Safety evaluation and antihyperlipidemia effect of aqueous extracts from fermented puerh tea

2016 ◽  
Vol 7 (6) ◽  
pp. 2667-2674 ◽  
Author(s):  
Ping Xu ◽  
Le Ying ◽  
Jing Wu ◽  
Dedong Kong ◽  
Yuefei Wang
Keyword(s):  
Micronucleus Test ◽  
Safety Evaluation ◽  
Aqueous Extracts ◽  
Test Mouse ◽  
Mouse Sperm ◽  
Feeding Study ◽  
Acute Toxicity Study ◽  
Sperm Abnormality ◽  
Rats And Mice ◽  
Oral Acute Toxicity

In the present paper, a safety evaluation of aqueous extracts from fermented puerh tea (EFPT) was performed, including an oral acute toxicity study in rats and mice, mutation tests, a mouse micronucleus test, mouse sperm abnormality test and a 30 day feeding study in rats.

Safety assessment of the fermented Phylloporia ribis (Lonicera japonica Thunb.) mycelia by oral acute toxicity study in mice and 90-day feeding study in rats

2014 ◽  
Vol 69 ◽  
pp. 18-24 ◽  
Author(s):  
Lianhua Lu ◽  
Yiou Fan ◽  
Wenhuan Yao ◽  
Wei Xie ◽  
Jie Guo ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Safety Assessment ◽  
Toxicity Study ◽  
Lonicera Japonica ◽  
Feeding Study ◽  
Acute Toxicity Study ◽  
Oral Acute Toxicity

scholarly journals Evaluation on Genotoxicity and Teratogenicity of Aqueous Extract fromCyclocarya paliurusLeaves

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Lihong Deng ◽  
Jiandu Lei ◽  
Jing He ◽  
Jing Liu ◽  
Luying Wang ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Aqueous Extract ◽  
Ames Test ◽  
Micronucleus Test ◽  
Drug Formulation ◽  
Aqueous Extracts ◽  
Tea Tree ◽  
Sperm Abnormality ◽  
Treatment Of Hypertension ◽  
Embryo Toxicity

Tremendous attentions have been attracted to the foods labeled with natural, green, organic, and nuisanceless conception of healthy diet. Therefore, it is of great significance to establish relative defining guidance for safe assessment of botanicals.Cyclocarya paliurus(Batal.) Iljinsk (family Cyclocaryaceae), called sweet tea tree, is a well-known edible and medicinal plant, which has been widely used in China as drug formulation for the treatment of hypertension and diabetes. Despite its benefits, no reports have been described on the safe assessment ofC. paliurusleaves aqueous extract. In this study, we have conducted the genotoxicity assay (including Ames test, bone marrow polychromatic erythrocyte micronucleus test, and sperm abnormality test in mice) and traditional teratogenicity assay in rats (maternal toxicity, embryo toxicity, and teratogenicity test) to assess the genetic and teratogenic safety of aqueous extracts fromC. paliurusleaves. Results of each assay show that the highest dose ofC. paliurusleaves aqueous extract is considered relatively nonmutagenic and nonteratogenic, revealing thatC. paliurusleaves possess safety and quality as a functional additional ingredient in food.

Preliminary Toxicology Evaluation of Silymarin

2014 ◽  
Vol 1049-1050 ◽  
pp. 544-546
Author(s):  
Fei Zhao ◽  
Xin Hua Li
Keyword(s):  
Bone Marrow ◽  
Acute Toxicity ◽  
Micronucleus Test ◽  
Animal Experiments ◽  
Maximum Tolerated Dose ◽  
Mouse Bone Marrow ◽  
Test Mouse ◽  
Sperm Abnormality ◽  
Grading Standards ◽  
Bone Marrow Micronucleus

Research silymarin food security through animal experiments. Acute toxicity test, mouse bone marrow micronucleus test, mice sperm abnormality test results were evaluated. Male and female mice by oral maximum tolerated dose (MTD) are more than 20.0g/kg body weight, according to the acute toxicity grading standards, which are non-toxic level. Mouse bone marrow micronucleus test, mice sperm abnormality test and genotoxicity test were negative. Showed that silymarin is a food safety component.

scholarly journals Acute and sub-acute Toxicity study of Aqueous extracts of Canscora heteroclita (L) Gilg in Rodents

2016 ◽  
Vol 8 (4) ◽  
pp. 399-410 ◽  
Author(s):  
Rajasekaran Aiyalu ◽  
Arivukkarasu Ramasamy
Keyword(s):  
Acute Toxicity ◽  
Toxicity Study ◽  
Aqueous Extracts ◽  
Acute Toxicity Study

Oral acute toxicity study as well as tissues oxidative stress and histopathological disorders in edible camphor administered rats

2017 ◽  
Vol 69 (2) ◽  
pp. 99-108 ◽  
Author(s):  
Oluwatobi T. Somade ◽  
Kafilat D. Adeniji ◽  
Abdul-Rahman A. Adesina ◽  
Oluremi J. Olurinde
Keyword(s):  
Oxidative Stress ◽  
Acute Toxicity ◽  
Toxicity Study ◽  
Acute Toxicity Study ◽  
Oral Acute Toxicity

Safety evaluation of E12, W8, X17, and Y9 potatoes: Nutritional evaluation and 90-day subchronic feeding study in rats

2020 ◽  
Vol 115 ◽  
pp. 104712
Author(s):  
Pushkor Mukerji ◽  
Gary W. Rudgers ◽  
Christopher Gibson ◽  
Jason M. Roper
Keyword(s):  
Safety Evaluation ◽  
Nutritional Evaluation ◽  
Feeding Study

Safety Evaluation of Zinc Threoninate Chelate

2010 ◽  
Vol 29 (4) ◽  
pp. 372-379 ◽  
Author(s):  
Xiao-bo Hu ◽  
Yi Gong ◽  
Lei Li ◽  
Shao-ping Nie ◽  
Yuan-xing Wang ◽  
...  
Keyword(s):  
Micronucleus Test ◽  
Lethal Dose ◽  
Clinical Signs ◽  
Organ Weight ◽  
Female Rats ◽  
Male Rats ◽  
Repeat Dose ◽  
Pregnant Rats ◽  
Sperm Abnormality ◽  
Daily Dose

The acute toxicity of zinc threoninate chelate was assessed. The oral lethal dose 50% (LD50) was 2710 mg/kg in female rats and 3160 mg/kg in male rats. Genotoxicity was assessed by Ames test in Salmonella typhimurium strains TA97, TA98, TA100, and TA102, by bone marrow mouse micronucleus test and a sperm abnormality test with mice. Thirty-day repeat dose toxicity study was conducted at oral daily doses of 0, 42, 169, and 675 mg/kg in rats. Teratogenicity was assessed at the same daily dose in pregnant rats by gavage. No significant changes in body weight, food consumption, organ weight, relative organ weight, hematology, blood biochemistry, histopathology, behavior, mortality, sperm abnormality, mutagenicity, and micronucleus formation were observed and no clinical signs or adverse effects were detected. Zinc threoninate chelate had no significant teratogenic effect at a daily dose of 42 mg/kg.

Studies of the Toxicological Potential of Tripeptides (L-Valyl-L-prolyl-L-proline and L-lsoleucyl-L-prolyl-L-proline): VII. Micronucleus Test of Tripeptides-Containing Casein Hydrolysate and Lactobacillus helveticus-fermented Milk Powders in Rats and Mice

2005 ◽  
Vol 24 (4_suppl) ◽  
pp. 91-96 ◽  
Author(s):  
Keiichi Matsuura ◽  
John H. Mennear ◽  
Masafumi Maeno ◽  
Bruce K. Bernard
Keyword(s):  
Bone Marrow Cells ◽  
Micronucleus Test ◽  
Casein Hydrolysate ◽  
Fermented Milk ◽  
Positive Control ◽  
Lactobacillus Helveticus ◽  
Oral Gavage ◽  
Mutagenic Potential ◽  
Polychromatic Erythrocytes ◽  
Rats And Mice

The objective of these in vivo experiments was to assess the mutagenic potential of tripeptides as reflected by the ability of the test compound to induce the formation of micronuclei in mouse polychromatic erythrocytes. The test agents used in these experiments were (1) powdered Aspergillus oryzae protease casein hydrolysate (CH) and (2) powdered Lactobacillus helveticus-fermented milk (FM). Both test agents contain two tripeptides, L-valyl-L-prolyl-L-proline (VPP) and L-isoleucyl-L-prolyl-L-proline (IPP). Male Sprague-Dawley rats (five per group) were administered doses of 0, 500, 1000, or 2000 mg (0, 3, 6, or 12 mg VPP plus IPP)/kg body weight (BW)/day CH by oral gavage for 2 days. Male CD-I mice (six per group) received a single oral gavage dose of 0, 500, 1000, or 2000 mg (0, 0.8, 1.6 or 3.3 mg VPP plus IPP)/kg BW of FM. Positive-control agents were cyclophosphamide (10 mg/kg, intraperitoneal [i.p.]) in rats and mitocycin C (2 mg/kg, i.p.) in mice. Twenty-four hours after the second dose of CH, or the dose of cyclophosphamide to rats, or FM or mitocycin C to mice, bone marrow cells were fixed and examined for the presence of polychromatic erythrocytes (PCEs) and the presence or absence of mi-cronucleated PCEs (MNPCEs). Administration of CH to rats and FM to mice produced neither changes in body weights nor signs of systemic toxicity. Similarly, neither CH nor FM caused statistically significant variations in the incidences of either PCEs or MNPCEs. Both positive-control agents caused unequivocal increases in the incidence of MNPCEs and cyclophosphamide significantly reduced the percent of rat erythrocytes appearing as PCEs. The results of these micronucleus assays conducted with either powdered CH or FM in rats and mice, respectively, show that neither form of the tripeptides possesses the potential to induce micronuclei formation in these rodent species.

Safety evaluation of yeast grown on hydrocarbons. II. One-year feeding study in rats with yeast grown on pure n-paraffins

1970 ◽  
Vol 8 (5) ◽  
pp. 499-507 ◽  
Author(s):  
A.P. de Groot ◽  
H.P. Til ◽  
V.J. Feron
Keyword(s):  
Safety Evaluation ◽  
Feeding Study ◽  
One Year
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