scholarly journals Sustainable drug release from polycaprolactone coated chitin-lignin gel fibrous scaffolds

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Tuerdimaimaiti Abudula ◽  
Kalamegam Gauthaman ◽  
Azadeh Mostafavi ◽  
Ahmed Alshahrie ◽  
Numan Salah ◽  
...  
Keyword(s):  
Drug Release ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Healthcare Systems ◽  
Limb Amputation ◽  
Complex Carbohydrate ◽  
Electrospun Scaffolds ◽  
Carbohydrate Polymers ◽  
Fibrous Scaffolds ◽  
Healing Wounds

AbstractNon-healing wounds have placed an enormous stress on both patients and healthcare systems worldwide. Severe complications induced by these wounds can lead to limb amputation or even death and urgently require more effective treatments. Electrospun scaffolds have great potential for improving wound healing treatments by providing controlled drug delivery. Previously, we developed fibrous scaffolds from complex carbohydrate polymers [i.e. chitin-lignin (CL) gels]. However, their application was limited by solubility and undesirable burst drug release. Here, a coaxial electrospinning is applied to encapsulate the CL gels with polycaprolactone (PCL). Presence of a PCL shell layer thus provides longer shelf-life for the CL gels in a wet environment and sustainable drug release. Antibiotics loaded into core–shell fibrous platform effectively inhibit both gram-positive and -negative bacteria without inducting observable cytotoxicity. Therefore, PCL coated CL fibrous gel platforms appear to be good candidates for controlled drug release based wound dressing applications.

A general method to greatly enhance ultrasound-responsiveness for common polymeric assemblies

2020 ◽  
Vol 11 (19) ◽  
pp. 3296-3304
Author(s):  
Jinkang Dou ◽  
Ruiqi Yang ◽  
Kun Du ◽  
Li Jiang ◽  
Xiayun Huang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Promising Technique ◽  
Polymeric Assemblies ◽  
General Method

Ultrasound-controlled drug release is a very promising technique for controlled drug delivery due to the unique advantages of ultrasound as the stimulus.

Water based PHEMA hydrogels for controlled drug delivery

2017 ◽  
Vol 43 (3) ◽  
pp. 228-239
Author(s):  
Hakan Ayhan ◽  
Fatma Ayhan
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Bacterial Strains ◽  
Buffer Solutions ◽  
Free Radical Photopolymerization ◽  
Water Based ◽  
Hydrogel Swelling ◽  
Drug Activities

Abstract Objective: In the scope of presented work, synthesis of water based acrylate hydrogels, characterization, and their usage in controlled drug release systems were aimed to investigate. Methods: Synthesis of acrylate based hydrogels that have different properties was carried out by free radical photopolymerization using photoinitiator. Because of its high biocompatibility, 2-hydroxyethyl metacrylate (HEMA) was used as monomer. Then drug release experiments were performed in pH 7.4 and 1.2 buffer solutions with certain ionic strength while the dynamic swelling behaviors were also determined. In the last part of the work, drug activities of synthesized drug-loaded hydrogels were tested in mediums containing Staphylococcus aureus and Pseudomonas aeruginosa bacteria cultures. Results: ATR-FTIR spectrums of all synthesized hydrogels were analyzed. The characteristic O-H, C-H, C=O, C-O tension vibrations bands were observed in the spectrums of the hydrogels. The rate of drug release in acidic pH 1.2 for two types of hydrogels was observed to be much faster than at pH 7.4. It was determined that hydrogel swelling ratio decrease with increasing monomer ratio. All drug loaded hydrogels were effective to inhibit the growth of both two bacterial strains. Conclusion: Hydrogels synthesized were found to be suitable for the controlled drug delivery applications.

pH-Responsive polymeric Janus containers for controlled drug delivery

2015 ◽  
Vol 6 (22) ◽  
pp. 4144-4153 ◽  
Author(s):  
Ziguang Zhao ◽  
Feiyan Zhu ◽  
Xiaozhong Qu ◽  
Qiuhua Wu ◽  
Qian Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Hollow Spheres ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Ph Responsive

In this study, we have successfully designed and fabricated pH-responsive polymeric Janus hollow spheres for controlled drug release.

Polymer–paclitaxel conjugates based on disulfide linkers for controlled drug release

RSC Advances ◽  
2015 ◽  
Vol 5 (10) ◽  
pp. 7559-7566 ◽  
Author(s):  
Wulian Chen ◽  
Luqman Ali Shah ◽  
Li Yuan ◽  
Mohammad Siddiq ◽  
Jianhua Hu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Diblock Copolymer ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Controlled Drug Delivery System ◽  
Disulfide Linkers ◽  
Covalently Linked

Controlled drug delivery system based on hydrophilic diblock copolymer covalently linked paclitaxel (PTX) via a disulfide linker.

Synthesis, Characterization and Controlled Drug Release of Thermosensitive Poly(NIPAAm-co-HEMA) and IPN(NIPAAm/HEMA) Hydrogels

2006 ◽  
Vol 11-12 ◽  
pp. 737-740 ◽  
Author(s):  
Yuan Xiao Wang ◽  
Xiu Fen Wang ◽  
Shi Wei Song
Keyword(s):  
Drug Release ◽  
Drug Delivery Systems ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Swelling Ratio ◽  
Interpenetrating Network ◽  
Different Temperatures ◽  
Swelling Characteristics ◽  
Kinetics Of

A series of thermo-sensitive copolymers and interpenetrating network hydrogels were prepared using PNIPAAm and HEMA.The effects of the PNIPAAm/HEMA ratio on the swelling ratio ,and deswelling and reswelling kinetics of gels at different temperatures and drug release characteristics in vitro were discussed. The results showed that the copolymer and IPN hydrogels exhibited thermo-sensitive swelling characteristics. Therefore, the hydrogels may be useful in the controlled drug delivery systems.

scholarly journals Dual stimuli-responsive polyphosphazene-based molecular gates for controlled drug delivery in lung cancer cells

RSC Advances ◽  
2020 ◽  
Vol 10 (46) ◽  
pp. 27305-27314
Author(s):  
Yolanda Salinas ◽  
Michael Kneidinger ◽  
Cristina Fornaguera ◽  
Salvador Borrós ◽  
Oliver Brüggemann ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Bottle Brush ◽  
Molecular Gates

Bottle-brush polyphosphazenes as dual, thermosensitive and pH responsive gatekeepers for mesoporous silica nanoparticles, and their use in controlled drug release.

Stimulus-cleavable chemistry in the field of controlled drug delivery

2021 ◽  
Author(s):  
Yufei Xue ◽  
Hua Bai ◽  
Bo Peng ◽  
Bin Fang ◽  
Jonathan Baell ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Research Areas ◽  
Potential Applications

This review comprehensively summarises stimulus-cleavable linkers from various research areas and their cleavage mechanisms, thus provides an insightful guideline to extend their potential applications to controlled drug release from nanomaterials.

scholarly journals NIR-triggered upconversion nanoparticles@thermo-sensitive liposome hybrid theranostic nanoplatform for controlled drug delivery

RSC Advances ◽  
2021 ◽  
Vol 11 (46) ◽  
pp. 29065-29072
Author(s):  
Yibin Yu ◽  
Yida Huang ◽  
Wanqian Feng ◽  
Mei Yang ◽  
Baiqi Shao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Upconversion Luminescence ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Upconversion Nanoparticles

A novel hybrid photothermal theranostic nanoplatform UCNPs@Bi@SiO2@GE HP-lips is developed. Upon NIR irradiation, the nanoplatform could photothermally trigger controlled drug release and present bright upconversion luminescence.

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