scholarly journals Blue LED phototherapy in preterm infants: effects on an oxidative marker of DNA damage

2020 ◽  
Vol 105 (6) ◽  
pp. 628-633
Author(s):  
Lori W E van der Schoor ◽  
Martijn H J R van Faassen ◽  
Ido Kema ◽  
Dyvonne H Baptist ◽  
Annelies J Olthuis ◽  
...  
Keyword(s):  
Dna Damage ◽  
Preterm Infants ◽  
Oxidative Dna Damage ◽  
Serum Bilirubin ◽  
Light Emitting Diode ◽  
Total Serum ◽  
Creatinine Ratio ◽  
Light Emitting ◽  
Led Phototherapy ◽  
Observational Cohort

BackgroundPhototherapy is used on the majority of preterm infants with unconjugated hyperbilirubinaemia. The use of fluorescent tube phototherapy is known to induce oxidative DNA damage in infants and has largely been replaced by blue light-emitting diode phototherapy (BLP). To date, it is unknown whether BLP also induces oxidative DNA damage in preterm infants.ObjectiveTo determine whether BLP in preterm infants induces oxidative DNA damage as indicated by 8-hydroxy-2′deoxyguanosine (8-OHdG).DesignObservational cohort study.MethodsUrine samples (n=481) were collected in a cohort of 40 preterm infants (24–32 weeks’ gestational age) during the first week after birth. Urine was analysed for the oxidative marker of DNA damage 8-OHdG and for creatinine, and the 8-OHdG/creatinine ratio was calculated. Durations of phototherapy and levels of irradiance were monitored as well as total serum bilirubin concentrations.ResultsBLP did not alter urinary 8-OHdG/creatinine ratios (B=0.2, 95% CI −6.2 to 6.6) at either low (10–30 µW/cm2/nm) or high (>30 µW/cm2/nm) irradiance: (B=2.3, 95% CI −5.7 to 10.2 and B=−3.0, 95% CI −11.7 to 5.6, respectively). Also, the 8-OHdG/creatinine ratios were independent on phototherapy duration (B=−0.1, 95% CI −0.3 to 0.1).ConclusionsBLP at irradiances up to 35 µW/cm2/nm given to preterm infants ≤32 weeks’ gestation does not affect 8-OHdG, an oxidative marker of DNA damage.

scholarly journals Comparison of Light Emitting Diode Phototherapy vs Conventional Phototherapy for Neonatal Hyperbilirubinemia: A Quasi-experimental Study

2021 ◽  
Author(s):  
Charul Mehta ◽  
K Gayatri ◽  
Dhruvika G Chaudhari ◽  
Bhavin Patel ◽  
Shashank Bansal ◽  
...  
Keyword(s):  
Experimental Study ◽  
Serum Bilirubin ◽  
Light Emitting Diode ◽  
Neonatal Hyperbilirubinemia ◽  
Total Serum ◽  
Care Hospital ◽  
Term Neonates ◽  
Light Emitting ◽  
Led Phototherapy ◽  
Quasi Experimental

Introduction: Neonatal hyperbilirubinemia is one of the most common problem encountered during the neonatal period. Phototherapy is a widely accepted, cheap, non-invasive relatively safe and effective method of treatment for neonatal hyperbilirubinemia. Aim: To compare the efficacy of Light Emitting Diode (LED) phototherapy vs Conventional Phototherapy for treatment of neonatal hyperbilirubinemia in healthy term neonates. Materials and Methods: A quasi experimental study was conducted in Neonatal Intensive Care Unit and Post-natal wards in a tertiary care hospital affiliated to Medical College and Hospital, Ahmedabad, Gujarat from July 2018 to April 2019 with a sample size of 135 in each group. They were assessed clinically by Kramers method just before initiation of phototherapy, then using Transcutaneous Bilirubinometer (TCB) Total Serum Bilirubin (TSB) level was measured. Bilirubin assessment by these methods were done for every neonate before initiation of phototherapy and then again repeated after 24 and 48 hours of phototherapy. Data was collected and analysed in Microsoft (MS) excel Statistical Package for the Social Sciences (SPSS) 0.26. Chi-square test was used for comparison. Results: In the present study, 158 (58.51%) babies were male and 112 (41.48%) babies were female. Initially, LED was found to be better than Compact Fluorescent (CFL) conventional phototherapy on comparing the average fall in the serum bilirubin level from baseline during the first 24 hours however no such difference in the efficacy between the two light sources was seen after a period of 48 hours. Total 9 (6.66%) patients developed rebound hyperbilirubinemia after completion of conventional phototherapy whereas 14 (10.37%) developed rebound hyperbilirubinemia after completion of 48 hours of LED phototherapy. Conclusion: LED and conventional phototherapy were equally efficacious in managing non haemolytic hyperbilirubinemia in healthy term neonates.

scholarly journals Comparison of light emitting diode and compact fluorescent lamp phototherapy in treatment of neonatal hyperbilirubinemia

2017 ◽  
Vol 4 (2) ◽  
pp. 341 ◽  
Author(s):  
Maharoof M.K. ◽  
Shamshad Ahmed Khan ◽  
Prakash Robert Saldanha ◽  
Reshad Mohamed
Keyword(s):  
Gestational Age ◽  
Serum Bilirubin ◽  
Light Emitting Diode ◽  
Neonatal Hyperbilirubinemia ◽  
Total Serum Bilirubin ◽  
Total Serum ◽  
Fluorescent Lamp ◽  
Light Emitting ◽  
The Mean ◽  
Compact Fluorescent Lamp

Background: High levels of total serum bilirubin can cause life threatening complications in neonates requiring management either with phototherapy or exchange blood transfusion. Most commonly used modality of phototherapy is with blue light. There are many bulbs like fluorescent tubes, halogen spotlights etc. Due to disadvantages of the available bulbs, newer method like light-emitting diodes (LEDs) has been investigated as possible alternatives as they produce low heat, has a longer life span with lower energy consumption and rapid reduction of serum bilirubin level. The aim was to compare the efficacy between phototherapy equipped with light emitting diode (LED) to compact fluorescent lamp (CFL) in the treatment of neonatal hyperbilirubinemia among neonates.Methods: A hospital-based intervention study was conducted among 50 neonates born in the hospital during the study period, with gestational age more than equal to 35 weeks, being breastfed and healthy in a private medical college teaching hospital in Dakshina Kannada district from August to September 2016.  Following ethical committee clearance the neonates looking icteric by clinical examination were randomly allocated to receive CFL or LED phototherapy. Baseline, 24 hour total serum bilirubin and rectal temperature was measured.  Results: A total of 50 neonates were randomly allocated into two groups with almost similar characteristics between the two groups with respect to gender, type of delivery and gestational age. The mean bilirubin values (in mg/dl) among neonates in the CFL group and LED group were 14.8 and 15.6 respectively and post 24 hour values were 11.54 and 10.68 respectively. The mean difference in the reduction in the bilirubin values before and after receiving phototherapy between the two groups were significant (p <0.001). The increase in temperature was lesser among LED treatment group.Conclusions: LED therapy is better than the CFL therapy in terms of mean reduction in the total serum bilirubin after a fixed duration of time and lesser raise in temperature among the neonates.  

scholarly journals Transcutaneous bilirubinometry during and after phototherapy in preterm infants: a prospective observational study

2020 ◽  
Vol 4 (1) ◽  
pp. e000681
Author(s):  
Ali Ahmed Raba ◽  
Anne O'Sullivan ◽  
Jan Miletin
Keyword(s):  
Preterm Infants ◽  
Prospective Observational Study ◽  
Serum Bilirubin ◽  
Observational Cohort Study ◽  
Total Serum ◽  
Prospective Observational Cohort Study ◽  
Outer Quadrant ◽  
Covered Area ◽  
Observational Cohort ◽  
Transcutaneous Bilirubinometry

ObjectiveTo examine the accuracy of transcutaneous bilirubinometry (TCB) measurements during and after phototherapy (PT) in preterm infants.DesignProspective observational cohort study.SettingLevel III neonatal centre.PatientsPreterm infants (from 23+0 to 36+6 weeks of gestation) born between June 2017 and May 2018 requiring PT.InterventionsTCB was measured from an exposed area of the skin (the sternum; TCBU) and the covered area of the skin under the nappy (the bony part of the upper outer quadrant of the buttock; TCBC) within an hour of obtaining total serum bilirubin (TSB).Main outcome measuresCorrelation and agreement between TCB (TCBU and TCBC) and TSB during and after PT.ResultsWe have enrolled 196 preterm infants. There was a significant correlation between TSB and TCB during PT (r=0.72, 95% CI 0.66 to 0.77 in covered area; r=0.75, 95% CI 0.70 to 0.80 in uncovered area) and after PT (r=0.87, 95% CI 0.83 to 0.91). TCB underestimated TSB level during PT, with a mean TCBC–TSB difference of −25±43 (95% agreement limits of 62 to −112) and a mean TCBU–TSB difference of −48±46 (95% agreement limits of 45 to −140). The agreement between TCB and TSB after cessation of PT improved, with TCB underestimating TSB by a mean TCB–TSB difference of −10±31 (95% agreement limits of 52 to −72).ConclusionTCB measurements correlated strongly with TSB levels during and after PT. However, there was a wide and clinically relevant disagreement between TCB and TSB measurements during the PT phase, improving significantly after PT.

scholarly journals Toluidine blue O and porphyrin-mediated photodynamic therapy on three main pathogenic bacteria of periodontitis using portable LED phototherapy device

2015 ◽  
Vol 08 (04) ◽  
pp. 1550017 ◽  
Author(s):  
Xuewei Jiang ◽  
Zhichao Fan ◽  
Yili Yu ◽  
Chenying Shao ◽  
Yuanzhen Suo ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Toluidine Blue ◽  
Pathogenic Bacteria ◽  
Light Emitting Diode ◽  
Red Light ◽  
In Vitro Screening ◽  
Light Emitting ◽  
Led Phototherapy ◽  
Prevotella Melaninogenica

Photodynamic therapy (PDT) has been commonly used in treating many diseases, such as cancer and infectious diseases. We investigated the different effects of PDT on three main pathogenic bacteria of periodontitis — Prevotella melaninogenica (P.m.), Porphyromonas gingivalis (P.g.) and Aggregatibacter actinomycetemcomitans (A.a.). The portable red light-emitting diode (LED) phototherapy device was used to assess the exogenous PDT effects with different light doses and photosensitizer concentrations (Toluidine blue O, TBO). The portable blue LED phototherapy device was used to assess the endogenous PDT effects with the use of endogenous photosensitizers (porphyrin) under different light doses. We found out that both exogenous and endogenous PDT were able to restrict the growth of all the three bacteria significantly. Moreover, the optimal PDT conditions for these bacteria were obtained through this in vitro screening and could guide the clinical PDT on periodontitis.

Effect of the laser and light-emitting diode (LED) phototherapy on midpalatal suture bone formation after rapid maxilla expansion: a Raman spectroscopy analysis

2013 ◽  
Vol 29 (3) ◽  
pp. 859-867 ◽  
Author(s):  
Cristiane Becher Rosa ◽  
Fernando Antonio Lima Habib ◽  
Telma Martins de Araújo ◽  
Juliana Silveira Aragão ◽  
Rafael Soares Gomes ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Bone Formation ◽  
Light Emitting Diode ◽  
Spectroscopy Analysis ◽  
Midpalatal Suture ◽  
Light Emitting ◽  
Led Phototherapy

scholarly journals Cognitive Oucome of Preterm Infants is Related to Maximal Total Serum Bilirubin

2011 ◽  
Vol 70 ◽  
pp. 348-348
Author(s):  
A B Schreuder ◽  
D E Van Imhoff ◽  
P H Dijk ◽  
M Schaaf ◽  
A F Bos ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Serum Bilirubin ◽  
Total Serum Bilirubin ◽  
Total Serum

scholarly journals Effectiveness of light emitting diode versus conventional phototherapy in neonatal hyperbilirubinemia: a hospital based observational study

2020 ◽  
Vol 8 (3) ◽  
pp. 1051
Author(s):  
Radheshyam Purkait ◽  
Manik Mondal
Keyword(s):  
Side Effects ◽  
Light Emitting Diode ◽  
Total Duration ◽  
Conventional Group ◽  
Light Sources ◽  
Fluorescent Lamp ◽  
Light Emitting ◽  
Led Phototherapy ◽  
Significant Difference ◽  
Compact Fluorescent Lamp

Background: The most commonly used light sources in the conventional phototherapy units are compact fluorescent lamp (CFL), halogen spotlights and fiberoptic blankets. Recently light emitting diodes (LED) has emerged as better light source for phototherapy and almost replacing all the available conventional light sources. Comparative studies on the efficacy of LED versus conventional phototherapy are limited from India. That is why; this study was undertaken.Methods: 48 neonates of ≥35 weeks gestational age with hyperbilirubinemia were participated in this study. Among them, 24 neonates received conventional phototherapy and rest of them received LED phototherapy. The rate of fall of bilirubin levels at 6 hours and at completion along with total duration of phototherapy in both groups was measured. Results analysed by standard statistical methods.Results: LED phototherapy units showed higher rate of fall in bilirubin at six hrs (LED group: 0.38±0.05 mg/dl/hr versus conventional group: 0.30±0.04 mg/dl/hr, p<0.05) and after completion of therapy (LED group:                      0.32±0.03 mg/dl/hr versus conventional group: 0.26±0.03 mg/dl/hr, p<0.05) compared to conventional group. Significant difference was documented in total duration of phototherapy in LED group (30.8±1.8 hours) when compared to conventional group (34.6±0.7 hours). None of the neonate showed phototherapy failure. Side effects were minimal and comparable in both the groups.Conclusions: The LED phototherapy units are more efficacious in terms of higher rate of fall of bilirubin levels and lesser duration of phototherapy compared to conventional phototherapy units.

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