Galantamine-loaded PLGA nanoparticles, from nano-emulsion templating, as novel advanced drug delivery systems to treat neurodegenerative diseases

Nanoscale ◽  
2015 ◽  
Vol 7 (28) ◽  
pp. 12076-12084 ◽  
Author(s):  
C. Fornaguera ◽  
N. Feiner-Gracia ◽  
G. Calderó ◽  
M. J. García-Celma ◽  
C. Solans
Keyword(s):  
Drug Delivery ◽  
Neurodegenerative Diseases ◽  
Energy Method ◽  
Drug Delivery Systems ◽  
Plga Nanoparticles ◽  
Delivery Systems ◽  
Low Energy ◽  
Schematic Representation ◽  
Nano Emulsion ◽  
Emulsion Templating

Schematic representation of the methodology used in this study to prepare GAL-loaded PLGA nanoparticles from nano-emulsion templating: nano-emulsification using the PIC low-energy method followed by solvent evaporation.

Influence of nonionic branched-chain alkyl glycosides on a model nano-emulsion for drug delivery systems

2014 ◽  
Vol 115 ◽  
pp. 267-274 ◽  
Author(s):  
Noraini Ahmad ◽  
Roland Ramsch ◽  
Meritxell Llinàs ◽  
Conxita Solans ◽  
Rauzah Hashim ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Alkyl Glycosides ◽  
Branched Chain ◽  
Nano Emulsion

scholarly journals Cytotoxicity of targeted PLGA nanoparticles: a systematic review

RSC Advances ◽  
2021 ◽  
Vol 11 (16) ◽  
pp. 9433-9449
Author(s):  
Hock Ing Chiu ◽  
Nozlena Abdul Samad ◽  
Lizhen Fang ◽  
Vuanghao Lim
Keyword(s):  
Systematic Review ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Plga Nanoparticles ◽  
Delivery Systems ◽  
Normal Cells ◽  
Anti Cancer ◽  
Targeted Drug ◽  
Targeted Drug Delivery Systems

Targeted drug delivery systems using PLGA as a nanocarrier for anti-cancer agents to improve efficacy and reduce toxicity in normal cells.

scholarly journals An overview on topical drug delivery system – Updated review

2020 ◽  
Vol 11 (1) ◽  
pp. 368-385 ◽  
Author(s):  
Sharadha M ◽  
Gowda D V ◽  
Vishal Gupta N ◽  
Akhila A R
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Skin Permeability ◽  
Topical Drug Delivery ◽  
Drug Substances ◽  
Novel Approach ◽  
Nano Emulsion

The paper reviews an overview of a conventional and novel approach in the topical drug delivery system. Drug delivery via the skin is becoming progressively popular due to its convenience and affordability. The skin is the most important mechanical barrier to the penetration of many drug substances and acts as an ideal site to deliver the drug both locally and systemically. The topical route has been a favored route of drug administration over the last decades. Despite conventional topical drug delivery systems limits in poor retention and low bioavailability. This drawback overcomes by extensive research to develop a novel topical drug delivery systems targeting to improve the safety, efficacy and to minimize side effects. The conventional review focuses on dusting powders, poultices, plasters, lotion, liniments, solution, emulsion, suspension, colloidions, tinctures, creams, gels, ointments, pastes, suppositories, transdermal delivery systems, tapes, and gauzes and rubbing alcohol while the novel review focuses on novel gels, aerosol foams, microsponges, muco-adhesive bio-adhesives, novel vesicular carriers, nano-emulsion & nano-emulgel, protein and peptide delivery, polymers, emulsifier-free formulations and fullerenes etc. The key purpose of a topical delivery system is to enhance the skin permeability and to retain in the dermis. This review addresses a basis for further advancement and up-gradation of current techniques and technologies.

Implantable and long-lasting drug delivery systems for infectious, inflammatory, endocrine, and neurodegenerative diseases

2022 ◽  
pp. 223-248
Author(s):  
Essyrose Mathew ◽  
Sarah A. Stewart ◽  
Emilia Utomo ◽  
Eneko Larrañeta ◽  
Dimitrios A. Lamprou
Keyword(s):  
Drug Delivery ◽  
Neurodegenerative Diseases ◽  
Drug Delivery Systems ◽  
Delivery Systems

scholarly journals Challenges in Biomaterial-Based Drug Delivery Approach for the Treatment of Neurodegenerative Diseases: Opportunities for Extracellular Vesicles

2020 ◽  
Vol 22 (1) ◽  
pp. 138
Author(s):  
Asit Kumar ◽  
Lina Zhou ◽  
Kaining Zhi ◽  
Babatunde Raji ◽  
Shelby Pernell ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Neurodegenerative Diseases ◽  
Drug Delivery System ◽  
Extracellular Vesicles ◽  
Delivery System ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Therapeutic Interventions ◽  
Invasive Approach

Biomaterials have been the subject of numerous studies to pursue potential therapeutic interventions for a wide variety of disorders and diseases. The physical and chemical properties of various materials have been explored to develop natural, synthetic, or semi-synthetic materials with distinct advantages for use as drug delivery systems for the central nervous system (CNS) and non-CNS diseases. In this review, an overview of popular biomaterials as drug delivery systems for neurogenerative diseases is provided, balancing the potential and challenges associated with the CNS drug delivery. As an effective drug delivery system, desired properties of biomaterials are discussed, addressing the persistent challenges such as targeted drug delivery, stimuli responsiveness, and controlled drug release in vivo. Finally, we discuss the prospects and limitations of incorporating extracellular vesicles (EVs) as a drug delivery system and their use for biocompatible, stable, and targeted delivery with limited immunogenicity, as well as their ability to be delivered via a non-invasive approach for the treatment of neurodegenerative diseases.

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