scholarly journals AtDOF5.4/OBP4, a DOF Transcription Factor Gene that Negatively Regulates Cell Cycle Progression and Cell Expansion in Arabidopsis thaliana

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Peipei Xu ◽  
Haiying Chen ◽  
Lu Ying ◽  
Weiming Cai
Keyword(s):  
Cell Cycle ◽  
Arabidopsis Thaliana ◽  
Transcription Factor ◽  
Cell Expansion ◽  
Cell Cycle Progression ◽  
Transcription Factor Gene ◽  
Cycle Progression ◽  
Factor Gene ◽  
Dof Transcription Factor

scholarly journals An R2R3-type transcription factor gene AtMYB59 regulates root growth and cell cycle progression in Arabidopsis

Cell Research ◽  
2009 ◽  
Vol 19 (11) ◽  
pp. 1291-1304 ◽  
Author(s):  
Rui-Ling Mu ◽  
Yang-Rong Cao ◽  
Yun-Feng Liu ◽  
Gang Lei ◽  
Hong-Feng Zou ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Transcription Factor ◽  
Root Growth ◽  
Cell Cycle Progression ◽  
Transcription Factor Gene ◽  
Cycle Progression ◽  
Factor Gene

scholarly journals The p110 Isoform of the CDP/Cux Transcription Factor Accelerates Entry into S Phase

2006 ◽  
Vol 26 (6) ◽  
pp. 2441-2455 ◽  
Author(s):  
Laurent Sansregret ◽  
Brigitte Goulet ◽  
Ryoko Harada ◽  
Brian Wilson ◽  
Lam Leduy ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Transcription Factor ◽  
Cell Cycle Progression ◽  
S Phase ◽  
Proteolytic Processing ◽  
Experimental Conditions ◽  
Division Rate ◽  
Cycle Progression ◽  
Processing Event

ABSTRACT The CDP/Cux transcription factor was previously found to acquire distinct DNA binding and transcriptional properties following a proteolytic processing event that takes place at the G1/S transition of the cell cycle. In the present study, we have investigated the role of the CDP/Cux processed isoform, p110, in cell cycle progression. Populations of cells stably expressing p110 CDP/Cux displayed a faster division rate and reached higher saturation density than control cells carrying the empty vector. p110 CDP/Cux cells reached the next S phase faster than control cells under various experimental conditions: following cell synchronization in G0 by growth factor deprivation, synchronization in S phase by double thymidine block treatment, or enrichment in G2 by centrifugal elutriation. In each case, duration of the G1 phase was shortened by 2 to 4 h. Gene inactivation confirmed the role of CDP/Cux as an accelerator of cell cycle progression, since mouse embryo fibroblasts obtained from Cutl1z/z mutant mice displayed a longer G1 phase and proliferated more slowly than their wild-type counterparts. The delay to enter S phase persisted following immortalization by the 3T3 protocol and transformation with H-RasV12. Moreover, CDP/Cux inactivation hindered both the formation of foci on a monolayer and tumor growth in mice. At the molecular level, expression of both cyclin E2 and A2 was increased in the presence of p110 CDP/Cux and decreased in its absence. Overall, these results establish that p110 CDP/Cux functions as a cell cycle regulator that accelerates entry into S phase.

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