Tumor-penetrant heat shock protein 70 (Hsp70)-targeting peptide for near-infrared fluorescent (NIR) tumor imaging

2014 ◽  
Vol 7 (45) ◽  
pp. 1335-1335
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Near Infrared ◽  
Tumor Imaging ◽  
Targeting Peptide

scholarly journals Targeted Imaging Agent to HSP70 Induced In Vivo

2020 ◽  
Vol 19 ◽  
pp. 153601212094268
Author(s):  
Pradip Ghosh ◽  
Brian E. O’Neill ◽  
King C. Li
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Normal Tissue ◽  
Near Infrared ◽  
Fluorescence Signal ◽  
Targeted Imaging ◽  
Heat Induction ◽  
Heat Shock Protein Expression

Heat shock protein expression can be induced by heat shock making it possible to artificially modulate their levels noninvasively in vivo in a spatially and temporally controlled manner. Here, we report the use of the major heat shock protein 70 (HSP70) as an inducible target by using the small molecule deoxyspergualin (DSG) conjugated to the near-infrared fluorophore (Cy5.5). We demonstrate that heat induction in the form of localized hyperthermia of normal tissue in living mice results in sufficient HSP70 overexpression for detection with DSG-Cy5.5 conjugate. This effect is dependent on total energy delivered and reaches maximum fluorescence signal in 6 to 8 hours post heat induction and declines over a period of up to 24 hours. These results suggest that DSG-Cy5.5 agent accumulates in tissue with elevated HSP70 by heat.

Ammonia aggravates emotional stress-induced gastric mucosal oxidative injury through the cancellation of heat shock protein 70 (HSP70)

2001 ◽  
Vol 120 (5) ◽  
pp. A152-A152
Author(s):  
H SUZUKI ◽  
S NAGAHASHI ◽  
M MIYAZAWA ◽  
M MORI ◽  
H NAGATA ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Emotional Stress ◽  
Heat Shock Protein 70 ◽  
Oxidative Injury
Sign in / Sign up

Export Citation Format

Share Document