Wettability patterning for high-rate, pumpless fluid transport on open, non-planar microfluidic platforms

Lab on a Chip ◽  
2014 ◽  
Vol 14 (9) ◽  
pp. 1538-1550 ◽  
Author(s):  
Aritra Ghosh ◽  
Ranjan Ganguly ◽  
Thomas M. Schutzius ◽  
Constantine M. Megaridis
Keyword(s):  
Fluid Transport ◽  
Microfluidic Devices ◽  
High Rate ◽  
Open Surface ◽  
Microfluidic Platforms

Wettability-patterned open-surface microfluidic devices facilitate pumpless transport of liquids (>350 μL s−1) and allow complex handling tasks including rise against gravity.

Recent developments in microfluidic paper-, cloth-, and thread-based electrochemical devices for analytical chemistry

2017 ◽  
Vol 36 (4) ◽  
Author(s):  
Radha S.P. Malon ◽  
Lee Yook Heng ◽  
Emma P. Córcoles
Keyword(s):  
Fluid Transport ◽  
Analytical Techniques ◽  
Microfluidic Devices ◽  
Development Stage ◽  
Pharmaceutical Chemical ◽  
Microfluidic Platforms ◽  
Cellulose Substrates ◽  
Recent Developments ◽  
Electrochemical Devices ◽  
And Performance

AbstractThe attractive structural and mechanical properties of cellulose substrates (paper, cloth, and thread), including passive fluid transport, biocompatibility, durability, and flexibility, have attracted researchers in the past few decades to explore them as alternative microfluidic platforms. The incorporation of electrochemical (EC) sensing broadened their use for applications such as clinical diagnosis, pharmaceutical chemical analyses, food quality, and environmental monitoring. This article provides a review on the microfluidic devices constructed on paper, cloth, and thread substrates. It begins with an overview on paper-based microfluidic devices, followed by an in-depth review on the various applications of EC detection incorporated on paper-based microfluidic devices reported to date. The review on paper-based microfluidic devices attempts to convey a few perspective directions that cloth- and thread-based microfluidic devices may take in its development. Finally, the research efforts on the development and evaluation, as well as current limitations of cloth- and thread-based microfluidic devices are discussed. Microfluidic devices constructed on paper, cloth, and thread substrates are still at an early development stage (prototype) requiring several improvements in terms of fabrication, analytical techniques, and performance to become mature platforms that can be adapted and commercialized as real world products. However, they hold a promising potential as wearable devices.

scholarly journals Disposable Voltammetric Immunosensors Integrated with Microfluidic Platforms for Biomedical, Agricultural and Food Analyses: A Review

Sensors ◽  
2018 ◽  
Vol 18 (12) ◽  
pp. 4124 ◽  
Author(s):  
Fabiana Felix ◽  
Alexandre Baccaro ◽  
Lúcio Angnes
Keyword(s):  
Quality Management ◽  
Signal Amplification ◽  
Screen Printing ◽  
Point Of Care ◽  
Microfluidic Devices ◽  
Strong Interactions ◽  
Point Of Care Testing ◽  
Microfluidic Platforms ◽  
Broad Variety ◽  
Interesting Alternative

Disposable immunosensors are analytical devices used for the quantification of a broad variety of analytes in different areas such as clinical, environmental, agricultural and food quality management. They detect the analytes by means of the strong interactions between antibodies and antigens, which provide concentration-dependent signals. For the herein highlighted voltammetric immunosensors, the analytical measurements are due to changes in the electrical signals on the surface of the transducers. The possibility of using disposable and miniaturized immunoassays is a very interesting alternative for voltammetric analyses, mainly, when associated with screen-printing technologies (screen-printed electrodes, SPEs), and microfluidic platforms. The aim of this paper is to discuss a carefully selected literature about different examples of SPEs-based immunosensors associated with microfluidic technologies for diseases, food, agricultural and environmental analysis. Technological aspects of the development of the voltammetric immunoassays such as the signal amplification, construction of paper-based microfluidic platforms and the utilization of microfluidic devices for point-of-care testing will be presented as well.

Skin-interfaced microfluidic devices with one-opening chambers and hydrophobic valves for sweat collection and analysis

Lab on a Chip ◽  
2020 ◽  
Vol 20 (15) ◽  
pp. 2635-2645 ◽  
Author(s):  
Yingxue Zhang ◽  
Yao Chen ◽  
Jielong Huang ◽  
Yangchengyi Liu ◽  
Jinfeng Peng ◽  
...  
Keyword(s):  
Microfluidic Devices ◽  
Microfluidic Platforms ◽  
Sweat Loss ◽  
Essential Insight ◽  
Insight Into ◽  
Sweat Collection

Soft, skin-interfaced microfluidic platforms are capable of capturing, storing, and assessing sweat chemistry and total sweat loss, which provides essential insight into human physiological health.

Fluid Transport in Partially Shielded Electrowetting on Dielectric Digital Microfluidic Devices

2016 ◽  
Vol 25 (4) ◽  
pp. 593-605 ◽  
Author(s):  
Andrew C. Madison ◽  
Matthew W. Royal ◽  
Richard B. Fair
Keyword(s):  
Fluid Transport ◽  
Microfluidic Devices ◽  
Electrowetting On Dielectric ◽  
Digital Microfluidic

Friction and the Continuum Limit – Where is the Boundary?

2000 ◽  
Vol 651 ◽  
Author(s):  
Yingxi Zhu ◽  
Steve Granick
Keyword(s):  
Continuum Limit ◽  
Fluid Transport ◽  
Liquid Surface ◽  
Microfluidic Devices ◽  
Slip Boundary Condition ◽  
Surface Interactions ◽  
Slip Boundary ◽  
Low Viscosity ◽  
Solid Liquid ◽  
The Continuum

AbstractThe no-slip boundary condition, believed to describe macroscopic flow of low-viscosity fluids, overestimates hydrodynamic forces starting at lengths corresponding to hundreds of molecular dimensions when water or tetradecane is placed between smooth nonwetting surfaces whose spacing varies dynamically. When hydrodynamic pressures exceed 0.1-1 atmospheres (this occurs at spacings that depend on the rate of spacing change), flow becomes easier than expected. Therefore solid-liquid surface interactions influence not just molecularly-thin confined liquids but also flow at larger length scales. This points the way to strategies for energy-saving during fluid transport and may be relevant to filtration, colloidal dynamics, and microfluidic devices, and shows a hitherto-unappreciated dependence of slip on velocity.

Microtiter Plate-Based Microfluidic Platforms: Sealing, Leakage Testing, and Performance of a 96-Well SPRI Device

2006 ◽  
Author(s):  
D. S. Park ◽  
M. Hupert ◽  
J. Guy ◽  
P. Datta ◽  
J.-B. Lee ◽  
...  
Keyword(s):  
High Throughput ◽  
Mold Insert ◽  
Microfluidic Devices ◽  
Microtiter Plate ◽  
Thickness Variation ◽  
Large Area ◽  
Microfluidic Platforms ◽  
Effective Manner ◽  
Micro Molding ◽  
Microtiter Plate Format

Highly parallelized biochemical analysis is a significant step toward achieving high throughput processing of patient samples for diagnosis and treatment monitoring. The standard microtiter plate is used to carry out multiple reactions for high throughput screening. By incorporating polymer microfluidic devices at each well in the microtiter plate format, the capability of the format could be significantly enhanced for high throughput processing of large numbers of biochemical samples in a cost-effective manner. Low cost replication of the microtiter plates is done using micro molding techniques, so microfabrication technology for making large area mold inserts (LAMIs) containing microfluidic devices at each well of a microtiter plate format is needed. A large area mold insert (LAMI) in the footprint of the standard microtiter plate was fabricated using an SU-8 based UV-LIGA technique. Excellent lithography results, with vertical sidewalls, were obtained by utilizing flycutting to minimize SU-8 film thickness variation and a UV filter for attenuating high absorbance UV wavelengths. Overplating of nickel in the SU-8 polymeric molds was used to make high quality metallic mold inserts with vertical sidewalls. Micro molding of polycarbonate (PC) was done using hot embossing, resulting in good replication fidelity over the large surface area. Thermal fusion bonding of the molded PC chips yielded good sealing results and the developed polymer microfluidic platforms showed good fluidic uniformity.

Guided assembly of nanowires and their integration in microfluidic devices

2011 ◽  
Vol 1346 ◽  
Author(s):  
Josep Puigmarti-Luis ◽  
Phillip Kuhn ◽  
Benjamin Z. Cvetković ◽  
Daniel Schaffhauser ◽  
Marta Rubio-Martínez ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Coordination Polymers ◽  
Microfluidic Devices ◽  
Hybrid Structures ◽  
Effective Strategy ◽  
Microfluidic Platforms ◽  
Guided Assembly

ABSTRACTIn this contribution, we present an effective strategy for assembling and integrating functional, in situ formed micro- and nanosized structures. Microfluidic platforms are employed to form anisotropic hybrid structures and coordination polymers at the interface of two precursor streams. Microstamps, embedded in the microfluidic device and actuated by pressure, provide a facile and reliable technology for structure trapping, localization and integration.

scholarly journals Rapid, Self-driven Liquid Mixing on Open-Surface Microfluidic Platforms

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Jared M. Morrissette ◽  
Pallab Sinha Mahapatra ◽  
Aritra Ghosh ◽  
Ranjan Ganguly ◽  
Constantine M. Megaridis
Keyword(s):  
Open Surface ◽  
Microfluidic Platforms ◽  
Liquid Mixing

Lowering of interstitial fluid pressure in rat submandibular gland: a novel mechanism in saliva secretion

2006 ◽  
Vol 290 (4) ◽  
pp. H1460-H1468 ◽  
Author(s):  
Ellen Berggreen ◽  
Helge Wiig
Keyword(s):  
Osmotic Pressure ◽  
Submandibular Gland ◽  
Interstitial Fluid ◽  
Fluid Transport ◽  
Fluid Pressure ◽  
Myoepithelial Cells ◽  
Colloid Osmotic Pressure ◽  
Interstitial Fluid Pressure ◽  
High Rate ◽  
Fluid Filtration

The submandibular gland transports fluid at a high rate through the interstitial space during salivation, but the exact level of all forces governing transcapillary fluid transport has not been established. In this study, our aim was to measure the relation between interstitial fluid volume (Vi) and interstitial fluid pressure (Pif) in salivary glands during active secretion and after systemically induced passive changes in gland hydration. We tested whether interstitial fluid could be isolated by tissue centrifugation to enable measurement of interstitial fluid colloid osmotic pressure. During control conditions, Vi averaged 0.23 ml/g wet wt (SD 0.014), with a corresponding mean Pif measured with micropipettes of 3.0 mmHg (SD 1.3). After induction of secretion by pilocarpine, Pif dropped by 3.8 mmHg (SD 1.5) whereas Vi was unchanged. During dehydration and overhydration of up to 20% increase of Vi above control, a linear relation was found between volume and pressure, resulting in a compliance (ΔVi/ΔPif) of 0.012 ml·g wet wt−1·mmHg−1. Interstitial fluid was isolated, and interstitial fluid colloid osmotic pressure averaged 10.4 mmHg (SD 1.2), which is 64% of the corresponding level in plasma. We conclude that Pif drops during secretion and, thereby, increases the net transcapillary pressure gradient, a condition that favors fluid filtration and increases the amount of fluid available for secretion. The reduction in Pif is most likely induced by contraction of myoepithelial cells and suggests an active and new role for these cells in salivary secretion. The relatively low interstitial compliance of the organ will enhance the effect of the myoepithelial cells on Pif during reduced Vi.

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