P <  0.05). The proportion of students in G1 group who responded to review setbacks in a mature way was significantly higher than that in G2 group, and the proportion of immature type was significantly lower than that of G2 group (P <  0.05). There was a very significant positive correlation between self-compassion and problem solving and asking for help (P <  0.001). CONCLUSIONS: Self-compassion concept can reduce students’ negative emotions facing external pressure and protect individual positive emotions. In conclusion, faced at external pressure and stress, individuals with high self-esteem would not escape from their own negative emotions, and were more inclined to choose a positive way to solve problems and seek help from others.

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