Dual-functionalized calcium carbonate based gene delivery system for efficient gene delivery

RSC Advances ◽  
2014 ◽  
Vol 4 (73) ◽  
pp. 38623-38629 ◽  
Author(s):  
Chao-Qun Wang ◽  
Meng-Qing Gong ◽  
Jin-Long Wu ◽  
Ren-Xi Zhuo ◽  
Si-Xue Cheng
Keyword(s):  
Calcium Carbonate ◽  
Gene Delivery ◽  
Delivery System ◽  
Gene Transfection ◽  
Cell Penetrating Peptide ◽  
Gene Delivery System ◽  
Dna Nanoparticles ◽  
Efficient Gene ◽  
Cell Penetrating ◽  
A Cell

Dual-functionalized KALA/PS/CaCO3/DNA nanoparticles containing a cell penetrating peptide (KALA) and protamine sulfate (PS) could effectively mediate gene transfection at a low DNA concentration.

Development of a Gene Delivery System Composed of a Cell-Penetrating Peptide and a Nontoxic Polymer

2020 ◽  
Vol 3 (11) ◽  
pp. 7418-7427
Author(s):  
Obdulia Covarrubias-Zambrano ◽  
Tej B. Shrestha ◽  
Marla Pyle ◽  
Maria Montes-Gonzalez ◽  
Deryl L. Troyer ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Cell Penetrating Peptide ◽  
Gene Delivery System ◽  
Cell Penetrating ◽  
A Cell

A gene delivery system for human cells mediated by both a cell-penetrating peptide and a piggyBac transposase

Biomaterials ◽  
2011 ◽  
Vol 32 (26) ◽  
pp. 6264-6276 ◽  
Author(s):  
Cheng-Yi Lee ◽  
Jheng-Fong Li ◽  
Ji-Sing Liou ◽  
Yuh-Chyang Charng ◽  
Yue-Wern Huang ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Human Cells ◽  
Cell Penetrating Peptide ◽  
Gene Delivery System ◽  
Cell Penetrating ◽  
A Cell

Construction of traceable cucurbit[7]uril-based virus-mimicking quaternary complexes with aggregation-induced emission for efficient gene transfection

2020 ◽  
Vol 8 (33) ◽  
pp. 7475-7482
Author(s):  
De-E Liu ◽  
Xiangjie Yan ◽  
Jinxia An ◽  
Jianbiao Ma ◽  
Hui Gao
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Gene Transfection ◽  
Delivery Systems ◽  
Endosomal Escape ◽  
Gene Delivery System ◽  
Aggregation Induced Emission ◽  
Efficient Gene ◽  
Novel Virus

A novel virus-mimicking gene delivery system with excellent endosomal escape, efficient transfection, and traceability is developed which can serve as a reference for the construction of novel multifunctional efficient gene delivery systems.

scholarly journals A Cell-Penetrating Peptide with a Guanidinylethyl Amine Structure Directed to Gene Delivery

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Makoto Oba ◽  
Takuma Kato ◽  
Kaori Furukawa ◽  
Masakazu Tanaka
Keyword(s):  
Gene Delivery ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
Amine Structure ◽  
A Cell

scholarly journals Echogenic PEGylated PEI-Loaded Microbubble As Efficient Gene Delivery System

2019 ◽  
Vol Volume 14 ◽  
pp. 8923-8941 ◽  
Author(s):  
Chun Liufu ◽  
Yue Li ◽  
Jiawei Tu ◽  
Hui Zhang ◽  
Jinsui Yu ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Gene Delivery System ◽  
System P ◽  
Efficient Gene

Enhanced activity of vancomycin by encapsulation in hybrid magnetic nanoparticles conjugated to a cell-penetrating peptide

Nanoscale ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 3855-3870 ◽  
Author(s):  
Wenjie Zhang ◽  
Reza Taheri-Ledari ◽  
Zoleikha Hajizadeh ◽  
Ehsan Zolfaghari ◽  
Mohammad Reza Ahghari ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Delivery System ◽  
Cell Penetrating Peptide ◽  
Enhanced Activity ◽  
Cell Penetrating ◽  
A Cell ◽  
Antibiotic Delivery

We describe a novel antibiotic delivery system based on magnetic nanoparticles (NPs) conjugated to a cell-penetrating peptide (CPP).

scholarly journals Local Gene Delivery System by Bubble Liposomes and Ultrasound Exposure into Joint Synovium

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Yoichi Negishi ◽  
Yuka Tsunoda ◽  
Yoko Endo-Takahashi ◽  
Yusuke Oda ◽  
Ryo Suzuki ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Transfer ◽  
Gene Delivery ◽  
Delivery System ◽  
Imaging System ◽  
Effective Means ◽  
Gene Delivery System ◽  
Highly Efficient ◽  
Efficient Gene

Recently, we have developed novel polyethylene glycol modified liposomes (bubble liposomes; BL) entrapping an ultrasound (US) imaging gas, which can work as a gene delivery tool with US exposure. In this study, we investigated the usefulness of US-mediated gene transfer systems with BL into synoviocytes in vitro and joint synovium in vivo. Highly efficient gene transfer could be achieved in the cultured primary synoviocytes transfected with the combination of BL and US exposure, compared to treatment with plasmid DNA (pDNA) alone, pDNA plus BL, or pDNA plus US. When BL was injected into the knee joints of mice, and US exposure was applied transcutaneously to the injection site, highly efficient gene expression could be observed in the knee joint transfected with the combination of BL and US exposure, compared to treatment with pDNA alone, pDNA plus BL, or pDNA plus US. The localized and prolonged gene expression was also shown by an in vivo luciferase imaging system. Thus, this local gene delivery system into joint synovium using the combination of BL and US exposure may be an effective means for gene therapy in joint disorders.

Sign in / Sign up

Export Citation Format

Share Document