Design, synthesis and biological evaluation of novel C3-functionalized oxindoles as potential Pim-1 kinase inhibitors

RSC Advances ◽  
2015 ◽  
Vol 5 (37) ◽  
pp. 29456-29466 ◽  
Author(s):  
Hong-bao Sun ◽  
Xiao-yan Wang ◽  
Guo-bo Li ◽  
Li-dan Zhang ◽  
Jie Liu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cancer Cell ◽  
Kinase Inhibitors ◽  
Human Cancer ◽  
Biological Evaluation ◽  
Cancer Cell Proliferation ◽  
Human Cancer Cell ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

A novel series of C3-functionalized oxindoles, 3-(2-oxo-4-phenylbut-3-en-1-ylidene) indolin-2-ones as potential Pim-1 kinase inhibitors, were designed, synthesized and investigated for inhibition of human cancer-cell proliferation.

scholarly journals Design, synthesis and biological evaluation of imidazopyridine–propenone conjugates as potent tubulin inhibitors

MedChemComm ◽  
2017 ◽  
Vol 8 (5) ◽  
pp. 1000-1006 ◽  
Author(s):  
Ibrahim Bin Sayeed ◽  
V. Lakshma Nayak ◽  
Mohd Adil Shareef ◽  
Neeraj Kumar Chouhan ◽  
Ahmed Kamal
Keyword(s):  
Antitumor Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Biological Evaluation ◽  
Human Cancer Cell ◽  
Design Synthesis ◽  
Human Cancer Cell Lines ◽  
Tubulin Inhibitors ◽  
Synthesis And Biological Evaluation

A library of imidazopyridine–propenone conjugates (8a–8u) were synthesized and evaluated for their antitumor activity against four human cancer cell lines.

Lycopene is a more potent inhibitor of human cancer cell proliferation than either α‐carotene or β‐carotene

1995 ◽  
Vol 24 (3) ◽  
pp. 257-266 ◽  
Author(s):  
Joseph Levy ◽  
Emili Bosin ◽  
Bianca Feldman ◽  
Yudit Giat ◽  
Anat Miinster ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cancer Cell ◽  
Potent Inhibitor ◽  
Human Cancer ◽  
Cancer Cell Proliferation ◽  
Human Cancer Cell ◽  
Β Carotene

Inhibitory effects of α-mangostin on mammalian DNA polymerase, topoisomerase, and human cancer cell proliferation

2013 ◽  
Vol 59 ◽  
pp. 793-800 ◽  
Author(s):  
Yoshiyuki Mizushina ◽  
Isoko Kuriyama ◽  
Tatsuo Nakahara ◽  
Yoshihito Kawashima ◽  
Hiromi Yoshida
Keyword(s):  
Cell Proliferation ◽  
Cancer Cell ◽  
Dna Polymerase ◽  
Human Cancer ◽  
Cancer Cell Proliferation ◽  
Human Cancer Cell ◽  
Inhibitory Effects

Novel phenotypes related to the breeding of purple-fruited tomatoes and effect of peel extracts on human cancer cell proliferation

2013 ◽  
Vol 72 ◽  
pp. 125-133 ◽  
Author(s):  
Andrea Mazzucato ◽  
Daniela Willems ◽  
Roberta Bernini ◽  
Maurizio E. Picarella ◽  
Enrico Santangelo ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Proliferation ◽  
Human Cancer Cell

Differential Inhibition of Human Cancer Cell Proliferation by Citrus Limonoids

2001 ◽  
Vol 40 (2) ◽  
pp. 180-184 ◽  
Author(s):  
Qingguo Tian ◽  
Edward G. Miller ◽  
Hassan Ahmad ◽  
Lili Tang ◽  
Bhimanagouda S. Patil
Keyword(s):  
Cell Proliferation ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Proliferation ◽  
Human Cancer Cell ◽  
Differential Inhibition

Pinophilins A and B, Inhibitors of Mammalian A-, B-, and Y-Family DNA Polymerases and Human Cancer Cell Proliferation

2012 ◽  
Vol 75 (2) ◽  
pp. 135-141 ◽  
Author(s):  
Yusuke Myobatake ◽  
Toshifumi Takeuchi ◽  
Kouji Kuramochi ◽  
Isoko Kuriyama ◽  
Tomomi Ishido ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cancer Cell ◽  
Human Cancer ◽  
Dna Polymerases ◽  
Cancer Cell Proliferation ◽  
Human Cancer Cell ◽  
Y Family
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