scholarly journals Tactile modulation of memory and anxiety requires dentate granule cells along the dorsoventral axis

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Chi Wang ◽  
Hui Liu ◽  
Kun Li ◽  
Zhen-Zhen Wu ◽  
Chen Wu ◽  
...  
Keyword(s):  
Life Stress ◽  
Structural Modification ◽  
Granule Cells ◽  
Early Life Stress ◽  
Memory Deficits ◽  
Dorsoventral Axis ◽  
Beneficial Effects ◽  
Cognition And Emotion ◽  
Adult Mice ◽  
Underlying Mechanisms

AbstractTouch can positively influence cognition and emotion, but the underlying mechanisms remain unclear. Here, we report that tactile experience enrichment improves memory and alleviates anxiety by remodeling neurons along the dorsoventral axis of the dentate gyrus (DG) in adult mice. Tactile enrichment induces differential activation and structural modification of neurons in the dorsal and ventral DG, and increases the presynaptic input from the lateral entorhinal cortex (LEC), which is reciprocally connected with the primary somatosensory cortex (S1), to tactile experience-activated DG neurons. Chemogenetic activation of tactile experience-tagged dorsal and ventral DG neurons enhances memory and reduces anxiety respectively, whereas inactivation of these neurons or S1-innervated LEC neurons abolishes the beneficial effects of tactile enrichment. Moreover, adulthood tactile enrichment attenuates early-life stress-induced memory deficits and anxiety-related behavior. Our findings demonstrate that enriched tactile experience retunes the pathway from S1 to DG and enhances DG neuronal plasticity to modulate cognition and emotion.

Hippocampal neuroligin-2 links early-life stress with impaired social recognition and increased aggression in adult mice

2015 ◽  
Vol 55 ◽  
pp. 128-143 ◽  
Author(s):  
Christine Kohl ◽  
Xiao-Dong Wang ◽  
Jocelyn Grosse ◽  
Céline Fournier ◽  
Daniela Harbich ◽  
...  
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Social Recognition ◽  
Adult Mice

The Effect of Early-Life Stress on Airway Inflammation in Adult Mice

2010 ◽  
Vol 17 (4) ◽  
pp. 229-239 ◽  
Author(s):  
Rattanjeet Vig ◽  
John R. Gordon ◽  
Bernard Thébaud ◽  
A. Dean Befus ◽  
Harissios Vliagoftis
Keyword(s):  
Airway Inflammation ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Adult Mice

scholarly journals Early Life Stress Enhances the Vulnerability to Chronic Psychosocial Stress and Experimental Colitis in Adult Mice

Endocrinology ◽  
2008 ◽  
Vol 149 (6) ◽  
pp. 2727-2736 ◽  
Author(s):  
Alexa H. Veenema ◽  
Stefan O. Reber ◽  
Sandra Selch ◽  
Florian Obermeier ◽  
Inga D. Neumann
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Psychosocial Stress ◽  
Early Life Stress ◽  
Experimental Colitis ◽  
Adult Mice ◽  
Chronic Psychosocial Stress

scholarly journals A high fat anti-inflammatory diet improves widespread allodynia despite worsening metabolic outcomes in adult mice exposed to neonatal maternal separation

2020 ◽  
Author(s):  
Olivia C. Eller ◽  
Rebecca M. Foright ◽  
Aaron D. Brake ◽  
Michelle K. Winter ◽  
Leonidas E. Bantis ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Life Stress ◽  
Maternal Separation ◽  
Caloric Intake ◽  
Early Life Stress ◽  
Preclinical Model ◽  
Dietary Interventions ◽  
Adult Mice ◽  
Neonatal Maternal Separation ◽  
Anti Inflammatory

AbstractInflammation plays a key role in the progression and maintenance of chronic pain, which impacts the lives of millions of Americans. Despite growing evidence that chronic pain can be improved by treating underlying inflammation, successful treatments are lacking and pharmaceutical interventions are limited due to drug side effects. Here we are testing whether an anti-inflammatory diet (AID) containing a combination of key anti-inflammatory compounds, at clinically relevant doses, improves pain-like behaviors in a preclinical model of chronic widespread hypersensitivity induced by neonatal maternal separation (NMS). Our results demonstrate a benefit of the AID on pain-like behaviors, despite the diet being high in fat, which led to increased caloric intake, adiposity, and weight gain. The AID specifically increased measures of metabolic syndrome and inflammation in female mice, compared to an isocaloric, macronutrient-matched diet lacking the anti-inflammatory compounds. Male mice, especially those exposed to NMS, were equally susceptible to both diets worsening metabolic measures. This work highlights important sexual dimorphic outcomes related to early life stress exposure and dietary interventions, as well as a potential disconnect between improvements in pain-like behaviors and metabolic measures.

scholarly journals Cerebral Erythropoietin Prevents Sex-Dependent Disruption of Respiratory Control Induced by Early Life Stress

2021 ◽  
Vol 12 ◽  
Author(s):  
Elizabeth Elliot-Portal ◽  
Christian Arias-Reyes ◽  
Sofien Laouafa ◽  
Rose Tam ◽  
Richard Kinkead ◽  
...  
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Maternal Separation ◽  
Stress Hormones ◽  
Respiratory Control ◽  
Early Life Stress ◽  
Whole Body ◽  
Wild Type ◽  
Adult Mice ◽  
Respiratory Disturbance

Injuries that occur early in life are often at the root of adult illness. Neonatal maternal separation (NMS) is a form of early life stress that has persistent and sex-specific effects on the development of neural networks, including those that regulate breathing. The release of stress hormones during a critical period of development contributes to the deleterious consequences of NMS, but the role of increased corticosterone (CORT) in NMS-induced respiratory disturbance is unknown. Because erythropoietin (EPO) is a potent neuroprotectant that prevents conditions associated with hyperactivation of the stress neuroaxis in a sex-specific manner, we hypothesized that EPO reduces the sex-specific alteration of respiratory regulation induced by NMS in adult mice. Animals were either raised under standard conditions (controls) or exposed to NMS 3 h/day from postnatal days 3–12. We tested the efficacy of EPO in preventing the effects of NMS by comparing wild-type mice with transgenic mice that overexpress EPO only in the brain (Tg21). In 7-days-old pups, NMS augmented CORT levels ~2.5-fold by comparison with controls but only in males; this response was reduced in Tg21 mice. Respiratory function was assessed using whole-body plethysmography. Apneas were detected during sleep; the responsiveness to stimuli was measured by exposing mice to hypoxia (10% O2; 15 min) and hypercapnia (5% CO2; 10 min). In wild-type, NMS increased the number of apneas and the hypercapnic ventilatory response (HcVR) only in males; with no effect on Tg21. In wild-type males, the incidence of apneas was positively correlated with HcVR and inversely related to the tachypneic response to hypoxia. We conclude that neural EPO reduces early life stress-induced respiratory disturbances observed in males.

Early-life stress-induced anxiety-related behavior in adult mice partially requires forebrain corticotropin-releasing hormone receptor 1

2012 ◽  
Vol 36 (3) ◽  
pp. 2360-2367 ◽  
Author(s):  
Xiao-Dong Wang ◽  
Christiana Labermaier ◽  
Florian Holsboer ◽  
Wolfgang Wurst ◽  
Jan M. Deussing ◽  
...  
Keyword(s):  
Hormone Receptor ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Adult Mice

The impact of early-life stress on the expression of HPA-associated genes in the adult murine brain

Behaviour ◽  
2018 ◽  
Vol 155 (2-3) ◽  
pp. 181-203 ◽  
Author(s):  
V.V. Reshetnikov ◽  
A.A. Studenikina ◽  
J.A. Ryabushkina ◽  
T.I. Merkulova ◽  
N.P. Bondar
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Maternal Separation ◽  
Early Life Stress ◽  
Long Term Memory ◽  
Adult Mice ◽  
Specific Manner ◽  
Behavioural Phenotypes ◽  
The Impact

Abstract Early life is an important period for the development of the nervous system and for the programming of behavioural phenotypes in adulthood. In our study, two types of early-life stress were used: prolonged separation of pups from their mothers (for 3 h/day, maternal separation (MS)) and brief separation (for 15 min/day, handling (HD)). We analysed the effects of early-life stress on behaviour and the expression of HPA-associated genes in the hypothalamus, hippocampus, and frontal cortex of male mice. Adult mice in the MS group demonstrated reduced locomotor activity and deficiencies in spatial long-term memory, while the HD showed no significant changes. Additionally, early-life MS resulted in reduced hippocampal Crhr1 mRNA, increased MR/GR mRNA in the hippocampus and hypothalamus. Both groups, HD and MS, showed increased Avp mRNA in the hypothalamus. Thus, prolonged maternal separation but not brief leads to adverse behavioural changes and influences the expression of HPA-associated genes in a brain region-specific manner.

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