Electrochemical determination of selected antihypertensive and antituberculosis drugs at a tyrosine-modified electrode

2014 ◽  
Vol 6 (17) ◽  
pp. 6774-6782 ◽  
Author(s):  
Srikanth Cheemalapati ◽  
Balamurugan Devadas ◽  
Shen-Ming Chen ◽  
M. Ajmal Ali ◽  
Fahad M. A. Al-Hemaid
Keyword(s):  
Modified Electrode ◽  
Electrochemical Method ◽  
Electrochemical Determination ◽  
Antituberculosis Drugs ◽  
Hydralazine Hydrochloride

A simple and sensitive electrochemical method was proposed for the determination of hydralazine hydrochloride (HDH), isoniazid (ISN), ethambutol hydrochloride (EBH) and pyrazinamide (PZM).

scholarly journals Electrochemical determination of ascorbic acid at p-phenylenediamine film-holes modified glassy carbon electrode

2015 ◽  
Vol 80 (9) ◽  
pp. 1161-1175 ◽  
Author(s):  
Bikila Olana ◽  
Shimeles Kitte ◽  
Tesfaye Soreta
Keyword(s):  
Ascorbic Acid ◽  
Detection Limit ◽  
Glassy Carbon Electrode ◽  
Modified Electrode ◽  
Glassy Carbon ◽  
Linear Response ◽  
Modified Electrodes ◽  
Electrochemical Determination ◽  
Carbon Electrode

In this work the determination of ascorbic acid (AA) at glassy carbon electrode (GCE) modified with a perforated film produced by reduction of diazonium generated in situ from p-phenylenediamine (PD) is reported. Holes were intentionally created in the modifier film by stripping a pre-deposited gold nanoparticles. The modified electrodes were electrochemically characterized by common redox probes: hydroquinone, ferrocyanide and hexamineruthenium(III). The cyclic voltammetric and amperometric response of AA using the modified electrodes was compared with that of bare GCE. The bare GCE showed a linear response to AA in the concentration range of 5 mM to 45 mM with detection limit of 1.656 mM and the modified GCE showed a linear response to AA in the concentration range of 5 ?M to 45 ?M with detection limit of 0.123 ?M. The effect of potential intereferents on amperometric signal of AA at the modified GCE was examined and found to be minimal. The inter-electrode reproducibility, stability, and accuracy were determined. The modified electrode showed excellent inter-electrode reproducibility, accuracy and stability. The modified electrode reported is a promising candidate for use in electroanalysis of AA.

scholarly journals Linear sweep polarographic determination of nucleic acids using acridine orange as a bioprobe

2007 ◽  
Vol 72 (11) ◽  
pp. 1085-1094 ◽  
Author(s):  
Wei Sun ◽  
Na Zhao ◽  
Xianlong Yuan ◽  
Kui Jiao
Keyword(s):  
Aqueous Solution ◽  
Acridine Orange ◽  
Electrochemical Method ◽  
Electrochemical Determination ◽  
Determination Method ◽  
Linear Regression Equation ◽  
Peak Potential ◽  
Linear Sweep ◽  
Buffer Solution

The interaction of acridine orange (AO) with double-stranded (ds) DNA in aqueous solution was investigated by linear sweep polarography (LSP) on a dropping mercury working electrode (DME). In pH 2.5 Britton-Robinson (B-R) buffer solution, AO had a sensitive linear sweep polarographic reductive peak at -0.89 V (vs. SCE), which could be greatly inhibited by the addition of dsDNA, with a positive shift of the peak potential. Based on the decrease of the reductive peak current, a new quantitative electrochemical determination method for dsDNA was developed with a linear range of 2.0?20.0 mg l-1 and the linear regression equation: ?Ip" (nA) = 111.90 C (mg l-1)+125.32 (n = 9, ? = 0.997). The influences of commonly co-existing substances, such as metal ions, amino acid, etc., on the determination were also investigated. The method is sensitive, rapid and simple with good selectivity. The new proposed method was further applied to the detection of RNA and three synthetic samples containing dsDNA with satisfactory results. The binding number and the equilibrium constant between dsDNA and AO were calculated by an electrochemical method.

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