Dysidaminones A–M, cytotoxic and NF-κB inhibitory sesquiterpene aminoquinones from the South China Sea sponge Dysidea fragilis

RSC Advances ◽  
2014 ◽  
Vol 4 (18) ◽  
pp. 9236-9246 ◽  
Author(s):  
Wei-Hua Jiao ◽  
Ting-Ting Xu ◽  
Hao-Bing Yu ◽  
Feng-Rong Mu ◽  
Jia Li ◽  
...  

Structural determination, absolute configuration assignments, and biological activities of new sesquiterpene aminoquinones from Dysidea fragilis.

Author(s):  
Song-Wei Li ◽  
Yue-Wei Guo

: Marine mollusks are a prolific source of secondary metabolites with complex/diverse structures and various aspects of biological activities. For above mentioned reason, these animals have been being extensively explored and became the hotspot of research subject in the recent years. It is well documented that mollusks can escape from predation by utilizing bioactive metabolites as defensive chemicals. In the last decade, the possible diet relationship between the South China Sea mollusks and their related potential prey organisms, including sponges, corals, algae, etc. have been systematically investigated. A series of interesting results have been obtained concerning the chemistry, chemoecology and pharmacological profiles of the studied marine organisms. The present review focuses on recent development dealing with chemistry, chemoecology, and bioactivity of the South China Sea mollusks and their dietary organisms.


2013 ◽  
Vol 8 (12) ◽  
pp. 1934578X1300801 ◽  
Author(s):  
Fei Cao ◽  
Jing Zhou ◽  
Kai-Xia Xu ◽  
Meng-Qi Zhang ◽  
Chang-Yun Wang

One new oxygenated cembranoid diterpene, named sarcophytol W (1), along with six known analogues (2–7) were isolated from a soft coral Sarcophyton sp. collected from the South China Sea. Their structures were elucidated by spectroscopic analyses and by comparison with previously reported data. The absolute configuration of 1 was assigned on the basis of the absolute configuration of the related congener 2, which was determined by application of the modified Mosher's method. All the compounds were evaluated for their antibacterial and antifouling activities.


Author(s):  
Jun Wu ◽  
Zhong-Ping Jiang ◽  
Ren-Jie Yan ◽  
Shi-Hao Sun ◽  
Yi Yu ◽  
...  

A sailboat-shaped 20-membered macrolide, named gibbosolide A, featuring a rare cis-fused 2-methylhexahydro-2H-furo[3,2-b]pyran motif, was obtained from the South China Sea dinoflagellate, Amphidinium gibbosum. Its planar structure and absolute configuration, containing...


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