scholarly journals Age-related changes in visual search: manipulation of colour cues based on cone contrast and opponent modulation space

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Shuto Tamura ◽  
Keiko Sato
Keyword(s):  
Visual Search ◽  
Visual Attention ◽  
Reaction Times ◽  
Visual Space ◽  
Preliminary Evidence ◽  
Human Lens ◽  
Search Performance ◽  
Older Individuals ◽  
Colour Perception ◽  
Age Related

AbstractReduced retinal illuminance affects colour perception in older adults, and studies show that they exhibit deficiencies in yellow-blue (YB) discrimination. However, the influence of colour cues on the visual attention in older individuals remains unclarified. Visual attention refers to the cognitive model by which we prioritise regions within the visual space and selectively process information. The present study aimed to explore the effect of colour on visual search performance in older observers. In our experiment, younger observers wearing glasses with a filter that simulated the spectral transmittance of the aging human lens and older observers performed two types of search tasks, feature search (FS) and conjunction search (CS), under three colour conditions: red-green, YB, and luminance. Targets and distractors were designed on the basis of the Derrington–Krauskopf–Lennie colour representation. In FS tasks, reaction times changed according to colour in all groups, especially under the YB condition, regardless of the presence or absence of distractors. In CS tasks with distractors, older participants and younger participants wearing glasses showed slower responses under chromatic conditions than under the achromatic condition. These results provide preliminary evidence that, for older observers, visual search performance may be affected by impairments in chromatic colour discrimination.

The Impact of Age on Visual Search Performance

1993 ◽  
Vol 37 (2) ◽  
pp. 172-176 ◽  
Author(s):  
P. Manivannan ◽  
Sara Czaja ◽  
Colin Drury ◽  
Chi Ming Ip
Keyword(s):  
Visual Search ◽  
Reaction Time ◽  
Selective Attention ◽  
Search Task ◽  
Visual Search Task ◽  
Age Groups ◽  
Search Performance ◽  
Performance Effect ◽  
Age Related ◽  
The Impact

Visual search is an important component of many real world tasks such as industrial inspection and driving. Several studies have shown that age has an impact on visual search performance. In general older people demonstrate poorer performance on such tasks as compared to younger people. However, there is controversy regarding the source of the age-performance effect. The objective of this study was to examine the relationship between component abilities and visual search performance, in order to identify the locus of age-related performance differences. Six abilities including reaction time, working memory, selective attention and spatial localization were identified as important components of visual search performance. Thirty-two subjects ranging in age from 18 - 84 years, categorized in three different age groups (young, middle, and older) participated in the study. Their component abilities were measured and they performed a visual search task. The visual search task varied in complexity in terms of type of targets detected. Significant relationships were found between some of the component skills and search performance. Significant age effects were also observed. A model was developed using hierarchical multiple linear regression to explain the variance in search performance. Results indicated that reaction time, selective attention, and age were important predictors of search performance with reaction time and selective attention accounting for most of the variance.

scholarly journals RNA sequencing and bioinformatics analysis of human lens epithelial cells in age-related cataract

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zhongying Wang ◽  
Dongmei Su ◽  
Shanhe Liu ◽  
Guiqian Zheng ◽  
Gaobo Zhang ◽  
...  
Keyword(s):  
Rna Sequencing ◽  
Molecular Mechanisms ◽  
Bioinformatics Analysis ◽  
Human Lens ◽  
Older Individuals ◽  
Disease Mechanism ◽  
Anterior Capsule ◽  
Bioinformatics Analyses ◽  
Age Related ◽  
Pathway Analyses

Abstract Background Age-related cataract (ARC) is the main cause of blindness in older individuals but its specific pathogenic mechanism is unclear. This study aimed to identify differentially expressed genes (DEGs) associated with ARC and to improve our understanding of the disease mechanism. Methods Anterior capsule samples of the human lens were collected from ARC patients and healthy controls and used for RNA sequencing to detect DEGs. Identified DEGs underwent bioinformatics analyses, including Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses. Subsequently, reverse transcription quantitative RT-qPCR was used to validate the different expression levels of selected genes. Results A total of 698 up-regulated DEGs and 414 down-regulated DEGs were identified in ARC patients compared with controls by transcriptome analysis. Through GO and KEGG bioinformatics analysis, the functions of significantly DEGs and their possible molecular mechanisms were determined. Sequencing results were verified by RT-qPCR as being accurate and reliable. Conclusions This study identified several genes associated with ARC, which improves our knowledge of the disease mechanism.

Preattentive Processes Guide Visual Search: Evidence from Patients with Unilateral Visual Neglect

1993 ◽  
Vol 5 (3) ◽  
pp. 288-302 ◽  
Author(s):  
Marcia Grabowecky ◽  
Lynn C. Robertson ◽  
Anne Treisman
Keyword(s):  
Visual Search ◽  
Reference Frame ◽  
Search Task ◽  
Visual Search Task ◽  
Visual Space ◽  
Search Performance ◽  
Visual Neglect ◽  
Baseline Levels ◽  
Definition Of ◽  
Contralesional Side

Preattentive processes such as perceptual grouping are thought to be important in the initial guidance of visual attention and may also operate in unilateral neglect by contributing to the definition of a task-appropriate reference frame. We explored this question with a visual search task in which patients with unilateral visual neglect (5 with right-, 2 with left-hemisphere damage) searched a diamond-shaped matrix for a conjunction target that shared one feature with each of two distractor elements. Additional grouping stimuli appeared as flanks either on the left, right, or both sides of the central matrix, and significantly changed performance in the search task. As expected, when flanks appeared only on the ipsilesional side a decrement in search performance was observed, but the further addition of contralesional flanks actually reduced the decrement and returned performance to near baseline levels. These data suggest that flanking stimuli on the neglected contralesional side of visual space can influence the reference frame by grouping with task-relevant stimuli, and that this preattentive influence can be preserved in patients with unilateral visual neglect.

The Influences of Goal and Laterality of a Prepared Hand Response on a Co-Occurring Visual Search

2015 ◽  
Vol 74 (1) ◽  
pp. 55-60 ◽  
Author(s):  
Alexandre Coutté ◽  
Gérard Olivier ◽  
Sylvane Faure
Keyword(s):  
Visual Search ◽  
Visual Target ◽  
Motor Planning ◽  
Search Performance ◽  
Response Preparation ◽  
Manual Response ◽  
Response Hand ◽  
Computer Screen ◽  
Left Hand ◽  
Manual Interaction

Computer use generally requires manual interaction with human-computer interfaces. In this experiment, we studied the influence of manual response preparation on co-occurring shifts of attention to information on a computer screen. The participants were to carry out a visual search task on a computer screen while simultaneously preparing to reach for either a proximal or distal switch on a horizontal device, with either their right or left hand. The response properties were not predictive of the target’s spatial position. The results mainly showed that the preparation of a manual response influenced visual search: (1) The visual target whose location was congruent with the goal of the prepared response was found faster; (2) the visual target whose location was congruent with the laterality of the response hand was found faster; (3) these effects have a cumulative influence on visual search performance; (4) the magnitude of the influence of the response goal on visual search is marginally negatively correlated with the rapidity of response execution. These results are discussed in the general framework of structural coupling between perception and motor planning.

Focusing of Visuospatial Attention

2001 ◽  
Vol 15 (4) ◽  
pp. 256-274 ◽  
Author(s):  
Caterina Pesce ◽  
Rainer Bösel
Keyword(s):  
Reaction Times ◽  
Visual Space ◽  
Spatial Relation ◽  
Stimulus Onset ◽  
Visuospatial Attention ◽  
Task Demands ◽  
Time Interval ◽  
Behavioral Studies ◽  
Task Conditions ◽  
Simple Rt

Abstract In the present study we explored the focusing of visuospatial attention in subjects practicing and not practicing activities with high attentional demands. Similar to the studies of Castiello and Umiltà (e. g., 1990) , our experimental procedure was a variation of Posner's (1980) basic paradigm for exploring covert orienting of visuospatial attention. In a simple RT-task, a peripheral cue of varying size was presented unilaterally or bilaterally from a central fixation point and followed by a target at different stimulus-onset-asynchronies (SOAs). The target could occur validly inside the cue or invalidly outside the cue with varying spatial relation to its boundary. Event-related brain potentials (ERPs) and reaction times (RTs) were recorded to target stimuli under the different task conditions. RT and ERP findings showed converging aspects as well as dissociations. Electrophysiological results revealed an amplitude modulation of the ERPs in the early and late Nd time interval at both anterior and posterior scalp sites, which seems to be related to the effects of peripheral informative cues as well as to the attentional expertise. Results were: (1) shorter latency effects confirm the positive-going amplitude enhancement elicited by unilateral peripheral cues and strengthen the criticism against the neutrality of spatially nonpredictive peripheral cueing of all possible target locations which is often presumed in behavioral studies. (2) Longer latency effects show that subjects with attentional expertise modulate the distribution of the attentional resources in the visual space differently than nonexperienced subjects. Skilled practice may lead to minimizing attentional costs by automatizing the use of a span of attention that is adapted to the most frequent task demands and endogenously increases the allocation of resources to cope with less usual attending conditions.

Age-related effects in the marking of old objects in visual search.

2000 ◽  
Vol 15 (2) ◽  
pp. 286-296 ◽  
Author(s):  
Arthur F. Kramer ◽  
Paul Atchley
Keyword(s):  
Visual Search ◽  
Age Related

Pathogenesis of Age-related Cataract: a systematic review of proteomic studies

2020 ◽  
Vol 17 ◽  
Author(s):  
Christina Karakosta ◽  
Argyrios Tzamalis ◽  
Michalis Aivaliotis ◽  
Ioannis Tsinopoulos
Keyword(s):  
Systematic Review ◽  
Oxidant Stress ◽  
Critical Role ◽  
Human Lens ◽  
Nuclear Cataract ◽  
Cataract Formation ◽  
Post Translational Modification ◽  
Ability To Act ◽  
Age Related

Background/Objective:: The aim of this systematic review is to identify all the available data on human lens proteomics with a critical role to age-related cataract formation in order to elucidate the physiopathology of the aging lens. Materials and Methods:: We searched on Medline and Cochrane databases. The search generated 328 manuscripts. We included nine original proteomic studies that investigated human cataractous lenses. Results:: Deamidation was the major age-related post-translational modification. There was a significant increase in the amount of αA-crystallin D-isoAsp58 present at all ages, while an increase in the extent of Trp oxidation was apparent in cataract lenses when compared to aged normal lenses. During aging, enzymes with oxidized cysteine at critical sites included GAPDH, glutathione synthase, aldehyde dehydrogenase, sorbitol dehydrogenase, and PARK7. Conclusion:: D-isoAsp in αA crystallin could be associated with the development of age-related cataract in human, by contributing to the denaturation of a crystallin, and decreasing its ability to act as a chaperone. Oxidation of Trp may be associated with nuclear cataract formation in human, while the role of oxidant stress in age-related cataract formation is dominant.

“Going Backward”: Effects of age and fatigue on posterior-directed falls in Parkinson disease

2021 ◽  
pp. 1-9
Author(s):  
Evan V. Papa ◽  
Rita M. Patterson ◽  
Nicoleta Bugnariu
Keyword(s):  
Postural Control ◽  
Parkinson Disease ◽  
Repeated Measures ◽  
Center Of Pressure ◽  
Angular Displacement ◽  
Reaction Times ◽  
Older Individuals ◽  
Peak Knee ◽  
Significant Difference ◽  
Fatiguing Exercise

BACKGROUND: Nearly half of persons with Parkinson disease (PD) report fatigue as a factor in their fall history. However, it is unknown whether these self-reported falls are caused by a sensation of fatigue or performance fatigue. OBJECTIVE: We sought to investigate the influences of performance fatigue and age on postural control in persons with PD. METHODS: Individuals with PD (n = 14) underwent postural control assessments before (T0) and immediately after (T1) fatiguing exercise. Biomechanical data were gathered on participants completing a treadmill-induced, posterior-directed fall. Performance fatigue was produced using lower extremity resistance exercise on an isokinetic ergometer. Repeated measures ANCOVAs were used with age as a covariate to determine the effects of performance fatigue on biomechanical variables. RESULTS: After adjustment for age, there was a statistically significant difference in peak center of pressure (COP) latency during the support phase of recovery. Pairwise comparisons demonstrated a decrease in peak ankle displacement from T0 to T1. Age was also found to be significantly related to reaction time and peak knee displacement while participants were fatigued. CONCLUSIONS: The decreased peak COP latency, along with decreased ankle angular displacement, suggest that persons with PD adopt a stiffening strategy in response to backward directed falls. Postural stiffening is not uncommon in persons with PD and could be a risk factor for falls. Older individuals with PD demonstrate slower mobility scores and decreased reaction times in the setting of fatigue, suggesting a combined effect of the aging and fatigue processes.

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