A Novel Method of Forming Joints in Gas and Water Mains—A Lead Joint Calked by Hydrostatic Pressure

1878 ◽  
Vol 5 (109supp) ◽  
pp. 1725-1726
Keyword(s):  
Hydrostatic Pressure ◽  
Water Mains ◽  
Novel Method

scholarly journals Preparation of a Nanoscaled Poly(vinyl alcohol)/Hydroxyapatite/DNA Complex Using High Hydrostatic Pressure Technology for In Vitro and In Vivo Gene Delivery

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Tsuyoshi Kimura ◽  
Yoichi Nibe ◽  
Seiichi Funamoto ◽  
Masahiro Okada ◽  
Tsutomu Furuzono ◽  
...  
Keyword(s):  
Hydrostatic Pressure ◽  
High Hydrostatic Pressure ◽  
Vinyl Alcohol ◽  
Transgene Expression ◽  
Transfection Efficiency ◽  
Endosomal Escape ◽  
Poly Vinyl Alcohol ◽  
Dna Nanoparticles ◽  
Novel Method

Our previous research showed that poly(vinyl alcohol) (PVA) nanoparticles incorporating DNA with hydrogen bonds obtained by high hydrostatic pressurization are able to deliver DNA without any significant cytotoxicity. To enhance transfection efficiency of PVA/DNA nanoparticles, we describe a novel method to prepare PVA/DNA nanoparticles encapsulating nanoscaled hydroxyapatites (HAps) prepared by high hydrostatic pressurization (980 MPa), which is designed to facilitate endosomal escape induced by dissolving HAps in an endosome. Scanning electron microscopic observation and dynamic light scattering measurement revealed that HAps were significantly encapsulated in PVA/HAp/DNA nanoparticles. The cytotoxicity, cellular uptake, and transgene expression of PVA/HAp/DNA nanoparticles were investigated using COS-7 cells. It was found that, in contrast to PVA/DNA nanoparticles, their internalization and transgene expression increased without cytotoxicity occurring. Furthermore, a similar level of transgene expression between plasmid DNA and PVA/HAp/DNA nanoparticles was achieved using in vivo hydrodynamic injection. Our results show a novel method of preparing PVA/DNA nanoparticles encapsulating HAp nano-crystals by using high hydrostatic pressure technology and the potential use of HAps as an enhancer of the transfection efficiency of PVA/DNA nanoparticles without significant cytotoxicity.

The removal and morphology of intact biofilms from implanted venous access devices

1995 ◽  
Vol 53 ◽  
pp. 1020-1021
Author(s):  
M.A. Gregory ◽  
G.P. Hadley
Keyword(s):  
Patient Selection ◽  
Surgical Oncology ◽  
Venous Access ◽  
Common Procedure ◽  
Indwelling Catheters ◽  
Careful Patient ◽  
Novel Method ◽  
The Subject ◽  
Vascular Catheters ◽  
Venous Access Devices

The insertion of implanted venous access systems for children undergoing prolonged courses of chemotherapy has become a common procedure in pediatric surgical oncology. While not permanently implanted, the devices are expected to remain functional until cure of the primary disease is assured. Despite careful patient selection and standardised insertion and access techniques, some devices fail. The most commonly encountered problems are colonisation of the device with bacteria and catheter occlusion. Both of these difficulties relate to the development of a biofilm within the port and catheter. The morphology and evolution of biofilms in indwelling vascular catheters is the subject of ongoing investigation. To date, however, such investigations have been confined to the examination of fragments of biofilm scraped or sonicated from sections of catheter. This report describes a novel method for the extraction of intact biofilms from indwelling catheters.15 children with Wilm’s tumour and who had received venous implants were studied. Catheters were removed because of infection (n=6) or electively at the end of chemotherapy.

Development of novel method for measuring optical activity of solids and its applications

1997 ◽  
Vol 71-72 (1-3) ◽  
pp. 403-425 ◽  
Author(s):  
J Kobayashi
Keyword(s):  
Optical Activity ◽  
Novel Method

Author response for "A novel method to identify Post‐Aire stages of medullary thymic epithelial cell differentiation"

2020 ◽  
Author(s):  
Pedro Ferreirinha ◽  
Camila Ribeiro ◽  
Junko Morimoto ◽  
Jonathan J. M. Landry ◽  
Minoru Matsumoto ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Epithelial Cell ◽  
Author Response ◽  
Thymic Epithelial Cell ◽  
Epithelial Cell Differentiation ◽  
Medullary Thymic Epithelial Cell ◽  
Novel Method

Longitudinal Changes in Individual BrainAGE in Healthy Aging, Mild Cognitive Impairment, and Alzheimer’s Disease

GeroPsych ◽  
2012 ◽  
Vol 25 (4) ◽  
pp. 235-245 ◽  
Author(s):  
Katja Franke ◽  
Christian Gaser
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Healthy Aging ◽  
Brain Aging ◽  
Elderly Subjects ◽  
Additional Increase ◽  
Longitudinal Changes ◽  
Novel Method ◽  
The Brain

We recently proposed a novel method that aggregates the multidimensional aging pattern across the brain to a single value. This method proved to provide stable and reliable estimates of brain aging – even across different scanners. While investigating longitudinal changes in BrainAGE in about 400 elderly subjects, we discovered that patients with Alzheimer’s disease and subjects who had converted to AD within 3 years showed accelerated brain atrophy by +6 years at baseline. An additional increase in BrainAGE accumulated to a score of about +9 years during follow-up. Accelerated brain aging was related to prospective cognitive decline and disease severity. In conclusion, the BrainAGE framework indicates discrepancies in brain aging and could thus serve as an indicator for cognitive functioning in the future.

The Hydrostatic Pressure Effect on Elastic Properties of B2-Phase Single Crystals Ti50Ni48Fe2and Ti50Ni45Fe5Alloys

1995 ◽  
Vol 05 (C8) ◽  
pp. C8-729-C8-734
Author(s):  
A.I. Lotkov ◽  
V.P. Lapshin ◽  
V.A. Goncharova ◽  
H.V Chernysheva ◽  
V.N. Grishkov ◽  
...  
Keyword(s):  
Hydrostatic Pressure ◽  
Single Crystals ◽  
Elastic Properties ◽  
Pressure Effect ◽  
B2 Phase

EFFECT OF HYDROSTATIC PRESSURE ON THE ISOMER SHIFTS OF THE 6.2 keV RESONANCE OF181Ta IN TRANSITION METALS

1974 ◽  
Vol 35 (C6) ◽  
pp. C6-184-C6-184
Author(s):  
J. BINDER ◽  
G. KAINDL ◽  
D. SALOMON ◽  
G. WORTMANN
Keyword(s):  
Hydrostatic Pressure ◽  
Transition Metals ◽  
Effect Of Hydrostatic Pressure

ELECTRICAL CONDUCTIVITY BEHAVIOUR OF Gd DOPED EuO UNDER HYDROSTATIC PRESSURE

1980 ◽  
Vol 41 (C5) ◽  
pp. C5-219-C5-222
Author(s):  
J. P. Desfours ◽  
C. Godart ◽  
J. P. Nadai ◽  
A. Mauger ◽  
G. Weill ◽  
...  
Keyword(s):  
Electrical Conductivity ◽  
Hydrostatic Pressure ◽  
Conductivity Behaviour
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