scholarly journals Prognostic value of neutrophil/lymphocyte ratio and mean platelet volume/platelet ratio for 1-year mortality in critically ill patients

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Sung Yeon Ham ◽  
Hei Jin Yoon ◽  
Sang Beom Nam ◽  
Byung Hwan Yun ◽  
Darhae Eum ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Mean Platelet Volume ◽  
Independent Predictor ◽  
Platelet Volume ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
The Third ◽  
Survivor Group ◽  
Kaplan Meier

AbstractSeveral studies have reported that the neutrophil to lymphocyte ratio (NLR) and mean platelet volume (MPV) are associated with poor prognosis. This study investigated whether NLR and/or the MPV/platelet ratio could function as predictive markers of mortality in critically ill patients. We retrospectively reviewed 1,154 patients admitted to the intensive care unit (ICU) between January 2017 and December 2017. Patients were divided into 2 groups according to 1-year mortality. We compared the NLR and MPV/platelet ratio on each day of ICU admission. Patients were classified into tertiles based on their NLR and MPV/platelet ratios, and the incidence of 1-year mortality was compared. Kaplan–Meier survival curves were plotted to evaluate their potential as prognostic factors for 1-year mortality. The NLR and MPV/platelet ratio were higher in the non-survivor group than in the survivor group. The incidence of 1-year mortality was the highest in the third tertile for both the NLR and MPV/platelet ratio. The MPV/platelet ratio was an independent predictor for 1-year mortality based on the Kaplan–Meier survival analysis. Our data showed that the MPV/platelet ratio is a predictive factor for 1-year mortality in critically ill patients.

Reliability of Haematological Parameters and Ratios Obtained from Automated Haematology Analysers in Predicting the Clinical Condition of the Patient - A Study from a Tertiary Care Hospital in New Delhi

2021 ◽  
Vol 8 (25) ◽  
pp. 2168-2172
Author(s):  
Anjali Sharma ◽  
Manju Kumari ◽  
Heena Heena ◽  
Mukul Singh ◽  
Sunil Ranga ◽  
...  
Keyword(s):  
Intensive Care ◽  
Platelet Count ◽  
Intensive Care Units ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Mean Platelet Volume ◽  
Platelet Volume ◽  
Platelet Indices ◽  
Lymphocyte Ratio ◽  
Significant Difference

BACKGROUND Modern automated analysers provide various haematological parameters which have gained a lot of clinical significance. Of these, platelet indices are the most recent one which need to be explored in various diseases. The present study was conducted to evaluate the significance of platelet indices, neutrophil-tolymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and mean platelet volume–to-platelet count in critically ill patients. METHODS This is a prospective study carried out in emergency laboratory of pathology department. 100 patients of intensive care units (ICU) and non-intensive care units (Non-ICU) visiting to the emergency department were included in the study. Fortyfive age and sex matched control patients were taken. The ethylenediamine tetra acetic acid (EDTA) blood sample was analysed on automated analyser. Platelet indices, NLR, MLR and mean platelet volume to platelet counts were calculated in ICU, Non-ICU and control groups. All these values were compared among these groups. RESULTS The study included 400 patients (200 critically ill and 200 non-critically ill) and 45 healthy controls from normal population. The male to female ratio in critically ill and non-critically ill patients was 1.3 : 1 (113 : 87) and 1.08 : 1 (104 : 96) respectively. The critically ill patients had significant leucocytosis (P = 0.019) with neutrophilia (P = 0.005) and lymphopenia (P = 0.048) when compared to noncritically ill patients. There was a significant difference of NLR (P = 0.010), MLR (P = 0.027) and MPV : Platelet count (P = 0.045) in these two groups. However, platelet count and platelet indices were not showing any significant difference in these groups. CONCLUSIONS In the era of modern auto analysers, we should try to utilize the maximum information that could be provided by these machines in forms of various indices and ratios. The present study highlights that neutrophilic leucocytosis with lymphopenia is seen in critically ill patients when compared to non-critically ill patients and normal control population. NLR, MLR and MPV to platelet ratios are also of great importance whereas platelet count and platelet indices are always not helpful in categorization of severity of the patient’s condition. KEYWORDS Intensive Care Unit Patients, Neutrophil Lymphocyte Ratio, Monocyte Lymphocyte Ratio, Mean Platelet Volume

scholarly journals Preoperative Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, and Mean Platelet Volume as Predictors of 1-Year Mortality in Patients Undergoing an Open Repair of Abdominal Aortic Aneurysms: A Retrospective Study

2021 ◽  
Vol 10 (22) ◽  
pp. 5410
Author(s):  
Da Eun Ko ◽  
Hei Jin Yoon ◽  
Sang Beom Nam ◽  
Suk Won Song ◽  
Gisong Lee ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Subgroup Analysis ◽  
Mean Platelet Volume ◽  
Odds Ratio ◽  
Neutrophil To Lymphocyte Ratio ◽  
Platelet Volume ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Survivor Group ◽  
Abdominal Aortic

Objectives: To investigate if preoperative neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), or mean platelet volume (MPV) could be used to predict 1-year mortality in patients undergoing open abdominal aortic aneurysm (AAA) repair. Methods: We retrospectively reviewed 382 patients who underwent open AAA repair between January 2008 and July 2019. We divided the patients into two groups based on 1-year mortality and compared the preoperative NLR, PLR, and MPV. The patients were then classified into tertiles based on their preoperative NLR (first tertile: < 2.41 (n = 111); second tertile: 2.41 ≤ NLR ≤6.07 (n = 111); and third tertile: > 6.07 (n = 112)). We compared the incidence of mortality and morbidity across the aforementioned tertiles. We performed a stepwise logistic regression analysis to evaluate the predictors for mortality. An additional subgroup analysis was performed by dividing the cases into non-ruptured and ruptured cases. Results: The preoperative NLR was significantly higher in the non-survivor group than in the survivor group (10.53 ± 7.60 vs. 5.76 ± 6.44, respectively, p = 0.003). The PLR and MPV were similar between the groups (145.35 ± 91.11 vs. 154.20 ± 113.19, p = 0.626, 9.38 ± 1.20 vs. 9.11 ± 1.39, p = 0.267, respectively). The incidence of 1-year mortality was 2.7%, 9.0%, and 14.3% in the first, second, and third NLR tertiles, respectively (p = 0.009). Higher NLR (odds ratio 1.085, 95% confidence interval 1.016–1.159, p = 0.015) and ruptured AAA (odds ratio 2.706, 95% confidence interval 1.097–6.673, p = 0.031) were the independent predictors of 1-year mortality in all patients. Moreover, the preoperative NLR was significantly higher in the ruptured AAA than in the non-ruptured AAA group (11.17 ± 7.90 vs. 4.10 ± 4.75, p < 0.001). In subgroup analysis, preoperative NLR (odds ratio 1.144, 95% confidence interval 1.031–1.271, p = 0.012) and PLR (odds ratio 0.986, 95% confidence interval 16 0.975–0.998, p = 0.017) was an independent predictor for 1-year mortality in ruptured cases. Conclusions: We demonstrated an independent relationship between the preoperative NLR and 1-year mortality in patients undergoing open AAA repair, besides PLR and MPV. Furthermore, the NLR and PLR had predictive power for 1-year mortality in ruptured cases.

scholarly journals The Role of Mean Platelet Volume as a Predictor of Mortality in Critically Ill Patients: A Systematic Review and Meta-Analysis

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Pattraporn Tajarernmuang ◽  
Arintaya Phrommintikul ◽  
Atikun Limsukon ◽  
Chaicharn Pothirat ◽  
Kaweesak Chittawatanarat
Keyword(s):  
Systematic Review ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Mean Platelet Volume ◽  
Meta Analysis ◽  
Small Sample ◽  
Mean Difference ◽  
Platelet Volume ◽  
Significant Difference ◽  
The Mean

Background. An increase in the mean platelet volume (MPV) has been proposed as a novel prognostic indicator in critically ill patients.Objective. We conducted a systematic review and meta-analysis to determine whether there is an association between MPV and mortality in critically ill patients.Methods. We did electronic search in Medline, Scopus, and Embase up to November 2015.Results. Eleven observational studies, involving 3724 patients, were included. The values of initial MPV in nonsurvivors and survivors were not different, with the mean difference with 95% confident interval (95% CI) being 0.17 (95% CI: −0.04, 0.38;p=0.112). However, after small sample studies were excluded in sensitivity analysis, the pooling mean difference of MPV was 0.32 (95% CI: 0.04, 0.60;p=0.03). In addition, the MPV was observed to be significantly higher in nonsurvivor groups after the third day of admission. On the subgroup analysis, although patient types (sepsis or mixed ICU) and study type (prospective or retrospective study) did not show any significant difference between groups, the difference of MPV was significantly difference on the unit which had mortality up to 30%.Conclusions. Initial values of MPV might not be used as a prognostic marker of mortality in critically ill patients. Subsequent values of MPV after the 3rd day and the lower mortality rate unit might be useful. However, the heterogeneity between studies is high.

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