scholarly journals Association of central obesity with sex hormonebinding globulin: a cross-sectional study of 1166 Chinese men

Open Medicine ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. 196-202
Author(s):  
Fangwei Liu ◽  
Xubo Shen ◽  
Ruifeng Wang ◽  
Na Yu ◽  
Yongjun Shi ◽  
...  
Keyword(s):  
Central Obesity ◽  
Cross Sectional Study ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Sectional Study ◽  
Hormone Binding ◽  
Height Ratio ◽  
Cross Sectional ◽  
Globulin Level ◽  
Waist To Height Ratio

AbstractBackground Both sex hormone-binding globulin and central obesity have been found to be associated with metabolic and cardiovascular diseases. However, the direct relation between sex hormone-binding globulin and central obesity has not been demonstrated.Methodology We performed a cross-sectional study of 1166 male participants from Zunyi, Guizhou, western China, in 2013. Each participant completed a questionnaire and had a brief clinical exam with a fasting blood sample taken. All blood samples underwent standard laboratory testing for sex hormone-binding globulin. Level of serum sex hormone-binding globulin was compared by demographic characteristics, and multiple linear regression was used to evaluate the independent association of variables and sex hormone-binding globulin level.Results The mean serum level of sex hormone-binding globulin was increased in old-aged men (older than 40 years; mean 44.68±20.58 nmol/L), low diastolic blood pressure (<90mmHg; 43.76±20.50 nmol/L), waist-to-height ratio <0.5 (48.73±20.59 nmol/L), no education (52.36±22.91 nmol/L), farm occupation (43.58±20.60nmol/L), non-alcohol or former user (44.78±20.94 nmol/L) and long-term medication history (44.79±21.50 nmol/L). Factors independently associated with sex hormone binding globulin level on multiple regression were waist-to-height ratio (β=- 11.84 [95% confidence interval -13.96,-9.72]), age(β=12.40 [9.63,15.17]) and diastolic blood pressure (β=-5.07 [-7.44,-2.71]).Conclusions Central obesity has an independent inverse relation with serum level of sex hormone binding globulin among western Chinese men

scholarly journals Prevalence of Elevated Blood Pressure and Association with Obesity in Egyptian School Adolescents

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Mostafa A. Abolfotouh ◽  
Sunny A. Sallam ◽  
Mohammed S. Mohammed ◽  
Amany A. Loutfy ◽  
Ali A. Hasab
Keyword(s):  
Blood Pressure ◽  
Central Obesity ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Height Ratio ◽  
Measures Of Association ◽  
Cross Sectional ◽  
Fourth Report ◽  
Waist To Height Ratio ◽  
The Relationship

Aim. To investigate the relationship between high blood pressure (HBP) and obesity in Egyptian adolescents.Methods. A cross-sectional study of 1500 adolescents (11–19 years) in Alexandria, Egypt, was conducted. Resting BP was measured and measurements were categorized using the 2004 fourth report on blood pressure screening recommendations. Additional measures included height, weight, and waist and hip circumferences. Obesity was determined based on BMI, waist circumference (WC) and waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) indicators. Crude and adjusted odds ratios were used as measures of association between BP and obesity.Results. Prevalence rates of prehypertension and hypertension were 5.7% and 4.0%, respectively. Obesity was seen in 34.6%, 16.1%, 4.5%, and 16.7% according to BMI, WHR, WC, and WHtR, respectively. Adjusting for confounders, HBP was significantly associated with overall obesity based on BMI (OR=2.18, 95%,CI=1.38-3.44) and central obesity based on WC(OR=3.14, 95%,CI=1.67-5.94).Conclusion. Both overall obesity and central obesity were significant predictors of HBP in Egyptian adolescents.

scholarly journals Low sex hormone-binding globulin is associated with hypertension: a cross-sectional study in a Swedish population

2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Bledar Daka ◽  
Thord Rosen ◽  
Per Anders Jansson ◽  
Charlotte A Larsson ◽  
Lennart Råstam ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Sectional Study ◽  
Hormone Binding ◽  
Swedish Population ◽  
Cross Sectional

scholarly journals BMI, waist to height ratio and waist circumference as a screening tool for hypertension in hospital out patients: a cross-sectional study

2020 ◽  
Author(s):  
Rajan Shrestha ◽  
Bijay Khatri ◽  
Madan P. Upadhyay ◽  
Janak R. Bhattarai ◽  
Manish Kayastha ◽  
...  
Keyword(s):  
Risk Factor ◽  
Waist Circumference ◽  
Low Income ◽  
Cross Sectional Study ◽  
Anthropometric Measurement ◽  
Sectional Study ◽  
Height Ratio ◽  
Cross Sectional ◽  
Obesity And Overweight ◽  
Waist To Height Ratio

Abstract BackgroundObesity has become a global epidemic and an important risk factor for non-communicable diseases. Earlier thought to be a problem of developed world, it has now become a problem of low- and middle-income countries like Nepal. In absence of a routine surveillance or a registry system, the actual burden and trend of obesity in Nepal is unknown. Obesity and overweight are recognized risk factors for hypertension and associated with cardiovascular disease. The aim of the study was to find out burden of obesity, using three commonly employed metrics in hospital outpatient setting of a low-income country as predictors of hypertension, and compare ability of different anthropometric measurements through a non-inferiority study to predict hypertension.MethodsThis cross-sectional study was conducted among 40-69 years outpatients in a tertiary Eye and ENT hospital in a semi-urban area of Nepal among randomly selected 2,256 participants from 6,769 outpatients who were evaluated in Health Promotion and risk factor screening service. We did correlation analysis to determine the relationship between anthropometric measurement and blood pressure. The area under the Receiver Operating characteristic curve of Body Mass Index (BMI), Waist to Height Ratio (WHtR) and Waist Circumference (WC) was calculated and compared. ResultsThe prevalence of obesity and overweight by BMI was 16.09% and 42.20% respectively; by Waist-to-Height-Ratio was 32.76% which is two times higher than obesity measured by BMI. High waist circumference was observed among 66.76% participants. Female participants had greater prevalence of high WC (77.46%) than male (53.73%) (p<0.001). Prevalence of hypertension and pre-hypertension was 40.67% and 36.77% respectively. The areas under the curve were significantly higher than 0.5 for BMI (0.593), WHtR (0.602) and WC (0.610).ConclusionWaist circumference correlated well with obesity and hypertension. It also had higher predicting ability than WHtR and BMI to predict hypertension. Waist circumference thus proved to be non-inferior to two other commonly used metrics. It proved superior in detecting obesity in female. This simple and inexpensive tape measurement may play an important role in future diagnosis of obesity and prediction of HTN in resource constrained settings of developing countries.

scholarly journals Using Anthropometric Indicator to Identify Hypertension in Adolescents: A Study in Sarawak, Malaysia

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Whye Lian Cheah ◽  
Ching Thon Chang ◽  
Helmy Hazmi ◽  
Grace Woei Feng Kho
Keyword(s):  
Predictive Power ◽  
School Setting ◽  
Cross Sectional Study ◽  
Cutoff Point ◽  
Sectional Study ◽  
Height Ratio ◽  
Cross Sectional ◽  
Anthropometric Indicators ◽  
Significant Area ◽  
Waist To Height Ratio

This cross-sectional study was conducted to determine the predictive power of anthropometric indicators and recommend cutoff points to discriminate hypertension among adolescents in Sarawak, Malaysia. A total of 2461 respondents aged 12-17 years participated in this study with mean age of 14.5±1.50 years. All anthropometric indicators had significant area under the ROC curve, with body mass index (BMI) and waist circumference (WC) ranging from 0.7 to 0.8. The best anthropometric indicators for predicting hypertension for boys were WC, BMI, and waist-to-height ratio (WHtR). For girls, BMI was the best indicators followed by WHtR and WC. The recommended BMI cutoff point for boys was 20 kg/m2 and 20.7 kg/m2 for girls. For WC, the recommended cutoff point was 67.1 cm for boys and 68.2 cm for girls. BMI and WC indicators were recommended to be used at the school setting where the measurement can easily be conducted.

scholarly journals Establishment of sex difference in circulating uric acid is associated with higher testosterone and lower sex hormone-binding globulin in adolescent boys

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yutang Wang ◽  
Fadi J. Charchar
Keyword(s):  
Uric Acid ◽  
Sex Difference ◽  
Weighted Least Squares ◽  
Cross Sectional Study ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Least Squares Regression ◽  
Hormone Binding ◽  
Adolescent Boys ◽  
Cross Sectional

AbstractMen have higher circulating levels of uric acid than women. This sex difference is suspected to be a result of suppressive effects of estradiol on uric acid. If so, estradiol would be inversely associated with circulating uric acid. This study aimed to test this hypothesis. This cross-sectional study included 9472 participants (weighted sample size of 184,342,210) aged 12–80 years from the 2013 to 2016 US National Health and Nutrition Examination Survey. Associations of sex hormones with uric acid were analyzed using weighted least squares regression, adjusting for demographic characteristics, lifestyle risk factors, and comorbidities. Neither free nor bioavailable estradiol was inversely associated with circulating uric acid in adolescent boys or girls, or adult men or women, or perimenopausal women after full adjustment. The sex difference in uric acid was established during adolescence as a result of a dramatic increase in uric acid in adolescent boys. During adolescence, the increase in estradiol in girls over time was accompanied by a relatively unchanged level of uric acid. All three fractions of estradiol (free, bioavailable, and total) were positively associated with uric acid in adolescent boys and girls after full adjustment. In adolescent boys, all three fractions of testosterone were positively associated with serum uric acid, and sex hormone-binding globulin was inversely associated with uric acid after full adjustment. These results suggest that estradiol is not inversely associated with circulating uric acid in adolescents and the establishment of sex difference in circulating uric acid during adolescence is associated with higher testosterone and lower sex hormone-binding globulin in adolescent boys.

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