scholarly journals Epidemiological characteristics of hand, foot, and mouth disease in Shandong, China, 2009–2016

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Jing Wang ◽  
Tao Hu ◽  
Dapeng Sun ◽  
Shujun Ding ◽  
Michael J. Carr ◽  
...  
Keyword(s):  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Foot And Mouth ◽  
Epidemiological Characteristics

scholarly journals Epidemiological study on hand, foot and mouth disease in Tongzhou District, Beijing, 2013–2017

2019 ◽  
Vol 47 (6) ◽  
pp. 2615-2625 ◽  
Author(s):  
Xiao-Feng Liu ◽  
Xiu-Mei Sun ◽  
Xiao-Wei Sun ◽  
Yu-Qing Yang ◽  
Cong-Hui Huang ◽  
...  
Keyword(s):  
Incidence Rate ◽  
Local Population ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Migrant Population ◽  
Enterovirus A71 ◽  
Tongzhou District ◽  
Foot And Mouth ◽  
Polymerase Chain ◽  
Epidemiological Characteristics

Objective To study the epidemiological characteristics of hand, foot and mouth disease (HFMD) in Tongzhou District, Beijing between 2013 and 2017. Methods Data on HFMD infections from 1 January 2013 to 31 December 2017 were collected from the Notifiable Infectious Diseases Reporting Information System and analysed. Serotyping of enteroviruses from samples from patients with HFMD was undertaken using reverse transcription–polymerase chain reaction. Results A total of 15 341 patients with HFMD were reported and 32 patients (0.2%) were classified as having severe HFMD. The annual mean incidence rate of HFMD was 219.3/100 000 of the general population. The incidence and case-severity rates of HFMD generally decreased between 2013 and 2017. In the floating migrant population, the incidence and cases-severity rates of HFMD were significantly higher than in the local population. The peak incidence and severity-case rates were at 2 years of age and > 90% of patients were ≤5 years. Enterovirus A71 and Coxsackievirus A16 were the predominant pathogens in 2013–2017. Conclusions During the 5-year period 2013–2017, the incidence rate and case-severity rate of HFMD generally decreased in Tongzhou District, Beijing. The floating migrant population and children ≤5 years of age were at the highest risk of HFMD.

Severe hand, foot and mouth disease in Shenzhen, South China: what matters most?

2013 ◽  
Vol 142 (4) ◽  
pp. 776-788 ◽  
Author(s):  
J. MOU ◽  
M. DAWES ◽  
Y. LI ◽  
Y. HE ◽  
H. MA ◽  
...  
Keyword(s):  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Early Use ◽  
Foot And Mouth ◽  
Report Data ◽  
Local Residents ◽  
Matched Case ◽  
Epidemiological Characteristics ◽  
Matched Case Control Study ◽  
Control Study

SUMMARYCase report data and a matched case-control study were used to investigate the epidemiological characteristics of hand, foot and mouth disease (HFMD) in children in Shenzhen, China between 2008 and 2011. Multivariate analyses were used to evaluate factors associated with severity of infection. Laboratory tests were performed to determine aetiological identification for samples from 163 severe and fatal cases as well as an outpatient-based HFMD sentinel surveillance system (n = 446). All identified EV71 belonged to sub-genotype C4a. No major changes in the CA16 and EV71 viruses were found until the end of 2011. Annual attack rates and the case-severity ratios (CSRs) rose from 0·82/1000 and 0·56/1000, respectively, in 2008 to 2·12/1000 and 6·13/1000 in 2011. The CSR was higher in migrants than in local residents. The adjusted odds ratio (OR) of having a severe attack for being a migrant was 2·45, having a fever >39°C (OR 5·77), visiting a private clinic (OR 2·65), longer time from symptom onset to diagnosis (OR 1·49), visiting a doctor (OR 1·51), early use of intramuscular pyrazolone (OR 3·36), early use of intravenous glucocorticoids (OR 2·28), or the combination of both (OR 3·75). The mortality and increasing case severity appears to be associated with socioeconomic factors including migration and is of worldwide concern.

scholarly journals Epidemiological characteristics and pathogens attributable to hand, foot, and mouth disease in Shanghai, 2008–2013

2016 ◽  
Vol 10 (06) ◽  
pp. 612-618 ◽  
Author(s):  
Yifei Fu ◽  
Qiao Sun ◽  
Bo Liu ◽  
Hongmei Xu ◽  
Yuanping Wang ◽  
...  
Keyword(s):  
Health Care Providers ◽  
Medical Center ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Public Health Issue ◽  
Care Providers ◽  
Passive Surveillance System ◽  
Foot And Mouth ◽  
Predominant Pathogen ◽  
Epidemiological Characteristics

Introduction: Hand, foot, and mouth disease (HFMD) is a common childhood illness caused by enteroviruses. A passive surveillance system has been implemented in Shanghai Pudong since 2008 and etiology surveillance since 2009.We characterized the epidemiology and the etiology of HFMD in Pudong from 2008–2013. Methodology: Health care providers were required to report any clinically diagnosed HFMD to Pudong District Center for Disease Control and Prevention. For all severe cases and randomly selected mild HFMD cases, throat or rectal swabs or feces were collected for enterovirus detection by real time reverse transcription polymerase chain reaction. Results: A total of 50,149 cases were reported, with average 8,508 per year (range: 3,577–13,202) and average incidence of 167.5/100,000 persons (range: 81.4–254.1/100,000 persons). HFMD was more likely to occur in children under five years of age (85.6%), while severe cases were more likely to happen in children under three years of age (63.9%). Every year in May or June, HFMD peaked in the region; two peaks were observed from 2011 to 2013.The most common etiologic agents are EV71 and CA16.Different types of enterovirus circulate in different years. EV71 was the predominant pathogen in severe cases. The proportions of EV71 in severe cases was higher than in mild cases at the children’s medical center (p<0.001). Conclusions: HFMD remains an important public health issue in Shanghai. HFMD pathogen surveillance is required for more types of enteroviruses besides EV71 and CA16, which would give a better picture of the etiology of HFMD.

scholarly journals Epidemiological characteristics of hand, foot, and mouth disease in Yunnan Province, China, 2008–2019

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Li Jiang ◽  
Hongchao Jiang ◽  
Xin Tian ◽  
Xueshan Xia ◽  
Tian Huang
Keyword(s):  
Vaccination Coverage ◽  
Yunnan Province ◽  
Enterovirus 71 ◽  
Case Fatality ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Vaccination Coverage Rate ◽  
Foot And Mouth ◽  
Before And After ◽  
Epidemiological Characteristics

Abstract Background Since 2016, enterovirus 71 (EV71) vaccines have been approved for market entry, and little is known about how the epidemiology of hand, foot, and mouth disease (HFMD) has been affected by the introduction of the vaccines in Yunnan Province. The study describes the epidemiological characteristics of HFMD before and after the introduction of EV71 vaccination in Yunnan Province. Methods Surveillance data collected between 2008 and 2019 were analyzed to produce epidemiological distribution on cases, etiologic composition, and EV71 vaccination coverage, as well as to compare these characteristics before and after EV71 vaccination. Results A total of 1,653,533 children received EV71 vaccines from 2016 through 2019 in Yunnan. The annual EV71 vaccination coverage rate ranged from 5.53 to 15.01% among children ≤5 years old. After the introduction of EV71 vaccines, the overall incidence of HFMD increased and reached over 200 cases per 100,000 population-years in 2018 and 2019. However, the case severity and case fatality rate decreased and remained lower than 1 and 0.005% after 2016, respectively. EV71-associated mild, severe and fatal cases sharply decreased. The predominant viral serotype changed to non-EV71/non-CV-A16 enteroviruses which were detected across the whole province. Conclusions Non-EV71/non-CV-A16 enteroviruses became the predominant strain and led to a higher incidence in Yunnan. Expanding EV71 vaccination and strengthening laboratory-based surveillance could further decrease the burden of severe HFMD and detect and monitor emerging enteroviruses.

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