scholarly journals Artificial intelligence application for rapid fabrication of size-tunable PLGA microparticles in microfluidics

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Safa A. Damiati ◽  
Damiano Rossi ◽  
Haakan N. Joensson ◽  
Samar Damiati

Abstract In this study, synthetic polymeric particles were effectively fabricated by combining modern technologies of artificial intelligence (AI) and microfluidics. Because size uniformity is a key factor that significantly influences the stability of polymeric particles, therefore, this work aimed to establish a new AI application using machine learning technology for prediction of the size of poly(d,l-lactide-co-glycolide) (PLGA) microparticles produced by diverse microfluidic systems either in the form of single or multiple particles. Experimentally, the most effective factors for tuning droplet/particle sizes are PLGA concentrations and the flow rates of dispersed and aqueous phases in microfluidics. These factors were utilized to develop five different and simple in structure artificial neural network (ANN) models that are capable of predicting PLGA particle sizes produced by different microfluidic systems either individually or jointly merged. The systematic development of ANN models allowed ultimate construction of a single in silico model which consists of data for three different microfluidic systems. This ANN model eventually allowed rapid prediction of particle sizes produced using various microfluidic systems. This AI application offers a new platform for further rapid and economical exploration of polymer particles production in defined sizes for various applications including biomimetic studies, biomedicine, and pharmaceutics.

2012 ◽  
Author(s):  
Khairiyah Mohd. Yusof ◽  
Fakhri Karray ◽  
Peter L. Douglas

This paper discusses the development of artificial neural network (ANN) models for a crude oil distillation column. Since the model is developed for real time optimisation (RTO) applications they are steady state, multivariable models. Training and testing data used to develop the models were generated from a reconciled steady-state model simulated in a process simulator. The radial basis function networks (RBFN), a type of feedforward ANN model, were able to model the crude tower very well, with the root mean square error for the prediction of each variable less than 1%. Grouping related output variables in a network model was found to give better predictions than lumping all the variables in a single model; this also allowed the overall complex, multivariable model to be simplified into smaller models that are more manageable. In addition, the RBFN models were also able to satisfactorily perform range and dimensional extrapolation, which is necessary for models that are used in RTO.


2022 ◽  
pp. 1287-1300
Author(s):  
Balaji Prabhu B. V. ◽  
M. Dakshayini

Demand forecasting plays an important role in the field of agriculture, where a farmer can plan for the crop production according to the demand in future and make a profitable crop business. There exist a various statistical and machine learning methods for forecasting the demand, selecting the best forecasting model is desirable. In this work, a multiple linear regression (MLR) and an artificial neural network (ANN) model have been implemented for forecasting an optimum societal demand for various food crops that are commonly used in day to day life. The models are implemented using R toll, linear model and neuralnet packages for training and optimization of the MLR and ANN models. Then, the results obtained by the ANN were compared with the results obtained with MLR models. The results obtained indicated that the designed models are useful, reliable, and quite an effective tool for optimizing the effects of demand prediction in controlling the supply of food harvests to match the societal needs satisfactorily.


2020 ◽  
Vol 12 (4) ◽  
pp. 35-47
Author(s):  
Balaji Prabhu B. V. ◽  
M. Dakshayini

Demand forecasting plays an important role in the field of agriculture, where a farmer can plan for the crop production according to the demand in future and make a profitable crop business. There exist a various statistical and machine learning methods for forecasting the demand, selecting the best forecasting model is desirable. In this work, a multiple linear regression (MLR) and an artificial neural network (ANN) model have been implemented for forecasting an optimum societal demand for various food crops that are commonly used in day to day life. The models are implemented using R toll, linear model and neuralnet packages for training and optimization of the MLR and ANN models. Then, the results obtained by the ANN were compared with the results obtained with MLR models. The results obtained indicated that the designed models are useful, reliable, and quite an effective tool for optimizing the effects of demand prediction in controlling the supply of food harvests to match the societal needs satisfactorily.


2014 ◽  
Vol 1017 ◽  
pp. 166-171
Author(s):  
Bin Zhao ◽  
Song Zhang ◽  
Jian Feng Li

Three-dimensional surface roughness parameters are widely applied to characterize frictional and lubricating properties, corrosion resistance, fatigue strength of surfaces. Among them, the functional parameters of surface roughness, such as Sbi, Sci, and Svi, are used to evaluate bearing and fluid retention properties of surfaces. In this study, the effects of grinding parameters, including wheel linear speed (Vs), workpiece linear speed (Vw), grinding depth (ap), longitudinal feed rate (fa), and dressing rate (F), on functional parameters were studied in grinding of cast iron. An artificial neural network (ANN) model was developed for predicting the functional parameters of three-dimensional surface roughness. The inputs of the ANN models were grinding parameters (Vs, Vw, ap, fa, F), and the output parameters of the models were functional parameters of surface roughness (Sbi, Sci, Svi). With small errors (e.g MSE = 0.09%, 0.61%, and 0.0014%. ), the ANN-based models are considered sufficiently accurate to predict functional parameters of surface roughness in grinding of cast iron.


2013 ◽  
Vol 284-287 ◽  
pp. 403-408
Author(s):  
Nur Alwani Ali Bashah ◽  
Mohd Roslee Othman ◽  
Norashid Aziz

Batch reactive distillation is an integrated unit of batch reactor and distillation. It provides benefits of having higher conversion and yield by continuous removal of side product. The aim of this paper is to develop an artificial neural network (ANN) based model for production of isopropyl myristate in an industrial scaled semibatch reactive distillation. Two cases of the MIMO model were developed. Case 1 does not consider historical data as inputs while case 2 does. The trained ANN for both cases was validated with independent validation data and the best architecture was optimized. Case 1 resulted to 8 inputs, 14 hidden nodes and 2 outputs [8-14-2] ANN while Case 2 resulted to [12-13-2] ANN. The results show that both ANN models have ability to predict the unknown validation and testing data very well. However, the [8-14-2] ANN model produce higher accuracy than [12-13-2] ANN model with MSE of 0.00094 and 0.0013, respectively.


2014 ◽  
Vol 49 (2) ◽  
pp. 144-162 ◽  
Author(s):  
Cindie Hebert ◽  
Daniel Caissie ◽  
Mysore G. Satish ◽  
Nassir El-Jabi

Water temperature is an important component for water quality and biotic conditions in rivers. A good knowledge of river thermal regime is critical for the management of aquatic resources and environmental impact studies. The objective of the present study was to develop a water temperature model as a function of air temperatures, water temperatures and water level data using artificial neural network (ANN) techniques for two thermally different streams. This model was applied on an hourly basis. The results showed that ANN models are an effective modeling tool with overall root-mean-square-error of 0.94 and 1.23 °C, coefficient of determination (R2) of 0.967 and 0.962 and bias of −0.13 and 0.02 °C, for Catamaran Brook and the Little Southwest Miramichi River, respectively. The ANN model performed best in summer and autumn and showed a poorer performance in spring. Results of the present study showed similar or better results to those of deterministic and stochastic models. The present study shows that the predicted hourly water temperatures can also be used to estimate the mean and maximum daily water temperatures. The many advantages of ANN models are their simplicity, low data requirements, their capability of modeling long-term time series as well as having an overall good performance.


2021 ◽  
Author(s):  
Jong Soo Kim ◽  
Yongil Cho ◽  
Tae Ho Lim

Abstract An orthogonal neural network (ONN), a new deep-learning structure for medical image localization, is developed and presented in this paper. This method is simple, efficient, and completely different from a convolution neural network (CNN). The diagnostic performance of ONN for detecting the location of pneumothorax in chest X-rays was assessed and compared to that of CNN. An area under the receiver operating characteristic (ROC) curve (AUC) of 0.870, an accuracy of 85.3%, a sensitivity of 75.0%, and a specificity of 86.5% were achieved; the ONN outperformed the CNN. The diagnostic performance of the ONN with a sigmoid activation function for all the nodes obviously outperformed the ONN with the rectified linear unit (RELU) activation function for all the nodes other than the output nodes. In addition, by applying ONN and CNN to predict the location of the glottis in laryngeal images, we achieved accurate and adjacent prediction rates of 70.5% and 20.5%, respectively, with the ONN. The prediction accuracy of the ONN was compared favorably with that of the CNN. Compared to a CNN, an ONN required only approximately 10% of the computations using a CNN trained on images with an input resolution of 256 × 256 pixels. A fully-connected small artificial neural network (ANN), selected by comparing the test results of several dozens of small ANN models, achieved the best location prediction performance on medical images. This study demonstrated that an ONN can be used as a quick selection criterion to compare ANN models for image localization since an ONN performed well compared decently with the selected ANN model.


10.29007/4sdt ◽  
2022 ◽  
Author(s):  
Vu Khanh Phat Ong ◽  
Quang Khanh Do ◽  
Thang Nguyen ◽  
Hoang Long Vo ◽  
Ngoc Anh Thy Nguyen ◽  
...  

The rate of penetration (ROP) is an important parameter that affects the success of a drilling operation. In this paper, the research approach is based on different artificial neural network (ANN) models to predict ROP for oil and gas wells in Nam Con Son basin. The first is the process of collecting and evaluating drilling parameters as input data of the model. Next is to find the network model capable of predicting ROP most accurately. After that, the study will evaluate the number of input parameters of the network model. The ROP prediction results obtained from different ANN models are also compared with traditional models such as the Bingham model, Bourgoyne & Young model. These results have shown the competitiveness of the ANN model and its high applicability to actual drilling operations.


Foods ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 834 ◽  
Author(s):  
Simona Violino ◽  
Luciano Ortenzi ◽  
Francesca Antonucci ◽  
Federico Pallottino ◽  
Cinzia Benincasa ◽  
...  

Extra virgin olive oil (EVOO) represents a crucial ingredient of the Mediterranean diet. Being a first-choice product, consumers should be guaranteed its quality and geographical origin, justifying the high purchasing cost. For this reason, it is important to have new reliable tools able to classify products according to their geographical origin. The aim of this work was to demonstrate the efficiency of an open source visible and near infra-red (VIS-NIR) spectrophotometer, relying on a specific app, in assessing olive oil geographical origin. Thus, 67 Italian and 25 foreign EVOO samples were analyzed and their spectral data were processed through an artificial intelligence algorithm. The multivariate analysis of variance (MANOVA) results reported significant differences (p < 0.001) between the Italian and foreign EVOO VIS-NIR matrices. The artificial neural network (ANN) model with an external test showed a correct classification percentage equal to 94.6%. Both the MANOVA and ANN tested methods showed the most important spectral wavelengths ranges for origin determination to be 308–373 nm and 594–605 nm. These are related to the absorption of phenolic components, carotenoids, chlorophylls, and anthocyanins. The proposed tool allows the assessment of EVOO samples’ origin and thus could help to preserve the “Made in Italy” from fraud and sophistication related to its commerce.


Author(s):  
Rudra P. Pradhan

This paper presents an application of Artificial Neural Network (ANN) to forecast inflation in India during the period 1994-2009. The study presents four different ANN models on the basis of inflation (WPI), economic growth (IIP), and money supply (MS). The first model is a univariate model based on past WPI only. The other three are multivariate models based on WPI and IIP, WPI and MS, WPI, and IIP and MS. In each case, the forecasting performance is measured by mean squared errors and mean absolute deviations. The paper finally concludes that multivariate models show better forecasting performance over the univariate model. In particular, the multivariate ANN model using WPI, IIP, and MS resulted in better performance than the rest of other models to forecast inflation in India.


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