scholarly journals Association of body mass index with bladder cancer risk: a dose-response meta-analysis of prospective cohort studies

Oncotarget ◽  
2017 ◽  
Vol 8 (20) ◽  
pp. 33990-34000 ◽  
Author(s):  
Limin Zhao ◽  
Xiaoqin Tian ◽  
Xueyan Duan ◽  
Yongxiu Ye ◽  
Min Sun ◽  
...  

2021 ◽  
pp. 1-14
Author(s):  
Dimitra Xenou ◽  
Lazaros Tzelves ◽  
Evangelos Terpos ◽  
Kimon Stamatelopoulos ◽  
Theodoros N. Sergentanis ◽  
...  


PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0120706 ◽  
Author(s):  
Junga Lee ◽  
Jeffrey A. Meyerhardt ◽  
Edward Giovannucci ◽  
Justin Y. Jeon


2019 ◽  
Vol 202 (3) ◽  
pp. 484-489 ◽  
Author(s):  
Mohammad Abufaraj ◽  
Fred K. Tabung ◽  
Shahrokh F. Shariat ◽  
Marco Moschini ◽  
Elizabeth Devore ◽  
...  


2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 3613-3613
Author(s):  
Junga Lee ◽  
Justin Y Jeon ◽  
Jeffrey A. Meyerhardt ◽  
Edward L. Giovannucci ◽  
Ji Young Kim ◽  
...  


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sepideh Soltani ◽  
Shima Abdollahi ◽  
Dagfinn Aune ◽  
Ahmad Jayedi

AbstractAlthough obesity has been associated with an increased cancer risk in the general population, the association in patients with type 2 diabetes (T2D) remains controversial. We conducted a dose–response meta-analysis of cohort studies of body mass index (BMI) and the risk of total and site-specific cancers in patients with T2D. A systematic literature search was conducted in PubMed, Scopus, and Medline until September 2020 for cohort studies on the association between BMI and cancer risk in patients with T2D. Summary relative risks (RRs) and 95% confidence intervals (CIs) were calculated using random effects models. Ten prospective and three retrospective cohort studies (3,345,031 participants and 37,412 cases) were included in the meta-analysis. Each 5-unit increase in BMI (kg/m2) was associated with a 6% higher risk of total cancer (RR: 1.06, 95% CI 1.01, 1.10; I2 = 55.4%, n = 6), and with a 12% increased risk in the analysis of breast cancer (RR: 1.12, 95% CI 1.05, 1.20; I2 = 0%, n = 3). The pooled RRs showed no association with prostate cancer (RR: 1.02, 95% CI 0.92, 1.13; I2 = 64.6%, n = 4), pancreatic cancer (RR: 0.97, 95% CI 0.84, 1.11; I2 = 71%, n = 3), and colorectal cancer (RR: 1.05, 95% CI 0.98, 1.13; I2 = 65.9%, n = 2). There was no indication of nonlinearity for total cancer (Pnon-linearity = 0.99), however, there was evidence of a nonlinear association between BMI and breast cancer (Pnon-linearity = 0.004) with steeper increases in risk from a BMI around 35 and above respectively. Higher BMI was associated with a higher risk of total, and breast cancer but not with risk of other cancers, in patients with T2D, however, further studies are needed before firm conclusions can be drawn.



2019 ◽  
Vol 11 (4) ◽  
pp. 254-263 ◽  
Author(s):  
Somayeh Tajik ◽  
Atieh Mirzababaei ◽  
Ehsan Ghaedi ◽  
Hamed Kord-Varkaneh ◽  
Khadijeh Mirzaei

Introduction: Risk of diabetes mellitus type 2 (T2DM) is variable between individuals due to different metabolic phenotypes. In present network meta-analysis, we aimed to evaluate the risk of T2DM related with current definitions of metabolic health in different body mass index (BMI) categories.<br /> Methods: Relevant articles were collected by systematically searching PubMed and Scopus databases up to 20 March 2018 and for analyses we used a random-effects model. Nineteen prospective cohort studies were included in the analyses and metabolically healthy normal weight (MHNW) was considered as the reference group in direct comparison for calculating indirect comparisons in difference type of BMI categories. <br /> Results: Total of 199403 participants and 10388 cases from 19 cohort studies, were included in our network meta-analysis. Metabolically unhealthy obesity (MUHO) group poses highest risk for T2DM development with 10 times higher risk when is compared with MHNW (10.46 95% CI; 8.30, 13.18) and after that Metabolically unhealthy overweight (MUOW) individuals were at highest risk of T2DM with 7 times higher risk comparing with MHNW (7.25, 95% CI; 5.49, 9.57). Metabolically healthy overweight and obese (MHOW/MHO) individuals have (1.77, 95% CI; 1.33, 2.35) and (3.00, 95% CI; 2.33, 3.85) risk ratio for T2DM development in comparison with MHNW respectively. <br /> Conclusion: In conclusion we found that being classified as overweight and obese increased the risk of T2DM in comparison with normal weight. In addition, metabolically unhealthy (MUH) individuals are at higher risk of T2DM in all categories of BMI compared with metabolically healthy individuals.



Oncotarget ◽  
2018 ◽  
Vol 9 (29) ◽  
pp. 20807-20815 ◽  
Author(s):  
Massimiliano Berretta ◽  
Agnieszka Micek ◽  
Alessandra Lafranconi ◽  
Sabrina Rossetti ◽  
Raffaele Di Francia ◽  
...  


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