Diagnostic accuracy of Kleihauer–Betke (Kb) testing to predict fetal outcomes associated with fetomaternal hemorrhage: a retrospective cohort study

Abstract Background: Blood urea nitrogen (BUN) and creatinine (SCr) are associated with gestational diabetes mellitus (GDM). However, there were limited data in the literature on the influence of BUN and SCr on maternal and fetal outcomes of pregnancy. We aimed to examine the association of BUN and SCr levels during gestation with the risk of selected adverse pregnancy outcomes.Methods: This retrospective cohort study included 1606 singleton mothers aged 22-44 years. Both BUN and SCr levels were collected and measured during the second (16-18th week), third (28-30th week) trimesters of gestation respectively and followed up pregnancy outcomes. Statistical analysis was used multivariate logistic regression. Results: In the multivariate adjusted logistic regression model, the highest level of SCr in the second trimester increased the risk of PROM by 45% (95% CI, 1.01-2.09). In the third trimester of gestation, compared with those in the lowest quartile, BUN levels in the highest quartile decreased the risk of macrosomia and LGA by 60%(95% CI, 0.20-0.78), 66%(95% CI, 0.21,0.55) , respectively, and increased the risk of SGA by 137%(1.06, 5.31), 186%(1.29,6.34) in the third and fourth quartiles, respectively. The adjusted OR (95%CI) for macrosomia in the fourth quartile was 0.46 (0.24, 0.87), for SGA in the third quartiles was 2.36 (1.10, 5.10), and for LGA in the fourth quartile was 0.61 (0.41,0.91) compared with those in the first quartile of SCr levels. The elevated changes of BUN (> 0.64mmol/L) was the risk factor of SGA (OR: 2.11, 95%CI: 1.03,4.32).Conclusion: Higher BUN and SCr levels during the 28-30th week of gestation even those towards the upper limit of the normal range can act as a warning sign of the impending SGA. Elevated changes of BUN and SCr during pregnancy also associated with the lower birth weight.

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Maternal and fetal outcomes in women with cerebrovascular malformations in pregnancy: a multicentre retrospective cohort study

BJOG An International Journal of Obstetrics & Gynaecology ◽

10.1111/1471-0528.17046 ◽

2021 ◽

Author(s):

Matthew Cauldwell ◽

Emma Bredaki ◽

Pooja Dassan ◽

Mandish K Dhanjal ◽

Mandeep Kaler ◽

...

Keyword(s):

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Fetal Outcomes ◽

In Pregnancy

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Simplified Clinical Decision Rule Using Clinically Important Events for Risk Prediction in Pediatric Head Injury: A Retrospective Cohort Study

Journal of Clinical Medicine ◽

10.3390/jcm10225248 ◽

2021 ◽

Vol 10 (22) ◽

pp. 5248

Author(s):

Naoki Yogo ◽

Chiaki Toida ◽

Takashi Muguruma ◽

Masayasu Gakumazawa ◽

Mafumi Shinohara ◽

...

Keyword(s):

Cohort Study ◽

Head Injury ◽

Diagnostic Accuracy ◽

Decision Rule ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Characteristic Curve ◽

Clinical Decision ◽

The Novel ◽

Clinical Decision Rule

Computed tomography (CT) scans are useful for confirming head injury diagnoses. However, there is no standard clinical decision rule (CDR) for determining the need for CT scanning in pediatric patients with head injuries. We developed a CDR and conducted a retrospective cohort study to evaluate its diagnostic accuracy in identifying children with clinically important traumatic brain injury (ciTBI). We selected predictors based on three existing CDRs: CATCH, CHALICE, and PECARN. Of the 2569 eligible patients, 645 (439 (68%) boys, median age: five years) were included in this study. In total, 59 (9%) patients showed ciTBI, and 129 (20%) were admitted to hospital. The novel CDR comprised six predictors of abnormal CT findings. It had a sensitivity of 79.5% (95% confidence interval (CI): 65.5–89.0%) and a specificity of 50.9% (95% CI: 48.9–52.3%). The area under the receiver-operating characteristic curve (0.72, 95% CI: 0.67–0.77) was non-inferior to those of CATCH, CHALICE, and PECARN (0.71, 95% CI: 0.66–0.77; 0.67, 95% CI: 0.61–0.74; and 0.69, 95% CI: 0.64–0.73, respectively; p = 0.57). The novel CDR was statistically noninferior in diagnostic accuracy compared to the three existing CDRs. Further development and validation studies are needed before clinical application.

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Diagnostic accuracy of CT for COVID-19 Re: Diagnostic accuracy of screening tests for patients suspected of COVID-19, a retrospective cohort study

Infectious Diseases ◽

10.1080/23744235.2021.1973090 ◽

2021 ◽

pp. 1-2

Author(s):

Sakib Kazi ◽

Marissa Absi ◽

Nayaar Islam ◽

Sanam Ebrahimzadeh ◽

Matthew D. F. McInnes

Keyword(s):

Cohort Study ◽

Diagnostic Accuracy ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Screening Tests

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Diagnostic accuracy of parathyroid hormone levels in washout samples of suspicious parathyroid adenomas: A single-centre retrospective cohort study

Clinical Endocrinology ◽

10.1111/cen.13812 ◽

2018 ◽

Vol 89 (4) ◽

pp. 489-495 ◽

Cited By ~ 1

Author(s):

Asena Gökçay Canpolat ◽

Mustafa Şahin ◽

Elif Ediboğlu ◽

Murat Faik Erdoğan ◽

Sevim Güllü ◽

...

Keyword(s):

Cohort Study ◽

Parathyroid Hormone ◽

Diagnostic Accuracy ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Single Centre ◽

Hormone Levels ◽

Parathyroid Adenomas

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Effect of advanced maternal age on pregnancy outcome - A retrospective cohort study

Indian Journal of Obstetrics and Gynecology Research ◽

10.18231/j.ijogr.2021.077 ◽

2021 ◽

Vol 8 (3) ◽

pp. 377-382

Keyword(s):

Cohort Study ◽

Gestational Diabetes ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Maternal Age ◽

Gestational Hypertension ◽

Preterm Labour ◽

Advanced Maternal Age ◽

Maternal Complications ◽

Fetal Outcomes

To determine the risks of pregnancy and to study the adverse maternal and fetal outcomes of pregnancy in advanced maternal age.This study was a retrospective cohort study. Which was conducted in the Department of Obstetrics and Gynaecology, Government Medical College, Kozhikode. Data were collected from Department Medical Records Library. Data consisted of study group with maternal age above 35 years and control group with age less than 35 years. Cases beyond 28 weeks of gestation, both primiparous and multiparous patients were included. Minimum 262 patients were included in each group. Gestational age, presentation, mode of delivery, indications for caesarean, maternal complications and fetal outcomes were analysed. Statistical analysis was done by SPSS16.0 statistical software. In this study statistically significant difference in maternal complications like incidence of gestational diabetes, gestational hypertension and preterm labour were observed in advanced maternal age women.Increasing incidence of maternal complications both obstetric and medical were observed in the advanced age mothers (AMA). There was a significant increase in preterm labour, increased caesarean delivery, PROM, PPROM, gestational hypertension, gestational diabetes, VLBW babies, intrauterine death in these elderly mothers. Due to the increase and advances of infertility treatments has made it common for mothers to become pregnant even at late forties.

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