scholarly journals Bright-light detector control emulates the local bounds of Bell-type inequalities

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Shihan Sajeed ◽  
Nigar Sultana ◽  
Charles Ci Wen Lim ◽  
Vadim Makarov
Keyword(s):  
Bright Light ◽  
Light Detector

Morning bright light therapy: a helpful tool for reducing comorbid symptoms of affective and behavioral dysregulation in juvenile depressed inpatients? A pilot trial

2017 ◽  
Vol 45 (1) ◽  
pp. 34-41 ◽  
Author(s):  
Sarah Bogen ◽  
Tanja Legenbauer ◽  
Stephanie Gest ◽  
Martin Holtmann
Keyword(s):  
Pilot Trial ◽  
Secondary Analysis ◽  
Bright Light ◽  
Light Therapy ◽  
Bright Light Therapy ◽  
Circadian Phase ◽  
Behavioral Dysregulation ◽  
Sleep Parameters ◽  
Circadian Effect ◽  
Dysregulation Profile

Abstract. Objective: In recent years, bright light therapy (BLT) has been used to treat depression and to stabilize circadian rhythms. In this study we evaluated whether it is also helpful for comorbid symptoms of affective and behavioral dysregulation in depressive inpatients. Method: This article reports a secondary analysis comparing two subgroups of depressive participants with comorbid affective and behavioral dysregulation, captured with the dysregulation-profile of the Strengths and Difficulties Questionnaire (SDQ-DP; n = 16 vs. n = 11). Participants were randomly allocated to active BLT (10,000 lux) or control BLT (approx. 100 lux), and received 45 minutes of BLT for 2 weeks. SDQ-DP scores, sleep parameters, and circadian preference were assessed at baseline, after the intervention, and 3 weeks later. Results: No direct effects on SDQ-DP scores were observed. Sleep improved in both conditions. Only in the active BLT condition was a circadian phase advance found. Correlation and regression analyses indicated an indirect, circadian effect for improved SDQ-DP scores. Conclusions: The data of this pilot trial should be considered preliminary and merely descriptive. Further research is warranted.


Sulfonamides Are an Overlooked Class of Electron Donors in Luminogenic Luciferins and Fluorescent Dyes

2018 ◽  
Author(s):  
Deepak K. Sharma ◽  
Spencer T. Adams ◽  
Kate L. Liebmann ◽  
Adam Choi ◽  
Stephen Miller
Keyword(s):  
Fluorescent Dyes ◽  
Bright Light ◽  
Firefly Luciferase ◽  
Electron Donors ◽  
Light Emitting

Many fluorophores, and all bright light-emitting substrates for firefly luciferase, contain hydroxyl or amine electron donors. Here we show that sulfonamides can serve as replacements for these canonical groups. Unlike “caged” carboxamides, sulfonamide analogues enable bioluminescence, and sulfonamidyl luciferins, coumarins, rhodols, and rhodamines are fluorescent in water. Sulfonamide donors thus have previously unappreciated potential to expand the functional repertoire of luminescent molecules.

Nonphotic entrainment of the human circadian pacemaker

1998 ◽  
Vol 274 (4) ◽  
pp. R991-R996 ◽  
Author(s):  
Elizabeth B. Klerman ◽  
David W. Rimmer ◽  
Derk-Jan Dijk ◽  
Richard E. Kronauer ◽  
Joseph F. Rizzo ◽  
...  
Keyword(s):  
Circadian Rhythms ◽  
Light Exposure ◽  
Core Body Temperature ◽  
Biological Clock ◽  
Bright Light ◽  
Circadian Pacemaker ◽  
Temperature Rhythms ◽  
Blind Individuals ◽  
Nonphotic Entrainment ◽  
Core Body

In organisms as diverse as single-celled algae and humans, light is the primary stimulus mediating entrainment of the circadian biological clock. Reports that some totally blind individuals appear entrained to the 24-h day have suggested that nonphotic stimuli may also be effective circadian synchronizers in humans, although the nonphotic stimuli are probably comparatively weak synchronizers, because the circadian rhythms of many totally blind individuals “free run” even when they maintain a 24-h activity-rest schedule. To investigate entrainment by nonphotic synchronizers, we studied the endogenous circadian melatonin and core body temperature rhythms of 15 totally blind subjects who lacked conscious light perception and exhibited no suppression of plasma melatonin in response to ocular bright-light exposure. Nine of these fifteen blind individuals were able to maintain synchronization to the 24-h day, albeit often at an atypical phase angle of entrainment. Nonphotic stimuli also synchronized the endogenous circadian rhythms of a totally blind individual to a non-24-h schedule while living in constant near darkness. We conclude that nonphotic stimuli can entrain the human circadian pacemaker in some individuals lacking ocular circadian photoreception.

737 Prediction of drop out in an adjunctive light treatment trial in patients with non-seasonal depression and evening chronotype

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A287-A288
Author(s):  
Joey W Chan ◽  
Y K Wing ◽  
S P Lam ◽  
Shirley Xin Li ◽  
J Zhang
Keyword(s):  
Clinical Characteristics ◽  
Red Light ◽  
Bright Light ◽  
Fold Increase ◽  
Light Therapy ◽  
Light Treatment ◽  
Drop Out ◽  
Sleep Diary ◽  
Significant Difference ◽  
Seasonal Depression

Abstract Introduction Drop out during treatment hampers therapeutic effect of interventions. The current study examines the possible predictors of drop out during the five-week light treatment in patients with unipolar non-seasonal depression and evening-chronotype. Methods Baseline characteristics including demographics, sleep diary parameters, light treatment prescribed, and early clinical outcomes changes were compared between the Drop out and Non drop out group. Logistic regression analysis was used to examine predictors for drop out. All data were analyzed in a modified intention to treat analysis with last observation carried forward approach. Results A total of 91 subjects (Female 79%, 46.3 ± 11.8 years old) were included in the analysis. There was no significant difference in the baseline demographic and clinical characteristics between the Drop out and Non drop out group. There was also no significant difference in the improvement of clinical parameters over the first week among the two groups. However, treatment non-adherence (in terms of compliance of less than 80% of prescribed duration) over the first treatment week predicts a five-fold increase in risk of drop out during light therapy. (OR: 5.85, CI: 1.414–24.205, p=0.015) after controlling for potential confounders including age, gender, treatment group, patient expectation, and treatment-emergent adverse events. Conclusion This study found that baseline clinical characteristics including depression severity and improvement of depressive symptoms in the initial week did not differ between the Drop out and Non drop out group. The drop out was also not affected by the type of light (dim red versus bright red light), indirectly supporting dim red light as a valid placebo in bright light therapy trial. Treatment adherence is the early phase of light treatment is an important predictor of drop out. Support (if any):

scholarly journals Fear of light: On the cause and remediation of photophobia

2021 ◽  
Vol 53 (5) ◽  
pp. 395-404
Author(s):  
A Wilkins
Keyword(s):  
Spatial Pattern ◽  
Bright Light ◽  
Visual Discomfort ◽  
Wide Range

Photophobia (fear of light) occurs in a wide range of ophthalmic, neurological and behavioural conditions, the most common of which is migraine. The visual discomfort associated with migraine can occur not only in response to bright light but also flicker, spatial pattern and colour. The principles that underlie the discomfort are explored and methods to reduce it are proposed.

No mood-altering effects found after treatment of normal subjects with bright light in the morning

1987 ◽  
Vol 22 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Norman E. Rosenthal ◽  
Annette Rotter ◽  
Fredrick M. Jacobsen ◽  
Robert G. Skwerer
Keyword(s):  
Bright Light ◽  
Normal Subjects

scholarly journals 0077 PHASE ADVANCING TEENS WITH WEEKEND MORNING BRIGHT LIGHT: HOW LONG IS ENOUGH?

SLEEP ◽  
2017 ◽  
Vol 40 (suppl_1) ◽  
pp. A29-A30
Author(s):  
LD Akacem ◽  
CI Eastman ◽  
SJ Crowley
Keyword(s):  
Bright Light

Photoinhibition of DCMU-Enhanced Fluorescence in Lake Ontario Phytoplankton

1987 ◽  
Vol 44 (12) ◽  
pp. 2144-2154 ◽  
Author(s):  
M. Putt ◽  
G. P. Harris ◽  
R. L. Cuhel
Keyword(s):  
Vertical Mixing ◽  
Natural Populations ◽  
Bright Light ◽  
Euphotic Zone ◽  
Lake Ontario ◽  
Enhanced Fluorescence ◽  
Low Light ◽  
Light Levels ◽  
Phosphorus Status

Measurement of 1-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU) enhanced fluorescence (FDCMU) suggested that photoinhibition of photosynthesis was frequently an artifact of in situ bottle incubations in Lake Ontario phytoplankton. In a seasonal study, FDCMU of all populations was depressed by bright light in an incubator. However, when the euphotic zone did not exceed the depth of the mixed layer, vertical transport of phytoplankton into either low-light or dark regions apparently allowed reversal of photoinhibition of FDCMU. Advantages of FDCMU as a bioassay of vertical mixing include rapidity of response time, ease of measurement in the field, and insensitivity of this parameter to changes in phosphorus status of the population. Because of seasonal changes in the photoadaptive response of natural populations, the rate constants and threshold light levels required to cause the response must be determined at each use if the method is to be quantitative.

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