Trace amines produced by skin bacteria accelerate wound healing in mice

: Wound healing is a process which starts with inflammatory response after damage occurrence. This process happens by restoring the wound surface coating tissue, migrating fibroblasts to form the needed collagen, forming a healing tissue and finally contortion and extraction of the wound. Today, various drugs are used to heal the wound. However, the used drugs to repair wounds have some defects and side effects. In spite of all attempts to accelerate wound healing definitely, no safe drug has been introduced for this purpose. Therefore, the necessity of identifying herbal plants in ethnopharmacology and ethnobotany documents with healing effect is felt essential. In this article we tried to review and present Iranian effective medicinal plants and herbal compounds used for wound healing. Searching was performed on databases including ISI Web of Science, PubMed, PubMed Central, Scopus, ISC, SID, Magiran and some other databases. The keywords used included wound healing, skin treatment, medicinal plants, ethnobotany, and phytotherapy. In this regard, 139 effective medicinal plants on wound healing were identified based on ethnopharmacology and ethnobotanical sources of Iran. Medicinal plants such as Salvia officinalis, Echium amoenum, Verbascum spp., G1ycyrrhiza glabra, Medicago sativa, Mentha pulegium, Datura stramonium L., Alhagi spp., Aloe vera, Hypericum perforatum, Pistacia atlantica and Prosopis cineraria were the most important and effective medicinal plants on wound healing in Iran. These native Iranian medicinal plants are full of antioxidants and biological compounds and might be used for wound healing and preparation of new drugs.

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Treatment of venous leg ulcers with an ointment containing yarrow (Achillea millefolium) extract / Primena preparata sa ekstraktom hajdučke trave (Achillea millefolium) u lečenju venskih ulkusa potkolenice

Serbian Journal of Dermatology and Venerology ◽

10.2478/v10249-011-0009-9 ◽

2009 ◽

Vol 1 (3) ◽

pp. 101-106 ◽

Cited By ~ 1

Author(s):

Milan Matić ◽

Verica Đuran ◽

Marina Jovanović ◽

Zorica Gajinov ◽

Aleksandra Matić ◽

...

Keyword(s):

Wound Healing ◽

Saline Solution ◽

Achillea Millefolium ◽

Control Group ◽

Leg Ulcers ◽

Herbal Preparations ◽

Venous Leg Ulcers ◽

Accelerate Wound Healing ◽

Venous Ulcers ◽

Experimental Group

Abstract Traditional medicine credits yarrow (Achillea millefolium) with the ability to accelerate wound healing. The purpose of this research was to determine the effects of yarrow on the epithelization of the lower leg venous ulcers. The study included 39 patients with venous leg ulcers. They were divided into two groups: the first (experimental) group of patients were treated with an ointment containing 7.5% of yarrow extract. In the second (control) group, saline solution dressings were applied to ulcers, within the period of three weeks. In the experimental group, at the beginning of the therapy, the total surface of all the ulcers was 44736 mm2. After three weeks, the total surface of all the ulcers was 27000 mm2 (a decrease of 39.64%). In the control group, at the beginning of the therapy, the total surface of all the ulcers was 46116 mm2. At the end of the study (21 days) the total surface of all the ulcers was 39153 mm2 (a decrease of 15.1%). Herbal preparations are suitable for application in the therapy of venous ulcers, but their efficiency in wound healing is still to be investigated.

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The neck burn scar contracture: a concept of effective treatment

Burns & Trauma ◽

10.1186/s41038-017-0086-8 ◽

2017 ◽

Vol 5 ◽

Cited By ~ 4

Author(s):

Sadanori Akita ◽

Kenji Hayashida ◽

Satoshi Takaki ◽

Yoshihisa Kawakami ◽

Takuto Oyama ◽

...

Keyword(s):

Wound Healing ◽

Growth Factor ◽

Surrounding Tissue ◽

Burn Scar ◽

Scar Contracture ◽

Accelerate Wound Healing ◽

Epigastric Artery ◽

Basic Fibroblastic Growth Factor ◽

Extensive Burns ◽

Reconstructive Methods

Abstract A neck scar contracture can severely and negatively affect the function of mastication, phonic, or breathing and result in neck pain and issues with esthetics. The best way is of course to avoid such contracture by means of non-surgical treatment such as use of a growth factor. The basic fibroblastic growth factor is clinically well proven in decreasing scar formation and improving healing. There are numerous reconstructive methods for neck contracture, especially when the lesions are relatively limited in part of the neck. However, a very severe and full circumferential scar contracture requires extensive reconstruction. The thin groin flap is one of the answers and well matches with the tissue texture and maintains the flexibility. Even with extensive burns and delayed reconstructions due to resuscitation first, the groin area is well preserved and can be safely harvested by dual vasculature systems of the superficial circumflex iliac artery and superficial epigastric artery, which warrant more reliability compared to the perforator flaps in this area. More demanding and stringent forms of the neck burn scar contracture are the sequelae of radiation. A radiation burn or radiation injury can be progressing and hard to heal. Adipose-derived stem cells can reverse the scar contracture as the surrounding tissue is softened and can accelerate wound healing. In this review, different types of neck burn scar contracture and reconstructive methods are summarized, including innovative use of bFGF and ADSCs in the management of difficult wound healing and scar contracture.

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Effects of Sleep Deprivation, Nicotine, and Selenium on Wound Healing in Rats

10.31219/osf.io/jshra ◽

2017 ◽

Author(s):

Kenan Gümüstekin ◽

Bedri Seven ◽

Nezihe Karabulut ◽

Ömer Aktas ◽

Nesrin Gürsan ◽

...

Keyword(s):

Lipid Peroxidation ◽

Wound Healing ◽

Sleep Deprivation ◽

Immunoglobulin G ◽

Male Rats ◽

Polymorphonuclear Leucocytes ◽

Sprague Dawley ◽

Accelerate Wound Healing ◽

Pathological Analysis

Effects of sleep deprivation (SD), nicotine, and selenium (Se) on woundhealing were studied in 50 male rats (Sprague-Dawley strain). Fullskin-thickness burns were produced in animals. Then, SD, nicotine, andSe administrations were applied to animals in different groups. Woundhealing was assessed by pathological analysis of wound by countingfibroblasts, capillary vessels, polymorphonuclear leucocytes (PNLs), andby measuring radiolabeled immunoglobulin G (IgG) amount in woundarea by radio-pharmaceutical and immunoscintigraphic procedures. Thenumber of fibroblasts and capillary vessels were higher in control andSe groups than in sleep deprivation and nicotine groups, and the numberof PNLs and the radiolabeled polyvalent IgG levels were higher inSD and nicotine groups than in control and Se groups. The resultssuggest that SD and nicotine may delay wound healing and that Sesupplementation may accelerate wound healing by preventing nicotineinducedoxidative stress and lipid peroxidation.

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EFFECT OF ALOE VERA EXTRACT AND DISCHARGE PLANNING TO ACCELERATE WOUND HEALING OF OLDER ADULT HERNIA SURGERY PATIENTS

Nurse and Health: Jurnal Keperawatan ◽

10.36720/nhjk.v8i2.121 ◽

2019 ◽

Vol 8 (2) ◽

pp. 124-133

Author(s):

Mukhammad Toha ◽

Mokh Sujarwadi ◽

Ida Zuhroidah

Keyword(s):

Wound Healing ◽

General Hospital ◽

Older Adult ◽

Discharge Planning ◽

Wound Care ◽

Aloe Vera ◽

Adult Patients ◽

Hernia Surgery ◽

Accelerate Wound Healing ◽

Inflammatory Phase

Background: Older adult patients who underwent hernia surgery commonly get obstacles in the process of wound healing as a result of decline of body functions. Aloe vera which contains of anti-inflammatory, anti-microbial and skin fibroblasts stimulator, can be used as adjunctive therapy in treating wounds.Objective: This study aimed to identify the effect of aloe vera extract and discharge planning to accelerate wound healing of older adult hernia surgery patients at dr. R. Soedarsono General Hospital, Pasuruan.Method: This study uses Quasi-Experimental with Static-group comparison approach. The population is all post-operative hernia patients aged 55-65 years at the operating room of dr. R. Soedarsono General Hospital, Pasuruan. The sample consists of 20 respondents taken according to the inclusion criteria. The independent variable is the treatment of wounds using aloe vera extract accompanied by discharge planning, while the dependent variable was the acceleration of wound healing especially inflammatory and proliferation phases. The data were collected through observation of macroscopic current wound care. Data were analyzed using nonparametric Mann Whitney test with significance level of < 0.05.Result: The results showed the effect of the treatment using aloe vera extract and discharge planning to accelerate wound healing of older adult hernia surgery patients, the inflammatory phase of healing occurs on the sixth day for inflammation, exudation, and edema (p = 0.022, p = 0.028, and p = 0.029, respectively). The proliferative phase occurs on day three with p = 0.015.Conclusion: This research indicates further research on the benefits of aloe vera and discharge planning for wound healing especially in older adult patients is required. Thus, a stronger basis for recommending aloe vera extract as complementary therapy for wound care is available.Â Key words: Aloe Vera, Discharge Planning, Surgical Wound, Older Adults Age.

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