The convenient aqueous synthesis and biological evaluation of ortho-(3,4,5-trimethoxybenzoyl)-acetanilides as novel anti-cancer agents

RSC Advances ◽  
2014 ◽  
Vol 4 (78) ◽  
pp. 41510-41520 ◽  
Author(s):  
Jianfei Sheng ◽  
Fei Mao ◽  
Jun Yan ◽  
Ling Huang ◽  
Xingshu Li
Keyword(s):  
Polyethylene Glycol ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Biological Evaluation ◽  
Pd Catalyst ◽  
Aqueous Synthesis ◽  
Mild Conditions ◽  
Cross Coupling Reaction ◽  
Anti Cancer ◽  
Synthesis And Biological Evaluation

A series of new ortho-(3,4,5-trimethoxybenzoyl)-acetanilides were synthesised by the cross-coupling reaction catalyzed with Pd catalyst in aqueous medium, with polyethylene glycol as additive under very mild conditions.

scholarly journals Synthesis and Biological Evaluation of Novel 2-Substituted ­Analogues of (–)-Pentenomycin I

Synlett ◽  
2020 ◽  
Vol 31 (05) ◽  
pp. 475-481
Author(s):  
Stavroula A. Zisopoulou ◽  
Spyridon Bousis ◽  
Jörg Haupenthal ◽  
Jennifer Herrmann ◽  
Rolf Müller ◽  
...  
Keyword(s):  
Natural Product ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Eukaryotic Cell ◽  
Biological Evaluation ◽  
Gram Positive Bacteria ◽  
Cross Coupling Reaction ◽  
Palladium Catalyzed ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of

A library of novel 2-substituted derivatives of the antibiotic natural product pentenomycin I is presented. The new collection of analogues is divided in two main classes, 2-alkynyl- and 2-aryl- derivatives, which are accessed by the appropriate type of palladium-catalyzed cross-coupling reaction of the 2-iodo-protected pentenomycin I with suitable nucleophiles. The new derivatives were tested for their activity against certain types of bacteria and one of them, compound 8h, was found to exhibit significant inhibitory activity against several Gram-positive bacteria but also displayed cytotoxic activity against eukaryotic cell lines.

Synthesis of 2-Substituted Pyrimidines via Cross-Coupling Reaction of Pyrimidin-2-yl Sulfonates with Nucleophiles in Polyethylene Glycol 400

Synlett ◽  
2010 ◽  
Vol 2010 (11) ◽  
pp. 1657-1660 ◽  
Author(s):  
Xi-Cun Wang ◽  
Guo-Jun Yang ◽  
Zheng-Jun Quan ◽  
Peng-Yan Ji ◽  
Jun-Ling Liang ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Polyethylene Glycol 400 ◽  
Cross Coupling Reaction

scholarly journals A New Heterogeneous Catalyst Obtained via Supramolecular Decoration of Graphene with a Pd2+ Azamacrocyclic Complex

Molecules ◽  
2019 ◽  
Vol 24 (15) ◽  
pp. 2714 ◽  
Author(s):  
Matteo Savastano ◽  
Paloma Arranz-Mascarós ◽  
Maria Paz Clares ◽  
Rafael Cuesta ◽  
Maria Luz Godino-Salido ◽  
...  
Keyword(s):  
Heterogeneous Catalyst ◽  
Self Assembly ◽  
Room Temperature ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Assembly Process ◽  
Efficient Catalyst ◽  
Mild Conditions ◽  
Cross Coupling Reaction ◽  
Green Procedure

A new G-(H2L)-Pd heterogeneous catalyst has been prepared via a self-assembly process consisting in the spontaneous adsorption, in water at room temperature, of a macrocyclic H2L ligand on graphene (G) (G + H2L = G-(H2L)), followed by decoration of the macrocycle with Pd2+ ions (G-(H2L) + Pd2+ = G-(H2L)-Pd) under the same mild conditions. This supramolecular approach is a sustainable (green) procedure that preserves the special characteristics of graphene and furnishes an efficient catalyst for the Cu-free Sonogashira cross coupling reaction between iodobenzene and phenylacetylene. Indeed, G-(H2L)-Pd shows an excellent conversion (90%) of reactants into diphenylacetylene under mild conditions (50 °C, water, aerobic atmosphere, 14 h). The catalyst proved to be reusable for at least four cycles, although decreasing yields down to 50% were observed.

Microwave-accelerated Suzuki cross-coupling reaction in polyethylene glycol (PEG)

2001 ◽  
Vol 3 (3) ◽  
pp. 146-148 ◽  
Author(s):  
Vasudevan V. Namboodiri ◽  
Rajender S. Varma
Keyword(s):  
Polyethylene Glycol ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Cross Coupling Reaction

scholarly journals Pd(CH3CN)2Cl2/Pipecolinic Acid as a Highly Efficient Catalytic System for Suzuki-Miyaura Cross-coupling Reaction of Bromoaryl Carboxylic Acids in Water

Catalysts ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 86 ◽  
Author(s):  
Xiaogang Li ◽  
Wenbin Zhang ◽  
Leiqing Fu ◽  
Mengping Guo
Keyword(s):  
Catalytic System ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Catalytic Performance ◽  
High Turnover ◽  
Mild Conditions ◽  
Highly Efficient ◽  
Cross Coupling Reaction ◽  
Pipecolinic Acid ◽  
Excellent Catalytic Performance

In this study, a convenient and highly efficient catalytic system for the Suzuki-Miyaura coupling reaction was investigated under mild conditions. A combination of Pd(CH3CN)2Cl2 and pipecolinic acid showed excellent catalytic performance and afforded high turnover numbers; turnover numbers were up to 4.9 × 105 for the coupling reaction of 4-bromobenzoic acid and tetraphenylboron sodium. The catalytic system was also effective for the indexes of 4-bromobenzoic acid, and high turnover numbers were obtained.

Pd/APN-Mn(BTC) as novel, highly efficient, and recyclable catalyst for Suzuki–Miyaura cross coupling reaction

2020 ◽  
Vol 98 (8) ◽  
pp. 445-452
Author(s):  
Hamid Aliyan ◽  
Razieh Fazaeli
Keyword(s):  
Palladium Nanoparticles ◽  
Metal Organic Framework ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Analytical Techniques ◽  
Mild Conditions ◽  
Cross Coupling Reaction ◽  
Highly Dispersed ◽  
Metal Organic ◽  
Adsorption Desorption

A novel, heterogeneous, and bifunctional metal organic framework containing palladium and manganese, Pd/APN-Mn(BTC), has been prepared and completely characterized using FTIR, XRD, SEM-EDS, N2 adsorption–desorption, TG-DTG, NH3-TPD, and ICP analytical techniques. The APN-Mn(BTC) framework has been shown to be a useful platform for the stabilization and support of palladium nanoparticles (Pd NPs). Very effective catalytic activity has been exhibited by the highly dispersed Pd particles, Pd-NPs/APN-Mn(BTC), in the Suzuki–Miyaura cross-coupling reaction with reasonable to excellent reaction yields under mild conditions in H2O–ethanol solvent.

Selective remote esterification of 8-aminoquinoline amides via copper(ii)-catalyzed C(sp2)–O cross-coupling reaction

2017 ◽  
Vol 15 (3) ◽  
pp. 531-535 ◽  
Author(s):  
Chengcai Xia ◽  
Kai Wang ◽  
Jun Xu ◽  
Chao Shen ◽  
Di Sun ◽  
...  
Keyword(s):  
Copper Catalyst ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Mild Conditions ◽  
Cross Coupling Reaction

The remote C–O coupling of quinoline amides at the C5 position has been established using cheap and readily available copper catalyst under mild conditions.

Synthesis of aromatic β-keto esters via a carbonylative Suzuki–Miyaura coupling reaction of α-iodo esters with arylboronic acids

2015 ◽  
Vol 2 (9) ◽  
pp. 1085-1087 ◽  
Author(s):  
Shuhei Sumino ◽  
Takahito Ui ◽  
Ilhyong Ryu
Keyword(s):  
Coupling Reaction ◽  
Cross Coupling ◽  
Catalytic Amount ◽  
Pd Catalyst ◽  
Arylboronic Acids ◽  
Keto Esters ◽  
Cross Coupling Reaction ◽  
Alkyl Iodides

Aromatic β-keto esters were synthesized via a carbonylative cross-coupling reaction of alkyl iodides and arylboronic acids in the presence of a catalytic amount of Pd catalyst.

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