scholarly journals Assessment of bone quality with trabecular bone score in patients with inflammatory bowel disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Iulia Soare ◽  
Anca Sirbu ◽  
Sorina Martin ◽  
Mircea Diculescu ◽  
Bogdan Mateescu ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Trabecular Bone ◽  
Bone Quality ◽  
Bowel Disease ◽  
Trabecular Bone Score ◽  
Study Cohort ◽  
Healthy Controls ◽  
Mineral Density ◽  
Lower Lumbar Spine ◽  
Inflammatory Bowel

AbstractInflammatory bowel disease (IBD) patients have a significant risk of developing bone loss. The trabecular bone score (TBS) is a relatively new parameter used to provide information on bone quality. The study cohort included 81 patients with IBD and 81 healthy controls. Blood tests, dual-energy x-ray absorptiometry (DXA), including TBS, were assessed. Harvey–Bradshaw Index (HBI) for Crohn's disease (CD) and the Partial Mayo Score for ulcerative colitis (UC) were used for evaluation of clinical disease activity. Compared with the healthy controls, the IBD patients had lower lumbar spine (LS) bone mineral density (BMD) (1.06 ± 0.18 vs. 1.16 ± 0.15 g/cm2, p < 0.005), hip BMD (0.88 ± 0.13 vs. 0.97 ± 0.13 g/cm2, p < 0.005) and TBS (1.38 ± 0.1 vs. 1.43 ± 0.1, p < 0.005) values. The patients with stricturing CD had lower TBS (1.32 ± 0.13 vs. 1.40 ± 0.9, p = 0.03) and LS BMD (0.92 ± 0.19 vs. 1.07 ± 0.1, p = 0.01) values compared with those with non-stricturing CD. Multivariate regression model analysis identified HBI as independent factor associated with TBS. Our results support that all DXA parameters are lower in patients with IBD than in healthy patients. Moreover, TBS is a valuable tool for assessment of bone impairment in active CD.

scholarly journals The added value of trabecular bone score over bone mineral density for identification of the bone architecture in patients with Inflammatory Bowel Disease

2021 ◽  
Author(s):  
Samaneh Tavassoli ◽  
Zakiye Esmaeilii ◽  
Sima Besharat ◽  
Alireza Norouzi ◽  
Ahmad Sohrabi ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Inflammatory Bowel Disease ◽  
Trabecular Bone ◽  
Bone Mineral ◽  
Bowel Disease ◽  
Trabecular Bone Score ◽  
Mineral Density ◽  
T Score ◽  
Duration Of Disease ◽  
Inflammatory Bowel

Abstract Background and aims:Patients with Inflammatory Bowel Disease (IBD) suffer from different level of bone diseases in density and architectures. This study has been designed to measure Bone Mineral Density (BMD) and Trabecular Bone Score (TBS) in IBD patients, Golestan province, northeast of Iran. Materials and methods:In this cross-sectional study during January 2018 to August 2018, 69 patients with IBD (UC=57 and Crohn’s disease=10; male: female 0.74; mean age, 39 years) recruited from the IBD registry in Golestan Research Center of Gastroentrology and Hepatology. After taking the informed consent, all patients have been interviewed by a trained physician and a questionnaire has been completed. Trabecular bone score (TBS) was performed using lumbar spine dual X-ray absorptiometry (DXA) images. After entering data into the SPSS-16 software, analysis was done using X2 and non-parametric tests.Results:Normal BMD (T Score>-1) was reported in 19 patients, low bone mass (-1 <T Score< -2.5) in 18 and osteoporosis (T Score <-2.5) in 4 patients. TBS results showed that 5 patients had partially degraded microarchitecture and 5 had fully degraded microarchitecture.Conclusion:In the present study on IBD patients, age, BMI, waist circumference and abdominal circumference had been correlated significantly with bone weakness. The duration of disease was correlated significantly with FRAX. The duration of disease was also correlated significantly with risk of major osteoporotic fracture in 10-years (FRAX adjusted MOF).

scholarly journals Bone Mineral Density and Bone Remodeling in Tunisian Patients with Inflammatory Bowel Disease

2019 ◽  
Vol 13 (1) ◽  
pp. 22-29
Author(s):  
Samar Ben Jemaa ◽  
Lassaad Chtourou ◽  
Rim Akrout ◽  
Khansa Chaabouni ◽  
Tarek Chaabouni ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Inflammatory Bowel Disease ◽  
Bone Remodeling ◽  
Bone Mineral ◽  
Bowel Disease ◽  
Healthy Controls ◽  
Mineral Density ◽  
High Prevalence ◽  
Inflammatory Bowel

Background:A high prevalence of osteopenia and osteoporosis is observed in patients with Inflammatory Bowel Disease (IBD).Objective:The aim of our study was to investigate the prevalence of bone loss, bone remodeling and risk factors in Tunisian patient with IBD.Patients and Methods:The study included 40 patients with IBD and 32 age- and sex-matched healthy controls subjects. All participants underwent bone densitometry by dual energy X-ray absorptiometry at the femoral neck and lumbar spine. Serum levels of 25-hydroxy vitamin D (25(OH)D), parathyroid hormone (PTH), osteocalcin(OC), and urinary degradation products of C-terminal telopeptide of type I collagen (CTXI) were measured in all participants to assess the bone metabolism status.Results:Twelve (30%) patients were normal, 32.5% were osteopenic and 37.5% were osteoporotic. Osteoporosis was more frequent in IBD patients than controls (p=0.0001). Age and inflammation were associated with low bone mineral density (BMD). Mean calcium, phosphorus and alkaline phosphatase levels were similar in both groups. Median 25(OH) D levels were significantly lower in IBD patients compared with controls (p=0.0001). Median urinary CTXI levels were significantly higher in IBD patients compared with healthy controls (p=0.007). No significant differences between IBD patients and controls concerning the median serum OC and PTH levels were found.Conclusion:In our study, there is a high prevalence of low BMD in IBD patients and an increase in bone resorption without a change of bone formation. Low BMI and hypovitaminoses D were identified as risk factors for low BMD.

P115 RELATIONS BETWEEN DISEASE STATUS AND BODY COMPOSITION IN PEDIATRIC INFLAMMATORY BOWEL DISEASE

2020 ◽  
Vol 26 (Supplement_1) ◽  
pp. S18-S19
Author(s):  
Saurabh Talathi ◽  
Pooja Nagaraj ◽  
Traci Jester ◽  
Jeanine Maclin ◽  
Taylor Knight ◽  
...  
Keyword(s):  
Physical Activity ◽  
Inflammatory Bowel Disease ◽  
Body Composition ◽  
Bowel Disease ◽  
Active Group ◽  
Lower Percentage ◽  
Physician Global Assessment ◽  
Healthy Controls ◽  
Mineral Density ◽  
Inflammatory Bowel

Abstract Objective To evaluate the effect of remission status on physical activity, and body composition in pediatric patients with inflammatory bowel disease (PIBD) and healthy peers. Methods Single center cohort study including 54 PIBD patients and 33 healthy peers. During initial study visit, a brief demographic questionnaire, physical activity questionnaire completed by participants and instructions on recording dietary intake were given. Physicians completed the Physician Global Assessment (PGA) for disease severity. Medical chart abstraction done to obtain disease variables of interest. DEXA scan completed one week later to obtain information on body composition. Variables of interest were compared between the three groups (IBD-Remission, IBD-Active and healthy controls) using an ANOVA or Chi square test as appropriate. Results IBD patients were older than controls, reported lower quality of life (73.9 vs 80.9) and engaged in less MVPA (195.4 versus 361.1). IBD-Active group had a significantly lower lean body mass, bone mineral density and time spent in MVPA compared to IBD-Remission group and healthy controls. IBD-Remission group had a significantly lower percentage of biologic use (55% vs 87%) and comorbidities (26% vs 44%) compared to IBD-active group. IBD-remission group also had a lower fat mass percentage. Discussion In this study, we report significantly favorable LBM, BMD, and time spent in MVPA in patients with IBD in remission compared to those not in remission with the former demonstrating a body composition resembling to that of healthy peers. While an improvement in BMD was observed with remission, the scores were still lower than controls.

Mo1824 A STUDY ON THE ASSOCIATION BETWEEN TRABECULAR BONE SCORE AND PATIENTS WITH INFLAMMATORY BOWEL DISEASE

2020 ◽  
Vol 158 (6) ◽  
pp. S-938
Author(s):  
Namseok Ham ◽  
Sung Wook Hwang ◽  
Jeongseok Kim ◽  
Eun Hye Oh ◽  
Sang Hyoung Park ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Trabecular Bone ◽  
Bowel Disease ◽  
Trabecular Bone Score ◽  
Inflammatory Bowel

scholarly journals SAT0462 ASSESSMENT OF BONE MINERAL DENSITY IN INFLAMMATORY BOWEL DISEASE

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1188.1-1188
Author(s):  
C. Daldoul ◽  
N. El Amri ◽  
K. Baccouche ◽  
H. Zeglaoui ◽  
E. Bouajina
Keyword(s):  
Bone Mineral Density ◽  
Inflammatory Bowel Disease ◽  
Bone Mineral ◽  
Bowel Disease ◽  
Mineral Density ◽  
Femoral Site ◽  
Significant Difference ◽  
History Of ◽  
Inflammatory Bowel ◽  
The Mean

Background:Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), is considered as a risk factor of low bone mineral density (BMD). In fact, the prevalence of osteoporosis ranges from 17% to 41% in IBD patients. The possible contributing factors may include malabsorption, glucocorticoid treatment and coexisting comorbiditiesObjectives:The purpose of our work was to determine the frequency and the determinants of osteoporosis in patients with IBD and to assess whether there is a difference in BMD status between UC and CD.Methods:This is a retrospective study, over a period of 5 years (from January 2014 to December 2018) and including patients followed for IBD who had a measurement of BMD by DEXA. Clinical, anthropometric and densitometric data (BMD at the femoral and vertebral site) were recorded. The WHO criteria for the definition of osteoporosis and osteopenia were applied.Results:One hundred and five patients were collected; among them 45 were men and 60 were women. The average age was 45.89 years old. The average body mass index (BMI) was 25.81 kg/m2 [16.44-44.15]. CD and UC were diagnosed in respectively 57.1% and 42.9%. A personal history of fragility fracture was noted in 4.8%. Hypothyroidism was associated in one case. Early menopause was recorded in 7.6%. 46.8% patients were treated with corticosteroids. The mean BMD at the vertebral site was 1.023 g/cm3 [0.569-1.489 g/cm3]. Mean BMD at the femoral site was 0.920g/cm3 [0.553-1.286g / cm3]. The mean T-score at the femoral site and the vertebral site were -1.04 SD and -1.27 SD, respectively. Osteoporosis was found in 25.7% and osteopenia in 37.1%. Osteoporosis among CD and UC patients was found in respectively 63% and 37%. The age of the osteoporotic patients was significantly higher compared to those who were not osteoporotic (52.23 vs 43.67 years, p = 0.01). We found a significantly higher percentage of osteoporosis among men compared to women (35.6% vs 18.3%, p=0.046). The BMI was significantly lower in the osteoporotic patients (23.87 vs 26.48 kg/m2, p=0.035) and we found a significant correlation between BMI and BMD at the femoral site (p=0.01). No increase in the frequency of osteoporosis was noted in patients treated with corticosteroids (27.9% vs 21.6%, p=0.479). Comparing the UC and CD patients, no difference was found in baseline characteristics, use of steroids or history of fracture. No statistically significant difference was found between UC and CD patients for osteoporosis(p=0.478), BMD at the femoral site (p=0.529) and at the vertebral site (p=0.568).Conclusion:Osteoporosis was found in 25.7% of IBD patients without any difference between CD and UC. This decline does not seem to be related to the treatment with corticosteroids but rather to the disease itself. Hence the interest of an early screening of this silent disease.Disclosure of Interests:None declared

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