Presence of sarcopenia does not affect the clinical results of balloon kyphoplasty for acute osteoporotic vertebral fracture

AbstractSarcopenia has been associated with poor clinical outcomes in several diseases. Herein, the clinical results of balloon kyphoplasty (BKP) for acute osteoporotic vertebral fracture (OVF) treatment were assessed and compared between sarcopenia and non-sarcopenia patients. Sixty patients who underwent BKP for treatment of acute OVF with poor prognostic factors between April 2016 and September 2017 and were assessed for sarcopenia were enrolled. Clinical results (back pain on visual analogue scale [VAS]; short-form [SF] 36; vertebral deformity; activities of daily living levels; and incidence of adjacent vertebral fractures) were compared between the two groups at 6 months post-BKP. Data analysis revealed that back pain on VAS, SF-36 scores, and vertebral deformity improved from baseline to 6 months after BKP. Thirty-nine patients (65.0%) were diagnosed with sarcopenia and demonstrated a lower body mass index (21.2 vs. 23.3 kg/m2, p = 0.02), skeletal muscle mass index (5.32 vs. 6.55 kg/m2, p < 0.01), hand-grip strength (14.7 vs. 19.2 kg, p = 0.01), and bone mineral density of the femoral neck (0.57 vs. 0.76 g/cm2, p < 0.01) than those of patients without sarcopenia. However, no significant differences were observed in the clinical results between these groups. Therefore, BKP’s clinical results for the treatment of acute OVF are not associated with sarcopenia.

Download Full-text

Is Bone Nonunion, Vertebral Deformity, or Spinopelvic Malalignment the Best Therapeutic Target for Amelioration of Low Back Pain After Osteoporotic Vertebral Fracture?

Spine ◽

10.1097/brs.0000000000003422 ◽

2020 ◽

Vol 45 (13) ◽

pp. E760-E767

Author(s):

Akira Iwata ◽

Masahiro Kanayama ◽

Fumihiro Oha ◽

Yukitoshi Shimamura ◽

Tomoyuki Hashimoto ◽

...

Keyword(s):

Low Back Pain ◽

Back Pain ◽

Vertebral Fracture ◽

Therapeutic Target ◽

Vertebral Deformity ◽

Osteoporotic Vertebral Fracture ◽

Low Back ◽

Bone Nonunion

Download Full-text

Comparison of radiological and clinical results of balloon kyphoplasty according to anterior height loss in the osteoporotic vertebral fracture

The Spine Journal ◽

10.1016/j.spinee.2014.01.028 ◽

2014 ◽

Vol 14 (10) ◽

pp. 2281-2289 ◽

Cited By ~ 13

Author(s):

Jae Hyup Lee ◽

Dong-Oh Lee ◽

Ji-Ho Lee ◽

Hyeong-Seok Lee

Keyword(s):

Vertebral Fracture ◽

Balloon Kyphoplasty ◽

Clinical Results ◽

Height Loss ◽

Osteoporotic Vertebral Fracture

Download Full-text

Simultaneous-onset infectious spondylitis with vertebral fracture mimicking an acute osteoporotic vertebral fracture erroneously treated with balloon kyphoplasty: illustrative case

Journal of Neurosurgery: Case Lessons ◽

10.3171/case2135 ◽

2021 ◽

Vol 2 (12) ◽

Author(s):

Noritaka Yonezawa ◽

Yuji Tokuumi ◽

Nobuhiko Komine ◽

Takaaki Uto ◽

Yasumitsu Toribatake ◽

...

Keyword(s):

Back Pain ◽

Vertebral Fracture ◽

Compression Fracture ◽

Balloon Kyphoplasty ◽

Illustrative Case ◽

Osteoporotic Vertebral Fracture ◽

Paravertebral Abscess ◽

Preoperative Magnetic Resonance ◽

Magnetic Resonance Imaging Mri ◽

Infectious Spondylitis

BACKGROUND Early balloon kyphoplasty (BKP) intervention for acute osteoporotic vertebral fracture (OVF) has been reported to be more effective than the conservative treatment. However, complications of early BKP intervention are still unknown. OBSERVATIONS A 71-year-old patient with OVF of L2 underwent BKP 2 weeks after symptom onset. Preoperative magnetic resonance imaging (MRI) and radiograph were compatible with new L2 OVF. Although computed tomography (CT) images revealed the atypical destruction of lower endplate of L2 as OVF, L2 BKP was planned. After BKP, his back pain improved dramatically. Two weeks after BKP, his lower back pain recurred. MRI and CT confirmed the diagnosis of infectious spondylitis with paravertebral abscess formation. With adequate antibiotic treatment and rehabilitation, he was symptom-free and completely ambulatory without signs of infection. LESSONS Signal changes on the fractured vertebral bodies during initial MRI and fractured vertebral instability on radiograph can mislead the surgeon to interpret the infection as a benign compression fracture. If the patients exhibit unusual destruction of the endplate on CT imaging, “simultaneous-onset” spondylitis with vertebral fracture should be included in the differential diagnosis. To determine the strategy for OVF, preoperative biopsy is recommended if simultaneous-onset spondylitis with vertebral fracture is suspected.

Download Full-text

Treatment of segmental tibial defects by bone transport with circular external fixation and a locking plate

Journal of International Medical Research ◽

10.1177/0300060520920407 ◽

2020 ◽

Vol 48 (4) ◽

pp. 030006052092040

Author(s):

Yao Lu ◽

Teng Ma ◽

Cheng Ren ◽

Zhong Li ◽

Liang Sun ◽

...

Keyword(s):

External Fixation ◽

Locking Plate ◽

Short Form ◽

Clinical Results ◽

Bone Transport ◽

Fixation Index ◽

Fixation Time ◽

Sf 36 ◽

Health Related ◽

The Mean

Objective To evaluate the effectiveness of bone transport involving circular external fixation and locking plate application for the treatment of segmental tibial defects. Methods A retrospective review of 12 patients with segmental tibial defects who underwent bone transport with circular external fixation and locking plate application. We evaluated external fixation time, external fixation index, time to achieve union, and complications. Clinical results were assessed using the Association for the Study and Application of the Methods of Ilizarov (ASAMI) score. Generic health-related outcome was assessed using the 36-Item Short-Form Health Survey questionnaire (SF-36). Results The mean follow-up was 25.8 months, and the mean defect size was 6.7 cm. All of the patients achieved union at the distraction callus and docking site. The average external fixation time was 299.5 days. The mean external fixation index was 16.5 days/cm, and the mean healing index was 44.9 days/cm. The functional outcomes were excellent in eight cases and good in four. The average SF-36 score was 92. Conclusion Bone transport with external fixation and locking plate application may be a promising method for the treatment of segmental tibial defects.

Download Full-text

Clinical Results of Unilateral Partial Vertebroplasty(UPVP) in Osteoporotic Vertebral Fracture

Journal of Korean Society of Spine Surgery ◽

10.4184/jkss.2011.18.2.64 ◽

2011 ◽

Vol 18 (2) ◽

pp. 64 ◽

Cited By ~ 3

Author(s):

Jun-Young Yang ◽

June-Kyu Lee ◽

Soo-Min Cha ◽

Yong-Bum Joo

Keyword(s):

Vertebral Fracture ◽

Clinical Results ◽

Osteoporotic Vertebral Fracture

Download Full-text

Risk factor analysis for persistent back pain of intravertebral vacuum cleft after osteoporotic vertebral fracture

Current Orthopaedic Practice ◽

10.1097/bco.0b013e318298452e ◽

2013 ◽

Vol 24 (4) ◽

pp. 414-419 ◽

Cited By ~ 1

Author(s):

Kaoru Suseki ◽

Yuzuru Takahashi ◽

Tomoaki Toyone ◽

Masashi Kito ◽

Masaomi Yamashita ◽

...

Keyword(s):

Factor Analysis ◽

Risk Factor ◽

Back Pain ◽

Vertebral Fracture ◽

Risk Factor Analysis ◽

Osteoporotic Vertebral Fracture ◽

Persistent Back Pain

Download Full-text

Risk Factors of Early Stage Residual Back Pain After Percutaneous Kyphoplasty or Vertebroplasty: A Retrospective Study of 853 Patients

10.21203/rs.3.rs-47430/v2 ◽

2021 ◽

Author(s):

Bo-bo Zhang ◽

Yi-min Yang ◽

Zhi-wei Ren ◽

Wei-zhou Yang ◽

Jin-tao Xiu ◽

...

Keyword(s):

Risk Factors ◽

Back Pain ◽

Vertebral Fracture ◽

Significant Proportion ◽

Smoking History ◽

Control Group ◽

Fracture Type ◽

Mineral Density ◽

Fracture Location ◽

Cement Distribution

Abstract Background: A small but significant proportion of patients experienced residual back pain after PVP or PKP treatment. The aim of the present study was to explore risk factors that may affect residual back pain after PKP or PVP. This study identified the risk factors of residual back pain after PKP or PVP, allowing proper intervention and improved clinical outcome.Methods: From January 2010 to January 2017, a total of 853 patients were treated by PVP or PKP at The First Affiliated Hospital of Xi’an Jiaotong University. We recorded the Visual Analog Scale (VAS) scores. Patients with a VAS score > 3 post-operatively and at the 1 month follow-up evaluation were grouped into the “residual back pain” group. The others were grouped into the control group. The following possible risk factors were collected: age; gender; weight; bone mineral density (BMD); surgical approach; surgical type; cement distribution; anesthesia; hypertension; diabetes; smoking; alcohol consumption; vertebral fracture type, and vertebral fracture location. Risk factors associated with residual back pain were evaluated using logistic regression analysis.Results: The incidence of residual back pain after PVP/PKP is 9.61%. Results showed that cement distribution, smoking, vertebral fracture type and vertebral fracture location were independently associated with residual back pain after PVP or PKP in the early post-operative stage. Conclusion: Unsatisfactory cement distribution, smoking history, osteogenic vertebral tumors, osteolytic vertebral tumors, and thoracic fractures were independently associated with residual back pain after PVP or PKP at the early post-operative stage.

Download Full-text

Motor performance in Prader-Willi syndrome patients and its potential influence on caregiver’s quality of life

PeerJ ◽

10.7717/peerj.4097 ◽

2017 ◽

Vol 5 ◽

pp. e4097 ◽

Cited By ~ 2

Author(s):

Valeria Jia-Yi Chiu ◽

Li-Ping Tsai ◽

Jang-Ting Wei ◽

I-Shiang Tzeng ◽

Hsin-Chi Wu

Keyword(s):

Quality Of Life ◽

Motor Performance ◽

Short Form ◽

Stress Index ◽

Timed Up And Go ◽

Sit To Stand ◽

Hand Grip ◽

Sf 36 ◽

Primary Family

Background Prader-Willi syndrome (PWS) is a complex, multisystem genetic disorder characterized by a variety of physical, cognitive, and behavioral impairments. PWS is a unique sarcopenia model characterized by an abnormal increase in body fat mass and a decrease in muscle mass that predisposes patients to reduced physical activity, functional limitations, and disability. These manifestations may require both symptomatic and supportive management, thus negatively influencing their lifelong family caregiver’s quality of life. The aim of this study was to examine the functional motor performance of adults with PWS in Taiwan and to measure the quality of life of their primary family caregivers. Methods The functional motor tests consisted of the following: (1) 30-s sit-to-stand test, (2) timed up-and-go test, (3) hand grip and lateral pinch strength tests, and (4) Berg Balance Scale. The World Health Organization Quality of Life-short form (WHOQOL-BREF) and the Short-Form 36 Health Survey Questionnaire (SF-36) were used to evaluate health-related quality of life, and the parenting stress index was used to assess the magnitude of stress within the parent-child system. Results The participants included seven adults (two females and five males) with genetically confirmed PWS and their respective main caregivers. The mean age of the adults with PWS was 25.28 years; range 18–31 years, SD 5.10; the mean BMI was 29.2 kg/m2, SD 6.43. All adults with PWS showed lower hand grip and lateral pinch strengths, fewer sit-to-stand cycles during the 30-s chair stand test, and greater average time during the timed up-and-go test when compared to the normative data on healthy adults. Balance was negatively correlated with the caregiver’s health concepts of social functioning (rs −0.879, P = 0.009) and with role limitations due to physical problems (rs −0.899, P = 0.006) and emotional problems (rs −0.794, P = 0.033); hand grip strength was negatively correlated with bodily pain (rs −0.800, P = 0.031), as assessed using the SF-36 questionnaire. The timed up-and-go test was positively correlated with the social relationship domain (rs 0.831, P = 0.021), as assessed using the WHOQOL-BREF questionnaire. The parenting stress index showed no association with the PWS patient’s physical activities. Conclusions All adults with PWS showed decreased upper and lower limb strength and functional mobility when compared to healthy adults. Some of their motor performance might have negative effects on their primary family members in terms of social participation and physical and emotional role limitations. Future research should explore the relationship between physical performances, psychological difficulties of PWS and caregiver’s QOL.

Download Full-text

Effect of teriparatide on quality of life in patients with postmenopausal osteoporosis: a retrospective cohort study

Journal of International Medical Research ◽

10.1177/0300060519876744 ◽

2019 ◽

Vol 48 (2) ◽

pp. 030006051987674

Author(s):

Tiansong Yang ◽

Chuwen Feng ◽

Yuanyuan Qu ◽

Qingyong Wang ◽

Yan Yang ◽

...

Keyword(s):

Back Pain ◽

Treatment Group ◽

Postmenopausal Osteoporosis ◽

Short Form ◽

Life Quality ◽

Control Group ◽

Teriparatide Treatment ◽

Sf 36 ◽

Vas Scores

Objective To evaluate the effect of teriparatide on life quality in patients with postmenopausal osteoporosis. Methods Patients treated from January 2014 to December 2016 were retrospectively included. Patients were divided into two groups according the treatment received. Those in the teriparatide treatment group were followed up for 24 months, and patients in the control group received calcium supplements and vitamin D. Scores for back pain using a visual analog scale (VAS) and score of the Oswestry Disability Index (ODI) and 36-item Short Form Health Survey of life quality (SF-36) were evaluated at 3, 6, 12, and 24 months and compared between the groups. Results In total, 126 patients were included in the teriparatide treatment group and 127 in the control group. There were no significant differences between the groups concerning body mass index, bone density, VAS back pain score, ODI, and SF-36 life quality scores at baseline. At 3, 6, 12, and 24 months’ follow-up, VAS scores were significantly lower in the treatment group than in controls; ODI and SF-36 scores were significantly higher in the treatment group than in the control group. Conclusion Teriparatide can significantly decrease pain and increase mobility and life quality in patients with postmenopausal osteoporosis.

Download Full-text