scholarly journals Choroidal structural evaluation in celiac disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Maddalena De Bernardo ◽  
Livio Vitiello ◽  
Michela Battipaglia ◽  
Francesca Mascolo ◽  
Claudio Iovino ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Healthy Subjects ◽  
Enhanced Depth Imaging ◽  
Depth Imaging ◽  
Structural Evaluation ◽  
Significant Difference ◽  
Choroidal Structure ◽  
Imaging Mode ◽  
Proportional Increase ◽  
Choroidal Vasculature

AbstractThis observational case–control study assessed the differences in choroidal structure between patients with celiac disease and healthy subjects utilizing the choroidal vascularity index (CVI). Seventy-four celiac patients and 67 healthy subjects underwent a complete ophthalmological evaluation, axial length (AL) measurements and spectral-domain optical coherence tomography with enhanced depth imaging mode (EDI SD-OCT) evaluation. These images were binarized and choroidal vasculature was analyzed. Choroidal total subfoveal area (TSA), luminal subfoveal area (LSA), stromal subfoveal area (SSA), CVI and subfoveal choroidal thickness (CT) were measured. Furthermore, subfoveal CT, TSA, LSA, SSA, and CVI were also correlated with AL. A statistically significant difference was found between the two groups for TSA, LSA, SSA and subfoveal CT, but not for CVI. In celiac patients, a significant correlation was found between AL and TSA, LSA and SSA, but not with CVI. Similar findings were also noticed in the healthy subjects. Thus, celiac patients have a thicker choroid than healthy subjects, regardless of the AL, due to a proportional increase in both the vascular and stromal components, which does not alter the CVI.

scholarly journals Choroidal thickness alterations in idiopathic acute retinal vasculitis

2021 ◽  
Vol 13 ◽  
pp. 251584142110228
Author(s):  
Ashok Kumar ◽  
Vikas Ambiya ◽  
Sanjay Kumar Mishra ◽  
Mayank Jhanwar
Keyword(s):  
Optical Coherence Tomography ◽  
Anterior Chamber ◽  
Healthy Subjects ◽  
Choroidal Thickness ◽  
Retinal Vasculitis ◽  
Enhanced Depth Imaging ◽  
Optical Coherence ◽  
Depth Imaging ◽  
Significant Difference ◽  
Fellow Eyes

Background: To evaluate changes in sub-foveal choroidal thickness in patients with acute idiopathic retinal vasculitis compared with age-matched healthy subjects and unaffected fellow eyes. Methods: This prospective observational study included 36 eyes of 23 acute idiopathic retinal vasculitis patients (group V) which included a sub-group of 10 eyes of 10 patients with unilateral vasculitis (group UV), and 50 eyes of 25 healthy subjects (group N). The assessment involved demographics, systemic examination, comprehensive ocular examination, fundus photography with/without fundus fluorescein angiography, and spectral domain–optical coherence tomography with enhanced depth imaging. Results: There was significant difference between the mean sub-foveal choroidal thickness in groups V and N (V: 338.86 ± 28.72 um; N: 296.72 ± 19.45 μm; p < 0.001). The eyes of patients with unilateral vasculitis compared with unaffected fellow eyes had no significant difference in best corrected visual acuity (group UV: median = 0.2; range = (0.0–0.3) and group N: median = 0.2; range = (0.0–0.3); p = 0.35) but the sub-foveal choroidal thickness was significantly increased in the involved eye (group UV: 333.5 ± 16.68 um; group N: 284.4 ± 15.68 um; p ⩽ 0.001). The BCVA was significantly lower in the eyes with anterior chamber inflammation (median = 0.2; range = (0.0–0.3) and; median = 0.1; range (0.0–0.3); p = 0.002), but there was no statistically significant difference in sub-foveal choroidal thickness measurement between the two groups of vasculitis patients with and without anterior chamber inflammation (334.3 ± 18.85 um and 336 ± 31.56 um; p = 0.22). Conclusion: The sub-foveal choroidal thickness increases during active inflammation in eyes with idiopathic retinal vasculitis compared with unaffected fellow eyes and healthy control eyes. Thus, measurement of the sub-foveal choroidal thickness on optical coherence tomography with enhanced depth imaging can serve as a non-invasive modality in the diagnosis and monitoring of acute idiopathic retinal vasculitis.

scholarly journals Assessment of the choroidal structure in pregnant women in the first trimester

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Keiko Azuma ◽  
Atsushi Okubo ◽  
Takafumi Suzuki ◽  
Nozomi Igarashi ◽  
Yoko Nomura ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Choroidal Thickness ◽  
Linear Mixed Model ◽  
First Trimester ◽  
Study Groups ◽  
Enhanced Depth Imaging ◽  
Significant Difference ◽  
Luminal Area ◽  
Choroidal Structure ◽  
First Trimester Of Pregnancy

AbstractWe investigated the anatomical differences in the choroidal structure between pregnant women in the first trimester of pregnancy and age-matched healthy nonpregnant women using enhanced depth imaging optical coherence tomography (EDI-OCT) and choroidal binarization analysis. The main parameters measured in the two study groups, namely, pregnant women in the first trimester and healthy nonpregnant women, were choroidal thickness and the choroidal luminal area. Binarization of the EDI-OCT images from each patient was performed, and the choroidal vascularity index (CVI) was calculated. The correlations between the baseline characteristics of the subjects and the CVI were investigated using linear mixed model analysis. As a result, there was no statistically significant difference in the mean age, best-corrected visual acuity, axial length, central retinal thickness, subfoveal choroidal thickness, systolic blood pressure (BP), or diastolic BP between the two study groups. Conversely, a significant difference was observed in the CVI (P = 0.012) between the two groups. The multivariate analysis identified a significant correlation between the CVI and the systolic BP (P = 0.0044, linear mixed test). Taken together, a larger choroidal luminal area was associated with a higher systolic BP, especially in the first trimester of pregnancy. Our findings may provide further insight into the choroidal changes that occur during pregnancy.

scholarly journals Influence of Fasting followed by Acute Water Ingestion on Subfoveal Choroidal Thickness in Eyes of Healthy Subjects

2017 ◽  
Vol 1 (1) ◽  
pp. oapoc.0000013
Author(s):  
Rocio Blanco-Garavito ◽  
Polina Astroz ◽  
Salomon Yves Cohen ◽  
Eric H. Souied
Keyword(s):  
Healthy Volunteers ◽  
Healthy Subjects ◽  
Choroidal Thickness ◽  
Enhanced Depth Imaging ◽  
Hydration Status ◽  
Subfoveal Choroidal Thickness ◽  
Water Ingestion ◽  
Case Series Study ◽  
Significant Difference ◽  
The Mean

Purpose To investigate the influence of at least 12 hours of fasting followed by acute water ingestion on macular choroidal thickness in eyes of healthy subjects. Methods Prospective case series study including healthy volunteers from April 1, 2015 to May 31, 2015. Macular choroidal thickness was measured on enhanced depth imaging optical coherence tomography (EDI-OCT) and on swept-source (SS)-OCT after 12 hours of fasting, and 60 minutes after acute water ingestion (750 mL in 5 minutes). Results A total of 52 eyes of 26 healthy volunteers were included in this study. The mean age for participants was 32 years old. After 12 hours of fasting, the mean (±SD) subfoveal choroidal thickness was 335.43 (±104.82) μm on EDI-OCT and 286.16 (±80.32) μm on SS-OCT. The mean (±SD) subfoveal choroidal thickness after acute water intake was 352.32 (±120.36) μm and 290.5 (±85.86) μm, respectively. There was no significant difference between the mean subfoveal thickness at baseline and 60 minutes after acute water ingestion for any of the choroidal imaging techniques (p = 0.1386 for EDI-OCT and p = 0.0659 for SS-OCT). Conclusions These results suggest that choroidal circulation can physiologically quickly adapt to systemic vascular changes in healthy eyes. Choroidal thickness did not depend upon the hydration status for the subjects participating in this study.

How does nepafenac affect the choroidal thickness after uneventful cataract surgery?

2020 ◽  
pp. 112067212097604
Author(s):  
Selim Cevher ◽  
Gülçin Aydoğdu
Keyword(s):  
Free Group ◽  
Choroidal Thickness ◽  
Enhanced Depth Imaging ◽  
Depth Imaging ◽  
Small Incision ◽  
Significant Difference ◽  
Ophthalmologic Examination ◽  
Imaging Optical Coherence Tomography ◽  
The Mean

Purpose: To investigate the effects of topical nepafenac on choroidal thickness (CT) following uneventful phacoemulsification surgery (UPS) using enhanced depth imaging optical coherence tomography (EDI-OCT). Methods: This prospective study included 45 randomly selected eyes (23 eyes of 23 patients used nepafenac (nepafenac group) and 22 eyes of 22 control patients did not use nepafenac (nepafenac-free group)) undergoing small-incision UPS. All participants underwent full ophthalmologic examination. CT measurements were performed at subfoveal, 1.0 mm temporal, and 1.0 mm nasal using the EDI-OCT preoperatively, 1 day, 1 week, and 1 month postoperatively. Results: The mean subfoveal, nasal, and temporal CT in the nepafenac-free group had changed from 268.95 ± 63.59 μm to 283.36 ± 65.63 μm, 237.22 ± 64.09 μm to 253.09 ± 67.27 μm, and 235.95 ± 75.22 μm to 259.09 ± 63.66 μm preoperatively to 1 month postoperatively, respectively ( p < 0.001, p < 0.001, p < 0.001, respectively). The mean subfoveal, nasal, and temporal CT in the nepafenac group had changed from 259.65 ± 55.99 μm to 276.65 ± 59.21 μm, 236.34 ± 55.40 μm to 251.00 ± 62.39 μm, and 247.56 ± 50.88 μm to 261.13 ± 53.73 μm preoperatively to 1 month postoperatively, respectively ( p < 0.001, p < 0.001, p < 0.001, respectively). The postoperative CT continued to increase significantly during the follow-up period in two groups. However, compared to the change from baseline to month 1, there was not a statistically significant difference between the groups at subfoveal, nasal, and temporal CT ( p: 0.633, p: 0.865, and p: 0.328, respectively). Conclusion: UPS may cause a significant increase in CT. Although increasing in the CT was lower in the nepafenac group than the nepafenac-free group, there was not a statistically significant difference between the groups.

Are There Any Changes in Posterior Ocular Structure Parameters in Pediatric Migraine Patients?

2016 ◽  
Vol 27 (4) ◽  
pp. 495-501 ◽  
Author(s):  
Pinar Nalcacioglu ◽  
Ayse G. Taslipinar Uzel ◽  
Mehmet M. Uzel ◽  
Nurullah Cagil ◽  
Aysegul N. Citak Kurt
Keyword(s):  
Healthy Subjects ◽  
Choroidal Thickness ◽  
Enhanced Depth Imaging ◽  
Optic Coherence Tomography ◽  
Inner Plexiform Layer ◽  
Structure Parameters ◽  
Imaging Protocol ◽  
Pediatric Migraine ◽  
Ocular Structure ◽  
Significant Difference

Purpose To evaluate the thickness of the peripapillary retinal nerve fiber layer (RNFL), total macula, macular ganglion cell layer (GCL), inner plexiform layer (IPL), and choroid in pediatric migraine patients and compare the values with healthy subjects. Methods This observational and cross-sectional study included 40 patients in the migraine group and 40 healthy control subjects. The thickness of the peripapillary RNFL, total macula, GCL, and IPL was analyzed with spectral-domain optic coherence tomography, while choroidal thickness was analyzed with the enhanced depth imaging protocol. All measurements of the migraine patients were taken in the attack-free period. Right eye selected per subject was included in the study. Results There was no significant difference between the 2 groups in age or sex (p>0.05). The peripapillary RNFL thickness was not significantly different between the 2 groups in any quadrant. The total macula, GCL, and IPL thickness were also not significantly different in the 9 separate macular areas defined on the basis of the Early Treatment Diabetic Retinopathy Study (p>0.05). The choroidal thickness at 5 different measurement points was not statistically significantly different between migraine patients during the attack-free period and the healthy subjects (p>0.05). Conclusions Childhood migraine does not cause changes in posterior ocular structure parameters.

scholarly journals The Acute Effects of Electronic Cigarette Vaping and Tobacco Cigarette Smoking on Choroidal Thickness in Young, Healthy, Habitual, Dual Smokers

Toxics ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 85
Author(s):  
Olga E. Makri ◽  
Athina Pallikari ◽  
Konstantinos Kagkelaris ◽  
Stylianos N. Mastronikolis ◽  
Georgios Karanasios ◽  
...  
Keyword(s):  
Choroidal Thickness ◽  
Electronic Cigarette ◽  
Enhanced Depth Imaging ◽  
Acute Effects ◽  
Foveal Thickness ◽  
Depth Imaging ◽  
The Past ◽  
Central Foveal Thickness ◽  
Imaging Mode ◽  
Acute Changes

The present study aims to evaluate and compare the acute effects of tobacco cigarettes (TC) smoking and electronic cigarette (EC) vaping on foveal and choroidal thickness (CT) in young, healthy, dual smokers. Participants underwent four trials: 5 min TC; 5 min EC; 30 min EC; and 60 min nothing (sham trial). Scans before and immediately after each trial were obtained using spectral domain optical coherence tomography with the enhanced depth imaging mode. Changes in central foveal thickness (CFT), subfoveal choroidal thickness (SFCT), and CT at fourother points, 500 μm and 1000 μm temporally and nasally to the fovea, were measured. Forty-seven participants (33 male, 14 female; mean age 24.85 ± 1.57 years) were included. They smoked 13.53 ± 5.27 TCs/day for 6 ± 2.3 years and vaped ECs for the past 2.4 ± 1.08 years. We did not observe any statistically significant change in SFCT, CFT, and CT of the other points after any of the fourtrials. The acute changes in CFT and CT after EC vaping or TC smoking did not differ significantly compared to the sham trial. Smoking and vaping does not seem to result in statistically significant acute alterations in foveal and CT in young, dual smokers.

Corneal cross-linking for keratoconus: Evaluation of the retina and choroid

2021 ◽  
pp. 112067212110213
Author(s):  
Kobra Nasrollahi ◽  
Fatemeh Razmjoo ◽  
Morteza Naderan ◽  
Alireza Peyman
Keyword(s):  
Choroidal Thickness ◽  
Structural Changes ◽  
Enhanced Depth Imaging ◽  
Cross Linking ◽  
Depth Imaging ◽  
Significant Difference ◽  
Corrected Distance Visual Acuity ◽  
Before And After ◽  
Imaging Optical Coherence Tomography ◽  
Choroidal Volume

Purpose: To investigate the possible structural changes of the central choroid and retina after collagen cross-linking (CXL) in patients with progressive keratoconus (KCN). Methods: Twenty-five eyes of 25 patients were included in this study. Patients underwent enhanced depth imaging optical coherence tomography (EDI-OCT) before and 1 month after CXL. The values for central macular thickness (CMT), subfoveal choroidal thickness (CHT), and choroidal volume (CHV) were evaluated. Results: CMT before and after CXL was 263.24 ± 16.25 μm and 263.20 ± 16.51 μm, respectively ( p = 0.98). CHT was 362.08 ± 36.80 μm and 367.84 ± 33.67 μm before and after CXL, respectively ( p = 0.26). CHV was 8.74 ± 0.33 mm3 and 8.68 ± 0.36 mm3 before and after CXL, respectively ( p = 0.11). There was no significant difference in the corrected distance visual acuity before and after CXL (0.06 ± 0.05 and 0.05 ± 0.05 logMAR, respectively, p = 0.65). Conclusion: Central retinal and choroidal thicknesses are not changed after corneal cross- linking.

scholarly journals Prevalence of focal lamina cribrosa defects in eyes with pachychoroid disease spectrum

2022 ◽  
Vol 15 (1) ◽  
pp. 77-82
Author(s):  
Hae Min Kang ◽  
◽  
Jeong Hoon Choi ◽  
Hyoung Jun Koh ◽  
Sung Chul Lee ◽  
...  
Keyword(s):  
Lamina Cribrosa ◽  
Cross Sectional Study ◽  
Enhanced Depth Imaging ◽  
Control Group ◽  
Cross Sectional ◽  
Depth Imaging ◽  
Disease Spectrum ◽  
Vitreous Floaters ◽  
Significant Difference ◽  
Male Patients

AIM: To determine the prevalence of focal lamina cribrosa (LC) defect among patients with pachychoroid disease spectrum (PDS) in the absence of peripapillary retinoschisis. METHODS: This retrospective, cross-sectional study comprised of 180 patients with PDS, including polypoidal choroidal vasculopathy (PCV), central serous chorioretinopathy, and pachychoroidal neovasculopathy. Medical records and optic nerve head evaluations conducted using spectral-domain optical coherence tomography with enhanced depth imaging were reviewed. As a control group, 236 patients who underwent ophthalmologic evaluation for vitreous floaters, without obvious ocular disease, were also included. RESULTS: The mean age of the PDS group, which included 118 male patients (65.6%), was 57.4±11.1y. There was no significant difference between the two groups in age (P=0.710) or sex (P=0.248). Six patients (3.3%) in the PDS group and none in the control group showed focal LC defect (P=0.318). Among the six patients with focal LC defect in the PDS group, four eyes had PCV, one eye was the fellow eye of a PCV eye, and one eye had pachychoroidal neovasculopathy. CONCLUSION: Focal LC defect can be defected in patients with PDS in the absence of peripapillary retinoschisis. However, the prevalence of focal LC defect was not different significantly between PDS patients and those who did not have PDS.

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