Anal human papillomavirus infection and its relationship with abnormal anal cytology among MSM with or without HIV infection in Japan

AbstractAnal high-risk human papillomavirus (hr-HPV) infection is widely considered a cause of anal cancer. However, epidemiological data are quite limited in Japan. This study investigated anal HPV infections and cytological abnormalities among MSM with or without HIV infection. Anal swabs were obtained, and cytological results were examined. Hybrid capture-based methodology was used for hr-HPV genotyping. The exclusion criterion was a history of vaccination against HPV. 644 subjects participated, and the overall prevalence of hr-HPV was 59.7% (95% CI 54.7–62.3), HIV-infected had higher prevalence than HIV-uninfected (68.9% vs 40.6%) p < .001. Among hr-HPV-infected participants, 82.8% (312/377) were infected with at least one of 9 valent vaccine-covered hr-HPV genotypes. From regression analysis, detection of abnormal cytology correlated positively with HIV infection (OR 2.17 [95% CI 1.51–3.13]), number of hr-HPV genotypes infected (OR 1.83 [1.59–2.10]), history of STI (OR 1.58 [1.14–2.22]) and No. of lifetime sexual partners (OR 1.56 [1.10–2.21]), albeit multivariate analysis identified the number of detected hr-HPV genotypes (adjusted OR 1.78 [1.54–2.06]) as the independent risk factor for abnormal cytology. High rates of anal hr-HPV infection, especially 9-valent HPV vaccine-preventable hr-HPV were detected among our MSM participants in Japan. HPV vaccination should also be encouraged for MSM in Japan.

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Anal human papillomavirus infection and its relations with abnormal anal cytology among MSM with or without HIV infection in Japan

10.21203/rs.3.rs-232653/v1 ◽

2021 ◽

Author(s):

Daisuke Shiojiri ◽

Daisuke Mizushima ◽

Misao Takano ◽

Koji Watanabe ◽

Naokatsu Ando ◽

...

Keyword(s):

Human Papillomavirus ◽

High Risk ◽

Hiv Infection ◽

Hpv Vaccination ◽

Epidemiological Data ◽

Hpv Infection ◽

Abnormal Cytology ◽

Hpv Genotypes ◽

Anal Cytology ◽

The Difference

Abstract Background Anorectal high-risk human papillomavirus (hr-HPV) infection is associated with anal malignancies. However, the epidemiological data is quite limited in Japan. Methods Anorectal swab was obtained from HIV-infected and –uninfected men who have sex with men (MSM). Only high-risk HPV genotypes were examined by the Hybrid Capture-based methodology. Anal cytology was determined by the modification of the Bethesda System classification. Results In total, 644 participants were included. No participant had history of HPV vaccination at inclusion. The overall prevalence of hr-HPV was 58.5% (95% confidence interval: 54.7-62.3). The most frequently detected hr-HPV genotypes in order were HPV-52, -16, and -58. Among the HPV infected subjects, 82.8% (312/377) were infected with at least one of the 9 valent vaccine covered genotypes. Incidence of abnormal cytology was positively correlated with the number of HPV genotypes infected rather than the difference in genotypes. Multivariate analysis identified the number of detected hr-HPV genotypes as well as HIV-infection were the independent risk factors for pre-cancer. Conclusion Nine valent vaccine preventable HPVs are currently prevalent among MSM in Japan. Also, increased numbers of hr-HPV genotypes were strongly associated with anorectal pre-cancer. Universal HPV vaccination should be considered for Japanese MSM.

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Are Muslim women less susceptible to oncogenic human papillomavirus infection? A study from rural eastern India

International Journal of Gynecological Cancer ◽

10.1136/ijgc-00009577-200403000-00016 ◽

2004 ◽

Vol 14 (2) ◽

pp. 293-303 ◽

Cited By ~ 4

Author(s):

C. Duttagupta ◽

S. Sengupta ◽

M. Roy ◽

D. Sengupta ◽

P. Bhattacharya ◽

...

Keyword(s):

Cervical Cancer ◽

Human Papillomavirus ◽

Muslim Women ◽

Epidemiological Data ◽

Hpv Infection ◽

Abnormal Cytology ◽

Papillomavirus Infection ◽

Atypical Cells ◽

Hindu Women ◽

Undetermined Significance

Muslim women are known to have lower incidences of cervical cancer and/or human papillomavirus (HPV) infection. Here we aim to determine any association that may be present between the oncogenic HPV16/18 infections and abnormal cytological lesions along with demographic and other attributes among Indian Muslim women (n = 478) and compare with the neighboring Hindus (n = 534) from a prospective cohort study. Agewise distribution of both subject-groups is similar. HPV16/18 infection is present in 9.6% Muslims and 7.5% Hindu women. Jointly atypical cells of undetermined significance (a typical cells of undetermined significance) and HPV16/18 are present in seven Muslim and two Hindu women. No high squamous intraepithelial lesions or cervical cancer is detected at the baseline. HPV16/18 infections show trends that varied with age, a nonlinear trend among Muslim women. In Hindu women the prevalence is highest at age ≤24 years, which linearly drops with increasing age. Abnormal cytology increases significantly in both religion-groups with increasing age. The data show that these Indian Muslim women are equally susceptible to HPV16/18 infection and for the development of abnormal cytology. There is a paucity in epidemiological data, which justifies the need to screen women of all religions for cervical cancer (that includes oncogenic HPV testing).

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Concurrent Infection With Multiple Human Papillomavirus Types Among Unvaccinated and Vaccinated 17-Year-Old Norwegian Girls

The Journal of Infectious Diseases ◽

10.1093/infdis/jiaa709 ◽

2020 ◽

Author(s):

Ida Laake ◽

Berit Feiring ◽

Christine Monceyron Jonassen ◽

John H-O Pettersson ◽

Torstein Gjølgali Frengen ◽

...

Keyword(s):

Logistic Regression ◽

Human Papillomavirus ◽

High Risk ◽

Hpv Vaccination ◽

Hpv Infection ◽

Concurrent Infection ◽

Birth Cohorts ◽

Mixed Effect ◽

Hpv Genotypes ◽

Hpv Types

Abstract Background Whether type-specific human papillomavirus (HPV) infection influences the risk of acquiring infections with other HPV types is unclear. We studied concurrent HPV infections in 17-year-old girls from 2 birth cohorts; the first vaccine-eligible cohort in Norway and a prevaccination cohort. Methods Urine samples were collected and tested for 37 HPV genotypes. This study was restricted to unvaccinated girls from the prevaccination cohort (n = 5245) and vaccinated girls from the vaccine-eligible cohort (n = 4904). Risk of HPV infection was modelled using mixed-effect logistic regression. Expected frequencies of concurrent infection with each pairwise combination of the vaccine types and high-risk types (6/11/16/18/31/33/35/39/45/51/52/56/58/59) were compared to observed frequencies. Results Infection with multiple HPV types was more common among unvaccinated girls than vaccinated girls (9.2% vs 3.7%). HPV33 and HPV51 was the only HPV pair that was detected together more often than expected among both unvaccinated (P = .002) and vaccinated girls (P < .001). No HPV pairs were observed significantly less often than expected. Conclusions HPV33 and HPV51 tended to be involved in coinfection among both unvaccinated and vaccinated girls. The introduction of HPV vaccination does not seem to have had an effect on the tendency of specific HPV types to cluster together.

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Epidemiologic Profile of Type-Specific Human Papillomavirus Infection after Initiation of HPV Vaccination

Vaccines ◽

10.3390/vaccines8030425 ◽

2020 ◽

Vol 8 (3) ◽

pp. 425

Author(s):

Masayuki Sekine ◽

Manako Yamaguchi ◽

Risa Kudo ◽

Sharon J. B. Hanley ◽

Megumi Hara ◽

...

Keyword(s):

Human Papillomavirus ◽

Hpv Vaccination ◽

Pap Test ◽

Hpv Infection ◽

Infection Rates ◽

Human Papillomavirus Vaccination ◽

Papillomavirus Infection ◽

Vaccination Recommendation ◽

Epidemiologic Profile ◽

The Government

Organized human papillomavirus vaccination (OHPV) in Japan was introduced in 2010 for girls aged 12–16 years who were born in 1994 or later. The rate of OHPV coverage was 70–80%. However, after suspension of the government vaccination recommendation, the coverage dramatically decreased. We aim to investigate the change in prevalence of HPV infection after the initiation of HPV vaccination. We recruited females aged 20–21 years attending public cervical cancer screening from 2014 to 2017 fiscal years (April 2014 to March 2018). Residual Pap test specimens were collected for HPV testing. We compared the prevalence of HPV type-specific infection between women registered in 2014 (born in 1993–1994, including the pre-OHPV generation) and registered in 2015–2017 (born in 1994–1997, the OHPV generation). We collected 2379 specimens. The vaccination coverage figures were 30.7%, 86.6%, 88.4% and 93.7% (p < 0.01) from 2014 to 2017, respectively. The prevalence of HPV16/18 infection significantly decreased from 1.3% in 2014 to 0% in 2017 (p = 0.02). The three most prevalent types were HPV52, 16 and 56 in 2014, and HPV52, 58 and 56 in 2015–2017, respectively. HPV16 and 33 infection rates decreased. On the other hand, the HPV58 infection rate was obviously increased after OHPV from 0.3% to 2.1%. Our study demonstrates that the prevalence of HPV16/18 infection dramatically decreased and the profile of type-specific HPV infection was changed after OHPV.

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Human Papillomavirus Infection and Prevention In The Adolescent

10.2310/obg.19119 ◽

2020 ◽

Author(s):

Alexandria Richards ◽

Joanna Stacey

Keyword(s):

Human Papillomavirus ◽

Hpv Vaccination ◽

Transmitted Disease ◽

Cervical Dysplasia ◽

Vaccine Safety ◽

Genital Warts ◽

Hpv Infection ◽

Sexually Transmitted ◽

Papillomavirus Infection

Human papillomavirus, or HPV, is a common sexually transmitted disease, most often acquired during the adolescence or the early 20s. It can be divided into oncogenic and nononcogenic serotypes. It is responsible for genital warts as well as pathologic diseases that can lead to genital cancers and cancers of the oropharyngeal tract in both males and females. The majority of adolescents who acquire HPV infections do not go on to develop cancer. New discoveries about the virus’ persistence and latency direct how we treat adolescents with HPV infections. Recommendations for prevention of HPV include use of the 9-valent vaccine against the most common oncogenic HPV serotypes. Screening should be delayed until the age of 21, with the exception of immunocompromised women. The HPV vaccination is safe and effective, and does not encourage sexual activity among adolescents. Both boys and girls should be vaccinated against HPV at 11 to 12 years of age but may receive the vaccination as early as 9 or as late as 21 (males) or 26 (females) years of age. The vaccine may now also be given in only two doses if the series was started before the age of 15. Follow-up studies in the years after the vaccine’s introduction have shown large decreases in HPV infection rates. This review contains 7 figures, 7 tables and 63 references Key Words: Oncogenic subtype, Oropharyngeal cancer, Infection persistence, Immune tolerance, Cervical dysplasia, Genital warts, 9-valent vaccine, Vaccine safety

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The epidemiology of anal human papillomavirus infection among women and men having sex with women

Sexual Health ◽

10.1071/sh12021 ◽

2012 ◽

Vol 9 (6) ◽

pp. 538 ◽

Cited By ~ 14

Author(s):

Alan G. Nyitray

Keyword(s):

Human Papillomavirus ◽

Anal Canal ◽

Hpv Vaccination ◽

Epidemiological Data ◽

Hpv Infection ◽

Common Finding ◽

Genotype Distribution ◽

Anal Sex ◽

Lifetime Number ◽

Receptive Anal Sex

The goal of this review is to summarise epidemiological data that support an understanding of the natural history of anal human papillomavirus (HPV) among women and men having sex with women (MSW). HPV is a common infection of the anal canal among women and MSW. Although there have been a limited number of studies to date, both oncogenic and nononcogenic HPV genotypes commonly occur among these populations even when individuals do not report receptive anal sex. Genotype distribution is quite diverse, with recent studies typically detecting more than two dozen genotypes in the anal canal in samples of women and MSW. Factors most consistently associated with HPV in the anal canal among both women and MSW are lifetime number of sexual partners and detection of HPV at the genitals. The common finding of genotypic concordance between the genitals and anal canal in women and MSW, and the infectious nature of HPV, in addition to a limited number of studies offering empirical evidence of anal-to-genital self-inoculation and evidence of HPV hand carriage, may help explain the detection of HPV in the anal canal outside the context of receptive anal sex. HPV vaccination has been shown to reduce anal HPV infection among women and is also a promising prevention strategy among MSW.

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Polymorphism in the promoter region of the Toll-like receptor 9 gene and cervical human papillomavirus infection

Journal of General Virology ◽

10.1099/vir.0.052811-0 ◽

2013 ◽

Vol 94 (8) ◽

pp. 1858-1864 ◽

Cited By ~ 11

Author(s):

Lucas Boeno Oliveira ◽

Karolina Louvanto ◽

Agnihotram V. Ramanakumar ◽

Eduardo L. Franco ◽

Luisa L. Villa ◽

...

Keyword(s):

Human Papillomavirus ◽

Natural History ◽

Promoter Region ◽

Pcr Amplification ◽

Hpv Infection ◽

Toll Like Receptor ◽

Mediating Role ◽

Papillomavirus Infection ◽

Tlr9 Gene ◽

History Of

Polymorphism in the Toll-like receptor (TLR) 9 gene has been shown to have a significant role in some diseases; however, little is known about its possible role in the natural history of human papillomavirus (HPV) infections. We investigated the association between a single-nucleotide polymorphism (SNP) (rs5743836) in the promoter region of TLR9 (T1237C) and type-specific HPV infections. Specimens were derived from a cohort of 2462 women enrolled in the Ludwig–McGill Cohort Study. We randomly selected 500 women who had a cervical HPV infection detected at least once during the study as cases. We defined two control groups: (i) a random sample of 300 women who always tested HPV negative, and (ii) a sample of 234 women who were always HPV negative but had a minimum of ten visits during the study. TLR9 genotyping was performed using bidirectional PCR amplification of specific alleles. Irrespective of group, the WT homozygous TLR9 genotype (TT) was the most common form, followed by the heterozygous (TC) and the mutant homozygous (CC) forms. There were no consistent associations between polymorphism and infection risk, either overall or by type or species. Likewise, there were no consistently significant associations between polymorphism and HPV clearance or persistence. We concluded that this polymorphism in the promoter region of TLR9 gene does not seem to have a mediating role in the natural history of the HPV infection.

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Effect of HIV infection on the natural history of anal human papillomavirus infection

AIDS ◽

10.1097/00002030-199810000-00010 ◽

1998 ◽

Vol 12 (10) ◽

pp. 1177-1184 ◽

Cited By ~ 110

Author(s):

Cathy W. Critchlow ◽

Stephen E. Hawes ◽

Jane M. Kuypers ◽

Gary M. Goldbaum ◽

King K. Holmes ◽

...

Keyword(s):

Human Papillomavirus ◽

Natural History ◽

Hiv Infection ◽

Human Papillomavirus Infection ◽

Papillomavirus Infection ◽

History Of

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Human papillomavirus infection and disease in men: Impact of HIV

Southern African Journal of HIV Medicine ◽

10.4102/sajhivmed.v14i4.55 ◽

2013 ◽

Vol 14 (4) ◽

pp. 183-188 ◽

Cited By ~ 4

Author(s):

Sinead Delany-Moretlwe ◽

A Chikandiwa ◽

J Gibbs

Keyword(s):

Human Papillomavirus ◽

Hpv Vaccination ◽

Hpv Infection ◽

Sub Saharan Africa ◽

Anogenital Warts ◽

African Countries ◽

Hpv Prevalence ◽

Papillomavirus Infection ◽

Significant Burden ◽

Sub Saharan

There is growing evidence of a significant burden of human papillomavirus (HPV) infection and associated disease in men. High rates of HPV infection have been observed in men from sub-Saharan Africa where HIV prevalence is high. HIV infection increases HPV prevalence, incidence and persistence and is strongly associated with the development of anogenital warts and anal, penile and head and neck cancers in men. Despite increasing access to antiretroviral therapy, there appears to be little benefit in preventing the development of these cancers in HIV-positive men, making prevention of infection a priority. New prevention options that are being introduced in many African countries include male circumcision and HPV vaccination. However, more data are needed on the burden of HPV disease in men before boys are included in HPV vaccination programmes.

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Anal Human Papillomavirus Infection among MSM Attending University in China: Implications for Vaccination

Vaccines ◽

10.3390/vaccines8020175 ◽

2020 ◽

Vol 8 (2) ◽

pp. 175

Author(s):

Song Fan ◽

Peiyang Li ◽

Lin Ouyang ◽

Tanwei Yuan ◽

Hui Gong ◽

...

Keyword(s):

Human Papillomavirus ◽

Sexual Behaviors ◽

Hpv Vaccination ◽

Northern China ◽

Hpv Infection ◽

High Risk Population ◽

Online Questionnaire ◽

Vaccination Programs ◽

Papillomavirus Infection ◽

Sex With Men

Men who have sex with men (MSM) attending university are a high-risk population for human papillomavirus (HPV) infection and are a neglected population of HPV vaccination programs in China. To provide evidence for HPV vaccination policies, we conducted this study to examine the prevalence and factors associated with anal HPV infection among MSM attending university in China. A self-administered online questionnaire was conducted to collect information on social demographics and sexual behaviors. A self-collected rectal swab specimen was collected to test for 37 HPV types. A total of 426 participants were tested for HPV. The median age was 20 years. HPV prevalence was 37.5% for any type, 29.8% for nine-valent vaccine types, 24.6% for four-valent vaccine types, 11.5% for HPV-16/18, and 15.7% for HPV-6/11. Men enrolled in a technical diploma, living in Northern China, having more than two sex partners, being bottom or versatile in anal sex, and having a human immunodeficiency virus (HIV) testing history were more likely to have positive anal HPV of any type. Our study found a high prevalence of anal HPV infection among MSM attending university in China, with HPV vaccine-preventable types being the most popular types in this group. Thus, our findings highlight the urgency of promoting HPV vaccination among teenage MSM.

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