scholarly journals YB-1 recruitment to stress granules in zebrafish cells reveals a differential adaptive response to stress

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Andrea Maria Guarino ◽  
Giuseppe Di Mauro ◽  
Gennaro Ruggiero ◽  
Nathalie Geyer ◽  
Antonella Delicato ◽  
...  
Keyword(s):  
Adaptive Response ◽  
Stress Granules ◽  
Response To Stress

Quantitative polymorphism of tandem repeats as a method of epigenetic regulation of the of human cells response to oxidative stress

2020 ◽  
pp. 68-70
Author(s):  
Н.Н. Вейко ◽  
Е.С. Ершова ◽  
М.С. Конькова ◽  
Е.М. Малиновская ◽  
С.В. Костюк
Keyword(s):  
Adaptive Response ◽  
Spatial Organization ◽  
Tandem Repeats ◽  
Spatial Configuration ◽  
Human Cells ◽  
Central Regions ◽  
Schizophrenic Patients ◽  
Response To Stress ◽  
Cell Genome ◽  
And Function

Пространственная организация хроматина важна для нормального функционирования клетки. На архитектуру ядра влияют размеры отдельных фрагментов генома, которые коррелируют с числом копий этих фрагментов. Перемещение локусов 1q12 от поверхности ядра в центральные области является ключевой стадией адаптивного ответа клетки на стресс. Мы предположили, что размер локусов 1q12, который коррелирует с содержанием повтора f-SatIII, может влиять на перемещение этих участков хроматина в ядре. Методом FISH на выделенных лимфоцитах показали, что в контроле локусы 1q12 расположены вблизи поверхности ядра, в ядрах лимфоцитов больных шизофренией (БШ) и облученных контрольных клеток локусы 1q12 расположены в центральных районах ядра. Длительное культивирование облученных лимфоцитов сопровождалось гибелью клеток, и снижением содержания f-SatIII в ДНК. Очевидно, что погибали клетки с большим размером 1q12 (много f-SatIII), обогащая популяцию клетками с низким содержанием f-SatIII. В клетках БШ и в облученных клетках мы обнаружили повышение уровня РНК SATIII. Размеры гетерохроматина 1q12 в клетках человека могут влиять на процессы пролиферации и ответа клетки на стресс. Количественный полиморфизм тандемных повторов генома - один из эпигенетических механизмов регуляции ответа клеток на окислительный стресс. The spatial organization of chromatin is important for the normal functioning of the cell. Genome repeat cluster sizes can affect the chromatin spatial configuration and function. The 1q12 heterochromatin loci movement from the periphery to the center of the nucleus is the cells’ universal response to various types of stress. We hypothesized that a large 1q12 domain could affect chromatin movement, thereby inhibiting adaptive response (AR). Using the FISH method, we shown that in the control, 1q12 loci are located near the surface of the nucleus; in the lymphocyte nuclei of schizophrenic patients and irradiated control cells, 1q12 loci are located in the central regions of the nucleus. During prolonged cultivation, the irradiated cells with a large Large f-SatIII amount die and the population is enriched with the cells with low f-SatIII content. In intact SZ patients’ lymphocytes and in irradiated cells we found an increase in SATIII RNA levels. The size of heterochromatin 1q12 loci in human cells can affect to the proliferation and cells’ adaptive response to stress. Quantitative polymorphism of tandem genome repeats is one of the epigenetic mechanisms of genome expression’s regulation.

scholarly journals Mitochondrial role in adaptive response to stress conditions in preeclampsia

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Polina A. Vishnyakova ◽  
Maria A. Volodina ◽  
Nadezhda V. Tarasova ◽  
Maria V. Marey ◽  
Daria V. Tsvirkun ◽  
...  
Keyword(s):  
Adaptive Response ◽  
Stress Conditions ◽  
Response To Stress

scholarly journals Adaptation or Malignant Transformation: The Two Faces of Epigenetically Mediated Response to Stress

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Aleksandar Vojta ◽  
Vlatka Zoldoš
Keyword(s):  
Malignant Transformation ◽  
Adaptive Response ◽  
Fundamental Property ◽  
Main Idea ◽  
Gene Clusters ◽  
Cellular Level ◽  
Evolutionary Potential ◽  
Strong Response ◽  
Response To Stress

Adaptive response to stress is a fundamental property of living systems. At the cellular level, many different types of stress elicit an essentially limited repertoire of adaptive responses. Epigenetic changes are the main mechanism for medium- to long-term adaptation to accumulated (intense, long-term, or repeated) stress. We propose the adaptive deregulation of the epigenome in response to stress (ADERS) hypothesis which assumes that the unspecific adaptive stress response grows stronger with the increasing stress level, epigenetically activating response gene clusters while progressively deregulating other cellular processes. The balance between the unspecific adaptive response and the general epigenetic deregulation is critical because a strong response can lead to pathology, particularly to malignant transformation. The main idea of our hypothesis is the continuum traversed by a cell subjected to accumulated stress, which lies between an unspecific adaptive response and pathological deregulation—the two extremes sharing the same underlying cause, which is a manifestation of a unified epigenetically mediated adaptive response to stress. The evolutionary potential of epigenetic regulation in multigenerational adaptation is speculatively discussed in the light of neo-Lamarckism. Finally, an approach to testing the proposed hypothesis is presented, relying on either the publicly available datasets or on conducting new experiments.

scholarly journals Plant natriuretic peptides induce proteins diagnostic for an adaptive response to stress

2014 ◽  
Vol 5 ◽  
Author(s):  
Ilona Turek ◽  
Claudius Marondedze ◽  
Janet I. Wheeler ◽  
Chris Gehring ◽  
Helen R. Irving
Keyword(s):  
Natriuretic Peptides ◽  
Adaptive Response ◽  
Response To Stress

scholarly journals Use of Oxidative Stress (MDA) Markers and Cytogenetic Markers in the Ecological‐Genetic Monitoring of the Northern Caspian Sea

2020 ◽  
Vol 15 (1) ◽  
pp. 99-106
Author(s):  
T. V. Kuzina ◽  
A. V. Kuzin
Keyword(s):  
Oxidative Stress ◽  
Free Radicals ◽  
Caspian Sea ◽  
Adaptive Response ◽  
Stress Factor ◽  
Genetic Monitoring ◽  
Aquatic Pollutants ◽  
Markers Of Oxidative Stress ◽  
Response To Stress ◽  
Somatic Mutagenesis

Aim. Assessment and subsequent long‐term dynamic observation of possible negative genetic consequences of the effect of pollutants on certain units of metabolism are important tasks in ecological‐genetic monitoring. Cytogenetic and biochemical biomarkers are used in biomonitoring studies to analyze the genotoxicity of aquatic pollutants. The purpose of the work was to analyse the use of markers of oxidative stress and cytogenetic disorders in goby fish caught at shallow and deep‐water stations of the Northern Caspian Sea in the ecological‐genetic monitoring system. Material and Methods. The study was undertaken on 227 specimens of goby fish by cytogenetic and biochemical analysis. Results. The correlation dependence between erythrocytes with micronuclei and erythrocytes with the quantity of damaged nuclei summarized as R= ‐0.83 (p˂0.05) was shown. The results of correlation analysis between oxidative stress indices and the number of destructive changes in erythrocyte nucleus are presented. Our analysis thus leads us to the conclusion that somatic mutagenesis (micronuclear formation) after exposure to free radicals can be an adaptive response to this stress factor.Conclusion. Analysis leadsus to the conclusion that somatic mutagenesis (formation of micro‐nuclei) after exposure to free radicals can be an adaptive response to stress factor in habitat conditions in areas of liquidated prospecting wells of LUKOIL‐Nizhnevolzhskneft in the Northern Caspian Sea.

scholarly journals Molecular structure of stress granules and their role in the eukaryotic cell

2021 ◽  
Vol 9 (1) ◽  
pp. 33-41
Author(s):  
Paulina Pietras ◽  
Marta Leśniczak ◽  
Mateusz Sowiński ◽  
Witold Szaflarski
Keyword(s):  
Viral Infections ◽  
Protein Biosynthesis ◽  
Stress Granules ◽  
Eukaryotic Cell ◽  
Active Protein ◽  
Translation Process ◽  
Defensive Role ◽  
Cell Components ◽  
Response To Stress ◽  
Cytoplasmic Structures

Abstract Stress granules (SGs) are cytoplasmic structures found in eukaryotic cells, from yeast to human cells. They are made up of proteins, RNA and small ribosome subunits (40S). They arise as a result of the rapid shutdown of active protein biosynthesis in the cell, which is the result of the appearance of a stress factor. The mechanism of regulation of protein biosynthesis in response to stress takes place at two control nodes: (1) phosphorylation of the α subunit of the eIF2 factor as a result of the action of stress-recognizing kinases or by modulation of the mTOR pathway activity, which regulates the initiation of protein biosynthesis by the formation of a complex within the so-called cap structure. The protein arrest causes aggregation of the translation process components and other cell components (other proteins or mRNA molecules) into SGs. A lot of data indicates the active participation of SGs in metabolic processes, their control role over pro- and anti-apoptotic processes as well as in the development of cancer, neurodegenerative diseases and their defensive role in viral infections. Running title: Stress granules in the cell

scholarly journals DNA METHYLATION AT THE CROSSROADS OF PHYSIOLOGICAL RESPONSE TO STRESS AND PATHOLOGICAL BIOLOGY

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S735-S735
Author(s):  
Shabnam Salimi
Keyword(s):  
Dna Methylation ◽  
Adaptive Response ◽  
Physiological Response ◽  
Stress Perception ◽  
Epigenetic Code ◽  
Body Organ ◽  
Response To Stress ◽  
Methylation Patterns ◽  
Body Response ◽  
Over Time

Abstract It is likely that the dimension and the scope of stress perception are different in different body systems conditioning their specific rates of aging. Moreover, in addition to between-individual variabilities in body response to stress, there is inter-organs variability in adaptations resulting in pleiotropy of phenotypes evolved with aging. Epigenetic measures may be considered possible readouts of the extent and proxy of the adaptive response to intrinsic and/or extrinsic stress in body organs. It is thus important to disentangle the epigenetic basis of stress, adaptation, and pathology. In this symposium we discuss a combination of the specific DNA methylation patterns relate to the diseases as an intrinsic stressor and adaptation responses imposed to bodily systems, and also accelerated body organ morbidities. We explain the static and dynamic DNA methylation differentiation over time as the “epigenetic code” of accelerated pathology across various age using longitudinal data.

scholarly journals Exosome in Cardiovascular Diseases: A Complex World Full of Hope

Cells ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 166 ◽  
Author(s):  
Gloria Bellin ◽  
Chiara Gardin ◽  
Letizia Ferroni ◽  
Juan Chachques ◽  
Massimo Rogante ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Adaptive Response ◽  
Cell Communication ◽  
Tissue Homeostasis ◽  
Bioactive Molecules ◽  
Complex World ◽  
Huge Number ◽  
Response To Stress ◽  
Important Means

Exosomes are a subgroup of extracellular vesicles containing a huge number of bioactive molecules. They represent an important means of cell communication, mostly between different cell populations, with the purpose of maintaining tissue homeostasis and coordinating the adaptive response to stress. This type of intercellular communication is important in the cardiovascular field, mainly due to the fact that the heart is a complex multicellular system. Given the growing interest in the role of exosomes in cardiovascular diseases and the numerous studies published in the last few decades, we focused on the most relevant results about exosomes in the cardiovascular filed starting from their characterization, passing through the study of their function, and ending with perspectives for their use in cardiovascular therapies.

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