pH-responsive cancer-targeted selenium nanoparticles: a transformable drug carrier with enhanced theranostic effects

2014 ◽  
Vol 2 (33) ◽  
pp. 5409-5418 ◽  
Author(s):  
Bo Yu ◽  
Xiaoling Li ◽  
Wenjie Zheng ◽  
Yanxian Feng ◽  
Yum-Shing Wong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Ph Responsive ◽  
Cell Organelles ◽  
Shape Transformation ◽  
Anticancer Efficacy

A cancer-targeted and structure-transformable drug delivery system has been constructed, which displays enhanced anticancer efficacy and exhibits the characteristics of shape transformation and pH-controlled drug release under acidifying cell organelles.

scholarly journals Carboxymethyl cellulose-grafted graphene oxide for efficient antitumor drug delivery

2018 ◽  
Vol 7 (4) ◽  
pp. 291-301 ◽  
Author(s):  
Zepeng Jiao ◽  
Bin Zhang ◽  
Chunya Li ◽  
Weicong Kuang ◽  
Jingxian Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carboxymethyl Cellulose ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Tumor Growth Inhibition

Abstract A drug delivery system based on carboxymethyl cellulose-grafted graphene oxide loaded by methotrexate (MTX/CMC-GO) with pH-sensitive and controlled drug-release properties was developed in this work. CMC was grafted on graphene oxide by ethylenediamine through hydrothermal treatment. CMC serves as a pH-sensitive trigger, while CMC-GO serves as a drug-carrying vehicle due to the curved layer and large plain surface. Different amounts of drugs could be loaded into CMC-GO nanocarriers by control of the original amount of drug/carrier ratios. Additionally, low cytotoxicity against NIH-3T3 cells and low in vivo toxicity was observed. In vivo tumor growth inhibition assays showed that MTX/CMC-GO demonstrated superior antitumor activity than free MTX against HT-29 cells. Moreover, prolonged survival time of mice was observed after MTX/CMC-GO administration. The MTX/CMC-GO drug delivery system has a great potential in colon cancer therapy.

Development of biodegradable polyesters based on a hydroxylated coumarin initiator towards fluorescent visible paclitaxel-loaded microspheres

2019 ◽  
Vol 7 (14) ◽  
pp. 2261-2276 ◽  
Author(s):  
Yufei Bian ◽  
Zhiyong Wei ◽  
Zefeng Wang ◽  
Zhu Tu ◽  
Liuchun Zheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Physical Properties ◽  
Drug Delivery System ◽  
Delivery System ◽  
Controlled Drug Release ◽  
Biodegradable Polyesters ◽  
Biomedical Field

A facile method of end-functionalization was used to synthesize a series of fluorescent biodegradable polyesters with tailorable physical properties, which can promisingly be applied in the biomedical field as a controllable and traceable drug delivery system, especially for long-term controlled drug release.

A pH-responsive AIE nanoprobe as a drug delivery system for bioimaging and cancer therapy

2015 ◽  
Vol 3 (37) ◽  
pp. 7401-7407 ◽  
Author(s):  
Haibo Wang ◽  
Gongyan Liu ◽  
Shihua Dong ◽  
Junjie Xiong ◽  
Zongliang Du ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cellular Imaging ◽  
Ph Responsive ◽  
Triggered Drug Release

A multifunctional drug delivery system with AIE character was designed and constructed for simultaneous cellular imaging and pH-triggered drug release.

Synthesis of lipid–black phosphorus quantum dot bilayer vesicles for near-infrared-controlled drug release

2018 ◽  
Vol 54 (47) ◽  
pp. 6060-6063 ◽  
Author(s):  
Shengyong Geng ◽  
Lie Wu ◽  
Haodong Cui ◽  
Wenyong Tan ◽  
Tianfeng Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Drug Release ◽  
Quantum Dot ◽  
Drug Delivery System ◽  
Delivery System ◽  
Near Infrared ◽  
Controlled Drug Release ◽  
Black Phosphorus ◽  
Black Phosphorus Quantum Dots

Black phosphorus quantum dots are incorporated into liposomal bilayers to produce a drug delivery system with excellent near-infrared (NIR) photothermal properties and drug release capability controlled by light.

Polymer–paclitaxel conjugates based on disulfide linkers for controlled drug release

RSC Advances ◽  
2015 ◽  
Vol 5 (10) ◽  
pp. 7559-7566 ◽  
Author(s):  
Wulian Chen ◽  
Luqman Ali Shah ◽  
Li Yuan ◽  
Mohammad Siddiq ◽  
Jianhua Hu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Diblock Copolymer ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Controlled Drug Delivery System ◽  
Disulfide Linkers ◽  
Covalently Linked

Controlled drug delivery system based on hydrophilic diblock copolymer covalently linked paclitaxel (PTX) via a disulfide linker.

scholarly journals pH-Sensitive N-doped carbon dots–heparin and doxorubicin drug delivery system: preparation and anticancer research

RSC Advances ◽  
2017 ◽  
Vol 7 (15) ◽  
pp. 9347-9356 ◽  
Author(s):  
Ming Zhang ◽  
Ping Yuan ◽  
Ninglin Zhou ◽  
Yutian Su ◽  
Maoni Shao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carbon Dots ◽  
Drug Carrier ◽  
Ph Sensitive ◽  
Triggered Drug Release ◽  
Model Drug ◽  
Doped Carbon Dots

In this study, doxorubicin (DOX) hydrochloride as a model drug, N-doped carbon dots as a drug carrier, and heparin as an auxiliary medicine were selected to design and prepare a multi-functional drug delivery system with pH-triggered drug release.

Dual-functional SFP/PAN based nano drug release system for treatment and nutrients

2021 ◽  
pp. 004051752098809
Author(s):  
Ling Han ◽  
Yingbo Ma ◽  
Hao Dou ◽  
Wei Fan
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Controlled Drug Release ◽  
Order Kinetic ◽  
Antimicrobial Drugs ◽  
Dual Functional ◽  
Nano Drug Delivery

Nano drug delivery systems can control the ordered release of drugs. To achieve the target of supplying therapeutics and nutrients at the same time, a novel nano drug delivery system with a core–shell structure was prepared by coaxial electrospinning. Polyacrylonitrile (PAN) has been used to produce a drug release scaffold in the shell section, mixed with absorbable silk fibroin peptide (SFP) as a nutrient. Ciprofloxacin (CPFX), a broad-spectrum antibiotic, was used as the core, as well as an antibacterial agent. Owing to its low molecular weight, using a pure SFP thin solution to manufacture nanofibers by electrospinning is still technically challenging. Thus, different ratios of PAN to SFP were used in the shell electrospinning solution. In this research, a novel nano dual-functionality drug delivery system has been successfully prepared. In vitro testing demonstrated that nanofibers could supply more nutrients with increasing SFP in shell solutions; however, the ability to maintain controlled release was reduced. It was found that the nanofiber membrane had the best controlled drug release capability for a PAN-to-SFP mass ratio of 95:5. Overall, most ciprofloxacin was released in the first 12 h, while the release of SFP was constant throughout the first 24 h. Our modeling demonstrated that the release of CPFX and SFP is best described using a first-order kinetic model. The developed drug delivery system is designed to release antimicrobial drugs in a controlled manner and provide absorbable nutrients simultaneously.

Smart mesoporous silica nanoparticles gated by pillararene-modified gold nanoparticles for on-demand cargo release

2016 ◽  
Vol 52 (95) ◽  
pp. 13775-13778 ◽  
Author(s):  
Xin Wang ◽  
Li-Li Tan ◽  
Xi Li ◽  
Nan Song ◽  
Zheng Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Release ◽  
On Demand

A new drug delivery system, based on mesoporous silica nanoparticles gated by carboxylatopillar[5]arene-modified gold nanoparticles, has been fabricated for controlled drug release.

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