Ormosil nanoparticles as a sustained-release drug delivery vehicle

RSC Advances ◽  
2014 ◽  
Vol 4 (96) ◽  
pp. 53498-53504 ◽  
Author(s):  
Indrajit Roy ◽  
Pramod Kumar ◽  
Rajiv Kumar ◽  
Tymish Y. Ohulchanskyy ◽  
Ken-Tye Yong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Delivery Vehicle ◽  
Drug Delivery Vehicle ◽  
Release Drug ◽  
Ormosil Nanoparticles ◽  
Release Profiles

Tem images (above) and release profiles (below) of encapsulated drug from ormosil nanoparticles with small (orm-s), medium (orm-m) and large (orm-l) sizes.

Formulation Optimization of Sustained Release Resinate Microcapsules of Tramadol Hydrochloride by Using 3/2 Factorial Design

2017 ◽  
Vol 6 (2) ◽  
pp. 57
Author(s):  
Kamble Ravindra K. ◽  
Chauhan Chetan S. ◽  
Kamble Priyadarshani R. ◽  
Naruka Pushpendra S.
Keyword(s):  
Drug Delivery ◽  
Ion Exchange ◽  
Sustained Release ◽  
Factorial Design ◽  
Linear Regression Analysis ◽  
Extended Period ◽  
Multiple Linear Regression Analysis ◽  
Water Soluble ◽  
Tramadol Hydrochloride ◽  
Release Drug

The main aim of the present work was to develop the microcapsules of tramadol hydrochloride for the oral sustained release drug delivery. Tramadol hydrochloride a BCS class I drug a centrally acting synthetic analgesic was complexed with Indion 254 ion exchange resin. The microcapsules were prepared by encapsulating the prepared resinates by o/o solvent evaporation technique. In the investigation 32 full factorial design was used to investigate the joint influence of two formulation variable amount of eudragit RS 100 and plasticized PEG 400. The results of multiple linear regression analysis indicated that for obtaining a sustained release drug delivery the optimum concentrations of both the plasticizer and coating solution to be used. The factorial models were used to prepare optimized microcapsules and optimized formulations showed sustained release profiles for the extended period of more than 12 hrs. From the present investigations concluded that resinate microcapsules of highly water soluble drug can provide controlled release of drug for extended period.Key Words: Tramadol hydrochloride, ion exchange resinate, microcapsules, sustained release

scholarly journals Recent advances in intraocular sustained-release drug delivery devices

2019 ◽  
Vol 24 (8) ◽  
pp. 1694-1700 ◽  
Author(s):  
Yiqi Cao ◽  
Karen E. Samy ◽  
Daniel A. Bernards ◽  
Tejal A. Desai
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Release Drug ◽  
Recent Advances ◽  
Drug Delivery Devices

scholarly journals Application of Pickering Emulsion with Cyclodextrin as an Emulsifier to a Transdermal Drug Delivery Vehicle

2019 ◽  
Vol 42 (1) ◽  
pp. 116-122 ◽  
Author(s):  
Hiroyuki Taguchi ◽  
Haruki Tanaka ◽  
Kaname Hashizaki ◽  
Yoshihiro Saito ◽  
Makiko Fujii
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Pickering Emulsion ◽  
Delivery Vehicle ◽  
Drug Delivery Vehicle

scholarly journals Self-Assembly Mechanism of a Peptide-Based Drug Delivery Vehicle

ACS Omega ◽  
2018 ◽  
Vol 3 (3) ◽  
pp. 3143-3155 ◽  
Author(s):  
Gopal Pandit ◽  
Karabi Roy ◽  
Umang Agarwal ◽  
Sunanda Chatterjee
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Delivery Vehicle ◽  
Drug Delivery Vehicle ◽  
Assembly Mechanism
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