scholarly journals LED-phototherapy does not induce oxidative DNA damage in hyperbilirubinemic Gunn rats

2019 ◽  
Vol 85 (7) ◽  
pp. 1041-1047 ◽  
Author(s):  
Lori W. E. van der Schoor ◽  
Christian V. Hulzebos ◽  
Martijn H. van Faassen ◽  
Ido P. Kema ◽  
Alain de Bruin ◽  
...  
Keyword(s):  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Led Phototherapy ◽  
Gunn Rats

scholarly journals Blue LED phototherapy in preterm infants: effects on an oxidative marker of DNA damage

2020 ◽  
Vol 105 (6) ◽  
pp. 628-633
Author(s):  
Lori W E van der Schoor ◽  
Martijn H J R van Faassen ◽  
Ido Kema ◽  
Dyvonne H Baptist ◽  
Annelies J Olthuis ◽  
...  
Keyword(s):  
Dna Damage ◽  
Preterm Infants ◽  
Oxidative Dna Damage ◽  
Serum Bilirubin ◽  
Light Emitting Diode ◽  
Total Serum ◽  
Creatinine Ratio ◽  
Light Emitting ◽  
Led Phototherapy ◽  
Observational Cohort

BackgroundPhototherapy is used on the majority of preterm infants with unconjugated hyperbilirubinaemia. The use of fluorescent tube phototherapy is known to induce oxidative DNA damage in infants and has largely been replaced by blue light-emitting diode phototherapy (BLP). To date, it is unknown whether BLP also induces oxidative DNA damage in preterm infants.ObjectiveTo determine whether BLP in preterm infants induces oxidative DNA damage as indicated by 8-hydroxy-2′deoxyguanosine (8-OHdG).DesignObservational cohort study.MethodsUrine samples (n=481) were collected in a cohort of 40 preterm infants (24–32 weeks’ gestational age) during the first week after birth. Urine was analysed for the oxidative marker of DNA damage 8-OHdG and for creatinine, and the 8-OHdG/creatinine ratio was calculated. Durations of phototherapy and levels of irradiance were monitored as well as total serum bilirubin concentrations.ResultsBLP did not alter urinary 8-OHdG/creatinine ratios (B=0.2, 95% CI −6.2 to 6.6) at either low (10–30 µW/cm2/nm) or high (>30 µW/cm2/nm) irradiance: (B=2.3, 95% CI −5.7 to 10.2 and B=−3.0, 95% CI −11.7 to 5.6, respectively). Also, the 8-OHdG/creatinine ratios were independent on phototherapy duration (B=−0.1, 95% CI −0.3 to 0.1).ConclusionsBLP at irradiances up to 35 µW/cm2/nm given to preterm infants ≤32 weeks’ gestation does not affect 8-OHdG, an oxidative marker of DNA damage.

Acrylamide Exposure and Oxidative DNA Damage, Lipid Peroxidation and Fasting Plasma Glucose Alteration: Association and Mediation Analyses in Chinese Urban Adults

2020 ◽  
Author(s):  
Bin Wang ◽  
Weihong Qiu ◽  
Shijie Yang ◽  
Limin Cao ◽  
Chunmei Zhu ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Dna Damage ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Oxidative Dna Damage ◽  
Adult Population ◽  
Prostaglandin F2α ◽  
Mediation Analyses ◽  
Mediating Role ◽  
Fasting Plasma

<a><b>OBJECTIVE: </b></a>Acrylamide exposure from daily-consumed food has raised global concern.<b> </b>We aimed to assess the exposure-response relationships of internal acrylamide exposure with oxidative DNA damage, lipid peroxidation and fasting plasma glucose (FPG) alteration, and investigate the mediating role of oxidative DNA damage and lipid peroxidation in the association of internal acrylamide exposure with FPG. <p><b>RESEARCH DESIGN AND METHODS:</b> FPG and urinary biomarkers of oxidative DNA damage (8-hydroxy-deoxy-guanosine, 8-OHdG), lipid peroxidation (8-iso-prostaglandin-F2α, 8-iso-PGF2α) and acrylamide exposure (N-acetyl-S-(2-carbamoylethyl)-L-cysteine, AAMA; N-acetyl-S-(2-carbamoyl-2-hydroxyethyl)-L-cysteine, GAMA) were measured for 3,270 general adults from the Wuhan-Zhuhai cohort. The associations of urinary acrylamide metabolites with 8-OHdG, 8-iso-PGF2α and FPG were assessed by linear mixed models. The mediating roles of 8-OHdG and 8-iso-PGF2α were evaluated by mediation analysis.</p> <p><b>RESULTS:</b> We found significant linear positive dose-response relationships of urinary acrylamide metabolites with 8-OHdG, 8-iso-PGF2α and FPG (except GAMA with FPG), and 8-iso-PGF2α with FPG. Each 1-unit increase in log-transformed level of AAMA, ΣUAAM (AAMA+GAMA) or 8-iso-PGF2α was associated with a 0.17-, 0.15- or 0.23-mmol/L increase in FPG, respectively (<i>P </i>or/and<i> P trend</i><0.05). Each 1% increase in AAMA, GAMA or ΣUAAM was associated with a 0.19%, 0.27% or 0.22% increase in 8-OHdG, respectively, and a 0.40%, 0.48% or 0.44% increase in 8-iso-PGF2α, respectively (<i>P </i>and<i> P trend</i><0.05). Increased 8-iso-PGF2α rather than 8-OHdG significantly mediated 64.29% and 76.92% of the AAMA and ΣUAAM associated-FPG increases, respectively.</p> <p><b>CONCLUSIONS:</b> Exposure of general adult population to acrylamide was associated with FPG elevation, oxidative DNA damage and lipid peroxidation, which in turn partly mediated acrylamide-associated FPG elevation.<b></b></p>

Serum of 8-OHdG as a potential biomarker of oxidative DNA damage in workers exposed to harmful working environments

2020 ◽  
pp. 783-783
Author(s):  
I. A. Umnyagina ◽  
L. A. Strakhova ◽  
T. V. Blinova
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Blood Serum ◽  
Oxidative Dna Damage ◽  
Working Environment ◽  
Working Environments ◽  
Potential Biomarker ◽  
High Level ◽  
Damage Marker

In the blood serum of 70% individuals exposed to harmful factors of the working environment, a high level of oxidative stress and the DNA damage marker 8-Hydroxy-2’-Deoxyguanosine (8-OHdG) were detected.

ANTIOXIDANT POTENTIAL AND OXIDATIVE DNA DAMAGE PREVENTIVE ACTIVITY OFCHRYSANTHEMUM INDICUMEXTRACTS

2012 ◽  
Vol 37 (4) ◽  
pp. 440-448 ◽  
Author(s):  
TRISHNA DEBNATH ◽  
HAI LAN JIN ◽  
MD ABUL HASNAT ◽  
YUNSUK KIM ◽  
NADIRA BINTE SAMAD ◽  
...  
Keyword(s):  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Antioxidant Potential ◽  
Preventive Activity

Assessment of oxidative DNA damage, oxidative stress responses and histopathological alterations in gill and liver tissues of Oncorhynchus mykiss treated with linuron

2020 ◽  
pp. 096032712098420
Author(s):  
Ahmet Topal ◽  
Arzu Gergit ◽  
Mustafa Özkaraca
Keyword(s):  
Dna Damage ◽  
Stress Responses ◽  
Oxidative Dna Damage ◽  
Chloride Cells ◽  
Histopathological Changes ◽  
Sod Activity ◽  
Antioxidant Responses ◽  
Secondary Lamellae ◽  
Antioxidant Parameters ◽  
Oxidative Stress Responses

We investigated changes in 8-hydroxy-2-deoxyguanosine (8-OHdG) activity which is a product of oxidative DNA damage, histopathological changes and antioxidant responses in liver and gill tissues of rainbow trout, following a 21-day exposure to three different concentrations of linuron (30 µg/L, 120 µg/L and 240 µg/L). Our results indicated that linuron concentrations caused an increase in LPO levels of liver and gill tissues ( p < 0.05). While linuron induced both increases and decreases in GSH levels and SOD activity, CAT activity was decreased by all concentrations of linuron ( p < 0.05). The immunopositivity of 8-OHdG was detected in the hepatocytes of liver and in the epithelial and chloride cells of the secondary lamellae of the gill tissues. Our results suggested that linuron could cause oxidative DNA damage by causing an increase in 8-OHdG activity in tissues, and it induces histopathological damage and alterations in the antioxidant parameters of the tissues.

Thymoquinone sensitizes human hepatocarcinoma cells to TRAIL-induced apoptosis via oxidative DNA damage

DNA Repair ◽  
2021 ◽  
pp. 103117
Author(s):  
Ruikui Zhang ◽  
Tao Wu ◽  
Peipei Zheng ◽  
Ming Liu ◽  
Guixiang Xu ◽  
...  
Keyword(s):  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Hepatocarcinoma Cells ◽  
Induced Apoptosis ◽  
Human Hepatocarcinoma Cells
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