Disruption of monocyte-macrophage differentiation and trafficking by a heme analog during active inflammation

2021 ◽  
Author(s):  
Rachel E. M. Schaefer ◽  
Rosemary C. Callahan ◽  
Shaikh M. Atif ◽  
David J. Orlicky ◽  
Ian M. Cartwright ◽  
...  
Keyword(s):  
Macrophage Differentiation ◽  
Active Inflammation

Influence of hepatocytes on macrophage differentiation

2016 ◽  
Vol 54 (12) ◽  
pp. 1343-1404
Author(s):  
W Stephanie ◽  
D Häussinger ◽  
JG Bode
Keyword(s):  
Macrophage Differentiation

Uric Acid in Metabolic and Cerebrovascular Disorders: A Review

2020 ◽  
Vol 18 (6) ◽  
pp. 610-618
Author(s):  
Francesca Cortese ◽  
Pietro Scicchitano ◽  
Anna M. Cortese ◽  
Giovanni Meliota ◽  
Andrea Andriani ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Cerebrovascular Disorders ◽  
Haemorrhagic Stroke ◽  
Cerebrovascular Diseases ◽  
Healthcare Research ◽  
Cochrane Library ◽  
Close Link ◽  
Mesh Terms ◽  
Active Inflammation

Background: Several studies showed a close link between metabolic syndrome (MetS), type 2 diabetes (T2DM) and cerebrovascular diseases. There is considerable debate regarding the role of uric acid (UA) as a risk factor in these conditions. Objective: The aim of this narrative review is to discuss the links between UA, MetS, T2DM and cerebrovascular disease. Methods: An extensive review has been conducted based on the scientific literature published in English, and indexed in MEDLINE (through PubMed), EMBASE, the Cochrane Library, the Agency for Healthcare Research and Quality, and Google Scholar from January to May 2019. Additional relevant studies published after the initial review were also considered during the period of June 2019-October 2019, during which, this manuscript was written. The Mesh Terms considered were: uric acid, antioxidant, oxidant, metabolic syndrome, diabetes, cerebrovascular diseases, stroke, haemorrhagic stroke, neurocognitive disorders, and their combinations. Results: The literature review shows a dose-dependent inflammatory action of UA, which occurs with serum concentrations >4 mg/dl (>0.24 mmol/l), representing one of the contributors to the chronic inflammatory process that underlies metabolic and cerebrovascular diseases. Conclusion: UA, which is associated with arterial hypertension and cardiovascular diseases, represents one of the indicators of oxidative homeostasis. Increasing concentrations represent a status of active inflammation which is observed with metabolic and cerebrovascular diseases.

scholarly journals Genomic Structure and Mapping of Human Orphan Receptor LXR Alpha : Upregulation of LXRa mRNA During Monocyte to Macrophage Differentiation

2000 ◽  
Vol 7 (3) ◽  
pp. 145-151 ◽  
Author(s):  
Takahide Kohro ◽  
Toshiaki Nakajima ◽  
Yoichiroh Wada ◽  
Akira Sugiyama ◽  
Masami Ishii ◽  
...  
Keyword(s):  
Genomic Structure ◽  
Orphan Receptor ◽  
Macrophage Differentiation

Mono-2-ethylhexylphthalate (MEHP) induces TNF-α release and macrophage differentiation through different signalling pathways in RAW264.7 cells

2012 ◽  
Vol 209 (1) ◽  
pp. 43-50 ◽  
Author(s):  
Anette Kocbach Bølling ◽  
Johan Ovrevik ◽  
Jan Tore Samuelsen ◽  
Jørn A. Holme ◽  
Kirsten E. Rakkestad ◽  
...  
Keyword(s):  
Raw264.7 Cells ◽  
Signalling Pathways ◽  
Macrophage Differentiation ◽  
Tnf Α

scholarly journals Complete heart block in cardiac sarcoidosis reversed by corticosteroid therapy: time course of resolution

2021 ◽  
Vol 14 (3) ◽  
pp. e240834
Author(s):  
Anna Tomdio ◽  
Huzaefah Syed ◽  
Kenneth Ellenbogen ◽  
Jordana Kron
Keyword(s):  
Heart Block ◽  
Time Course ◽  
Cardiac Sarcoidosis ◽  
Complete Heart Block ◽  
Positron Emission ◽  
Av Conduction ◽  
Magnetic Resonance Imaging Mri ◽  
High Level ◽  
Active Inflammation ◽  
Lateral Walls

A 53-year-old man was admitted for recurrent syncope and found to have complete heart block (CHB). Cardiac magnetic resonance imaging MRI) showed extensive patchy late gadolinium enhancement in the apical and lateral walls, consistent with cardiac sarcoidosis (CS) but no scar in the septum. A fluorodeoxyglucose (FDG)–positron emission tomography showed FDG uptake in the septum and basal lateral walls. Imaging suggested active inflammation in the septum affecting atrioventricular (AV) conduction but no irreversible fibrosis. Diagnosis of isolated CS requires a high level of suspicion and multidisciplinary teamwork involving heart failure specialists, electrophysiologists and rheumatologists. After specialist and patient discussion, treatment of the disease was initiated with prednisone 40 mg daily, 11 months after presenting with CHB. Three weeks later, ECG with pacing inhibited showed second-degree AV block Mobitz type II and 4 weeks later, AV conduction recovery. This highlights the importance of immediate therapy in reversing AV conduction abnormalities in CS.

Strontium-doped gelatin scaffolds promote M2 macrophage switch and angiogenesis through modulating the polarization of neutrophils

2021 ◽  
Vol 9 (8) ◽  
pp. 2931-2946
Author(s):  
Tao Li ◽  
Hongtao He ◽  
Zezheng Yang ◽  
Junjie Wang ◽  
Yuxin Zhang ◽  
...  
Keyword(s):  
Signal Pathway ◽  
M2 Macrophage ◽  
Macrophage Differentiation ◽  
Inflammation Resolution

Sr incorporated scaffolds promote the polarization of neutrophils to the N2 phenotype through STAT3 activation and inhibition of the NF-κB signal pathway, which induced M2 macrophage differentiation, inflammation resolution and angiogenesis.

scholarly journals Fecal Calprotectin, CRP and Leucocytes in IBD Patients: Comparison of Biomarkers With Biopsy Results

2020 ◽  
Author(s):  
Barry D Kyle ◽  
Terence A Agbor ◽  
Shajib Sharif ◽  
Usha Chauhan ◽  
John Marshall ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Fecal Calprotectin ◽  
Dependent Manner ◽  
Ascending Colon ◽  
C Reactive Protein ◽  
Concentration Dependent Manner ◽  
Reactive Protein ◽  
Inflammatory Bowel ◽  
Descending Colon ◽  
Active Inflammation

Abstract Background This study aimed to compare fecal calprotectin (FC) levels with other commonly used parameters as part of patient care during evaluation for inflammatory bowel disease (IBD). Methods We recruited adult IBD patients with ulcerative colitis (UC) and Crohn’s disease (CD) and compared the results of the patient’s biopsy results (i.e., inflamed versus noninflamed) for six sites (i.e., ileum, ascending colon, transverse colon, descending colon, sigmoid colon, rectum) with concentrations of C-reactive protein (CRP), total leucocytes and fecal calprotectin (FC). Results We found that FC was significantly elevated in a concentration-dependent manner that correlated with the number of active inflammation sites reported in biopsy. Although CRP and leucocyte measurements trended upwards in line with inflammation reported from biopsy, the results were highly variable and highlighted poor reliability of these biomarkers for indicating IBD inflammation. Conclusions These results strongly suggest that FC correlates best with biopsy reports and is a superior marker than CRP and leucocytes.

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