scholarly journals Effects of marine n-3 fatty acid supplementation on lipoprotein subclasses measured by nuclear magnetic resonance in subjects with type II diabetes

2007 ◽  
Vol 62 (3) ◽  
pp. 419-429 ◽  
Author(s):  
I L Mostad ◽  
K S Bjerve ◽  
S Lydersen ◽  
V Grill
Diabetes Care ◽  
1989 ◽  
Vol 12 (4) ◽  
pp. 276-281 ◽  
Author(s):  
K. E. Friday ◽  
M. T. Childs ◽  
C. H. Tsunehara ◽  
W. Y. Fujimoto ◽  
E. L. Bierman ◽  
...  

2006 ◽  
Vol 89 (4) ◽  
pp. 1071-1076 ◽  
Author(s):  
Giovanna Vlahov

Abstract Linear models were selected from a large data set acquired for Italian olive oil samples by quantitative 13C nuclear magnetic resonance (NMR) spectroscopy with distortionless enhancement by polarization transfer (DEPT). The models were used to determine the composition of the 2 fatty acid pools esterifying the 1,3- and 2-positions of triacylglycerols. The linear models selected proved that the 1,3- and 2-distribution of saturated, oleate, and linoleate chains in olive oil triacylglycerols deviated from the random distribution pattern to an extent that depended on the concentration of the fatty acid in the whole triacylglycerol. To calculate the fatty acid composition of the 1,3- and 2-positions of olive oil triacylglycerols, the equations of the selected linear models were applied to the fatty acid percentages determined by gas chromatography. These data were compared with the values predicted by the computer method (used to determine the theoretical amounts of triacylglycerols), which is based on the 1,3-random-2-random theory of the fatty acid distribution in triacylglycerols. The biggest differences were found in the linoleate chain, which is the chain that deviated the most from a random distribution pattern. The results confirmed that the 1,3-random-2-random distribution theory provides an approximate method for determining the structure of triacylglycerols; however, the linear models calculated by the direct method that applies 13C NMR spectroscopy represent a more precise measurement of the composition of the 2 fatty acid pools esterifying the 1,3- and 2-positions of triacylglycerols.


2004 ◽  
Vol 50 (7) ◽  
pp. 1189-1200 ◽  
Author(s):  
David S Freedman ◽  
James D Otvos ◽  
Elias J Jeyarajah ◽  
Irina Shalaurova ◽  
L Adrienne Cupples ◽  
...  

Abstract Background: The sex differential in coronary heart disease (CHD) risk, which is not explained by male/female differences in lipid and lipoprotein concentrations, narrows with age. We examined whether this differential CHD risk might, in part, be attributable to the sizes of lipoprotein particles or concentrations of lipoprotein subclasses. Methods: We analyzed frozen plasma samples from 1574 men and 1692 women from exam cycle 4 (1988–1990) of the Framingham Offspring Study. Nuclear magnetic resonance (NMR) spectroscopy was used to determine the subclass concentrations and mean sizes of VLDL, LDL, and HDL particles. Concentrations of lipids and apolipoproteins were measured by standard chemical methods. Results: In addition to the expected sex differences in concentrations of triglycerides, LDL-cholesterol, and HDL-cholesterol, women also had a lower-risk subclass profile consisting of larger LDL (0.4 nm) and HDL (0.5 nm) particles. The sex difference was most pronounced for HDL, with women having a twofold higher (8 vs 4 μmol/L) concentration of large HDL particles than men. Furthermore, similar to the narrowing of the sex difference in CHD risk with age, the observed male/female difference in HDL particle size also decreased with age. Although lipoprotein particle sizes were highly correlated with lipid and lipoprotein concentrations, the sex differences in the mean sizes of lipoprotein particles persisted (P <0.001) even after adjustment for lipid and lipoprotein concentrations. Conclusions: Women have a less atherogenic subclass profile than men, even after accounting for differences in lipid concentrations.


2019 ◽  
Vol 177 ◽  
pp. 111-116 ◽  
Author(s):  
Simoni Symeou ◽  
Constantinos G. Tsiafoulis ◽  
Ioannis P. Gerothanassis ◽  
Despoina Miltiadou ◽  
Ouranios Tzamaloukas

1998 ◽  
Vol 44 (7) ◽  
pp. 1529-1534 ◽  
Author(s):  
Irene Messana ◽  
Franca Forni ◽  
Franco Ferrari ◽  
Cristina Rossi ◽  
Bruno Giardina ◽  
...  

Abstract Serial urine samples of 33 type II diabetic patients and 20 control subjects were examined by 1H nuclear magnetic resonance (NMR). Metabolites including lactate, citrate, glycine, alanine, hippurate, trimethylamine-N-oxide, and dimethylamine were identified in all subjects although in higher concentrations in diabetic patients. Other analytes, such as creatine, acetate, betaine, and ketone bodies, were found more frequently and in greater concentrations in diabetics than in controls. In addition, although lactate, citrate, alanine, and hippurate concentrations increased with increasing glycosuria and glycohemoglobin, trimethylamine-N-oxide and dimethylamine were present at high concentrations even in diabetics with good metabolic control. 1H NMR spectroscopy permitted us to explore the relationships among the metabolites present in the urine samples and to obtain information about the disease status in type II diabetic patients.


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