scholarly journals The link between attention deficit hyperactivity disorder (ADHD) symptoms and obesity-related traits: genetic and prenatal explanations

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ville Karhunen ◽  
Tom A. Bond ◽  
Verena Zuber ◽  
Tuula Hurtig ◽  
Irma Moilanen ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Association Analysis ◽  
Attention Deficit ◽  
Association Studies ◽  
Risk Scores ◽  
Genome Wide Association Studies ◽  
Adhd Symptoms ◽  
Hyperactivity Disorder ◽  
Inattention And Hyperactivity ◽  
The Impact

AbstractAttention-deficit/hyperactivity disorder (ADHD) often co-occurs with obesity, however, the potential causality between the traits remains unclear. We examined both genetic and prenatal evidence for causality using Mendelian Randomisation (MR) and polygenic risk scores (PRS). We conducted bi-directional MR on ADHD liability and six obesity-related traits using summary statistics from the largest available meta-analyses of genome-wide association studies. We also examined the shared genetic aetiology between ADHD symptoms (inattention and hyperactivity) and body mass index (BMI) by PRS association analysis using longitudinal data from Northern Finland Birth Cohort 1986 (NFBC1986, n = 2984). Lastly, we examined the impact of the prenatal environment by association analysis of maternal pre-pregnancy BMI and offspring ADHD symptoms, adjusted for PRS of both traits, in NFBC1986 dataset. Through MR analyses, we found evidence for bidirectional causality between ADHD liability and obesity-related traits. PRS association analyses showed evidence for genetic overlap between ADHD symptoms and BMI. We found no evidence for a difference between inattention and hyperactivity symptoms, suggesting that neither symptom subtype is driving the association. We found evidence for association between maternal pre-pregnancy BMI and offspring ADHD symptoms after adjusting for both BMI and ADHD PRS (association p-value = 0.027 for inattention, p = 0.008 for hyperactivity). These results are consistent with the hypothesis that the co-occurrence between ADHD and obesity has both genetic and prenatal environmental origins.

scholarly journals Are there causal relationships between attention-deficit/hyperactivity disorder and body mass index? Evidence from multiple genetically informed designs

2020 ◽  
Author(s):  
Chao-Yu Liu ◽  
Tabea Schoeler ◽  
Neil M Davies ◽  
Hugo Peyre ◽  
Kai-Xiang Lim ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Attention Deficit Hyperactivity Disorder ◽  
Body Mass ◽  
Attention Deficit ◽  
Association Studies ◽  
Genome Wide Association Studies ◽  
Causal Relationships ◽  
Adhd Symptoms ◽  
Multiple Sources ◽  
Hyperactivity Disorder

Abstract Background Attention-deficit/hyperactivity disorder (ADHD) and body mass index (BMI) are associated. However, it remains unclear whether this association reflects causal relationships in either direction or confounding. Here, we implemented genetically informed methods to examine bidirectional causality and potential confounding. Methods Three genetically informed methods were employed: (i) cross-lagged twin-differences analyses to assess bidirectional effects of ADHD symptoms and BMI at ages 8, 12, 14 and 16 years in 2386 pairs of monozygotic twins from the Twins Early Development Study (TEDS); (ii) within- and between-family ADHD and BMI polygenic score (PS) analyses in 3320 pairs of dizygotic TEDS twins; and (iii) two-sample bidirectional Mendelian randomization (MR) using summary statistics from genome-wide association studies (GWAS) on ADHD (N = 55,374) and BMI (N = 806,834). Results Mixed results were obtained across the three methods. Twin-difference analyses provided little support for cross-lagged associations between ADHD symptoms and BMI over time. PS analyses were consistent with bidirectional relationships between ADHD and BMI, with plausible time-varying effects from childhood to adolescence. MR findings also suggested bidirectional causal effects between ADHD and BMI. Multivariable MR indicated the presence of substantial confounding in bidirectional relationships. Conclusions The three methods converged to highlight multiple sources of confounding in the association between ADHD and BMI. PS and MR analyses suggested plausible causal relationships in both directions. Possible explanations for mixed causal findings across methods are discussed.

The Impact of Copper in Children with Attention Deficit Hyperactivity Disorder

2017 ◽  
Vol 68 (2) ◽  
pp. 279-283
Author(s):  
Mihail Silviu Tudosie ◽  
Elena Truta ◽  
Ana Maria Davitoiu ◽  
Luminita Stanciulescu ◽  
George Jinescu ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Copper Concentration ◽  
Graphite Furnace ◽  
Urine Samples ◽  
Health State ◽  
Adhd Symptoms ◽  
Children With Adhd ◽  
Hyperactivity Disorder ◽  
The Impact

During one year (september 2013 � september 2014), 50 children from the residential institution for children SOS Satele Copiilor Bucharest, where included in our research. The children were distributed in two groups: Group A which consisted of 25 children (12 girls, 13 boys) who were not diagnosed with attention deficit hyperactivity disorder (ADHD) and Group B which consisted of 25 children (14 boys, 11 girls) who were diagnosed with ADHD. Initially, the two groups were subjected at a psycho-diagnostic battery of tests, one of them being the Evaluating the Health State of children with ADHD questionnaire elaborated by us, particularly for this research, with the purpose of highlighting the direct link between the children health state and their ADHD symptoms. This study sought to determine the concentration of copper in urine samples from a group of children with ADHD and a group of normal children, to highlight the role of copper in the development of ADHD symptoms. Levels of copper concentration in urine samples from the two groups were processed by Student�s t-Test. Statistical analysis showed that the arithmetic averages of copper concentration in urine samples, of the two groups do not differ significantly, so copper may be causing ADHD symptoms occur. The copper content in urine samples has been determined using atomic absorption spectrometry with graphite furnace.

scholarly journals Transcriptome-wide association study of attention deficit hyperactivity disorder identifies associated genes and phenotypes

2019 ◽  
Author(s):  
Calwing Liao ◽  
Alexandre D. Laporte ◽  
Dan Spiegelman ◽  
Fulya Akçimen ◽  
Ridha Joober ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Association Study ◽  
Attention Deficit ◽  
Posterior Probability ◽  
Association Studies ◽  
Brain Regions ◽  
Genome Wide Association Studies ◽  
Hyperactivity Disorder ◽  
Dorsolateral Prefrontal ◽  
Causal Genes

AbstractAttention deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental psychiatric disorders. Previous studies have shown that the disorder is highly heritable and associated with several different risk-taking behaviors. Additionally, brain-imaging studies have identified various brain regions such as the cerebellum and frontal cortex to be altered in ADHD. Large genome-wide association studies (GWAS) have identified several loci associated with ADHD. However, understanding the biological relevance of these genetic loci has proven to be difficult. Here, we conducted the largest ADHD transcriptome-wide association study (TWAS) to date consisting of 19,099 cases and 34,194 controls and identified 9 transcriptome-wide significant hits. We successfully demonstrate that several previous GWAS hits can be largely explained by expression. Probabilistic causal fine-mapping of TWAS signals prioritized KAT2B with a posterior probability of 0.467 in the dorsolateral prefrontal cortex and TMEM161B with a posterior probability of 0.838 in the amygdala. Furthermore, pathway enrichments identified dopaminergic and norepinephrine pathways, which are highly relevant for ADHD. Finally, we used the top eQTLs associated with the TWAS genes to identify phenotypes relevant to ADHD and found an inverse genetic correlation with educational attainment and a positive correlation with “ever smoker”, maternal smoking at birth, BMI, and schizophrenia. Overall, our findings highlight the power of TWAS to identify novel risk loci and prioritize putatively causal genes.

scholarly journals Sub-clinical levels of attention deficit-hyperactivity disorder are associated with tobacco consumption in male but not in female smokers

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Rebecca L. Douglas ◽  
Sean P. Barrett ◽  
Neil T. Hanley ◽  
Robert O. Pihl
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Tobacco Use ◽  
Attention Deficit ◽  
Tobacco Consumption ◽  
Clinical Population ◽  
Adhd Symptoms ◽  
Hyperactivity Disorder ◽  
Diagnostic Threshold ◽  
Inattention And Hyperactivity ◽  
The Relationship

An abudance of evidence has demonstrated an association between symptoms of attention deficit hyperactivity disorder (ADHD) and tobacco consumption. However, previous research has focused solely on populations meeting full diagnostic criteria for ADHD, despite evidence suggesting that symptoms below diagnostic threshold can be associated with impairment. Furthermore, the role of gender in the relationship between ADHD symptoms and tobacco consumption has not been determined. To examine the relationship between ADHD symptoms, tobacco use, and gender in a non-clinical population, symptoms of inattention, hyperactivity and impulsivity were assessed in 230 undergraduate students (22 male and 45 female smokers, and 66 male and 97 female nonsmokers). Overall, relative to nonsmokers, the smoking subjects reported significantly higher levels of inattention and hyperactivity. In male smokers, both inattentive and hyperactive/impulsive symptoms were positively associated with the number of cigarettes smoked daily. This relationship did not hold for female smokers, for whom no association was found between symptoms and nicotine consumption. Findings imply that even sub-clinical levels of inattention and hyperactivity/impulsivity are related to indices of tobacco use in males, and support previous research suggesting that significant gender differences may exist in tobacco smoking motives. Results also have potential implications for tobacco cessation programs, which may require more individual tailoring.l glutamic pyruvic transaminase is identified in an elderly subject.

Do maternal attention-deficit/hyperactivity disorder symptoms exacerbate or ameliorate the negative effect of child attention-deficit/hyperactivity disorder symptoms on parenting?

2008 ◽  
Vol 20 (1) ◽  
pp. 121-137 ◽  
Author(s):  
Lamprini Psychogiou ◽  
Dave M. Daley ◽  
Margaret J. Thompson ◽  
Edmund J. S. Sonuga-Barke
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Expressed Emotion ◽  
Adhd Symptoms ◽  
Hyperactivity Disorder ◽  
Child Adhd ◽  
Negative Effect ◽  
Quality Of Parenting ◽  
The Impact ◽  
Maternal Adhd

AbstractThe impact of similarity in parent and child characteristics on the quality of parenting is underresearched. The current study examined the interaction between mother and child attention-deficit/hyperactivity disorder (ADHD) symptoms on parenting. Two hypotheses were tested: the similarity-fit hypothesis, which predicted that parent and child similarity will improve parenting, and the similarity-misfit hypothesis, which predicted the opposite. Study 1 examined the associations between maternal and child ADHD symptoms and child-specific rearing attitudes of 95 mothers with school-aged children. In Study 2 this analysis was extended to more objective observer-rated mother–child interaction and maternal expressed emotion in 192 mothers of preschool children. Child ADHD symptoms were associated with negative maternal comments and maternal ADHD symptoms with negative expressed emotion. In both studies maternal ADHD symptoms appeared to ameliorate the effects of child ADHD symptoms on negative parenting. Parental response to children with high ADHD symptoms was more positive and affectionate when the mother also had high ADHD symptoms. The results support the similarity-fit hypothesis and highlight the importance of considering both child and maternal ADHD symptoms in studies of parenting.

scholarly journals Correlations between Quality of Life, School Bullying, and Suicide in Adolescents with Attention-Deficit Hyperactivity Disorder

2020 ◽  
Vol 17 (9) ◽  
pp. 3262
Author(s):  
Yi-Lung Chen ◽  
Hsing-Ying Ho ◽  
Ray C. Hsiao ◽  
Wei-Hsin Lu ◽  
Cheng-Fang Yen
Keyword(s):  
Quality Of Life ◽  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Well Being ◽  
School Bullying ◽  
Life Questionnaire ◽  
Adhd Symptoms ◽  
Hyperactivity Disorder ◽  
Inattention And Hyperactivity

Although adolescents with attention-deficit hyperactivity disorder (ADHD) have a higher risk of suicidality and more problems related to school bullying, and quality of life (QoL) is reportedly associated with school bullying, suicide, and ADHD, no study has examined their correlation. This study examined the complex relationships between QoL, school bullying, suicide, and ADHD symptoms. A total of 203 adolescents with ADHD aged between 12 and 18 years were recruited. School bullying and QoL were examined using the Chinese version of the School Bullying Experience Questionnaire and the Taiwanese Quality of Life Questionnaire for Adolescents. Network model analysis was conducted to graphically present their relationships. We identified triangular correlations between school bullying, QoL, and suicidality, indicating possible pathways from school bullying to suicidality, and the originating or mediating roles of personal competence and psychological well-being. Furthermore, the ADHD symptoms of inattention and hyperactivity/impulsivity may differentially regulate these pathways. Longitudinal studies are warranted to confirm these findings.

scholarly journals Transcriptome-wide association study of attention deficit hyperactivity disorder identifies associated genes and phenotypes

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Calwing Liao ◽  
Alexandre D. Laporte ◽  
Dan Spiegelman ◽  
Fulya Akçimen ◽  
Ridha Joober ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Association Study ◽  
Attention Deficit ◽  
Posterior Probability ◽  
Association Studies ◽  
Genome Wide Association Studies ◽  
Hyperactivity Disorder ◽  
Genome Wide ◽  
Dorsolateral Prefrontal ◽  
Causal Genes

Abstract Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental psychiatric disorder. Genome-wide association studies (GWAS) have identified several loci associated with ADHD. However, understanding the biological relevance of these genetic loci has proven to be difficult. Here, we conduct an ADHD transcriptome-wide association study (TWAS) consisting of 19,099 cases and 34,194 controls and identify 9 transcriptome-wide significant hits, of which 6 genes were not implicated in the original GWAS. We demonstrate that two of the previous GWAS hits can be largely explained by expression regulation. Probabilistic causal fine-mapping of TWAS signals prioritizes KAT2B with a posterior probability of 0.467 in the dorsolateral prefrontal cortex and TMEM161B with a posterior probability of 0.838 in the amygdala. Furthermore, pathway enrichment identifies dopaminergic and norepinephrine pathways, which are highly relevant for ADHD. Overall, our findings highlight the power of TWAS to identify and prioritize putatively causal genes.

scholarly journals Exposure to environmental and lifestyle factors and attention-deficit / hyperactivity disorder in children — A review of epidemiological studies

2012 ◽  
Vol 25 (4) ◽  
Author(s):  
Kinga Polańska ◽  
Joanna Jurewicz ◽  
Wojciech Hanke
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Environmental Factors ◽  
Tobacco Smoke ◽  
Attention Deficit ◽  
Lifestyle Factors ◽  
Environmental Toxicants ◽  
Adhd Symptoms ◽  
Child Exposure ◽  
Hyperactivity Disorder ◽  
The Impact

AbstractAttention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders in children. Although the mechanisms that lead to the development of ADHD remain unclear, genetic and environmental factors have been implicated. These include heavy metals and chemical exposures, nutritional and lifestyle/psychosocial factors. The aim of this review was to investigate the association between ADHD or ADHD-related symptoms and widespread environmental factors such as phthalates, bisphenol A (BPA), tobacco smoke, polycyclic aromatic hydrocarbons (PAHs), polyfluoroalkyl chemicals (PFCs) and alcohol. Medline, PubMed and Ebsco search was performed to identify the studies which analyze the association of prenatal and postnatal child exposure to environmental toxicants and lifestyle factors and ADHD or ADHD-related symptoms. The review is restricted to human studies published since 2000 in English in peer reviewed journals. Despite much research has been done on the association between environmental risk factors and ADHD or ADHD symptoms, results are not consistent. Most studies in this field, focused on exposure to tobacco smoke, found an association between that exposure and ADHD and ADHD symptoms. On the other hand, the impact of phthalates, BPA, PFCs, PAHs and alcohol is less frequently investigated and does not allow a firm conclusion regarding the association with the outcomes of interest.

Malingered Attention Deficit/Hyperactivity Disorder on the Conners’ Adult ADHD Rating Scales: Do Reasons for Malingering Matter?

2017 ◽  
Vol 36 (6) ◽  
pp. 552-561 ◽  
Author(s):  
Carolyn Cook ◽  
Melissa T. Buelow ◽  
Esther Lee ◽  
Ashley Howell ◽  
Brittni Morgan ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Adult Adhd ◽  
Rating Scales ◽  
Adhd Group ◽  
Adhd Symptoms ◽  
Extra Time ◽  
Hyperactivity Disorder ◽  
The Impact ◽  
Adhd Rating Scales

Malingering is a significant assessment concern in adults undergoing evaluations for attention deficit/hyperactivity disorder (ADHD) and may occur for a number of reasons, including access to medication and/or accommodations. Therefore, it is important to investigate ways to determine accuracy of self-reported ADHD symptoms. The present study used a simulation design to examine the impact of reasons for malingering on the Conners’ Adult ADHD Rating Scales (CAARS) Symptom subscales and the CAARS infrequency index (CII). Participants ( N = 157) were randomly assigned to one of three conditions: best effort, malingering for stimulant medication, or malingering for extra time accommodations. The three groups were compared with 34 individuals reporting previous diagnosis of ADHD. Results showed that individuals in both malingering groups scored higher than controls on all CAARS subscales and CII. Individuals in the medication malingering group, but not the extra time malingering group, scored higher than the ADHD group on CII and several CAARS subscales whose content overtly reflects ADHD symptomatology. Findings emphasize the influence of malingering on self-reported ADHD symptoms and the need to assess for malingering in ADHD evaluation. Results also suggest that reason for malingering might differentially affect self-report of ADHD symptoms.

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