A novel Affibody bioconjugate for dual-modality imaging of ovarian cancer

2014 ◽  
Vol 50 (85) ◽  
pp. 12832-12835 ◽  
Author(s):  
Yihong Wang ◽  
Zheng Miao ◽  
Gang Ren ◽  
Yingding Xu ◽  
Zhen Cheng
Keyword(s):  
Ovarian Cancer ◽  
Optical Imaging ◽  
Tumor Imaging ◽  
Dual Modality ◽  
Imaging Probe ◽  
Imaging Quality ◽  
Metal Chelator ◽  
Dual Modality Imaging ◽  
Dual Imaging

An Affibody based dual imaging probe (PET and optical imaging) has been successfully developed. Dendrimer PAMAM G0 was used as a platform to assemble an NIRF dye, a metal chelator, and Affibody for dual modality imaging of ovarian cancer. Excellent tumor imaging quality was achieved in both modalities in the living tumor mice models.

Conjugation of multivalent ligands to gold nanoshells and designing a dual modality imaging probe

2015 ◽  
Vol 3 (9) ◽  
pp. 1788-1800 ◽  
Author(s):  
Mathieu Bédard ◽  
Pramod K. Avti ◽  
Tina Lam ◽  
Léonie Rouleau ◽  
Jean-Claude Tardif ◽  
...  
Keyword(s):  
Gold Nanoshells ◽  
Multivalent Ligands ◽  
Dual Modality ◽  
Imaging Probe ◽  
Hollow Gold Nanoshells ◽  
Dual Modality Imaging ◽  
Dual Imaging

Hollow gold nanoshells functionalized with branched multivalent ligands provide an excellent platform to develop nanoprobes with dual imaging capabilities.

Synthesis of a multifunctional manganese(ii)–carbon dots hybrid and its application as an efficient magnetic-fluorescent imaging probe for ovarian cancer cell imaging

2016 ◽  
Vol 4 (35) ◽  
pp. 5798-5802 ◽  
Author(s):  
Cuiping Han ◽  
Huiting Xu ◽  
Ru Wang ◽  
Keying Wang ◽  
Yue Dai ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Optical Imaging ◽  
Cancer Cell ◽  
Carbon Dots ◽  
Cell Imaging ◽  
Ovarian Cancer Cell ◽  
Fluorescent Imaging ◽  
Imaging Probe ◽  
Cancer Cell Targeting ◽  
Hybrid Nanoprobe

A magnetic-fluorescent manganese(ii)–carbon dots hybrid nanoprobe was successfully prepared for ovarian cancer cell targeting and bifunctional MRI and optical imaging.

scholarly journals Ferumoxytol-based Dual-modality Imaging Probe for Detection of Stem Cell Transplant Rejection

2018 ◽  
Vol 2 (4) ◽  
pp. 306-319 ◽  
Author(s):  
Kai Li ◽  
Carmel T. Chan ◽  
Hossein Nejadnik ◽  
Olga D. Lenkov ◽  
Cody Wolterman ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplant ◽  
Transplant Rejection ◽  
Cell Transplant ◽  
Dual Modality ◽  
Imaging Probe ◽  
Dual Modality Imaging

scholarly journals Improved Intraoperative Detection of Ovarian Cancer by Folate Receptor Alpha Targeted Dual-Modality Imaging

2017 ◽  
Vol 14 (10) ◽  
pp. 3457-3463 ◽  
Author(s):  
Marlène C. H. Hekman ◽  
Otto C. Boerman ◽  
Desirée L. Bos ◽  
Leon F. A. G. Massuger ◽  
Susan Weil ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Folate Receptor ◽  
Folate Receptor Alpha ◽  
Dual Modality ◽  
Receptor Alpha ◽  
Intraoperative Detection ◽  
Dual Modality Imaging

A potential dual-modality optical imaging probe based on the pH-responsive micelle

2016 ◽  
Vol 23 (9) ◽  
Author(s):  
Shan Xia ◽  
Hongyu Yang ◽  
Lijie Duan ◽  
Guang Hui Gao ◽  
Xiumei Zhang
Keyword(s):  
Optical Imaging ◽  
Ph Responsive ◽  
Dual Modality ◽  
Imaging Probe

Functionalization of NaGdF4 nanoparticles with a dibromomaleimide-terminated polymer for MR/optical imaging of thrombosis

2020 ◽  
Vol 11 (5) ◽  
pp. 1010-1017 ◽  
Author(s):  
Yuhuan Li ◽  
Fangyun Xin ◽  
Jinming Hu ◽  
Shweta Jagdale ◽  
Thomas P. Davis ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Magnetic Resonance ◽  
Optical Imaging ◽  
Dual Modality ◽  
Imaging Probe ◽  
Molecular Imaging Probe ◽  
Targeted Molecular Imaging

A thrombosis-targeted molecular imaging probe with magnetic resonance (MR) and optical dual-modality capacity using dibromomaleimide (DBM)-bearing polymer-grafted NaGdF4 nanoparticles.

A functionalized heterobimetallic99mTc/Re complex as a potential dual-modality imaging probe: synthesis, photophysical properties, cytotoxicity and cellular imaging investigations

2014 ◽  
Vol 43 (2) ◽  
pp. 439-450 ◽  
Author(s):  
Alison François ◽  
Céline Auzanneau ◽  
Valérie Le Morvan ◽  
Chantal Galaup ◽  
Hannah S. Godfrey ◽  
...  
Keyword(s):  
Photophysical Properties ◽  
Cellular Imaging ◽  
Dual Modality ◽  
Imaging Probe ◽  
Dual Modality Imaging

scholarly journals Dual-Modality Imaging Probes with High Magnetic Relaxivity and Near-Infrared Fluorescence Based Highly Aminated Mesoporous Silica Nanoparticles

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Zhu Fei-Peng ◽  
Chen Guo-Tao ◽  
Wang Shou-Ju ◽  
Liu Ying ◽  
Tang Yu-Xia ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Near Infrared ◽  
Mesoporous Silica Nanoparticles ◽  
Near Infrared Fluorescence ◽  
Dual Modality ◽  
Imaging Probe ◽  
Nir Fluorescence ◽  
Imaging Probes ◽  
Dual Modality Imaging

Dual-modal imaging by combining magnetic resonance (MR) and near-infrared (NIR) fluorescence can integrate the advantages of high-resolution anatomical imaging with high sensitivity in vivo fluorescent imaging, which is expected to play a significant role in biomedical researches. Here we report a dual-modality imaging probe (NIR/MR-MSNs) fabricated by conjugating NIR fluorescent heptamethine dyes (IR-808) and MR contrast agents (Gd-DTPA) within highly aminated mesoporous silica nanoparticles (MSNs-NH2). The dual-modality imaging probes NIR/MR-MSNs possess a size of ca. 120 nm. The NIR/MR-MSNs show not only near-infrared fluorescence imaging property with an emission peak at 794 nm, but also highly MRT1relaxivity of 14.54 mM−1 s−1, which is three times more than Gd-DTPA. In vitro experiment reveals high uptake and retention abilities of the nanoprobes, while cell viability assay demonstrates excellent cytocompatibility of the dual-modality imaging probe. After intratumor injection with the NIR/MR-MSNs, MR imaging shows clear anatomical border of the enhanced tumor region while NIR fluorescence exhibits high sensitive tumor detection ability. These intriguing features suggest that this newly developed dual-modality imaging probes have great potential in biomedical imaging.

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