scholarly journals The Pro12Ala polymorphism of the PPAR-γ2 gene affects associations of fish intake and marine n−3 fatty acids with glucose metabolism

2007 ◽  
Vol 62 (12) ◽  
pp. 1432-1439 ◽  
Author(s):  
S K Ylönen ◽  
◽  
I Salminen ◽  
V Lyssenko ◽  
S M Virtanen ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Glucose Metabolism ◽  
Fish Intake ◽  
Pro12ala Polymorphism ◽  
Γ2 Gene

Effects of nonesterified fatty acids on glucose metabolism after glucose ingestion

Diabetes ◽  
1997 ◽  
Vol 46 (10) ◽  
pp. 1586-1593 ◽  
Author(s):  
Y. T. Kruszynska ◽  
M. I. Mulford ◽  
J. G. Yu ◽  
D. A. Armstrong ◽  
J. M. Olefsky
Keyword(s):  
Fatty Acids ◽  
Glucose Metabolism ◽  
Nonesterified Fatty Acids ◽  
Glucose Ingestion

Plasma n-3 polyunsaturated fatty acids in chronic heart failure in the GISSI-Heart Failure Trial: Relation with fish intake, circulating biomarkers, and mortality

2013 ◽  
Vol 165 (2) ◽  
pp. 208-215.e4 ◽  
Author(s):  
Serge Masson ◽  
Roberto Marchioli ◽  
Dariush Mozaffarian ◽  
Roberto Bernasconi ◽  
Valentina Milani ◽  
...  
Keyword(s):  
Heart Failure ◽  
Fatty Acids ◽  
Chronic Heart Failure ◽  
Polyunsaturated Fatty Acids ◽  
Fish Intake ◽  
Circulating Biomarkers ◽  
Heart Failure Trial

Effect of insulin on free fatty acid uptake by hepatocytes in the duck

1984 ◽  
Vol 102 (3) ◽  
pp. 381-386 ◽  
Author(s):  
R. Gross ◽  
P. Mialhe
Keyword(s):  
Fatty Acids ◽  
Growth Hormone ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Glucose Metabolism ◽  
Free Fatty Acids ◽  
Fatty Acid Uptake ◽  
Acid Uptake ◽  
Low Doses ◽  
Higher Doses

ABSTRACT To elucidate the hypolipacidaemic effect of insulin in ducks, its action on the uptake of free fatty acids (FFA) by duck hepatocytes was determined. At low doses (10 mu./l) insulin stimulated FFA uptake. This effect was not observed with higher doses of insulin (20, 30 and 50 mu./l). Growth hormone at physiological concentrations and corticosterone (14·4 nmol/l) decreased basal activity, probably by reducing glucose metabolism and consequently α-glycerophosphate (α-GP) supply. Insulin was able to reverse the inhibition induced by GH and corticosterone on both FFA uptake and α-GP production. These results therefore suggest that the hypolipacidaemic effect of insulin may be partly mediated by its action on hepatic FFA uptake. J. Endocr. (1984) 102, 381–386

scholarly journals Polymorphism and Human Health

PPAR Research ◽  
2009 ◽  
Vol 2009 ◽  
pp. 1-15 ◽  
Author(s):  
Weimin He
Keyword(s):  
Fatty Acids ◽  
Insulin Sensitivity ◽  
Unsaturated Fatty Acids ◽  
Polycystic Ovary ◽  
Human Subjects ◽  
Saturated Fatty Acids ◽  
Nuclear Hormone Receptor ◽  
Peroxisome Proliferator ◽  
Pro12ala Polymorphism ◽  
Peroxisome Proliferator Activated Receptor

The nuclear hormone receptor peroxisome proliferator activated receptor gamma (PPAR) is an important transcription factor regulating adipocyte differentiation, lipid and glucose homeostasis, and insulin sensitivity. Numerous genetic mutations of PPAR have been identified and these mutations positively or negatively regulate insulin sensitivity. Among these, a relatively common polymorphism of PPAR, Pro12Ala of PPAR2, the isoform expressed only in adipose tissue has been shown to be associated with lower body mass index, enhanced insulin sensitivity, and resistance to the risk of type 2 diabetes in human subjects carrying this mutation. Subsequent studies in different ethnic populations, however, have revealed conflicting results, suggesting a complex interaction between the PPAR2 Pro12Ala polymorphism and environmental factors such as the ratio of dietary unsaturated fatty acids to saturated fatty acids and/or between the PPAR2 Pro12Ala polymorphism and genetic factors such as polymorphic mutations in other genes. In addition, this polymorphic mutation in PPAR2 is associated with other aspects of human diseases, including cancers, polycystic ovary syndrome, Alzheimer disease and aging. This review will highlight findings from recent studies.

scholarly journals Influence of trans fatty acids on glucose metabolism in soleus muscle of rats fed diets enriched in or deprived of linoleic acid

2017 ◽  
Vol 57 (4) ◽  
pp. 1343-1355
Author(s):  
Ana C. Fariña ◽  
Sandro Hirabara ◽  
Juliana Sain ◽  
Marcela González ◽  
Rui Curi ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Linoleic Acid ◽  
Glucose Metabolism ◽  
Soleus Muscle ◽  
Trans Fatty Acids

scholarly journals Fish Cooking Methods and Impaired Glucose Metabolism Among Japanese Workers: The Furukawa Nutrition and Health Study

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1775
Author(s):  
Akiko Nanri ◽  
Ayane Takazaki ◽  
Takeshi Kochi ◽  
Masafumi Eguchi ◽  
Isamu Kabe ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Fasting Blood Glucose ◽  
Fish Intake ◽  
Health Study ◽  
Cooking Methods ◽  
Deep Frying ◽  
Impaired Glucose Metabolism ◽  
Cooking Method ◽  
Cross Sectional ◽  
Fish And Shellfish

The aim of this study was to examine the cross-sectional association between fish and shellfish intake and impaired glucose metabolism with consideration for cooking methods in a Japanese working population. Participants were 1774 workers aged 18–69 years. Dietary intake was assessed using a validated self-administered diet history questionnaire. Participants were asked about their most frequently used cooking method for fish, and the method was classified as either “raw and stewing” or “broiling, deep-frying, and stir-frying”. Impaired glucose metabolism was defined by a history of diabetes, current use of anti-diabetic drugs, fasting blood glucose ≥110 mg/dl, or HbA1c ≥6.0%. Logistic regression analysis was used to estimate the odds ratios of impaired glucose metabolism for fish intake by cooking method. Fish intake was not associated with impaired glucose metabolism in either group. When the outcome was defined as diabetes, the odds of diabetes increased with fish intake among participants who most frequently used broiling, deep-frying, or stir-frying methods, albeit they were not statistically significant; the multivariable-adjusted odds ratio for the highest versus the lowest tertiles of fish intake was 1.95 (95%CI, 0.71–5.41). Cooking methods for fish may not modify the association between fish intake and impaired glucose metabolism among Japanese populations.

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