Estimating the impact of body mass index on bladder cancer risk: Stratification by smoking status

Mutations in UGT1A gene have been associated with the development and prognosis of urinary bladder cancer (UBC). UGT1A proteins are involved in a spectrum of detoxification processes, hence the biological mechanism between UGT1A and UBC is difficult to elucidate. Concurrently, mild hyperbilirubinemia, caused by alterations in UGT1A, has been associated with multiple health outcomes. We have investigated the potential effect of mild hyperbilirubinemia on UBC risk and prognosis, using a Mendelian Randomization (MR) approach in the UK Biobank. Data on 1,281 UBC patients and 4,071 controls was available for a two-stage least squares MR estimation with rs6742078 as an instrumental variable. First, linear regression was fitted to establish the relationship between the rs6742078 and bilirubin levels (total and unconjugated). Secondly, bilirubin values were used to predict tested outcomes under a logistic model. Both stages were adjusted for participant sex, smoking status, and age. MR analysis showed no significant effects of bilirubin levels on UBC risk (total bilirubin: OR=1.02, 95% CI: 0.99-1.04; unconjugated bilirubin: OR=1.02, 95% CI: 0.99-1.05). No effects were observed for events of UBC recurrence, progression, or survival. Our study suggests mild hyperbilirubinemia is not associated with urinary bladder cancer risk and prognosis.

Download Full-text

Meta-Analysis Reveals no Significant Association between ERCC6 Polymorphisms and Bladder Cancer Risk

The International Journal of Biological Markers ◽

10.5301/jbm.5000236 ◽

2017 ◽

Vol 32 (1) ◽

pp. 113-117

Author(s):

Zhengdong Hong ◽

Jinxian Wu ◽

Qiang Li ◽

Shouhua Zhang ◽

Zimin Shi

Keyword(s):

Bladder Cancer ◽

Cancer Risk ◽

Gene Polymorphisms ◽

Excision Repair ◽

Smoking Status ◽

Meta Analysis ◽

Bladder Cancer Risk ◽

China National Knowledge Infrastructure ◽

Knowledge Infrastructure ◽

Strict Selection

Background Numerous studies have been conducted to evaluate the association between excision repair cross-complementing group 6 (ERCC6) gene polymorphisms and bladder cancer risk, but their findings have been inconsistent. Here we performed a meta-analysis to attempt to clarify this association. Methods Studies were retrieved from the PubMed and China National Knowledge Infrastructure databases up to October 1, 2015, with strict selection and exclusion criteria. A total of 5,032 samples, comprising samples from 2,475 bladder cancer patients and 2,557 controls from 5 studies, were included in the meta-analysis. The odds ratio (OR) with 95% confidence interval (CI) was used to evaluate the strength of the associations. Results Regarding the Met1097Val polymorphism, no significant association with bladder cancer risk was found in any of the genetic models evaluated (Val vs. Met: OR = 1.10, 95% CI, 0.97-1.25; Val/Val vs. Met/Met: OR = 1.23, 95% CI, 0.86-1.75; Val/Val + Val/Met vs. Met/Met: OR = 1.12, 95% CI, 0.96-1.30; Val/Val vs. Met/Met + Val/Met: OR = 0.81, 95% CI, 0.57-1.14). Similarly, as regards the Arg1230Pro polymorphism, we also found no positive results. Conclusions According to the results of our meta-analysis, there is no evidence of a link between the ERCC6 gene polymorphisms and bladder cancer risk. Well-designed further studies, with larger sample sizes and adjustment for confounders such as smoking status, are needed to confirm these conclusions.

Download Full-text

137Superficial bladder cancer risk category and the impact of review pathology

European Urology Supplements ◽

10.1016/s1569-9056(05)80146-0 ◽

2005 ◽

Vol 4 (3) ◽

pp. 37

Author(s):

J.A. Witjes ◽

P. Moonen ◽

A. Van der Heijden ◽

M. Susani ◽

D. Bostwick ◽

...

Keyword(s):

Bladder Cancer ◽

Cancer Risk ◽

Risk Category ◽

Bladder Cancer Risk ◽

The Impact

Download Full-text

Vegetable intake and the risk of bladder cancer in the BLadder Cancer Epidemiology and Nutritional Determinants (BLEND) international study

BMC Medicine ◽

10.1186/s12916-021-01931-8 ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Evan Yi-Wen Yu ◽

Anke Wesselius ◽

Siamak Mehrkanoon ◽

Mieke Goosens ◽

Maree Brinkman ◽

...

Keyword(s):

Bladder Cancer ◽

Cancer Risk ◽

Cohort Studies ◽

Vegetable Intake ◽

Smoking Status ◽

Cox Proportional Hazards ◽

Dietary Factors ◽

Inverse Association ◽

Bladder Cancer Risk ◽

Diet Diversity

Abstract Background Although a potential inverse association between vegetable intake and bladder cancer risk has been reported, epidemiological evidence is inconsistent. This research aimed to elucidate the association between vegetable intake and bladder cancer risk by conducting a pooled analysis of data from prospective cohort studies. Methods Vegetable intake in relation to bladder cancer risk was examined by pooling individual-level data from 13 cohort studies, comprising 3203 cases among a total of 555,685 participants. Pooled multivariate hazard ratios (HRs), with corresponding 95% confidence intervals (CIs), were estimated using Cox proportional hazards regression models stratified by cohort for intakes of total vegetable, vegetable subtypes (i.e. non-starchy, starchy, green leafy and cruciferous vegetables) and individual vegetable types. In addition, a diet diversity score was used to assess the association of the varied types of vegetable intake on bladder cancer risk. Results The association between vegetable intake and bladder cancer risk differed by sex (P-interaction = 0.011) and smoking status (P-interaction = 0.038); therefore, analyses were stratified by sex and smoking status. With adjustment of age, sex, smoking, energy intake, ethnicity and other potential dietary factors, we found that higher intake of total and non-starchy vegetables were inversely associated with the risk of bladder cancer among women (comparing the highest with lowest intake tertile: HR = 0.79, 95% CI = 0.64–0.98, P = 0.037 for trend, HR per 1 SD increment = 0.89, 95% CI = 0.81–0.99; HR = 0.78, 95% CI = 0.63–0.97, P = 0.034 for trend, HR per 1 SD increment = 0.88, 95% CI = 0.79–0.98, respectively). However, no evidence of association was observed among men, and the intake of vegetable was not found to be associated with bladder cancer when stratified by smoking status. Moreover, we found no evidence of association for diet diversity with bladder cancer risk. Conclusion Higher intakes of total and non-starchy vegetable are associated with reduced risk of bladder cancer for women. Further studies are needed to clarify whether these results reflect causal processes and potential underlying mechanisms.

Download Full-text