scholarly journals Exposure to paternal tobacco smoking increased child hospitalization for lower respiratory infections but not for other diseases in Vietnam

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Reiko Miyahara ◽  
Kensuke Takahashi ◽  
Nguyen Thi Hien Anh ◽  
Vu Dinh Thiem ◽  
Motoi Suzuki ◽  
...  
Keyword(s):  
Risk Factor ◽  
Tobacco Smoking ◽  
Respiratory Infections ◽  
Disease Incidence ◽  
Population Attributable Fraction ◽  
Birth Cohort Study ◽  
Effective Interventions ◽  
Paternal Smoking ◽  
Observation Period

Abstract Exposure to environmental tobacco smoke (ETS) is an important modifiable risk factor for child hospitalization, although its contribution is not well documented in countries where ETS due to maternal tobacco smoking is negligible. We conducted a birth cohort study of 1999 neonates between May 2009 and May 2010 in Nha Trang, Vietnam, to evaluate paternal tobacco smoking as a risk factor for infectious and non-infectious diseases. Hospitalizations during a 24-month observation period were identified using hospital records. The effect of paternal exposure during pregnancy and infancy on infectious disease incidence was evaluated using Poisson regression models. In total, 35.6% of 1624 children who attended follow-up visits required at least one hospitalization by 2 years of age, and the most common reason for hospitalization was lower respiratory tract infection (LRTI). Paternal tobacco smoking independently increased the risk of LRTI 1.76-fold (95% CI: 1.24–2.51) after adjusting for possible confounders but was not associated with any other cause of hospitalization. The population attributable fraction indicated that effective interventions to prevent paternal smoking in the presence of children would reduce LRTI-related hospitalizations by 14.8% in this epidemiological setting.

scholarly journals Burden of cancers attributable to modifiable risk factors in Malaysia

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
H. S. Teh ◽  
Y. L. Woon
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Tobacco Smoking ◽  
Physical Inactivity ◽  
Alcohol Intake ◽  
Population Attributable Fraction ◽  
Excess Weight ◽  
Modifiable Risk Factors ◽  
Systematic Assessment ◽  
Two Parameters

Abstract Background This is a systematic assessment of the burden of cancers in Malaysia in 2018 using epidemiologic approach. The purpose of this study was to identify the proportion of cancers in Malaysia that were attributable to the modifiable risk factors of excess weight, alcohol intake, physical inactivity, tobacco smoking and to estimate the number of cancer cases that could be prevented if the exposure to the modifiable risk factor was reduced. Methods We estimated the Population Attributable Fraction (PAF) of the modifiable risk factors to cancers incidences in Malaysia. The two parameters used for the estimation were exposure prevalence from national representative surveys and the relative risk of getting the cancers from worldwide literature review. Results Among 38,426 cancer incidences in 2018 from Globocan data, we estimated that 22.2% (95% confidence interval (CI):14.9 to 29.6%) of the cancer incidences included in this study were attributable to the investigated modifiable risk factors. 39.1% (95% CI:27.2 to 49.7%) and 10.5% (95% CI:5.8 to 15.7%) of cancers in male and female respectively, were attributable to the studied modifiable risk factors. The top main cancers attributed by the risk factors were lung cancer (65.1%; 95% CI:56.4 to 72.9%), laryngeal cancer (63.6%; 95% CI:39.9 to 80.5%), and oesophageal cancer (51.5%; 95% CI:39.9 to 62.0%). For each risk factor studied across genders, tobacco smoking contributed the most (14.3%; 95% CI:9.9 to 17.3%), followed by excess weight (7.0%; 95% CI:4.1 to 10.2%), physical inactivity (1.0%; 95% CI:0.4 to 1.7%) and alcohol intake (0.6%; 95% CI:0.2 to 1.0%). Conclusion Findings from this study suggests that tobacco smoking and excess weight are the two predominant factors out of the four studied risk factors for cancer cases in Malaysia. Nationwide public health prevention campaigns tailored to these risk factors are recommended. However, the other risk factors such as physical inactivity and alcohol intake shall not be neglected. PAFs are estimated based on the best available data that we have currently. Regular collection of other risk factor exposure prevalence data is vital for future analyses.

scholarly journals Effects of Tobacco Smoking in Pregnancy on Offspring Intelligence at the Age of 5

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Hanne-Lise Falgreen Eriksen ◽  
Ulrik Schiøler Kesmodel ◽  
Theresa Wimberley ◽  
Mette Underbjerg ◽  
Tina Røndrup Kilburn ◽  
...  
Keyword(s):  
Home Environment ◽  
Tobacco Smoking ◽  
Parental Education ◽  
Smoking In Pregnancy ◽  
Maternal Alcohol Consumption ◽  
Significant Decrement ◽  
Residual Confounding ◽  
Paternal Smoking ◽  
In Pregnancy

The aim of the study was to examine the effects of tobacco smoking in pregnancy on children’s IQ at the age of 5. A prospective follow-up study was conducted on 1,782 women, and their offspring were sampled from the Danish National Birth Cohort. At 5 years of age, the children were tested with the Wechsler Preschool and Primary Scale of Intelligence-Revised. Parental education, maternal IQ, maternal alcohol consumption in pregnancy, the sex and age of the child, and tester were considered core confounders, but the full model also controlled for prenatal paternal smoking, maternal age and Bodymass Mass Index, parity, family/home environment, postnatal parental smoking, breast feeding, the child’s health status, and indicators for hearing and vision impairments. Unadjusted analyses showed a statistically significant decrement of 4 points on full-scale IQ (FSIQ) associated with smoking 10+ cigarettes per day compared to nonsmoking. After adjustment for potential confounders, no significant effects of prenatal exposure to tobacco smoking were found. Considering the indisputable teratogenic effects of tobacco smoking, these findings should be interpreted with caution. Still, the results may indicate that previous studies that failed to control for important confounders, particularly maternal intelligence, may be subject to substantial residual confounding.

Risk factor analysis of diarrhoeal disease incidence in faecal sludge-applying farmers’ households in Tamale, Ghana

2013 ◽  
Vol 3 (2) ◽  
pp. 134-143
Author(s):  
Razak Seidu ◽  
Owe Löfman ◽  
Pay Drechsel ◽  
Thor Axel Stenström
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Disease Transmission ◽  
Disease Incidence ◽  
Population Attributable Fraction ◽  
Diarrhoeal Disease ◽  
Wealth Status ◽  
Drying Time ◽  
Sludge Drying ◽  
Faecal Sludge

This study assesses the effect of risk factors and their inter-related mediation on diarrhoeal disease incidence in households applying faecal sludge in agricultural fields in Tamale, Ghana. Risk factors were assigned to three inter-related blocks: distal socio-economic, proximal public and domestic domains. The study involved 1,431 individuals living in 165 faecal sludge-applying households followed bi-weekly for 12 months. The incidence rate of diarrhoeal disease in the sludge-applying households was 1.09 (95% CI: 0.78–1.23) diarrhoeal episodes per person year at risk. Risk factors for diarrhoeal disease transmission in the public domain included sludge drying time (population attributable fraction (PAF) of 6%) and distance covered to collect water (PAF = 18%). The main distal socio-economic risk factor was wealth status (PAF = 15%). In the domestic domain, the risk factor significantly associated with diarrhoeal disease transmission was, not washing hands with soap after defecation (PAF = 18%). About 17% of the effect of sludge drying time (including distance to water facilities) was mediated by the domestic domain risk factors. The study recommends risk management strategies in sludge-applying households that address public and domestic domain risk factors in addition to specific farm level interventions.

Tobacco smoking as a risk factor for depression. A 26-year population-based follow-up study

2011 ◽  
Vol 45 (2) ◽  
pp. 143-149 ◽  
Author(s):  
Trine Flensborg-Madsen ◽  
Mikael Bay von Scholten ◽  
Esben Meulengracht Flachs ◽  
Erik Lykke Mortensen ◽  
Eva Prescott ◽  
...  
Keyword(s):  
Risk Factor ◽  
Tobacco Smoking ◽  
Population Based ◽  
Follow Up Study

Abstract MP089: Cardiovascular Protection Profile and All-cause and CVD Mortality among U.S. Adults

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Quanhe Yang ◽  
Mary Cogswell ◽  
W. Dana Flanders ◽  
Yuling Hong ◽  
Zefeng Zhang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Disease Incidence ◽  
Population Attributable Fraction ◽  
Population Based ◽  
Normal Blood ◽  
Cvd Risk ◽  
Incidence And Mortality ◽  
Reduced Risk ◽  
Cvd Mortality

Introduction: Epidemiologic studies suggest that multiple cardiovascular (CVD) protection-factors (i.e., non-smoking, physically active, normal blood pressure, normal blood glucose, normal total cholesterol, non-obese, and healthy diet) are associated with significantly reduced risk of cardiovascular disease incidence and mortality. Hypothesis: We assessed the hypothesis that the increased number of CVD protection-factors is associated with reduced risk for all-cause and CVD mortality and adherence to low CVD risk profile could result in significant lower rates of all-cause and CVD mortality. Methods: We used the Third National Health and Nutrition Examination Survey (NHANES III 1988-1994) Linked Mortality File (through 2006), a prospective cohort study of a nationally representative sample of 12,861 U.S. adults to examine the prevalence, associations, and population attributable fraction (PAF) of seven CVD protection-factors in relation to risk of all-cause and CVD mortality. Results: Only 3.1% of U.S. adults had all seven CVD protection-factors. The average follow-up was 14.5 years. After multivariable adjustment for potential confounders, hazard ratios (HR) were: 0.30 (95% CI 0.22-0.40), 0.21 (0.12-0.34), and 0.17 (0.09-0.32), comparing individuals with ≥six protection-factors to those with ≤one protection-factors for all-cause, CVD, and IHD mortality respectively. Elevated blood pressure was responsible for the largest number of all-cause and CVD death followed by smoking and poor diet. Overall, 59% (95% CI 27-78) of total deaths and 66% (95% CI 22-88) CVD death would have been avoided during the average of 14.5 years follow-up if the population were changed to the high CVD protection-factors status (with ≥six protection-factors). Conclusions: Few adults in this U.S.-based study population had all seven desirable CVD protection-factors. The presence of an increasing number of CVD protection-factors was associated with a progressively lower risk of total and CVD mortality. Comprehensive population-based initiatives are needed to improve modifiable CVD risk factors, resulting in substantial reductions of all-cause and CVD mortality in the U.S. population.

Self- perceived Health and Alzheimer Disease Incidence Risk. Data from a Population Based Cohort in Spain: NEDICES Study

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
F. Bermejo-Pareja ◽  
R. Trincado ◽  
C. Rodriguez ◽  
M. Fernandez ◽  
S. Vega ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Alzheimer Disease ◽  
Disease Incidence ◽  
Perceived Health ◽  
Population Based ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Incident Dementia

Background:Self-perceived health is a well-recognised predictor of later health outcomes and mortality, but its relationship to incident dementia has been scarcely explored.Objective:To analyze self- perceived health as a risk factor for dementia and Alzheimer disease (AD) in a population- based survey of the elderly (NEDICES) Study.Methods:Participants were evaluated at baseline (1994-1995) with a standardized questionnaire that included subjective and objective (chronic disorders) health status and screening questions for depression and neurologic disorders. At follow-up (a median of 3.2 years later in 1997-1998) an analogous protocol and neurological assessment were performed.Results:Of 5,278 participants evaluated at baseline there were 306 prevalent dementia cases, and 161 incident dementia cases were identified among 3,891 individuals assessed at follow-up (D: 115).Cox hazard ratio analyses showed that age, stroke and illiteracy were independent risk factors for dementia and AD. Aggregation of vascular risk factors was related to a higher risk of both dementia and AD. Good (and very good) versus less than good (fair, bad and very bad) self-perceived health was an independent risk factor for dementia (CI 95% 1.13- 2.16; p= .006) and AD (CI 95% 1.02- 2.18; p= .038) after adjusting by age, sex education and vascular risk factors.Discussion:Self-perceived health increased the risk for incident dementia and AD in the NEDICES cohort as it was previously described in the United Kindom MRC- CFA Study of dementia incidence. Global health measurements (self-perceived health, quality of life) needs farther studies as risk for dementia and AD.

Hemmkörperentwicklung bei Hämophilie-Patienten nach Präparate wechsel

2012 ◽  
Vol 32 (S 01) ◽  
pp. S39-S42 ◽  
Author(s):  
S. Kocher ◽  
G. Asmelash ◽  
V. Makki ◽  
S. Müller ◽  
S. Krekeler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Observational Study ◽  
Retrospective Observational Study ◽  
Frequent Change ◽  
Patient Age ◽  
Treatment Regimens ◽  
Patient Âgé ◽  
The Relationship ◽  
Observation Period

SummaryThe retrospective observational study surveys the relationship between development of inhibitors in the treatment of haemophilia patients and risk factors such as changing FVIII products. A total of 119 patients were included in this study, 198 changes of FVIII products were evaluated. Results: During the observation period of 12 months none of the patients developed an inhibitor, which was temporally associated with a change of FVIII products. A frequent change of FVIII products didn’t lead to an increase in inhibitor risk. The change between plasmatic and recombinant preparations could not be confirmed as a risk factor. Furthermore, no correlation between treatment regimens, severity, patient age and comorbidities of the patients could be found.

HRA Model for Hypercholesterolemia Based on a Longitudinal Health Database

1998 ◽  
Vol 37 (02) ◽  
pp. 130-133
Author(s):  
T. Kishimoto ◽  
Y. Iida ◽  
K. Yoshida ◽  
M. Miyakawa ◽  
H. Sugimori ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Proportional Hazards ◽  
Proportional Hazards Model ◽  
Model Analysis ◽  
Serum Total Cholesterol ◽  
Hazards Model ◽  
The Mean ◽  
Health Database ◽  
Observation Period

AbstractTo evaluate the risk factors for hypercholesterolemia, we examined 4,371 subjects (3,207 males and 1,164 females) who received medical checkups more than twice at an AMHTS in Tokyo during the period from 1976 through 1991; and whose serum total cholesterol was under 250 mg/dl. The mean follow-up duration was 6.6 years. A self-registering questionnaire was administered at the time of the health checkup. The endpoint of this study was the onset of hypercholesterolemia when the level of serum total cholesterol was 250 mg/dl and over. We compared two prognosis groups (normal and hypercholesterol) in terms of age, examination findings and lifestyle. After assessing each variable, we employed Cox's proportional hazards model analysis to determine the factors related to the occurrence of hypercholesterolemia. According to proportional hazards model analysis, total cholesterol, triglyceride and smoking at the beginning, and hypertension during the observation period were selected in males; and total cholesterol at the beginning and age were selected in females to determine the factors related to the occurrence of hypercholesterolemia.

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