scholarly journals Establishment of sex difference in circulating uric acid is associated with higher testosterone and lower sex hormone-binding globulin in adolescent boys

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yutang Wang ◽  
Fadi J. Charchar
Keyword(s):  
Uric Acid ◽  
Sex Difference ◽  
Weighted Least Squares ◽  
Cross Sectional Study ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Least Squares Regression ◽  
Hormone Binding ◽  
Adolescent Boys ◽  
Cross Sectional

AbstractMen have higher circulating levels of uric acid than women. This sex difference is suspected to be a result of suppressive effects of estradiol on uric acid. If so, estradiol would be inversely associated with circulating uric acid. This study aimed to test this hypothesis. This cross-sectional study included 9472 participants (weighted sample size of 184,342,210) aged 12–80 years from the 2013 to 2016 US National Health and Nutrition Examination Survey. Associations of sex hormones with uric acid were analyzed using weighted least squares regression, adjusting for demographic characteristics, lifestyle risk factors, and comorbidities. Neither free nor bioavailable estradiol was inversely associated with circulating uric acid in adolescent boys or girls, or adult men or women, or perimenopausal women after full adjustment. The sex difference in uric acid was established during adolescence as a result of a dramatic increase in uric acid in adolescent boys. During adolescence, the increase in estradiol in girls over time was accompanied by a relatively unchanged level of uric acid. All three fractions of estradiol (free, bioavailable, and total) were positively associated with uric acid in adolescent boys and girls after full adjustment. In adolescent boys, all three fractions of testosterone were positively associated with serum uric acid, and sex hormone-binding globulin was inversely associated with uric acid after full adjustment. These results suggest that estradiol is not inversely associated with circulating uric acid in adolescents and the establishment of sex difference in circulating uric acid during adolescence is associated with higher testosterone and lower sex hormone-binding globulin in adolescent boys.

scholarly journals Establishment of sex difference in circulating uric acid is associated with higher testosterone and lower sex hormone-binding globulin in adolescent boys

2021 ◽  
Author(s):  
Yutang Wang ◽  
Fadi J Charchar
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Sex Difference ◽  
Free Testosterone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Adult Women ◽  
Inverse Association ◽  
Hormone Binding ◽  
Adolescent Boys

Abstract Men have higher circulating levels of uric acid than women. This sex difference is suspected to be a result of suppressive effects of estradiol on uric acid. If so, estradiol would be inversely associated with circulating uric acid. This study aimed to test this hypothesis. This cross-sectional study included 9 472 participants (weighted sample size of 184 342 210) aged 12–80 years from the 2013 to 2016 US National Health and Nutrition Examination Survey. Associations of sex hormones with uric acid were analyzed using weighted least squares regression, adjusting for demographic characteristics, lifestyle risk factors, and comorbidities. Neither free nor bioavailable estradiol was inversely associated with circulating uric acid in males or females or adolescents or adults or females around menopausal age (47–56 years). Log-transformed free testosterone was positively associated with serum uric acid in adolescent boys (β = 0.250, P < 0.001), girls (β = 0.159, P < 0.001), adult women (β = 0.131, P < 0.001) and women around menopausal age (β = 0.143, P < 0.001) after adjustment for all tested confounders. The results from bioavailable testosterone were similar to those from free testosterone. In addition, log-transformed sex hormone-binding globulin was inversely associated with serum uric acid in males (β=- 0.171, P < 0.001) and females (β=-0.181, P < 0.001) after adjustment for all tested confounders and the inverse association remained in all sub-cohorts. Moreover, sex difference in circulating uric acid was established during adolescence and this establishment coincided with a dramatic increase in testosterone and a dramatic decrease in sex hormone-binding globulin in boys. These results suggest that estradiol is not inversely associated with circulating uric acid and the establishment of sex difference in circulating uric acid is associated with higher testosterone and lower sex hormone-binding globulin in adolescent boys.

scholarly journals Low sex hormone-binding globulin is associated with hypertension: a cross-sectional study in a Swedish population

2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Bledar Daka ◽  
Thord Rosen ◽  
Per Anders Jansson ◽  
Charlotte A Larsson ◽  
Lennart Råstam ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Sectional Study ◽  
Hormone Binding ◽  
Swedish Population ◽  
Cross Sectional

scholarly journals Association of central obesity with sex hormonebinding globulin: a cross-sectional study of 1166 Chinese men

Open Medicine ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. 196-202
Author(s):  
Fangwei Liu ◽  
Xubo Shen ◽  
Ruifeng Wang ◽  
Na Yu ◽  
Yongjun Shi ◽  
...  
Keyword(s):  
Central Obesity ◽  
Cross Sectional Study ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Sectional Study ◽  
Hormone Binding ◽  
Height Ratio ◽  
Cross Sectional ◽  
Globulin Level ◽  
Waist To Height Ratio

AbstractBackground Both sex hormone-binding globulin and central obesity have been found to be associated with metabolic and cardiovascular diseases. However, the direct relation between sex hormone-binding globulin and central obesity has not been demonstrated.Methodology We performed a cross-sectional study of 1166 male participants from Zunyi, Guizhou, western China, in 2013. Each participant completed a questionnaire and had a brief clinical exam with a fasting blood sample taken. All blood samples underwent standard laboratory testing for sex hormone-binding globulin. Level of serum sex hormone-binding globulin was compared by demographic characteristics, and multiple linear regression was used to evaluate the independent association of variables and sex hormone-binding globulin level.Results The mean serum level of sex hormone-binding globulin was increased in old-aged men (older than 40 years; mean 44.68±20.58 nmol/L), low diastolic blood pressure (<90mmHg; 43.76±20.50 nmol/L), waist-to-height ratio <0.5 (48.73±20.59 nmol/L), no education (52.36±22.91 nmol/L), farm occupation (43.58±20.60nmol/L), non-alcohol or former user (44.78±20.94 nmol/L) and long-term medication history (44.79±21.50 nmol/L). Factors independently associated with sex hormone binding globulin level on multiple regression were waist-to-height ratio (β=- 11.84 [95% confidence interval -13.96,-9.72]), age(β=12.40 [9.63,15.17]) and diastolic blood pressure (β=-5.07 [-7.44,-2.71]).Conclusions Central obesity has an independent inverse relation with serum level of sex hormone binding globulin among western Chinese men

scholarly journals Associations of insulin resistance, sex hormone-binding globulin, triglyceride, and hormonal profiles in polycystic ovary syndrome: A cross-sectional study

2021 ◽  
Author(s):  
Bahia Namavar Jahromi ◽  
Niloofar Borzou ◽  
Mohammad Ebrahim Parsanezhad ◽  
Zahra Anvar ◽  
Parvin Ghaemmaghami ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Positive Association ◽  
Cross Sectional Study ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Ovary Syndrome ◽  
Cross Sectional

Background: Insulin resistance (IR) occurs in 50–70% of women with polycystic ovary syndrome (PCOS) and can be applied as a prediabetic feature in PCOS. Objective: In this study, indirect methods including fasting blood sugar (FBS), fasting insulin (FI), FBS/FI ratio, and quantitative insulin sensitivity check index (QUICKI) were compared with the homeostasis model assessment of insulin resistance (HOMA-IR) as a standard technique. The association of IR to sex hormone-binding globulin (SHBG) and several hormones was also analyzed. Materials and Methods: This cross-sectional study was performed on 74 PCOS women. Sensitivity and specificity of each IR method was calculated based on HOMA-IR. Hormonal profiles of the patients were compared between the groups with defined normal and abnormal values of IR. Results: Triglyceride levels had a positive association with FBS and HOMA-IR (p = 0.002 and p = 0.01, respectively) with a negative association to QUICKI and SHBG (p = 0.02 and p = 0.02, respectively). SHBG showed a significant negative association with FBS (p = 0.001). Dehydroepiandrosterone sulfate showed a positive association with FI (p = 0.002). Seven PCOS women showed abnormal SHBG levels (< 36 nmol/L) while expressed normal values of the rest of the studied variables. FI and QUICKI had the highest sensitivity while FBS/FI and QUICKI had the highest specificity when HOMA-IR was applied as a standard test. Conclusion: SHBG and triglyceride had a significant negative and positive association with IR, respectively. HOMA-IR followed by FI and QUICKI is the most sensitive test for the detection of IR. SHBG levels can be a helpful biomarker for the diagnosis of PCOS. Key words: Polycystic ovary syndrome, Insulin resistance, Sex hormone-binding globulin.

Cross-sectional association between testosterone, sex hormone-binding globulin and metabolic syndrome: The Healthy Twin Study

2017 ◽  
Vol 87 (5) ◽  
pp. 523-531 ◽  
Author(s):  
Heesun Moon ◽  
Inyoung Choi ◽  
Somi Kim ◽  
Hyeonyoung Ko ◽  
Jinyoung Shin ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Twin Study ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Cross Sectional
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