Risk factor analysis of diarrhoeal disease incidence in faecal sludge-applying farmers’ households in Tamale, Ghana

2013 ◽  
Vol 3 (2) ◽  
pp. 134-143
Author(s):  
Razak Seidu ◽  
Owe Löfman ◽  
Pay Drechsel ◽  
Thor Axel Stenström
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Disease Transmission ◽  
Disease Incidence ◽  
Population Attributable Fraction ◽  
Diarrhoeal Disease ◽  
Wealth Status ◽  
Drying Time ◽  
Sludge Drying ◽  
Faecal Sludge

This study assesses the effect of risk factors and their inter-related mediation on diarrhoeal disease incidence in households applying faecal sludge in agricultural fields in Tamale, Ghana. Risk factors were assigned to three inter-related blocks: distal socio-economic, proximal public and domestic domains. The study involved 1,431 individuals living in 165 faecal sludge-applying households followed bi-weekly for 12 months. The incidence rate of diarrhoeal disease in the sludge-applying households was 1.09 (95% CI: 0.78–1.23) diarrhoeal episodes per person year at risk. Risk factors for diarrhoeal disease transmission in the public domain included sludge drying time (population attributable fraction (PAF) of 6%) and distance covered to collect water (PAF = 18%). The main distal socio-economic risk factor was wealth status (PAF = 15%). In the domestic domain, the risk factor significantly associated with diarrhoeal disease transmission was, not washing hands with soap after defecation (PAF = 18%). About 17% of the effect of sludge drying time (including distance to water facilities) was mediated by the domestic domain risk factors. The study recommends risk management strategies in sludge-applying households that address public and domestic domain risk factors in addition to specific farm level interventions.

scholarly journals Exposure to paternal tobacco smoking increased child hospitalization for lower respiratory infections but not for other diseases in Vietnam

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Reiko Miyahara ◽  
Kensuke Takahashi ◽  
Nguyen Thi Hien Anh ◽  
Vu Dinh Thiem ◽  
Motoi Suzuki ◽  
...  
Keyword(s):  
Risk Factor ◽  
Tobacco Smoking ◽  
Respiratory Infections ◽  
Disease Incidence ◽  
Population Attributable Fraction ◽  
Birth Cohort Study ◽  
Effective Interventions ◽  
Paternal Smoking ◽  
Observation Period

Abstract Exposure to environmental tobacco smoke (ETS) is an important modifiable risk factor for child hospitalization, although its contribution is not well documented in countries where ETS due to maternal tobacco smoking is negligible. We conducted a birth cohort study of 1999 neonates between May 2009 and May 2010 in Nha Trang, Vietnam, to evaluate paternal tobacco smoking as a risk factor for infectious and non-infectious diseases. Hospitalizations during a 24-month observation period were identified using hospital records. The effect of paternal exposure during pregnancy and infancy on infectious disease incidence was evaluated using Poisson regression models. In total, 35.6% of 1624 children who attended follow-up visits required at least one hospitalization by 2 years of age, and the most common reason for hospitalization was lower respiratory tract infection (LRTI). Paternal tobacco smoking independently increased the risk of LRTI 1.76-fold (95% CI: 1.24–2.51) after adjusting for possible confounders but was not associated with any other cause of hospitalization. The population attributable fraction indicated that effective interventions to prevent paternal smoking in the presence of children would reduce LRTI-related hospitalizations by 14.8% in this epidemiological setting.

scholarly journals Pneumococcal Pneumonia and Invasive Pneumococcal Disease in Those 65 and Older: Rates of Detection, Risk Factors, Vaccine Effectiveness, Hospitalisation and Mortality

Geriatrics ◽  
2021 ◽  
Vol 6 (1) ◽  
pp. 13
Author(s):  
Roger E. Thomas
Keyword(s):  
Risk Factors ◽  
Nursing Home ◽  
Invasive Pneumococcal Disease ◽  
Disease Transmission ◽  
Pneumococcal Disease ◽  
Pneumococcal Pneumonia ◽  
Clinical Symptoms ◽  
Disease Incidence ◽  
Family Members ◽  
Vaccination Rates

Pneumococcal pneumonia (PP) and invasive pneumococcal disease (IPD) are important causes of morbidity and mortality in seniors worldwide. Incidence rates and serious outcomes worsen with increasing frailty, numbers of risk factors and decreasing immune competence with increasing age. Literature reviews in Medline and Embase were performed for pneumococcal disease incidence, risk factors, vaccination rates and effectiveness in the elderly. The introduction of protein-conjugated pneumoccal vaccines (PCV) for children markedly reduced IPD and PP in seniors, but serotypes not included in vaccines and with previously low levels increased. Pneumococcal polysaccharide (PPV23) vaccination does not change nasal and pharyngeal carriage rates. Pneumococcal and influenza vaccination rates in seniors are below guideline levels, especially in older seniors and nursing home staff. Pneumococcal and influenza carriage and vaccination rates of family members, nursing home health care workers and other contacts are unknown. National vaccination programmes are effective in increasing vaccination rates. Detection of IPD and PP initially depend on clinical symptoms and new chest X ray infiltrates and then varies according to the population and laboratory tests used. To understand how seniors and especially older seniors acquire PP and IPD data are needed on pneumococcal disease and carriage rates in family members, carers and contacts. Nursing homes need reconfiguring into small units with air ventilation externally from all rooms to minimise respiratory disease transmission and dedicated staff for each unit to minimise transmision of infectious diseaases.

scholarly journals Burden of cancers attributable to modifiable risk factors in Malaysia

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
H. S. Teh ◽  
Y. L. Woon
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Tobacco Smoking ◽  
Physical Inactivity ◽  
Alcohol Intake ◽  
Population Attributable Fraction ◽  
Excess Weight ◽  
Modifiable Risk Factors ◽  
Systematic Assessment ◽  
Two Parameters

Abstract Background This is a systematic assessment of the burden of cancers in Malaysia in 2018 using epidemiologic approach. The purpose of this study was to identify the proportion of cancers in Malaysia that were attributable to the modifiable risk factors of excess weight, alcohol intake, physical inactivity, tobacco smoking and to estimate the number of cancer cases that could be prevented if the exposure to the modifiable risk factor was reduced. Methods We estimated the Population Attributable Fraction (PAF) of the modifiable risk factors to cancers incidences in Malaysia. The two parameters used for the estimation were exposure prevalence from national representative surveys and the relative risk of getting the cancers from worldwide literature review. Results Among 38,426 cancer incidences in 2018 from Globocan data, we estimated that 22.2% (95% confidence interval (CI):14.9 to 29.6%) of the cancer incidences included in this study were attributable to the investigated modifiable risk factors. 39.1% (95% CI:27.2 to 49.7%) and 10.5% (95% CI:5.8 to 15.7%) of cancers in male and female respectively, were attributable to the studied modifiable risk factors. The top main cancers attributed by the risk factors were lung cancer (65.1%; 95% CI:56.4 to 72.9%), laryngeal cancer (63.6%; 95% CI:39.9 to 80.5%), and oesophageal cancer (51.5%; 95% CI:39.9 to 62.0%). For each risk factor studied across genders, tobacco smoking contributed the most (14.3%; 95% CI:9.9 to 17.3%), followed by excess weight (7.0%; 95% CI:4.1 to 10.2%), physical inactivity (1.0%; 95% CI:0.4 to 1.7%) and alcohol intake (0.6%; 95% CI:0.2 to 1.0%). Conclusion Findings from this study suggests that tobacco smoking and excess weight are the two predominant factors out of the four studied risk factors for cancer cases in Malaysia. Nationwide public health prevention campaigns tailored to these risk factors are recommended. However, the other risk factors such as physical inactivity and alcohol intake shall not be neglected. PAFs are estimated based on the best available data that we have currently. Regular collection of other risk factor exposure prevalence data is vital for future analyses.

scholarly journals The impact of risk factors for dementia in China

2020 ◽  
Vol 49 (5) ◽  
pp. 850-855 ◽  
Author(s):  
Yingxu Liu ◽  
Shu Zhang ◽  
Yasutake Tomata ◽  
Dieta Nurrika ◽  
Yumi Sugawara ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Chinese Population ◽  
Physical Inactivity ◽  
Population Attributable Fraction ◽  
Cross Sectional ◽  
National Surveys ◽  
Low Education ◽  
The Impact ◽  
Incidence Of Dementia

Abstract Brief summary We evaluated the impact of seven risk factors for dementia in China. Physical inactivity, midlife hypertension and low education are proposed to be the largest fraction contributors to dementia. 55% of dementia were attributable to one or more of the seven risk factors. Background Previous studies have highlighted the impact of seven risk factors (midlife obesity, physical inactivity, smoking, low education, diabetes mellitus, midlife hypertension and depression) against dementia. However, the impact of these risk factors on dementia has not been evaluated among the Chinese population. Objective To clarify the impact of seven major risk factors on the incidence of dementia in China. Design The prevalence of risk factors was derived from the latest national surveys. Relative risks of corresponding risk factors were derived from the latest cohort or cross-sectional studies. Setting and subjects Three national surveys were included in the present study to obtain prevalence data of seven risk factors: the China Chronic Disease and Risk Factor Surveillance Survey (CCDRFSS) (2013), which covered about 170,000 adults (aged ≥18 years) from 31 provinces; (2) China National Survey of Chronic Kidney Disease (CNSCKD) (2010), which covered about 50,000 adults (aged ≥18 years) from 13 provinces; and (3) China Family Panel Studies Survey (CFPSS) (2012), which covered about 30,000 adults (aged ≥18 years) from 25 provinces. Methods Levin’s formula was used to calculate the population attributable fraction (PAF) for each risk factor for dementia. The combined PAF of the seven risk factors was calculated assuming the independence of each risk factor. Results Physical inactivity (PAF, 24.3%), midlife hypertension (PAF, 22.1%) and low education (PAF: 11.9%) were the top three factors that contributed to dementia. The total PAF of the seven risk factors was 55% in the Chinese population. Conclusions promotion of physical activity, control of hypertension and improvement of nationwide educational level may be helpful public health strategies to decrease the incidence of dementia in China.

scholarly journals The burden of cancer attributable to modifiable risk factors: the Australian cancer-PAF cohort consortium

BMJ Open ◽  
2017 ◽  
Vol 7 (6) ◽  
pp. e016178 ◽  
Author(s):  
Maria E Arriaga ◽  
Claire M Vajdic ◽  
Karen Canfell ◽  
Robert MacInnis ◽  
Peter Hull ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Population Attributable Fraction ◽  
Cancer Control ◽  
Population Based ◽  
Competing Risk ◽  
Body Fatness ◽  
Risk Of Death ◽  
Two Factors ◽  
Individual Participant

PurposeTo estimate the Australian cancer burden attributable to lifestyle-related risk factors and their combinations using a novel population attributable fraction (PAF) method that accounts for competing risk of death, risk factor interdependence and statistical uncertainty.Participants365 173 adults from seven Australian cohort studies. We linked pooled harmonised individual participant cohort data with population-based cancer and death registries to estimate exposure-cancer and exposure-death associations. Current Australian exposure prevalence was estimated from representative external sources. To illustrate the utility of the new PAF method, we calculated fractions of cancers causally related to body fatness or both tobacco and alcohol consumption avoidable in the next 10 years by risk factor modifications, comparing them with fractions produced by traditional PAF methods.Findings to dateOver 10 years of follow-up, we observed 27 483 incident cancers and 22 078 deaths. Of cancers related to body fatness (n=9258), 13% (95% CI 11% to 16%) could be avoided if those currently overweight or obese had body mass index of 18.5–24.9 kg/m2. Of cancers causally related to both tobacco and alcohol (n=4283), current or former smoking explains 13% (11% to 16%) and consuming more than two alcoholic drinks per day explains 6% (5% to 8%). The two factors combined explain 16% (13% to 19%): 26% (21% to 30%) in men and 8% (4% to 11%) in women. Corresponding estimates using the traditional PAF method were 20%, 31% and 10%. Our PAF estimates translate to 74 000 avoidable body fatness-related cancers and 40 000 avoidable tobacco- and alcohol-related cancers in Australia over the next 10 years (2017–2026). Traditional PAF methods not accounting for competing risk of death and interdependence of risk factors may overestimate PAFs and avoidable cancers.Future plansWe will rank the most important causal factors and their combinations for a spectrum of cancers and inform cancer control activities.

scholarly journals Modifiable Risk Factor of Coronary Heart Disease Incident on Patients with Diabetes Mellitus Type 2

2016 ◽  
Vol 5 (3) ◽  
pp. 341
Author(s):  
Masrizal Dt Mangguang ◽  
Sri Hardian
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Coronary Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Disease Incidence ◽  
Income Level ◽  
Coronary Heart Disease Incidence ◽  
Type 2 Dm

The aim of this research is to determine the risk factors related to coronary heart disease incidence in type 2 diabetes mellitus patient at Dr. M. Djamil Padang Hospital. This was an analytic research with case control study design around October 2014 until May 2015. Samples consisted of 39 cases and 39 controls with matching age and sex. The data were analyzed by using univariate, bivariate by using McNemar test, multivariate by using regression logistic test and stratification. The result showed that hypertension p=0.002 (OR=5, 95%CI 1.09-22.82), obesity p= 0.0001 (OR=6, 95%CI 2.08-17.29), duration of DM p= 0.01 (OR=3.2, 95% CI 1.17-8.73) and smooking  p= 0.002 (OR=7, 95%CI 1.59-30.80) were associated with coronary heart disease incidence in type 2 DM patient. The most dominant risk factor that was associated with coronary heart disease incidence in type 2 DM patient at Dr. M. Djamil Hospital was obesity p= 0.0001 (OR=10.2, 95% CI 3.08-33.81). Hypertension OR=11.25, duration of DM OR=18, smooking OR=16.2, sport activity OR=18.6 and income level OR=15.7 had interaction of the association between obesity and coronary heart disease incidence in type 2 DM patient. Hypertension, obesity, duration of DM and smooking were risk factors that associated to coronary heart disease incidence in type 2 DM patient. Then, the most dominant risk factor that associated to coronary heart disease incidence in type 2 DM patient at Dr. M. Djamil Padang was obesity. Hypertension, duration of DM, smooking, sporct activity and income level had interaction of the association between obesity and coronary heart disease incidence in type 2 DM patient.

scholarly journals Hyperkalemia Was an Independent Risk Factor for Death While Under Mechanical Ventilation Among Children Hospitalized With Diarrhea in Bangladesh

2018 ◽  
Vol 5 ◽  
pp. 2333794X1775400 ◽  
Author(s):  
Fahmida Chowdhury ◽  
Probir Kumar Ghosh ◽  
K. M. Shahunja ◽  
Abu S. M. S. B. Shahid ◽  
Lubaba Shahrin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Mechanical Ventilation ◽  
Risk Factor ◽  
Poisson Regression ◽  
Clinical Characteristics ◽  
Independent Risk Factor ◽  
Diarrhoeal Disease ◽  
Disease Research ◽  
Robust Poisson Regression

Objectives. We sought to evaluate the admission and hospital risk factors for death in children with diarrhea requiring mechanical ventilation (MV). Methods. This was a retrospective study. We enrolled children aged 0 to 59 months admitted with diarrhea to the intensive care unit of the Dhaka Hospital of International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) between August 2009 and July 2013 and required MV. To evaluate the risk factors for death in MV, we compared the clinical and laboratory characteristics of the children requiring MV. We matched up to the clinical characteristics presented on admission and subsequently developed before MV during hospital stay with the survivors and deaths of children having MV. Results. Among 73 enrolled children, 58 (80%) died. Incidence of death in MV was higher among children having hyperkalemia ( P ≤ .001), hypoglycemia ( P ≤ .001), and metabolic acidosis ( P = .06) on admission and lower in children having tracheal isolates ( P ≤ .001) during hospitalization. After adjusting for covariates by using multivariate robust Poisson regression, children with hyperkalemia (incidence ratio = 1.34; P = .03; confidence interval = 1.02-1.76) on admission was the only independent risk factor for death of children with MV. Conclusion. Children with hyperkalemia on admission and subsequently requiring MV were more likely to die compared with those without hyperkalemia.

scholarly journals Is zinc deficiency a risk factor for atherosclerosis?

2004 ◽  
Vol 91 (2) ◽  
pp. 177-181 ◽  
Author(s):  
John H. Beattie ◽  
In-Sook Kwun
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Risk Factor ◽  
Disease Incidence ◽  
Nutritional Risk ◽  
Zn Deficiency ◽  
Incidence Studies ◽  
Zn Status ◽  
The Relationship ◽  
Epidemiological Approach

The development of atherosclerosis is influenced by genetic, lifestyle and nutritional risk factors. Zn and metallothionein deficiency can enhance oxidative-stress-related signalling processes in endothelial cells, and since changes in available plasma Zn may affect the Zn status of the endothelium, Zn deficiency could be a risk factor for IHD. Although the association of Zn with many proteins is essential for their function, three key signalling processes are highlighted as being principal targets for the effect of Zn deficiency: the activation of NF-κB, the activation of caspase enzymes and the signalling of NO. The need to develop a reliable indicator of Zn status is critical to any epidemiological approach for studying the relationship between Zn status and disease incidence. Studies using appropriate animal models and investigating how the plasma Zn pool influences endothelial intracellular labile Zn would be helpful in appreciating the importance of Zn deficiency in atherogenesis.

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