Treating hypotension in the preterm infant: when and with what: a critical and systematic review

ContextThe association between maternal diabetes and outcomes of infants who are born preterm is unclear.ObjectiveTo perform a systematic review and meta-analysis of clinical studies exploring the association between maternal diabetes and preterm infant outcomes.MethodsMedline, PubMed and Cumulative Index of Nursing and Allied Health Literature databases were searched without language restriction from 1 January 2000 until 19 August 2019. Studies examining preterm infants <37 weeks gestational age and reporting prespecified outcomes of this review based on maternal diabetes as primary exposure variable were included.ResultsOf 7956 records identified through database searches, 9 studies were included in the study. No significant association was found between maternal diabetes and in-hospital mortality (adjusted RR (aRR) 0.90 (95% CI 0.73 to 1.11); 6 studies; participants=1 191 226; I2=83%). Similarly, no significant association was found between maternal diabetes and bronchopulmonary dysplasia (aRR 1.00 (95% CI 0.92 to 1.07); 4 studies; participants=107 902; I2=0%), intraventricular haemorrhage or cystic periventricular leukomalacia (aRR 0.91 (95% CI 0.80 to 1.03); 3 studies; participants=115 050; I2=0%), necrotising enterocolitis (aRR 1.13 (95% CI 0.90 to 1.42); 5 studies; participants=142 579; I2=56%) and retinopathy of prematurity (ROP) (aRR 1.17 (95% CI 0.85 to 1.61); 5 studies; participants=126 672; I2=84). A sensitivity analysis where low risk of bias studies were included in the meta-analyses showed similar results; however, the heterogeneity was lower for in-hospital mortality and ROP.ConclusionMaternal diabetes was not associated with in-hospital mortality and severe neonatal morbidities in preterm infants. Future studies should explore the association between the severity of maternal diabetes with preterm infant outcomes.

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Effects of breast-feeding compared with formula-feeding on preterm infant body composition: a systematic review and meta-analysis

British Journal Of Nutrition ◽

10.1017/s0007114516001720 ◽

2016 ◽

Vol 116 (1) ◽

pp. 132-141 ◽

Cited By ~ 14

Author(s):

Pan Huang ◽

Jianghua Zhou ◽

Yanan Yin ◽

Wenjuan Jing ◽

Biru Luo ◽

...

Keyword(s):

Systematic Review ◽

Body Composition ◽

Preterm Infant ◽

Preterm Infants ◽

Breast Feeding ◽

Fat Mass ◽

Fixed Effects ◽

Meta Analysis ◽

Formula Feeding ◽

Mean Difference

AbstractWe conducted a systematic review and meta-analysis to compare the effect of breast-feeding and formula-feeding on body composition of preterm infants. We searched the literature using PubMed, Cochrane Central Library Issue, Ovid (Medline), Embase and other resources such as Google Scholar, electronic databases and bibliographies of relevant articles; two reviewers collected and extracted data independently. All the authors assessed risk of bias independently using the Newcastle–Ottawa Scale (NOS). A fixed-effects meta-analysis was undertaken with RevMan 5 software (The Cochrane Collaboration) using the inverse variance method (P≥0·05;χ2test). In contrast, a random-effects meta-analysis was carried out. Altogether, 630 articles were identified using search strategy, and the references within retrieved articles were also assessed. A total of six studies were included in this systematic review. In formula-fed infants, fat mass was higher at term (mean difference 0·24 (95 % CI 0·17, 0·31) kg), fat-free mass was higher at 36 weeks of gestational (mean difference 0·12 (95 % CI 0·04, 0·21) kg) and the percentage of fat mass was higher at 36 weeks of gestation (mean difference 3·70 (95 % CI 1·81, 5·59) kg) compared with breast-fed infants. Compared with breast-feeding, formula-feeding is associated with altered body composition from birth to term in preterm infants. The effects of formula-feeding on preterm infant body composition from term to 12-month corrected age are inconclusive in our study. Well-designed studies are required in the future to explore the effects of formula-feeding compared with breast-feeding.

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Factors Affecting the Implementation of Developmental Care in the Care of Premature Babies in NICU Nurses: A Systematic Review

Pediomaternal Nursing Journal ◽

10.20473/pmnj.v7i2.27508 ◽

2021 ◽

Vol 7 (2) ◽

pp. 77

Author(s):

CH.R. Yeni Suryandari ◽

Yuni Sufyanti Arief ◽

Sri Utami

Keyword(s):

Systematic Review ◽

Preterm Infant ◽

Organizational Support ◽

Care Program ◽

Cross Sectional ◽

Substantial Impact ◽

Factors Affecting ◽

Developmental Care ◽

Self Confidence ◽

Premature Babies

Introduction: Developmental care-based preterm infant care management that aims to protect the neurological system and reduce adverse effects has developed over the last few decades. The study aimed to explore the factors that influence the implementation of developmental care among NICU nurses.Methods: The study was systematically identified by searching an electronic database using keywords "preterm infant" AND "developmental care" AND "nursing care" AND "NICU" and consisted of 2130 articles from Scopus, Science Direct, goggle scholar, ProQuest, and PubMed. Data sources were limited to articles published from 2015 to 2020 and those published in English. Thirteen studies were included in this systematic review. The inclusion criteria were nurses caring for preterm infants at the NICU, a cross-sectional descriptive study of quantitative or qualitative research.Results: Thirteen articles indicated that the developmental care implementation among NICU nurses was influenced by positive, perceptions knowledge, attitudes of developmental care. Professional skills are the most substantial impact on developmental care implementation to improve nurses' nursing development and increase the competence of individual nurses.Conclusion: Positive perceptions about organizational support and developmental care are needed. The training care program also benefits to nurses by increase self-confidence in implementing developmental care for premature babies.

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Omega 3 Fatty Acids in Enteral Nutrition for Very Low Birth Weight Preterm Infants: A Systematic Review (P11-085-19)

Current Developments in Nutrition ◽

10.1093/cdn/nzz048.p11-085-19 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

Author(s):

Lisa Moloney ◽

Mary Rozga ◽

Kathleen Gura ◽

Camilia Martin

Keyword(s):

Systematic Review ◽

Fatty Acids ◽

Enteral Nutrition ◽

Human Milk ◽

Preterm Infant ◽

Preterm Infants ◽

Visual Development ◽

Risk Of Bias ◽

Omega 3 Fatty Acids ◽

Omega 3

Abstract Objectives To investigate the evidence for the effect of omega 3 fatty acids via enteral nutrition on identified outcomes in the very low birthweight preterm infant population. Methods A literature search was conducted in EMBASE, CINAHL, Cochrane Central, PubMed databases for the period of January 1980-November 2017 for all peer-reviewed articles examining preterm infant nutrition. A multidisciplinary volunteer expert Workgroup and staff screened articles according to defined inclusion criteria (randomized controlled trials, enteral fed preterm infants < 1500 gm, economically developed nations). Data was extracted and risk of bias was evaluated for each included article using the Academy's Quality Criteria Checklist and Cochrane's Risk of Bias Tool. Data was summarized and conclusion statements were developed and graded for each identified outcome using the GRADE framework and Academy methodology. Results The search identified in 25,264 articles, and six studies published in 13 articles were included. Two included studies had low risk of bias. Remaining studies had bias in the following Cochrane domains: attrition (2), detection (3), selection (2), performance (2), and reporting (1). Eleven conclusion statements were developed, 4 were graded as good, 2 as fair, 5 as limited. Though evidence quality describing the effect of 64mg of omega 3s daily on mortality and retinopathy of prematurity was good, there were no significant effects reported [RR (95% CI) was 1.31 (0.88 to 1.96) and 0.96 (0.61, 1.50), respectively]. Similarly, there were no significant effects found for type of fat intake by VLBW infants on bronchopulmonary disease, atopy, necrotizing enterocolitis, anthropometrics, neuro- or visual development or gastrointestinal health. Conclusions This systematic review revealed high heterogeneity amongst interventions, including in feeding types (formula, formula or human milk, or human milk), mode of supplementation, and amount and composition of supplement (DHA, EPA, ARA, MCT). Funding Sources Academy of Nutrition and Dietetics.

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Associations between preterm infant stress, epigenetic alteration, telomere length and neurodevelopmental outcomes: A systematic review

Early Human Development ◽

10.1016/j.earlhumdev.2019.03.003 ◽

2019 ◽

Vol 131 ◽

pp. 63-74 ◽

Cited By ~ 6

Author(s):

Sharon G. Casavant ◽

Xiaomei Cong ◽

James Moore ◽

Angela Starkweather

Keyword(s):

Systematic Review ◽

Preterm Infant ◽

Telomere Length ◽

Neurodevelopmental Outcomes ◽

Epigenetic Alteration

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Preterm Infant Growth Velocity Calculations: A Systematic Review

PEDIATRICS ◽

10.1542/peds.2016-2045 ◽

2017 ◽

Vol 139 (3) ◽

pp. e20162045 ◽

Cited By ~ 39

Author(s):

Tanis R. Fenton ◽

Hilton T. Chan ◽

Aiswarya Madhu ◽

Ian J. Griffin ◽

Angela Hoyos ◽

...

Keyword(s):

Systematic Review ◽

Preterm Infant ◽

Growth Velocity ◽

Infant Growth

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Magnetic resonance diffusion tractography of the preterm infant brain: a systematic review

Developmental Medicine & Child Neurology ◽

10.1111/dmcn.12250 ◽

2013 ◽

Vol 56 (2) ◽

pp. 113-124 ◽

Cited By ~ 32

Author(s):

Kerstin Pannek ◽

Simon M Scheck ◽

Paul B Colditz ◽

Roslyn N Boyd ◽

Stephen E Rose

Keyword(s):

Systematic Review ◽

Magnetic Resonance ◽

Preterm Infant ◽

Diffusion Tractography ◽

Infant Brain

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The effect of donor human milk on the length of hospital stay in very low birthweight infants: a systematic review and meta-analysis

International Breastfeeding Journal ◽

10.1186/s13006-020-00332-6 ◽

2020 ◽

Vol 15 (1) ◽

Author(s):

Rui Yang ◽

Danqi Chen ◽

Qingqi Deng ◽

Xinfen Xu

Keyword(s):

Systematic Review ◽

Hospital Stay ◽

Preterm Infant ◽

Infant Formula ◽

Low Birthweight ◽

Meta Analysis ◽

Length Of Hospital Stay ◽

Vlbw Infants ◽

Donor Human Milk ◽

Mother’S Own Milk

Abstract Background Donor human milk (DHM) is an alternative to preterm infant formula if the mother’s own milk is not available. Since the lactation period and preservation treatment of DHM are different from those of mother’s own milk, we aimed to determine the reduction in the length of hospital stay by DHM compared to preterm infant formula. Methods In this systematic review, we searched PubMed/MEDLINE, EMBASE, and the Cochrane Library to retrieve studies on the impact of DHM on the clinical outcomes of preterm infants published before 1 November 2019. The study included very low birthweight (VLBW) infants taking either DHM or infant formula with data on the length of hospital stay. Data were analysed using Review Manager 5.3 software. Results The literature search yielded 136 articles, and four randomised controlled trials (RCTs) and eight observational studies met the inclusion criteria. A meta-analysis of the RCTs (N = 725) showed no reduction in the length of hospital stay in both the DHM and infant formula groups (− 0.22 days; 95% CI -6.38, 5.95 days), whereas that of the eight observational studies (N = 2496) showed a significant reduction in the length of hospital stay in the DHM group (− 11.72 days; 95% CI -22.07, − 1.37 days). A subgroup analysis of the RCTs revealed that the incidence of necrotising enterocolitis (NEC) was significantly lower in the DHM group when the analysis included high-quality RCTs (RR = 0.32; 95% CI 0.15, 0.69). Conclusions This systematic review of RCTs showed that DHM neither prolonged nor shortened the length of hospital stay in VLBW infants compared to preterm infant formula; however, it reduced the incidence of NEC, further validating the protective role of DHM in the health and safety of VLBW infants.

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