Construction of traceable cucurbit[7]uril-based virus-mimicking quaternary complexes with aggregation-induced emission for efficient gene transfection

A novel virus-mimicking gene delivery system with excellent endosomal escape, efficient transfection, and traceability is developed which can serve as a reference for the construction of novel multifunctional efficient gene delivery systems.

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Dual-functionalized calcium carbonate based gene delivery system for efficient gene delivery

RSC Advances ◽

10.1039/c4ra05468g ◽

2014 ◽

Vol 4 (73) ◽

pp. 38623-38629 ◽

Cited By ~ 11

Author(s):

Chao-Qun Wang ◽

Meng-Qing Gong ◽

Jin-Long Wu ◽

Ren-Xi Zhuo ◽

Si-Xue Cheng

Keyword(s):

Calcium Carbonate ◽

Gene Delivery ◽

Delivery System ◽

Gene Transfection ◽

Cell Penetrating Peptide ◽

Gene Delivery System ◽

Dna Nanoparticles ◽

Efficient Gene ◽

Cell Penetrating ◽

A Cell

Dual-functionalized KALA/PS/CaCO3/DNA nanoparticles containing a cell penetrating peptide (KALA) and protamine sulfate (PS) could effectively mediate gene transfection at a low DNA concentration.

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Echogenic PEGylated PEI-Loaded Microbubble As Efficient Gene Delivery System

International Journal of Nanomedicine ◽

10.2147/ijn.s217338 ◽

2019 ◽

Vol Volume 14 ◽

pp. 8923-8941 ◽

Cited By ~ 3

Author(s):

Chun Liufu ◽

Yue Li ◽

Jiawei Tu ◽

Hui Zhang ◽

Jinsui Yu ◽

...

Keyword(s):

Gene Delivery ◽

Delivery System ◽

Gene Delivery System ◽

System P ◽

Efficient Gene

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554. The Role of the Blood Proteins in Gene Transfection of Cationic Liposome-Mediated Gene Delivery System

Molecular Therapy ◽

10.1016/s1525-0016(16)40996-2 ◽

2003 ◽

Vol 7 (5) ◽

pp. S216

Keyword(s):

Gene Delivery ◽

Delivery System ◽

Gene Transfection ◽

Cationic Liposome ◽

Blood Proteins ◽

Gene Delivery System

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Next Generation Delivery System for Proteins and Genes of Therapeutic Purpose: Why and How?

BioMed Research International ◽

10.1155/2014/327950 ◽

2014 ◽

Vol 2014 ◽

pp. 1-11 ◽

Cited By ~ 17

Author(s):

Ashish Ranjan Sharma ◽

Shyamal Kumar Kundu ◽

Ju-Suk Nam ◽

Garima Sharma ◽

C. George Priya Doss ◽

...

Keyword(s):

Gene Therapy ◽

Gene Delivery ◽

Delivery System ◽

Delivery Systems ◽

Therapeutic Protein ◽

Gene Delivery System ◽

Next Generation ◽

Therapeutic Purpose ◽

Detailed Explanation ◽

Or Gene

Proteins and genes of therapeutic interests in conjunction with different delivery systems are growing towards new heights. “Next generation delivery systems” may provide more efficient platform for delivery of proteins and genes. In the present review, snapshots about the benefits of proteins or gene therapy, general procedures for therapeutic protein or gene delivery system, and different next generation delivery system such as liposome, PEGylation, HESylation, and nanoparticle based delivery have been depicted with their detailed explanation.

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Local Gene Delivery System by Bubble Liposomes and Ultrasound Exposure into Joint Synovium

Journal of Drug Delivery ◽

10.1155/2011/203986 ◽

2011 ◽

Vol 2011 ◽

pp. 1-7 ◽

Cited By ~ 13

Author(s):

Yoichi Negishi ◽

Yuka Tsunoda ◽

Yoko Endo-Takahashi ◽

Yusuke Oda ◽

Ryo Suzuki ◽

...

Keyword(s):

Gene Expression ◽

Gene Transfer ◽

Gene Delivery ◽

Delivery System ◽

Imaging System ◽

Effective Means ◽

Gene Delivery System ◽

Highly Efficient ◽

Efficient Gene

Recently, we have developed novel polyethylene glycol modified liposomes (bubble liposomes; BL) entrapping an ultrasound (US) imaging gas, which can work as a gene delivery tool with US exposure. In this study, we investigated the usefulness of US-mediated gene transfer systems with BL into synoviocytes in vitro and joint synovium in vivo. Highly efficient gene transfer could be achieved in the cultured primary synoviocytes transfected with the combination of BL and US exposure, compared to treatment with plasmid DNA (pDNA) alone, pDNA plus BL, or pDNA plus US. When BL was injected into the knee joints of mice, and US exposure was applied transcutaneously to the injection site, highly efficient gene expression could be observed in the knee joint transfected with the combination of BL and US exposure, compared to treatment with pDNA alone, pDNA plus BL, or pDNA plus US. The localized and prolonged gene expression was also shown by an in vivo luciferase imaging system. Thus, this local gene delivery system into joint synovium using the combination of BL and US exposure may be an effective means for gene therapy in joint disorders.

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