scholarly journals Generalized and social anxiety disorder interactomes show distinctive overlaps with striosome and matrix interactomes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kalyani B. Karunakaran ◽  
Satoko Amemori ◽  
N. Balakrishnan ◽  
Madhavi K. Ganapathiraju ◽  
Ken-ichi Amemori
Keyword(s):  
Anxiety Disorder ◽  
Social Anxiety ◽  
Anxiety Disorders ◽  
Social Anxiety Disorder ◽  
Gene Expression Analysis ◽  
Protein Interaction Networks ◽  
Anterior Cingulate ◽  
Protein Protein Interaction ◽  
The Matrix ◽  
Protein Protein Interaction Networks

AbstractMechanisms underlying anxiety disorders remain elusive despite the discovery of several associated genes. We constructed the protein–protein interaction networks (interactomes) of six anxiety disorders and noted enrichment for striatal expression among common genes in the interactomes. Five of these interactomes shared distinctive overlaps with the interactomes of genes that were differentially expressed in two striatal compartments (striosomes and matrix). Generalized anxiety disorder and social anxiety disorder interactomes showed exclusive and statistically significant overlaps with the striosome and matrix interactomes, respectively. Systematic gene expression analysis with the anxiety disorder interactomes constrained to contain only those genes that were shared with striatal compartment interactomes revealed a bifurcation among the disorders, which was influenced by the anterior cingulate cortex, nucleus accumbens, amygdala and hippocampus, and the dopaminergic signaling pathway. Our results indicate that the functionally distinct striatal pathways constituted by the striosome and the matrix may influence the etiological differentiation of various anxiety disorders.

scholarly journals Repetitive Transcranial Magnetic Stimulation (rTMS) to Treat Social Anxiety Disorder: Case Reports and a Review of the Literature

2013 ◽  
Vol 9 (1) ◽  
pp. 180-188 ◽  
Author(s):  
Flávia Paes ◽  
Tathiana Baczynski ◽  
Felipe Novaes ◽  
Tamires Marinho ◽  
Oscar Arias-Carrión ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Anxiety Disorder ◽  
Social Anxiety ◽  
Anxiety Disorders ◽  
Social Anxiety Disorder ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Case Reports ◽  
Therapeutic Option ◽  
The Right

Objectives: Social anxiety disorder (SAD) is a common and debilitating anxiety disorders. However, few studies had been dedicated to the neurobiology underlying SAD until the last decade. Rates of non-responders to standard methods of treatment remain unsatisfactorily high of approximately 25%, including SAD. Advances in our understanding of SAD could lead to new treatment strategies. A potential non invasive therapeutic option is repetitive transcranial magnetic stimulation (rTMS). Thus, we reported two cases of SAD treated with rTMS Methods: The bibliographical search used Pubmed/Medline, ISI Web of Knowledge and Scielo databases. The terms chosen for the search were: anxiety disorders, neuroimaging, repetitive transcranial magnetic stimulation. Results: In most of the studies conducted on anxiety disorders, except SAD, the right prefrontal cortex (PFC), more specifically dorsolateral PFC was stimulated, with marked results when applying high-rTMS compared with studies stimulating the opposite side. However, according to the “valence hypothesis”, anxiety disorders might be characterized by an interhemispheric imbalance associated with increased right-hemispheric activity. With regard to the two cases treated with rTMS, we found a decrease in BDI, BAI and LSAS scores from baseline to follow-up. Conclusion: We hypothesize that the application of low-rTMS over the right medial PFC (mPFC; the main structure involved in SAD circuitry) combined with high-rTMS over the left mPFC, for at least 4 weeks on consecutive weekdays, may induce a balance in brain activity, opening an attractive therapeutic option for the treatment of SAD.

scholarly journals Behavioral Inhibition in Childhood as A Risk Factor for Development of Social Anxiety Disorder: A Longitudinal Study

2020 ◽  
Vol 17 (11) ◽  
pp. 3941
Author(s):  
Garcia-Lopez Luis-Joaquin ◽  
Espinosa-Fernández Lourdes ◽  
Muela-Martínez José A
Keyword(s):  
Anxiety Disorder ◽  
Social Anxiety ◽  
Anxiety Disorders ◽  
Social Anxiety Disorder ◽  
Behavioral Inhibition ◽  
Time Data ◽  
Interview Schedule ◽  
School Settings ◽  
The Stability ◽  
Home And School

Previous research has suggested the association between behavioral inhibition (BI) and the development of social anxiety disorder in childhood. However, there is scarce research using longitudinal methodology in Spanish-speaking populations. To cover this gap, the sample comprised 73 children ranging from six to eight years who had been examined for BI two years earlier in home and school settings. Children and their parents were administered the Anxiety Disorders Interview Schedule for DSM-5-Child and Parent Versions to assess the presence of possible anxiety disorders. The results revealed the stability of BI symptomatology over time. Data also showed that BI children were almost ten times more likely to develop social anxiety disorder two years later, compared to no-BI children. As a result, findings suggest behavioral inhibition strongly predicts social anxiety disorder, making BI a logical focus for selective preventive interventions. Therefore, screening for behavioral inhibition holds promise for primary prevention.

Anterior cingulate neurochemistry in social anxiety disorder: 1H-MRS at 4???Tesla

Neuroreport ◽  
2005 ◽  
Vol 16 (2) ◽  
pp. 183-186 ◽  
Author(s):  
K. Luan Phan ◽  
Daniel A. Fitzgerald ◽  
Bernadette M. Cortese ◽  
Navid Seraji-Bozorgzad ◽  
Manuel E. Tancer ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Social Anxiety ◽  
Social Anxiety Disorder ◽  
Anterior Cingulate ◽  
1H Mrs

scholarly journals Evaluation of the Clinical Global Impression Scale among individuals with social anxiety disorder

2003 ◽  
Vol 33 (4) ◽  
pp. 611-622 ◽  
Author(s):  
T. I. ZAIDER ◽  
R. G. HEIMBERG ◽  
D. M. FRESCO ◽  
F. R. SCHNEIER ◽  
M. R. LIEBOWITZ
Keyword(s):  
Anxiety Disorder ◽  
Social Anxiety ◽  
Anxiety Disorders ◽  
Social Anxiety Disorder ◽  
Clinical Global Impression ◽  
Severity Of Illness ◽  
Anxiety Symptoms ◽  
Self Report ◽  
Clinical Global Impression Scale ◽  
Additional Variance

Background. The clinical Global Impression Scale (CGI) is commonly used as a primary outcome measure in studies evaluating the efficacy of treatments for anxiety disorders. The current study evaluated the psychometric properties and predictors of clinicians' ratings on an adapted version of the CGI among individuals with social anxiety disorders.Method. An independent assessor administered the CGI Severity of Illness and Improvement ratings to 123 patients at baseline and the subset of treated patients again mid- and post-treatment.Results. Improvement ratings were strongly related to both concurrent Severity of Illness and changes in Severity of Illness ratings from baseline. Additionally, both CGI ratings were positively correlated with both self-report and clinician-administered measures of social anxiety, depression, impairment and quality of life. Measures of social anxiety symptoms accounted for a large portion of the variance in Severity of Illness ratings, with significant additional variance accounted for by measures of impairment and depression. Changes in social anxiety symptoms from baseline accounted for significant variance in Improvement ratings, but no significant additional variance was accounted for by changes in impairment and depressive symptoms.Conclusions. Our findings support the utility of the CGI as an index of global severity and symptom-specific improvement among individuals with social anxiety disorder.

scholarly journals Social Anxiety Disorder

2013 ◽  
Vol 19 (3) ◽  
pp. 5
Author(s):  
S Seedat
Keyword(s):  
Anxiety Disorder ◽  
Social Anxiety ◽  
Anxiety Disorders ◽  
Social Phobia ◽  
Social Anxiety Disorder ◽  
Epidemiological Studies ◽  
Font Size ◽  
Specific Phobias

<div style="left: 70.8662px; top: 324.72px; font-size: 15.45px; font-family: serif; transform: scaleX(0.971046);" data-canvas-width="419.81549999999993">According to epidemiological studies, rates of social anxiety disorder</div><div style="left: 70.8662px; top: 344.72px; font-size: 15.45px; font-family: serif; transform: scaleX(1.11655);" data-canvas-width="424.26750000000004">(SAD) or social phobia range from 3% to 16% in the general</div><div style="left: 70.8662px; top: 364.72px; font-size: 15.45px; font-family: serif; transform: scaleX(0.987995);" data-canvas-width="69.1185">population.</div><div style="left: 139.985px; top: 365.947px; font-size: 9.00733px; font-family: serif; transform: scaleX(0.952064);" data-canvas-width="16.423109999999998">[1,2]</div><div style="left: 156.408px; top: 364.72px; font-size: 15.45px; font-family: serif; transform: scaleX(0.977187);" data-canvas-width="334.422">Social phobia and specific phobias have an earlier age</div>of onset than other anxiety disorders.

The Effects of Exercise Training on Anxiety

2013 ◽  
Vol 8 (6) ◽  
pp. 388-403 ◽  
Author(s):  
Matthew P. Herring ◽  
Jacob B. Lindheimer ◽  
Patrick J. O’Connor
Keyword(s):  
Anxiety Disorder ◽  
Social Anxiety ◽  
Exercise Training ◽  
Anxiety Disorders ◽  
Social Anxiety Disorder ◽  
Chronically Ill ◽  
Healthy Adults ◽  
Generalized Anxiety ◽  
Therapeutic Effects ◽  
Generalized Anxiety Disorders

This review summarizes the extant evidence of the effects of exercise training on anxiety among healthy adults, adults with a chronic illness, and individuals diagnosed with an anxiety disorder. A brief discussion of selected proposed mechanisms that may underlie relations of exercise and anxiety is also provided. The weight of the available empirical evidence indicates that exercise training reduces symptoms of anxiety among healthy adults, chronically ill patients, and patients with panic disorder. Preliminary data suggest that exercise training can serve as an alternative therapy for patients with social anxiety disorder, generalized anxiety disorder, and obsessive–compulsive disorder. Anxiety reductions appear to be comparable to empirically supported treatments for panic and generalized anxiety disorders. Large trials aimed at more precisely determining the magnitude and generalizability of exercise training effects appear to be warranted for panic and generalized anxiety disorders. Future well-designed randomized controlled trials should (a) examine the therapeutic effects of exercise training among understudied anxiety disorders, including specific phobias, social anxiety disorder and posttraumatic stress disorder; (b) focus on understudied exercise modalities, including resistance exercise training and programs that combine exercise with cognitive-behavioral therapies; and (c) elucidate putative mechanisms of the anxiolytic effects of exercise training.

scholarly journals Anterior cingulate cortex activity as a candidate biomarker for treatment selection in social anxiety disorder

BJPsych Open ◽  
2018 ◽  
Vol 4 (3) ◽  
pp. 157-159 ◽  
Author(s):  
Andreas Frick ◽  
Jonas Engman ◽  
Kurt Wahlstedt ◽  
Malin Gingnell ◽  
Mats Fredrikson ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Social Anxiety ◽  
Anterior Cingulate Cortex ◽  
Social Anxiety Disorder ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Cingulate Cortex ◽  
Demographic Variables ◽  
Treatment Selection ◽  
Anterior Cingulate ◽  
Potential Biomarker

SummaryWe aimed to identify biomarkers to guide the decision to add selective serotonin reuptake inhibitors (SSRI) to psychological treatment for social anxiety disorder (SAD). Forty-eight patients with SAD underwent functional magnetic resonance imaging and collection of clinical and demographic variables before treatment with cognitive–behavioural therapy, combined on a double-blind basis with either escitalopram or placebo for 9 weeks. Pre-treatment neural reactivity to aversive faces in the dorsal anterior cingulate cortex (ACC), but not clinical/demographic variables, moderated clinical outcomes. Cross-validated individual-level predictions accurately identified 81% of responders/non-responders. Dorsal ACC reactivity is thus a potential biomarker for SAD treatment selection.Declaration of interestNone.

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