Anal Human Papillomavirus Infection among MSM Attending University in China: Implications for Vaccination

Men who have sex with men (MSM) attending university are a high-risk population for human papillomavirus (HPV) infection and are a neglected population of HPV vaccination programs in China. To provide evidence for HPV vaccination policies, we conducted this study to examine the prevalence and factors associated with anal HPV infection among MSM attending university in China. A self-administered online questionnaire was conducted to collect information on social demographics and sexual behaviors. A self-collected rectal swab specimen was collected to test for 37 HPV types. A total of 426 participants were tested for HPV. The median age was 20 years. HPV prevalence was 37.5% for any type, 29.8% for nine-valent vaccine types, 24.6% for four-valent vaccine types, 11.5% for HPV-16/18, and 15.7% for HPV-6/11. Men enrolled in a technical diploma, living in Northern China, having more than two sex partners, being bottom or versatile in anal sex, and having a human immunodeficiency virus (HIV) testing history were more likely to have positive anal HPV of any type. Our study found a high prevalence of anal HPV infection among MSM attending university in China, with HPV vaccine-preventable types being the most popular types in this group. Thus, our findings highlight the urgency of promoting HPV vaccination among teenage MSM.

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Improving the Acceptability of Human Papillomavirus Vaccines Among Men Who Have Sex With Men According to the Associated Factors: A Systematic Review and Meta-analysis

Frontiers in Pharmacology ◽

10.3389/fphar.2021.600273 ◽

2021 ◽

Vol 12 ◽

Author(s):

Yang Zhao ◽

Xiaoli Xin ◽

Huiwen Deng ◽

Junjie Xu ◽

Wenjia Weng ◽

...

Keyword(s):

Human Papillomavirus ◽

Sexual Behaviors ◽

Associated Factors ◽

Meta Analysis ◽

Hpv Vaccination ◽

Hpv Infection ◽

Hpv Vaccines ◽

Related Disease ◽

Time Restrictions ◽

Sex With Men

Objectives: To investigate the acceptability of human papillomavirus (HPV) vaccination among men who have sex with men (MSM) and its associated factors.Methods: We searched studies written in English in PubMed, EMBASE, and Web of Science with no geographical or time restrictions. We evaluated the quality of the included literature. We calculated the pooled acceptability and performed meta-analysis of selected studies, including factors associated with the acceptability among MSM, using Review Manager (v5.3).Results: The acceptability among the 15 studies (n = 8,658) was 50% (95% CI: 0.27–0.72). The meta-analysis of seven articles (n = 4,200) indicated that having a college or higher degree (OR = 1.62, 95% CI: 1.35–1.95), disclosure of sexual orientation to healthcare professionals (HCPs; OR = 2.38, 95% CI: 1.47–3.86), vaccination with at least one dose for hepatitis A or B (OR = 2.10, 95% CI: 1.42–3.10), awareness of HPV (OR = 1.85, 95% CI: 1.21–2.83), knowledge of HPV (SMD = 0.28, 95% CI: 0.16–0.39), perceived susceptibility to HPV infection (SMD = 0.31, 95% CI: 0.11–0.50), and perceived severity of HPV-related disease (SMD = 0.40, 95% CI: 0.28–0.51) can promote acceptance of HPV vaccines. Meanwhile, people who have had unprotected anal sex or have more sex partners tend to have low acceptance of HPV vaccines.Conclusions: HPV education should be actively promoted according to the factors that influence the acceptability of HPV vaccines among the MSM population. HPV education should be especially aimed at people with low academic qualifications and people with risky sexual behaviors, and should emphasize the aspects of susceptibility to and severity of HPV-related disease. More intervention trials should be conducted to increase the credibility of the results.

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Prevalence and Genotype distribution of Human Papillomavirus Infection in Different Anatomical Sites among Men Who Have Sex with Men (MSM): A Systematic Review and Meta-Analysis

10.21203/rs.3.rs-17873/v1 ◽

2020 ◽

Author(s):

Mohammad Farahmand ◽

Seyed Hamidreza Monavari ◽

Ahmad Tavakoli

Keyword(s):

Systematic Review ◽

Human Papillomavirus ◽

High Risk ◽

Sexual Behaviors ◽

Meta Analysis ◽

Hpv Infection ◽

Genotype Distribution ◽

Increased Risk ◽

Pertinent Data ◽

Sex With Men

Abstract Background: Homosexual men or men who have sex with men (MSM) are at increased risk of human papillomavirus (HPV) infection because of their high-risk sexual behaviors. In this large study, a meta-analytic approach was used to systematically analyze the literature to elucidate the prevalence and genotype distribution of anal, penile, oral, and urethral HPV infection among MSM in the world.Methods: To carry out this systematic review, five electronic databases were searched for relevant studies published from January 2012 through to November 2019, and pertinent data were collected from the eligible articles. The pooled HPV prevalences were calculated for each anatomical region using random-effect model weighted by the inverse variance method. Subgroup analyses were performed to identify the probable sources of heterogeneity. The meta-analysis was performed using the “Metaprop” function in the R package Meta.Results: The overall pooled prevalence of anal, penile, oral, and urethral HPV infection among MSM were 78.11 % (95% CI: 75.50%-80.52%), 36.26% (95% CI: 29.13%–44.05%), 17.33% (95% CI: 13.65%–21.75%), and 15.40% (95% CI: 7.86%–27.97%), respectively. Stratified analyses showed that the prevalences of HPV were significantly higher in HIV-positive than HIV-negative MSM. The most frequent HPV high-risk type detected in the anus, penis, and oral cavity was HPV-16 (20.32%, 4.96%, and 3.16%, respectively). Conclusion: HPV infection is on the dramatic rise in MSM because of high-risk sexual behaviors, strongly suggesting the increased risk of developing HPV-related diseases and malignancies in this population. Among different sexual orientations, male homosexuality is associated with the highest risk of acquiring sexually transmitted infections.

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Prevalence and risk factors of anogenital human papillomavirus infection in a community sample of men who have sex with men in Taiwan: baseline findings from a cohort study

Sexually Transmitted Infections ◽

10.1136/sextrans-2018-053629 ◽

2019 ◽

Vol 96 (1) ◽

pp. 62-66

Author(s):

Carol Strong ◽

Huachun Zou ◽

Nai-Ying Ko ◽

Ya-Lun Liang ◽

Wen-Wei Ku ◽

...

Keyword(s):

Risk Factors ◽

Human Papillomavirus ◽

Cost Effectiveness ◽

Community Sample ◽

Hpv Vaccination ◽

Hpv Infection ◽

Sex Partners ◽

Anal Sex ◽

The Past ◽

Sex With Men

ObjectivesMen who have sex with men (MSM) are a highly neglected population in the current recommendation of girls-only human papillomavirus (HPV) vaccination programmes in many countries. To better assess the cost effectiveness of HPV vaccination among men requires data on the prevalence of HPV infection in MSM using a community sample, which is still sparse in several regions. We examined the prevalence of and factors associated with anogenital HPV infection among MSM in Taiwan.MethodsMSM 20 years of age and older were recruited from the community and social media in Taiwan in 2015–2016 and screened for HPV infection to detect 37 genotypes. MSM were seen at baseline and were/will be seen at 6, 12, 24 and 36 months. Men completed a questionnaire regarding their sexual experiences. Multivariable regression analyses were conducted to identify associated behavioural risk factors using the baseline data.ResultsA total of 253 MSM were recruited; 87 % were below 35 years of age. Diagnosis of HIV was reported in 4% of men; just over 20% had three or more anal sex partners in the past year. The prevalence of any tested HPV type was 29.4% at the anal site and 11% at the penile site. One quarter of MSM were infected with any of the 9-valent vaccine HPV types. Anal HPV detection was associated with having three or more receptive anal sex partners in the past year (adjusted odds ratio (aOR)=2.92, 95% CI 1.29 to 6.61) and having older sex partners (aOR=2.51, 95% CI 1.07 to 5.90).ConclusionsOur data provide the base to calculate the reproductive rate for HPV transmission in a low-risk community sample and cost-effectiveness to include men in HPV vaccination policies. Adding evidence from a community sample adds comprehensiveness for future estimates of disease transmission and vaccine effectiveness.

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Prevalence of oral human papillomavirus in men attending an Italian sexual health clinic

Sexual Health ◽

10.1071/sh16155 ◽

2016 ◽

Vol 13 (6) ◽

pp. 597 ◽

Cited By ~ 4

Author(s):

Francesco Drago ◽

Astrid Herzum ◽

Giulia Ciccarese ◽

Roberto Bandelloni

Keyword(s):

Human Papillomavirus ◽

Hpv Infection ◽

Health Clinic ◽

High Risk Population ◽

Hpv Dna ◽

Hpv Prevalence ◽

Sexually Transmissible Infections ◽

High Prevalence ◽

Oral Hpv ◽

Sex With Men

A high-risk population, formed by 79 consecutive male attendees of our sexually transmissible infections clinic, and who did not have any overt signs of human papillomavirus (HPV) infection, were examined. Oral HPV prevalence (37%) was much higher than previously reported. Periurethral HPV-DNA was found in 49% of the patients and anal HPV-DNA was found in 43% of the patients. Considering the high prevalence of oral HPV obtained in the current study, it is important to further investigate the burden of oral HPV, not only in men who have sex with men, but also in heterosexual men and in women.

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Review of Evidence and Recommendation for Human Papillomavirus (HPV) Vaccination of Canadian Males Over the Age of 26 Years

Journal of Cutaneous Medicine and Surgery ◽

10.1177/1203475420911635 ◽

2020 ◽

Vol 24 (3) ◽

pp. 285-291 ◽

Cited By ~ 2

Author(s):

Alex Derstenfeld ◽

Kyle Cullingham ◽

Zhuo Cai Ran ◽

Ivan V. Litvinov

Keyword(s):

Human Papillomavirus ◽

Sexually Transmitted Infection ◽

Hpv Vaccine ◽

Hpv Vaccination ◽

Older Men ◽

Hpv Infection ◽

Transmitted Infection ◽

Vaccination Programs ◽

Sexually Transmitted ◽

Control And Prevention

Human papillomavirus (HPV) remains the most common sexually transmitted infection with a lifetime incidence of over 75%. Based on US data from the Centers for Disease Control and Prevention (CDC), 64% of invasive HPV-associated cancers are attributable to HPV 16 or 18 (65% for females; 63% males) and may be prevented by vaccination with either the quadrivalent or nonavalent HPV vaccine. Public HPV vaccination programs are now the norm for women aged 9-45 years and men aged 9-26 years in Canada. Yet, only recently have guidelines begun to consider vaccination of men older than 26 years of age. There now exist compelling reasons to recommend vaccination against HPV amongst males >26 years of age. Recognizing that the risks posed by HPV infection persist beyond 26 years of age, that the vaccination of men aged 26-45 years with HPV vaccine confers immunogenicity at levels demonstrably efficacious against HPV-related diseases, and that the Food and Drug Administration recently expanded the HPV vaccination to include older men, it is argued that HPV vaccination in men older than 26 years of age should be routinely recommended.

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Type-Specific Identification of Genital Human Papillomavirus Infection in Women with Cytological Abnormality

Acta Cytologica ◽

10.1159/000446389 ◽

2016 ◽

Vol 60 (3) ◽

pp. 211-216

Author(s):

Hernán Vargas ◽

Jenny P. Sánchez ◽

Mónica L. Guerrero ◽

Leider T. Ortiz ◽

Dayanne M. Rodríguez ◽

...

Keyword(s):

Human Papillomavirus ◽

Pap Smear ◽

Hpv Vaccination ◽

Hpv Infection ◽

Epidemiological Surveillance ◽

Molecular Technique ◽

Genotype Distribution ◽

Vaccination Programs ◽

Hpv Dna ◽

Cytological Abnormality

Objectives: To estimate the frequency of human papillomavirus (HPV) infection and the genotype distribution of HPV among women with a Pap smear showing atypical squamous cells of undetermined significance (ASC-US) attending the Program for the Detection and Control of Cervical Cancer in Bogotá, Colombia. Study Design: Cervical samples from 200 women with an ASC-US Pap smear were analyzed for the presence of HPV DNA and genotype distribution using a commercial molecular technique (Linear Array®; Roche Molecular Systems, USA). Results: HPV infection was found in 140 women (70%). High-risk HPV types were present in 46.4% of the samples; 16.4% showed a low-risk HPV type, and 37.1% showed both. Of the positive samples, 42.9% were infected with a single viral genotype, whereas 57.1% exhibited multiple HPV infections. The most common HPV genotypes were HPV 16, 53, and 52 with a prevalence of 26.4, 16.4, and 13.6%, respectively. Conclusion: The epidemiological characterization of HPV infections described in this study might guide actions for epidemiological surveillance to strengthen the program in Bogotá and to develop appropriate HPV vaccination programs.

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Epidemiology and Burden of Human Papillomavirus and Related Diseases, Molecular Pathogenesis, and Vaccine Evaluation

Frontiers in Public Health ◽

10.3389/fpubh.2020.552028 ◽

2021 ◽

Vol 8 ◽

Author(s):

Arnaud John Kombe Kombe ◽

Bofeng Li ◽

Ayesha Zahid ◽

Hylemariam Mihiretie Mengist ◽

Guy-Armel Bounda ◽

...

Keyword(s):

Human Papillomavirus ◽

System Development ◽

Hpv Vaccination ◽

Hpv Infection ◽

Cold Chain ◽

Anatomical Site ◽

Upper Aerodigestive Tract ◽

Vaccination Programs ◽

High Risk Women ◽

Novel Approach

Diagnosed in more than 90% of cervical cancers, the fourth deadliest cancer in women, human papillomavirus (HPV) is currently the most common pathogen responsible for female cancers. Moreover, HPV infection is associated with many other diseases, including cutaneous and anogenital warts, and genital and upper aerodigestive tract cancers. The incidence and prevalence of these pathologies vary considerably depending on factors including HPV genotype, regional conditions, the study population, and the anatomical site sampled. Recently, features of the cervicovaginal microbiota are found to be associated with the incidence of HPV-related diseases, presenting a novel approach to identify high-risk women through both blood and cervical samples. Overall, the HPV repartition data show that HPV infection and related diseases are more prevalent in developing countries. Moreover, the available (2-, 4-, and 9-valent) vaccines based on virus-like particles, despite their proven effectiveness and safety, present some limitations in terms of system development cost, transport cold chain, and oncogenic HPV variants. In addition, vaccination programs face some challenges, leading to a considerable burden of HPV infection and related diseases. Therefore, even though the new (9-valent) vaccine seems promising, next-generation vaccines as well as awareness programs associated with HPV vaccination and budget reinforcements for immunization are needed.

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Epidemiologic Profile of Type-Specific Human Papillomavirus Infection after Initiation of HPV Vaccination

Vaccines ◽

10.3390/vaccines8030425 ◽

2020 ◽

Vol 8 (3) ◽

pp. 425

Author(s):

Masayuki Sekine ◽

Manako Yamaguchi ◽

Risa Kudo ◽

Sharon J. B. Hanley ◽

Megumi Hara ◽

...

Keyword(s):

Human Papillomavirus ◽

Hpv Vaccination ◽

Pap Test ◽

Hpv Infection ◽

Infection Rates ◽

Human Papillomavirus Vaccination ◽

Papillomavirus Infection ◽

Vaccination Recommendation ◽

Epidemiologic Profile ◽

The Government

Organized human papillomavirus vaccination (OHPV) in Japan was introduced in 2010 for girls aged 12–16 years who were born in 1994 or later. The rate of OHPV coverage was 70–80%. However, after suspension of the government vaccination recommendation, the coverage dramatically decreased. We aim to investigate the change in prevalence of HPV infection after the initiation of HPV vaccination. We recruited females aged 20–21 years attending public cervical cancer screening from 2014 to 2017 fiscal years (April 2014 to March 2018). Residual Pap test specimens were collected for HPV testing. We compared the prevalence of HPV type-specific infection between women registered in 2014 (born in 1993–1994, including the pre-OHPV generation) and registered in 2015–2017 (born in 1994–1997, the OHPV generation). We collected 2379 specimens. The vaccination coverage figures were 30.7%, 86.6%, 88.4% and 93.7% (p < 0.01) from 2014 to 2017, respectively. The prevalence of HPV16/18 infection significantly decreased from 1.3% in 2014 to 0% in 2017 (p = 0.02). The three most prevalent types were HPV52, 16 and 56 in 2014, and HPV52, 58 and 56 in 2015–2017, respectively. HPV16 and 33 infection rates decreased. On the other hand, the HPV58 infection rate was obviously increased after OHPV from 0.3% to 2.1%. Our study demonstrates that the prevalence of HPV16/18 infection dramatically decreased and the profile of type-specific HPV infection was changed after OHPV.

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Human Papillomavirus Infection and Prevention In The Adolescent

10.2310/obg.19119 ◽

2020 ◽

Author(s):

Alexandria Richards ◽

Joanna Stacey

Keyword(s):

Human Papillomavirus ◽

Hpv Vaccination ◽

Transmitted Disease ◽

Cervical Dysplasia ◽

Vaccine Safety ◽

Genital Warts ◽

Hpv Infection ◽

Sexually Transmitted ◽

Papillomavirus Infection

Human papillomavirus, or HPV, is a common sexually transmitted disease, most often acquired during the adolescence or the early 20s. It can be divided into oncogenic and nononcogenic serotypes. It is responsible for genital warts as well as pathologic diseases that can lead to genital cancers and cancers of the oropharyngeal tract in both males and females. The majority of adolescents who acquire HPV infections do not go on to develop cancer. New discoveries about the virus’ persistence and latency direct how we treat adolescents with HPV infections. Recommendations for prevention of HPV include use of the 9-valent vaccine against the most common oncogenic HPV serotypes. Screening should be delayed until the age of 21, with the exception of immunocompromised women. The HPV vaccination is safe and effective, and does not encourage sexual activity among adolescents. Both boys and girls should be vaccinated against HPV at 11 to 12 years of age but may receive the vaccination as early as 9 or as late as 21 (males) or 26 (females) years of age. The vaccine may now also be given in only two doses if the series was started before the age of 15. Follow-up studies in the years after the vaccine’s introduction have shown large decreases in HPV infection rates. This review contains 7 figures, 7 tables and 63 references Key Words: Oncogenic subtype, Oropharyngeal cancer, Infection persistence, Immune tolerance, Cervical dysplasia, Genital warts, 9-valent vaccine, Vaccine safety

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Acceptability of the Human Papillomavirus Vaccine Among Urban Adolescent Males

American Journal of Men s Health ◽

10.1177/1557988312456697 ◽

2012 ◽

Vol 7 (1) ◽

pp. 27-36 ◽

Cited By ~ 25

Author(s):

Baudelio Gutierrez ◽

Anthony Leung ◽

Kevin Trimell Jones ◽

Peter Smith ◽

Randee Silverman ◽

...

Keyword(s):

Human Papillomavirus ◽

Hpv Vaccine ◽

Hpv Vaccination ◽

Hpv Infection ◽

Adolescent And Young Adult ◽

Human Papillomavirus Vaccine ◽

Adult Males ◽

Urban Adolescent ◽

Increased Risk ◽

Sex With Men

The human papillomavirus (HPV) vaccine was recently approved for use in males. Certain groups, such as men who have sex with men (MSM), are at increased risk of HPV infection. The purpose of the study was to understand perceptions of HPV and the vaccine among adolescent and young adult males, both heterosexual and MSM. Seventy-six males (45 heterosexual, 31 MSM) completed a questionnaire and participated in a focus group. Overall, 42% had heard of HPV and 39% had heard of the HPV vaccine. Males had moderate to favorable attitudes toward vaccination, although intentions to vaccinate were more neutral. MSM were more knowledgeable, aware, and in control of the decision to vaccinate than heterosexual males. Increasing awareness and knowledge about HPV and the vaccine may be necessary to encourage vaccination; certain subgroups of males may be more receptive to HPV vaccination than others.

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